Article
Biochemistry & Molecular Biology
Juliana Domingues dos Santos Carvalho, Renata Santos Rabelo, Miriam Dupas Hubinger
Summary: The study investigated the thermal and rheological properties of methylcellulose and hydroxypropyl methylcellulose hydrogels with the addition of chitosan. The results indicated that the addition of chitosan allowed these polymers to form gels at lower temperatures, which could benefit the processing of oil carrier systems under milder thermal conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Zhenhua Xiao, Yong Liu, Junsheng Yang, Han Jiang, Liqun Tang, Heng Chen, Tao Lin Sun
Summary: The study investigated the tensile and fracture behavior of physically and chemically crosslinked HA/chitosan hydrogels at different stretch velocities. It was found that the fracture energy of highly chemically crosslinked hydrogels scales with the crack velocity as a power law relation, while the fracture energy of physically and lightly chemically crosslinked hydrogels increases with the crack velocity as a complex growth function. This indicates that the viscoelastic energy dissipation around the crack tip dominates the fracture energy of highly chemically crosslinked hydrogels, while the fracture energy of physically and lightly chemically crosslinked hydrogels is dominated by the unzipping of the polyion complex structure and viscous energy dissipation.
MECHANICS OF MATERIALS
(2021)
Review
Chemistry, Applied
Xiangquan Zeng, Weibo Jiang, He Li, Qianqian Li, Jozef L. Kokini, Zhenjiao Du, Yu Xi, Jian Li
Summary: Nowadays, food hydrogels are widely used in food processing to deliver functional components. Mesona chinensis Benth polysaccharides (MCBP), the main compounds of Mesona chinensis Benth, have been developed as stabilizers, coagulants, and binders in the food industry. However, MCBP needs to interact with other biomacromolecules to form hydrogels due to the insufficient viscosity of single MCBP solution. Researchers have prepared novel composite hydrogels by interacting MCBP with different polysaccharides. The addition of these polysaccharides significantly affects the properties of MCBP, such as pasting, gelling, textural, rheological, thermal, retrogradation, color, optical, and in vitro digestible properties. The physicochemical properties of composite hydrogels are greatly influenced by treatments like heat, urea, alkali, and salt ions, which affect the interactions between two polysaccharides. Overall, MCBP shows great potential for the development of novel functional hydrogels in the future.
FOOD HYDROCOLLOIDS
(2023)
Article
Polymer Science
Abigail K. Grosskopf, Joseph L. Mann, Julie Baillet, Hector Lopez Hernandez, Anton A. A. Autzen, Anthony C. Yu, Eric A. Appel
Summary: Designing high water content nanocomposite hydrogel materials with desired functional properties is a significant challenge. The dynamic cross-linking interactions within the polymer network can be controlled by modulating the chemical composition of the materials, leading to high extensibility and yielding of stress fluids.
Article
Polymer Science
Kalyani Prusty, Sarat K. Swain
Summary: This article discusses the synthesis of hybrid nanocomposite hydrogels for drug release, their structure, properties, and antibacterial activity.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Polymer Science
Hengwei Zhu, Suan P. Quah-Ivarson, Yugang Zhang, Andrei Fluerasu, Xiaoxi Yu, Bingqian Zheng, Xuechen Yin, Weiping Liu, Surita R. Bhatia
Summary: Passive microrheology techniques, such as dynamic light scattering (DLS) and X-ray photon correlation spectroscopy (XPCS), have become important methods for characterizing the dynamics and viscoelastic properties of soft polymeric biomaterials. This study investigated a model thermoreversible polymeric hydrogel using DLS-microrheology with different size and concentrations of polystyrene probe particles, as well as XPCS-microrheology with inorganic nanoparticles. The results showed that probe particles slightly larger than the characteristic length scale of the gel structure aligned most closely with macroscopic rheology measurements. However, larger probe particles exhibited more dominated elastic behavior, while small inorganic nanoparticles resulted in a more viscous response compared to bulk rheology. This study demonstrates the utility of passive DLS and XPCS-based microrheology for characterizing the rheological properties of complex polymeric biomaterials and emphasizes the importance of experimental design and choice of probe particles.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Ju-Zhen Yi, Kunhua Lin, Hao Wu, Xuhong Mao, Li-Ming Zhang, Liqun Yang
Summary: The hydrogel composed of CPUL-ConA was prepared with glucose-sensitivity and encapsulated acarbose effectively. The smart release of acarbose in gastrointestinal fluids was demonstrated to inhibit alpha-glucosidase activity and control blood glucose levels, with potential benefits for postprandial hyperglycemia and type 2 diabetes. Rheological analysis indicated the stability of the Acar/CPUL-ConA hydrogel under gastric and intestinal peristalsis, suggesting its potential therapeutic efficacy improvement.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Polymer Science
Zhaoyu Guo, Zhuwei Yao, Feifei Pan, Weiyu Cao
Summary: The study found that water can be used as a gel accelerator for PAN/DMSO solution, affecting the size and distribution of PAN coils through rheological testing. Dynamic light scattering testing showed that the gel accelerator can increase the average size of PAN coils and alter the mobility of PAN chains during the cooling process.
