Article
Chemistry, Medicinal
Yara Campanelli-Morais, Cynthia Haynara Ferreira Silva, Marina Rocha do Nascimento Dantas, Diego Araujo Sabry, Guilherme Lanzi Sassaki, Susana Margarida Gomes Moreira, Hugo Alexandre Oliveira Rocha
Summary: The objective of this study was to generate blends containing SPGb and ChrPic that exhibit enhanced antioxidant activity compared to SPGb or ChrPic alone. B5 was identified as the best antioxidant blend, which showed no cytotoxicity and genotoxicity. These findings suggest that B5 could be further tested in vivo to confirm its antioxidant action and potentially used as a nutraceutical agent.
Article
Biotechnology & Applied Microbiology
Jose Cirlanio Sousa Albuquerque, Marjory Lima Holanda Araujo, Maria Valderez Ponte Rocha, Bartolomeu Warlene Silva de Souza, George Meredite Cunha de Castro, Edna Maria Silva Cordeiro, Jouciane de Sousa Silva, Norma Maria Barros Benevides
Summary: The study optimized the hydrolysis conditions of G. birdiae algal biomass, finding that biomass concentration greatly affected glucose and galactose concentrations, while sulfuric acid concentration had the most impact on 5-HMF and organic acid production. The most suitable conditions for producing various compounds were determined through experimentation.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Biotechnology & Applied Microbiology
Antonia Livania Linhares de Aguiar, Marjory Lima Holanda Araujo, Norma Maria Barros Benevides, Adriano Lincoln Albuquerque Mattos, Idila Maria da Silva Araujo, Elisabeth Mary Cunha da Silva
Summary: This study evaluated the sequential extraction of R-phycoerythrin (R-PE) and agar from Gracilaria birdiae, and investigated their yield, recovery, purity index, and physicochemical characterization. Three extraction strategies were evaluated, and the most promising pigmented fractions were F25/35, F35/45, and F25/45. The agar obtained from the residue of R-PE extraction showed a high yield and similar properties to commercial agar.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Agronomy
Joseanna de Paiva Alves, Ambrosio Paula Bessa Junior, Gustavo Gonzaga Henry-Silva
Summary: This study found that the growth of Gracilaria birdiae is affected by salinity, negatively impacted by salinities equal to or below 10 ppt and equal to 60 ppt, but demonstrating good tolerance to salinities of 20, 30, 40 and 50 ppt.
Article
Polymer Science
Bilal Muhammad Khan, Li-Xin Zheng, Wajid Khan, Aftab Ali Shah, Yang Liu, Kit-Leong Cheong
Summary: This study filled the gap in the physical and chemical characterization of Gracilaria blodgettii polysaccharides, revealing its antioxidant potential and potential applications in the functional food industry.
Article
Biochemistry & Molecular Biology
Md. Akibul Hasan Bakky, Ngoc Tuan Tran, Ming Zhang, Yongsheng Zhang, Huifen Liang, Yilei Wang, Yueling Zhang, Hongyu Ma, Huaiping Zheng, Shengkang Li
Summary: This study characterized the polysaccharide from Gracilaria lemaneiformis and investigated its fermentation by rabbitfish intestinal microbes. The study found that the polysaccharide was mainly composed of galactose and anhydrogalactose, and it enhanced the production of short-chain fatty acids and altered the gut microbiota. The findings suggest that the polysaccharide has prebiotic potential and could be used as a functional feed additive in aquaculture.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Spectroscopy
Junlan Zhong, Tatsuya Mori, Takanari Kashiwagi, Midori Yamashiro, Shinji Kusunose, Hidetoshi Mimami, Manabu Tsujimoto, Teruhiko Tanaka, Hidehisa Kawashima, Shin Nakagawa, Junko Ito, Masashi Kijima, Masatoshi Iji, Makoto M. Watanabe, Kazuo Kadowaki
Summary: Paramylon is a long-chain polysaccharide that forms a helical structure and exhibits high thermal resistance and transparency for thermoplastic applications. Paramylon and paramylon-esters show unique absorption features at different frequencies, allowing for detection and identification purposes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biotechnology & Applied Microbiology
Deborah Cavalcante, Mariana Garcia, Maria Aranha, Andre Almeida, Felipe Mendes Merey, Bruno do Amaral Crispim, Alexeia Barufatti, Luciana Pisani, Gustavo Fonseca, Anna Rafaela Cavalcante Braga, Veridiana Vera de Rosso, Juliana Perobelli
Summary: The study focused on characterizing the antioxidant properties of red algae (Gracilaria birdiae) powder and investigating its potential protective effects in male rats. While in vitro tests showed potential as a food supplement, in vivo tests revealed reproductive toxicity and DNA damage. Contrary to expectations, no beneficial effects were observed in animals co-exposed to agrochemicals. These findings highlight the importance of discussing the use of food supplementation for health and regulating natural supplements.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Polymer Science
Azusa Togo, Keiko Uechi, Osamu Mizutani, Satoshi Kimura, Tadahisa Iwata
Summary: In this study, high molecular weight nigeran was extracted from mycelium and various nigeran esters were synthesized with different ester chain lengths. These nigeran esters showed unique crystallization behavior with high melting points, regardless of the length of ester groups. The molecular conformation of nigeran remained stable and highly crystalline even after chemical modification with esterification.
