Review
Pharmacology & Pharmacy
Dan Li, Yu Long, Shuang Yu, Ai Shi, Jinyan Wan, Jing Wen, Xiaoqiu Li, Songyu Liu, Yulu Zhang, Nan Li, Chuan Zheng, Ming Yang, Lin Shen
Summary: Ligusticum chuanxiong (CX) is a traditional herbal medicine that has been used for over 2000 years in Japanese, Korean, and other traditional medicine. This article provides a systematic summary of its material basis, molecular mechanism, and clinical efficacy in the treatment of cardiovascular diseases, highlighting its pharmacological effects and multi-target therapeutic effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yihan Qin, Fangfang Chen, Zizhong Tang, Hongjiao Ren, Qing Wang, Nayu Shen, Wenjie Lin, Yirong Xiao, Ming Yuan, Hui Chen, Tongliang Bu, Qingfeng Li, Lin Huang
Summary: Ligusticum chuanxiong (CX) is a medicinal and edible plant known for its antioxidant, anti-aging, and neuroprotective effects. This study explored the effects of CX leaves (CXL) and rhizome (CXR) extracts on oxidative stress, lifespan, and neuroprotection. The results showed that CX extracts protected against oxidative stress, extended lifespan, reduced lipofuscin and reactive oxygen species accumulation, and improved movement and antioxidant enzyme activity in C. elegans. Specifically, only CXR reduced beta-amyloid peptide-induced paralysis and improved chemosensory behavior dysfunction. The mechanisms behind the anti-aging effects of CXL and CXR involved the expression of antioxidant pathway genes and the reduction of ROS accumulation, which depended on DAF-16 and HSF-1. These findings provide a basis for the development of functional foods and drugs to alleviate aging and AD symptoms.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Jing Zuo, Tian-Hao Zhang, Cheng Peng, Bin-Jie Xu, Ou Dai, Yan Lu, Qin-Mei Zhou, Liang Xiong
Summary: Chuanxiong essential oil alleviates neuroinflammation through the NF-kappa B signaling pathway, providing a theoretical foundation for the clinical application of Chuanxiong essential oil in migraine treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Zhanling Zhang, Lele Zhong, Wanting Xiao, Yaping Du, Guiqi Han, Zhuyun Yan, Dongmei He, Chuan Zheng
Summary: In this study, we investigated the physiological and transcriptomic responses of Ligusticum chuanxiong plants to cadmium (Cd) stress. Cd stress inhibited biomass accumulation and root development, while activating the antioxidant system in L. chuanxiong. Root tissues were the primary site of Cd accumulation, with Cd being distributed in the soluble fraction and cell wall. Transcriptomic analysis revealed downregulation of differential genes involved in photosynthetic pathways under Cd stress, while the plant hormone signaling pathway and the antioxidant system exhibited positive responses. The upregulation of differential genes related to cell wall modification suggested a potential mechanism for enhancing root cell wall capabilities in isolating and sequestering Cd. Specific metal transport proteins, including ATPases, MSR2, and HAM3, played significant roles in Cd movement within the plant.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Kan Zhang, Kai-Li Fang, Tian Wang, Lin-Tao Xu, Yu Zhao, Xiao-Ning Wang, Lan Xiang, Tao Shen
Summary: The study identified two new phthalides from Ligusticum chuanxiong rhizome, with twelve compounds showing potential Nrf2 activating activity, and levistolide A (LA) demonstrating promising therapeutic effects for diabetic nephropathy.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Multidisciplinary Sciences
Wanting Xiao, Zhanling Zhang, Hai Wang, Guiqi Han, Zhu-Yun Yan, Dongmei He
Summary: The cultivation of Ligusticum chuanxiong Hort. in different regions and transplantation to the same region showed significant differences in plant performance and changes in endophytic bacteria. The community structure of endophytic bacteria in L. chuanxiong after transplantation was related to the bacterial community in soils. Furthermore, the accumulation of potentially beneficial Actinobacteriota in L. chuanxiong in mountainous areas may be an important factor in promoting germplasm rejuvenation.