Review
Biochemistry & Molecular Biology
Ilker S. Bayer
Summary: Polymer nanofibers have high surface area for efficient transport, while hydrogels combine flexibility and customizable transport properties. Combining nanofibers with hydrogels advances biomedical applications, especially in sustained drug delivery. Nanofiber hydrogels can maintain drug release rates for days to months and are crucial for 3D or 4D printable systems.
Article
Polymer Science
Petruta Preda, Ana-Maria Enciu, Cristiana Tanase, Maria Dudau, Lucian Albulescu, Monica-Elisabeta Maxim, Raluca Nicoleta Darie-Nita, Oana Brincoveanu, Marioara Avram
Summary: This study aimed to investigate and develop amorphous and crosslinked hydrogels based on natural compounds, such as sodium alginate, aloe vera gel powder, and chitosan, for tumor spheroid formation. The results showed that adding chitosan allowed the formation of spheroids at pH 5, while low viscosity and pH 12 aloe vera gels also promoted spheroid formation. Crosslinked hydrogel variants enhanced spheroid formation efficiency.
Article
Food Science & Technology
Jingsong Zhu, Mohamed Eid, Jing Li, Fang Geng, Bin Li
Summary: This research investigates the physicochemical properties of mixtures blending konjac glucomannan (KGM) and welan gum (WL). The study analyzes the ratio and concentration effects on the rheological properties of KGM and WL mixtures. Several analytical techniques are used to determine the authenticity of the gels and a model of the interaction force is constructed to elucidate the interaction mechanism during heating. The results show that the KGM and WL mixtures exhibit pseudogel behavior, and the synergy effect is positively correlated with concentration.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Jiancheng Zhang, Da Huang, Shuifeng Liu, Zijun Yang, Xianming Dong, Hongwu Zhang, Wenhua Huang, Shuzhen Zhou, Yen Wei, Weijian Hua, Yifei Jin, Wuyi Zhou, Wenxu Zheng
Summary: The development of light-based 3D printing has revolutionized manufacturing processes in various fields. Customized materials offer advantages such as excellent precision, high repeatability, and a wide range of build materials, making them suitable for aerospace, biomedical, engineering, and other applications. However, the commonly used photoactive macromolecules suffer from limitations such as poor water solubility and high biological stimulation, hindering their widespread use in biomanufacturing. To address this, researchers have modified a natural hydrogel to create a new photocurable material with good biocompatibility and photocrosslinking activity. The resulting composite hydrogel enables rapid prototyping and high precision manufacturing, with tunable mechanical properties and swelling behavior. It has also been shown to support cell survival and proliferation, demonstrating its biocompatibility.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Sara P. Cuellar -Bermudez, Dries Bleus, Maarten A. Mees, Tom Struyf, Sanjaya Lama, Dries Vandamme, Peter Adriaensens, Roger Scherrers, Wim Thielemans, Wim Van den Ende, Ruddy Wattiez, Koenraad Muylaert
Summary: In this study, polysaccharides were isolated from an Arthrospira farm's spent culture medium and purified. These polysaccharides were rich in uronic acid, had low sulfate content, and contained various monosaccharides. The polysaccharides formed stable gel beads and exhibited stable gel properties. This research demonstrates the potential for using these recovered polysaccharides in food and biotechnological applications.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Polymer Science
Zhen Zhang, Lucian Lucia
Summary: Smart self-healing sustainable hydrogels containing soy protein polymer and/or graphene nanoplatelets were fabricated using slime chemistry, exhibiting impressive self-healing behavior and high ductility under mechanical stimuli, pH modulation, and thermo sensitivity. The synergy between SPP and GNP contributed to improved mechanical properties and heat resistance, with an unexpected reinforcing effect and enhanced resistance to gel flowability.