Article
Chemistry, Applied
Xiaoshan Long, Xiao Hu, Shucheng Liu, Chuang Pan, Shengjun Chen, Laihao Li, Bo Qi, Xianqing Yang
Summary: Gracilaria lemaneiformis polysaccharide (GLP) is a type of red algae rich in nutrients and functional components, with reported physiological activities such as regulating glycolipid metabolism, immune response, anti-tumor effects, and anti-inflammatory properties. This article summarizes the extraction, purification, structural characteristics, and physiological activities of GLP, providing a theoretical basis for future research and development.
Article
Fisheries
Gustavo Gonzaga Henry-Silva, Joseanna Alves, Dallas Flickinger, Renata Gomes-Reboucas, Ambrosio Bessa-Junior
Summary: The study evaluated the potential of a polyculture system with Pacific white shrimp and the macroalga Gracilaria birdiae to remove nutrients. Nitrogen and phosphorus concentrations initially decreased in the treatments with macroalgae, but the reduction was not sustained. The biomass of G. birdiae remained stable, possibly due to high water turbidity, and there was no economic advantage in using G. birdiae in an integrated multitrophic system with L. vannamei at high density and high water turbidity conditions.
Article
Biochemistry & Molecular Biology
Sunisa Khongthong, Yongyuth Theapparat, Natthrit Roekngam, Chinnapatch Tantisuwanno, Michael Otto, Pipat Piewngam
Summary: Sulfated galactans (SG) isolated from G. fisheri, particularly SG-1, with an estimated molecular mass of 100 kDa, activate murine macrophages via the dectin-1 signaling pathway, enhancing nitric oxide secretion and mRNA levels of pro-inflammatory cytokines. Treatment with G. fisheri SG-1 displays immune-stimulatory activities comparable to or surpassing lipopolysaccharide treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Nayonara Lanara Sousa Dutra, Tarcisio Vieira de Brito, Diva de Aguiar Magalhaes, Stefany Guimaraes Sousa, Jalles Arruda Batista, Cynthia Maria Carvalho Pereira, Jayro dos Santos Ferreira, Lauanda da Rocha Rodrigues, Jose Victor do Nascimento Lima, Ieda Figueira de Albuquerque, Roosevelt Delano S. Bezerra, Carlos Eduardo da Silva Monteiro, Alvaro Xavier Franco, Pedro Marcos Gomes Soares, David Di Lenardo, Daniel Fernando Pereira Vasconcelos, Francisco Clark Nogueira Barros, Ana Lucia Ponte Freitas, Andre Luiz dos Reis Barbosa
Summary: Marine macroalgae contain sulfated polysaccharides (PLS) with antioxidant and anti-inflammatory effects. Extracted PLS from Gracilaria caudata show therapeutic potential for UC, reducing inflammatory processes and oxidative stress in mice models.