Article
Plant Sciences
Lei Kang, Dongmei He, Hai Wang, Guiqi Han, Hongyang Lv, Wanting Xiao, Zhanling Zhang, Zhuyun Yan, Luqi Huang
Summary: Transplanting Ligusticum chuanxiong from dam areas to mountains increases the diversity and richness of endophytic fungi, with significant changes observed in the endophytic fungus structure as a result of remote transplantation. Cultivation in mountainous areas isolates more fungi that can promote plant growth and development, enhancing plant activity.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Energy & Fuels
Yao Wen, Xiang Zeng, Huijia Dai, Bing Liu
Summary: The purpose of this research was to optimize the extraction process of total flavonoids from Ligusticum chuanxiong and evaluate its biological activity. The flavonoid components were extracted using ultrasonic assisted method and the best extraction process was determined using response surface methodology. The obtained extracts were purified and their hypoglycemic and antioxidant levels were measured. The total flavonoids exhibited high levels of inhibition against certain enzymes and radicals, and the activity was further increased after purification.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Plant Sciences
Xin Yu, Jun-Hong Chai, Xiang-Wen Kong, Chen-Xi Bai, Jun Liang, Hai-Xue Kuang, Yong-Gang Xia
Summary: The study investigates the Yin-Jing effects of Ligusticum chuanxiong Hort. (LC) through pharmacokinetics and tissue distributions. It found that LC has the function of guiding components into brain tissues and Fr. B and Fr. C are suggested to be the pharmacodynamic material basis for the Yin-Jing effect of LC. This research provides a certain foundation for further study on the Yin-Jing efficacy of LC.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Applied
Jie Wang, Lei Wang, Hui Zhou, Xiao-dong Liang, Meng-tian Zhang, Ying-xue Tang, Ji-hui Wang, Jin-long Mao
Summary: Ligusticum chuanxiong, a widely used medicinal herb in traditional Chinese medicine for treating plague, has recently been incorporated into prescriptions against COVID-19. Ligusticum chuanxiong polysaccharide (LCPs) is an effective substance with various activities including anti-oxidation, immune modulation, anti-tumor, and anti-bacterial effects. This article provides a review of the isolation, purification, structural features, and biological activities of LCPs in recent years, as well as discusses the potential of LCPs against viral infections and areas for future research.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Bin Yu, Yao Yao, Xiaofeng Zhang, Ming Ruan, Zhennian Zhang, Li Xu, Tao Liang, Jinfu Lu
Summary: LCH and borneol have a complementary effect in attenuating brain ischemia, with the former promoting neural stem cell proliferation, neurogenesis, and mature neuron preservation, possibly related to astrocyte transformation, while the latter focuses on maintaining BBB integrity to support neurogenesis in a homeostatic environment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shi-Jie Wan, Han-Gui Ren, Jia-Ming Jiang, Gang Xu, Yu Xu, Si-Min Chen, Gan Chen, Dan Zheng, Man Yuan, Hong Zhang, Hong-Xi Xu
Summary: In this study, a pair of unusual epimeric lignan trimers, ligustchuanes A and B, were isolated from the rhizomes of Ligusticum chuanxiong, and their absolute configurations were determined. Ligustchuane B showed outstanding inhibitory effect on alpha-hemolysin expression in Staphylococcus aureus, and it was also demonstrated to attenuate MRSA virulence in a mouse infection model.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Qingrong Han, Fei Liu, Chengjiu Wang, Zhentao Tang, Cheng Peng, Yuzhu Tan
Summary: In recent years, there has been great attention worldwide to the quality and safety issues of Chinese medicinal herbs, especially heavy metal contamination. This study designed and synthesized a magnetic nanomaterial, Fe3O4@MIL-101(Cr)@PEG, to efficiently remove heavy metals from Ligusticum chuanxiong Hort decoction. The results showed that the nanomaterial had good removal efficiency for As5+, Cd2+, and Pb2+, with certain removal efficiency for Ni2+ and Zn2+, without significantly affecting the effective components of the decoction. This material is recommended for heavy metal removal from aqueous solutions of medicinal herbs.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yina Tang, Qingmiao Li, Chongjun Yuan, Shuai Chen, Sen Luo, Junxia Guo, Huajun Zhang, Tiezhu Chen
Summary: This study developed a rapid and accurate compound identification solution based on the chemometric method of entropy minimization algorithm. Using headspace GC-MS, the volatile chemical profiles of Chuanxiong Rhizoma (CR) and its adulterants were analyzed. The EM algorithm was proven to deliver accurate and high-confidence results, and the chemical profiles of the adulterants were distinct from that of the authentic CR.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Liu-Yan Wang, Wen-Yan Li, Hao-Feng Zhou, Xue-Yu Zhao, Xiao-Nian Li, Xing-De Wu, Qin-Shi Zhao
Summary: Two pairs of unprecedented enantiomeric phthalide dimers, spiroligustolides A and B, were isolated from the roots of Ligusticum chuanxiong. Their structures and relative configurations were determined by various analytical methods, and their absolute configurations were established through electronic circular dichroism (ECD) data. The possible biosynthetic pathway of these compounds was proposed. Furthermore, compounds 1, 1b, and 2b exhibited significant inhibitory activities on Ca(v)3.1 calcium channel.
BIOORGANIC CHEMISTRY
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)