Article
Nanoscience & Nanotechnology
Gaia De Angelis, Viviane Lutz-Bueno, Esther Amstad
Summary: Ionically crosslinked hydrogels with metal coordination motifs have attracted researchers' interest due to their self-healing and adhesive properties. However, little is known about thin viscoelastic membranes with similar chelator-ion pair motifs. This study compares the mechanical properties of ionically crosslinked hydrogels and viscoelastic membranes, and finds that the viscoelastic membranes follow a similar trend as the hydrogels, becoming stronger with increased ion-chelator affinity. These findings enable the targeted design of self-healing, adhesive membranes with tunable mechanical properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Patrizia N. Hanieh, Jacopo Forte, Chiara Di Meo, Maria Grazia Ammendolia, Elena Del Favero, Laura Cantu, Federica Rinaldi, Carlotta Marianecci, Maria Carafa
Summary: Hyaluronic acid (HA) is a widely used biopolymer in drug delivery systems due to its biocompatibility and targeting properties. HA can be chemically modified to enhance its application, such as coating nanovesicles with cholesterol derivatives for improved targeting. Coated nanocarriers show promising features for active targeting strategies.
Article
Polymer Science
Tommasina Coviello, Franco Alhaique, Chiara Di Meo, Pietro Matricardi, Elita Montanari, Nicole Zoratto, Mario Grassi, Michela Abrami
Summary: This study investigates the effects of the addition of borax on a mixed system of Scleroglucan and guar gum. It reveals synergistic effects in terms of critical time, mesh size, and crosslinking density. The study also finds that the flexible chains of guar gum contribute to the self-healing properties of the mixed gel system.
EXPRESS POLYMER LETTERS
(2022)
Article
Pharmacology & Pharmacy
Nicole Zoratto, Laura Forcina, Roberto Matassa, Luciana Mosca, Giuseppe Familiari, Antonio Musaro, Maurizio Mattei, Tommasina Coviello, Chiara Di Meo, Pietro Matricardi
Summary: The study shows the activity of hyaluronan-cholesterol nanogels as ocular permeation enhancers, enhancing the penetration of drugs in the eye and improving bioavailability, particularly for treating anterior and posterior eye segment diseases.
Article
Instruments & Instrumentation
Sabina Di Matteo, Chiara Di Meo, Guido Carpino, Nicole Zoratto, Vincenzo Cardinale, Lorenzo Nevi, Diletta Overi, Daniele Costantini, Claudio Pinto, Elita Montanari, Marco Marzioni, Luca Maroni, Antonio Benedetti, Marco Viola, Tommasina Coviello, Pietro Matricardi, Eugenio Gaudio, Domenico Alvaro
Summary: The intrahepatic biliary epithelium plays a significant role in excreting bicarbonate in bile. Recent studies have shown that budesonide enhances the efficacy of ursodeoxycholic acid in primary biliary cholangitis patients. This study investigates the effects of dexamethasone-loaded nanohydrogels (NHs) on transport processes in the biliary epithelium and liver injury induced by experimental cholestasis. The results suggest that NHs/dex formulation could be a promising candidate for further investigation in preclinical models of cholangiopathies.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rosa Calderon-Jacinto, Pietro Matricardi, Virginie Gueguen, Graciela Pavon-Djavid, Emmanuel Pauthe, Violeta Rodriguez-Ruiz
Summary: This study focuses on the development and evaluation of a dual nanostructured lipid carrier (NLC)/Carbopol(R)-based hydrogel system for the topical delivery of curcumin to the skin. The results demonstrate that CUR-NLCs have high curcumin antioxidant activity and moderate anti-migration/proliferation effect. The dual CUR-NLC/hydrogel system shows potential application in adjuvant treatment for topical dermatological applications.