FOOD HYDROCOLLOIDS
(2021)
Review
Polymer Science
Svetlana R. Derkach, Nikolay G. Voron'ko, Yulia A. Kuchina
Summary: This review summarizes recent advances in the study of polysaccharide-gelatin complexes, focusing on data obtained by spectroscopic methods. The discussion highlights the complexing polysaccharides of marine origin, such as sodium alginate, kappa-carrageenan, and chitosan. The prospects for creating polysaccharide-gelatin complexes with desired physicochemical properties are outlined.
Article
Food Science & Technology
Antonia Livania Linhares de Aguiar, Marjory Lima Holanda Araujo, Jessica Roberta Pereira Martins, Isabele Braga da Silva, Elisabeth Mary Cunha da Silva
Summary: This study investigated the physical-chemical characteristics and antioxidant activity of R-phycoerythrin from Gracilaria birdiae (CE-Gb), as well as its spectroscopic stability against different additives. The results showed that the antioxidant activity of R-PE was dependent on its concentration. Additionally, CE-Gb without preservatives had the highest degradation of R-PE, but the addition of ascorbic acid (AA) helped to reduce color loss during storage. G. birdiae was identified as a potential source of R-PE, which could be utilized as a dye in the food industry.
JOURNAL OF AQUATIC FOOD PRODUCT TECHNOLOGY
(2023)
Article
Chemistry, Applied
Antonia Carla de Jesus Oliveira, Luise Lopes Chaves, Fabio de Oliveira Silva Ribeiro, Lais Ramos Monteiro de Lima, Thaisa Cardoso Oliveira, Fatima Garcia-Villen, Cesar Viseras, Regina C. M. de Paula, Pedro Jose Rolim-Neto, Fernando Hallwass, Edson C. Silva-Filho, Durcilene Alves da Silva, Jose Lamartine Soares-Sobrinho, Monica Felts de la Roca Soares
Summary: Chemical modification of polysaccharides using microwave irradiation for the synthesis of phthalated cashew gum was investigated in this study, showing promising properties for improving the treatment of Chagas disease. The modified biopolymers were characterized for their structural and physicochemical properties, and the nanoparticles used for drug delivery systems exhibited specific characteristics such as size, zeta potential, and in vitro release behavior.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Lais Ramos Monteiro Lima, Everton Lucas de Lima Ramos, Maria Francilene Souza Silva, Fabio de Oliveira Silva Ribeiro, Jeanlex S. Sousa, Claudia Pessoa, Durcilene Alves Silva, Judith P. A. Feitosa, Haroldo C. B. Paula, Regina Celia Monteiro de Paula
Summary: In this study, aminated poly(N-isopropylacrylamide) was successfully grafted onto oxidized galactomannan polysaccharide from Delonix regia via Schiff base reaction. The self-organizing ability of the obtained nanoparticle copolymers was investigated, showing promising potential for drug delivery with good cell viability and transition temperature close to human body temperature. The use of free aldehyde groups in the oxidized polysaccharide for pro-drug formation with substances possessing NH2 groups was also highlighted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Environmental
Diego Alves do Vale, Claudia Brandao Vieira, Manuella Ferreira Vidal, Rayanne Leitao Claudino, Fabia Karine Andrade, Juliana Rabelo Sousa, Men de Sa Moreira Souza Filho, Andre Luis Coelho da Silva, Bartolomeu Warlene Silva de Souza
Summary: The chitosan films produced from crab residues show promising optical and mechanical properties as well as antimicrobial activity. These films have potential applications in food packaging and can serve as future biodegradable materials.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Irisvan S. Ribeiro, Francisco J. G. Pontes, Maria J. M. Carneiro, Nayara A. Sousa, Vicente P. T. Pinto, Fabio O. S. Ribeiro, Durcilene A. Silva, Gisele S. Araujo, Jose D. B. Marinho Filho, Ana J. Araujo, Haroldo C. B. Paula, Judith P. A. Feitosa, Regina C. M. de Paula
Summary: Polymer-based nanoparticles prepared in this study showed excellent drug encapsulation, controlled release performance, and biocompatibility, making them promising for drug delivery applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Lindauro C. Pereira Junior, Fernando G. Nascimento, Samara R. B. D. Oliveira, Glauber C. Lima, Francisco Diego S. Chagas, Venicios G. Sombra, Judith P. A. Feitosa, Eliane M. Soriano, Marcellus H. L. P. Souza, Guilherme J. Zocolo, Lorena M. A. Silva, Regina C. M. de Paula, Renan O. S. Damasceno, Ana Lucia P. Freitas
Summary: The study isolated and characterized a polysaccharide from the marine alga Acanthophora spicifera, which exhibited protective potential against chemically-induced gastric mucosa injury. The sulfated polysaccharide showed promising gastroprotective effects by preventing lipid peroxidation and enhancing the defense mechanisms of the gastric mucosa.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Maria J. M. Carneiro, Claudio B. A. Paula, Irisvan S. Ribeiro, Lais R. M. de Lima, Fabio O. S. Ribeiro, Durcilene A. Silva, Gisele S. Araujo, Jose D. B. Marinho Filho, Ana J. Araujo, Rosemayre S. Freire, Judith P. A. Feitosa, Regina C. M. de Paula
Summary: Stimulus-responsive nanoparticles with dextran-graft-poly (N-isopropylacrylamide) copolymers synthesized via Schiff base formation show thermal and pH dual responsiveness. Conjugation of doxorubicin to the copolymers results in nanoparticles that exhibit selective release of the drug in tumor cells, demonstrating high cytotoxicity against cancer cells and low toxicity towards non-tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Thaisa Cardoso de Oliveira, Antonia Carla de Jesus Oliveira, Yuri Basilio Gomes Patriota, Luise Lopes Chaves, Fabio de Oliveira Silva Ribeiro, Regina C. M. de Paula, Edson Cavalcanti Silva-Filho, Durcilene Alves da Silva, Monica Felts de La Roca Soares, Jose Lamartine Soares-Sobrinho
Summary: A new hydrophobic polymer based on angico gum (AG) was developed, and new nanoparticles were produced to expand the applications of natural polysaccharides in nanomedicine. By utilizing Plackett-Burman's experimental design, nanoparticles with different characteristics were successfully produced. NVP-loaded PAG nanoparticles showed significant promotion of drug release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Maria K. S. O. Abreu, Maria A. S. Silva, Dieric S. Abreu, Ana R. Richter, Regina C. M. de Paula, Vera R. L. Constantino, Igor F. Vasconcelos, Francisco G. S. de Oliveira, Acacio S. de Melo, Marcio A. Correa, Izaura C. N. Diogenes
Summary: This study improves the colloidal stability of CoFe2O4 in water media by encapsulating it in CMCG. The results show that after encapsulation, CoFe2O4 forms a polymer-caged MNPs aggregate with a negatively charged layer. Despite the dilution effect of CMCG, the material maintains magnetization.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Biochemistry & Molecular Biology
Fabio de Oliveira Silva Ribeiro, Fatima de Cassia Evangelista de Oliveira, Claudia Pessoa, Jhones do Nascimento Dias, Patricia Albuquerque, Edymilais da Silva Sousa, Sidney Goncalo de Lima, Lais Ramos Monteiro de Lima, Venicios G. Sombra, Regina Celia Monteiro de Paula, Even Herlany Pereira Alves, Daniel Fernando Pereira Vasconcelos, Darllan Damasceno Fontenele, Bruno Iles, Jand Venes Rolim Medeiros, Alyne Rodrigues de Araujo, Durcilene Alves da Silva, Jose Roberto de Souza de Almeida Leite
Summary: Lemon gum (LG) was isolated and characterized from Citrus x latifolia in Brazil. The biocompatibility of LG was evaluated in vitro and in vivo, and it showed antiproliferative activity against human prostate adenocarcinoma cancer cells. The results indicate the potential of LG for biomedical and biotechnological applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Raimundo Fernandes de Araujo Junior, George A. Lira, Timo Schomann, Romulo S. Cavalcante, Natalia Feitosa Vilar, Regina Celia Monteiro de Paula, Raelle Ferreira Gomes, Chih Kit Chung, Carla Jorquera-Cordero, Olena Vepris, Alan B. Chan, Luis J. Cruz