Article
Biology
Domenico Nuzzo, Pasquale Picone, Jesus Lozano Sanchez, Isabel Borras-Linares, Alessandro Guiducci, Emanuela Muscolino, Daniela Giacomazza, Tiziana Sanfilippo, Rossella Guggino, Donatella Bulone, Clelia Dispenza, Pier Luigi San Biagio, Romano Lapasin
Summary: Consumer demand for healthy food drives the manufacturing industry to search for food molecules with high nutritional value, stability, safety, and health benefits. This study focuses on characterizing biscuit dough enriched with pomegranate peel powder to support therapy for chronic inflammatory diseases of the intestinal tract.
Review
Biochemistry & Molecular Biology
Pasquale Picone, Tiziana Sanfilippo, Sonya Vasto, Sara Baldassano, Rossella Guggino, Domenico Nuzzo, Donatella Bulone, Pier Luigi San Biagio, Emanuela Muscolino, Roberto Monastero, Clelia Dispenza, Daniela Giacomazza
Summary: Alzheimer's disease is the most common neurodegenerative disorder in the elderly, characterized by senile plaques and neurofibrillary tangles. There is currently a lack of treatment options aside from symptomatic medications. This review presents research results on the use of peptides of different sizes for the treatment of Alzheimer's disease.
Article
Polymer Science
Marco Viola, Claudia Migliorini, Pietro Matricardi, Chiara Di Meo
Summary: Polyacrylic acid (PAA) is a synthetic homopolymer with rheological and mucoadhesive properties, making it important in pharmaceutical and cosmetic fields. It can be modified to create new derivatives with enhanced and tuned properties, such as block copolymers, cross-linked gels, and amphiphilic polymers. This study reports the preparation and characterization of a novel water-soluble polymer with amphiphilic properties, achieved through functionalization with cholesterol moieties. The polymer also shows potential in improving the solubility of poorly water-soluble drug molecules.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Pauline Marie Chichiricco, Pietro Matricardi, Bruno Colaco, Pedro Gomes, Christine Jerome, Julie Lesoeur, Joelle Veziers, Gildas Rethore, Pierre Weiss, Xavier Struillou, Catherine Le Visage
Summary: In recent years, multicomponent hydrogels, such as interpenetrating polymer networks (IPNs), have gained attention as innovative biomaterials due to their synergistic combination of properties. This study explores an innovative non-animal IPN hydrogel that combines self-setting silanized hydroxypropyl methylcellulose (Si-HPMC) with photochemically cross-linkable dextran methacrylate (DexMA) as a potential alternative to porcine collagen membranes in guided bone regeneration. Results showed that the IPN hydrogel exhibited improved physicochemical properties and instant gel formation under visible light. The cytocompatibility and mineral deposition in critical-size defects were comparable to the positive control, demonstrating the potential of this IPN hydrogel as an alternative to animal-derived collagen membranes.
BIOENGINEERING-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Celeste Caruso Bavisotto, Alessia Provenzano, Rosa Passantino, Antonella Marino Gammazza, Francesco Cappello, Pier Luigi San Biagio, Donatella Bulone
Summary: Similar to GroEL, Hsp60 is a folding machine that can stabilize aggregation-prone molecules by a holding-like mechanism. This study investigated the relationship between the oligomeric conformation of Hsp60 and its ability to inhibit fibrillization of Ab40 peptide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Ju Wang, Marco Viola, Claudia Migliorini, Luca Paoletti, Silvia Arpicco, Chiara Di Meo, Pietro Matricardi
Summary: Nanocarriers, particularly polysaccharide-based nanogels, offer great potential as drug delivery systems to overcome biological barriers and enhance treatment efficacy.
Article
Engineering, Biomedical
Marco Viola, Claudia Migliorini, Fabio Ziarelli, Stephane Viel, Claudia Cencetti, Daniel Di Risola, Luciana Mosca, Laura Masuelli, Pietro Matricardi, Chiara Di Meo
Summary: The novel amphiphilic polyacrylate grafted with cholesterol moieties, PAAbCH, has been extensively characterized and investigated, showing promising potential as an innovative excipient. It can enhance drug solubility, viscosity, and emulsifying properties, and forms stable hydrogel complexes with chitosan.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