Summary: This study investigates the down-regulation of interaction between tumour-associated macrophages (TAMs) and colorectal cancer cells by nanoparticles (NPs) loaded with retinoic acid (RA) and coated with cholesterol (CHO), in combination with an anti-PD-L1 immune checkpoint inhibitor. The IL-10R/IL-10 axis is shown to overstimulate the STAT3 pathway and downregulate the NF-kappa B signalling pathway, leading to immunosuppression and epithelial-mesenchymal-transition of colorectal cancer. The use of RA-loaded NPs coated with CHO and anti-PD-L1 is found to be more effective in blocking this signalling pathway.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Polymer Science
Francisco das C. M. Brito, Wilton C. Lopes, Fabio O. S. Ribeiro, Raiza Raianne Luz Rodrigues, Klinger Antonio da Franca Rodrigues, Fabricio dos Santos Machado, Ana Jersia Araujo, Jose Delano Barreto Marinho Filho, Antonia Carla J. Oliveira, Edson C. S. Filho, Irisvan S. Ribeiro, Regina C. M. de Paula, Fernando Hallwass, Vicente Galber F. Viana, Durcilene A. Silva
Summary: This study modified the cashew gum through an amine reaction, which changed its molecular weight and surface charge. The amine group binding to the gum was confirmed, and cytotoxicity tests showed that the modified gum had increased thermal stability and no cytotoxic potential at concentrations below 50.0 mg/L.
Article
Chemistry, Multidisciplinary
Aline T. dos Santos, Emerson L. da Silva, Raquel C. Montenegro, Jeanlex S. de Sousa, Regina C. M. de Paula, Judith P. A. Feitosa
Summary: Copolymers of N-isopropylacrylamide (NIPAm) grafted with Dextran sulfate (DS) hold great potential for drug release, especially in targeted delivery to inflamed regions. Two different ratios of the copolymers were synthesized and confirmed using spectroscopic techniques. These copolymers demonstrated self-organization behavior in aqueous medium at temperatures above 34°C, with sizes smaller than 300 nm and spherical shapes. DS-g-3PNIPAm showed specificity to leukemic cells without affecting normal cell proliferation. Encapsulating and delivering the poorly water-soluble drug MTX using DS-g-3PNIPAm can overcome its severe side effects and improve bioactivity and stability. Among the thermo-responsive copolymers and targeted MTX nanocarriers, the DS-g-PNIPam exhibited the best performance.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Ana R. Richter, Jose G. Veras-Neto, Jeanlex S. Sousa, Josilayne F. S. Mendes, Raquel O. S. Fontenelle, Stephanie A. N. M. Silva, Jose D. B. Marinho-Filho, Ana J. Araujo, Judith P. A. Feitosa, Haroldo C. B. Paula, Francisco M. Goycoolea, Regina C. M. de Paula
Summary: This study reports the effect of acyl chain length on hydrophobized cashew gum derivatives. By using different anhydrides, the properties of nanoparticles and drug delivery were investigated, resulting in nanoparticles with desirable properties.
COLLOIDS AND INTERFACES
(2022)
Article
Chemistry, Applied
Lais R. M. Lima, Clara M. W. S. A. Cavalcante, Maria J. M. Carneiro, Josilayne F. S. Mendes, Nayara A. Sousa, Rosimeyre S. Freire, Vicente P. T. Pinto, Raquel O. S. Fontenelle, Judith P. A. Feitosa, Regina C. M. de Paula
Summary: Thermo-responsive copolymers were synthesized for loading galactomannan and antifungal drug amphotericin-B, showing good hemocompatibility and controlled release profile. The copolymer nanoparticles demonstrated effective antifungal activity with improved hemocompatibility compared to commercial amphotericin-B.
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS
(2021)
Article
Polymer Science
Carlos Pinheiro Chagas de Lima, Andreia Hansen Oster, Fabio Rossi Cavalcanti, Regina Celia Monteiro de Paula, Judith Pessoa Andrade Feitosa
Summary: The study showed that sulfated chicha gum (SCHG) can act as an effective elicitor, enhancing the activity of guaiacol peroxidase and polyphenol oxidases while increasing the lignin content in apple fruits. Plant exudate may serve as an abundant, renewable, and safe source of elicitors.
POLIMEROS-CIENCIA E TECNOLOGIA
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
