期刊
CANCER TREATMENT REVIEWS
卷 39, 期 2, 页码 180-188出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2012.03.005
关键词
Mesenchymal stem cells; Cancer; Tumor microenvironment; Tumor stroma; PI3K/Akt pathway
类别
资金
- Norwegian Cancer Society
- Norwegian Research Council
- Innovest AS
- Strategic Research Programme
- Helse-Vest
- Haukeland University Hospital
- Bergen Translational Research Program
- Centre Recherche de Public de la Sante Luxembourg
- Medical Faculty, University of Bergen
Mesenchymal (multipotent) stem/stromal cells (MSCs) may affect cancer progression through a number of secreted factors triggering activation of various cell signaling pathways. Depending on receptor status, phosphatase and tensin homolog (PTEN) status, or Wnt activation in the cancer cells, the signals may either result in increased growth and metastasis or lead to inhibition of growth with increased cell death. Thus, MSCs can play a dual role in cancer progression depending on the cellular context wherein they reside. The phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway has a central role in regulating tumor growth, and several MSC secreted factors stimulate activation of this pathway. A comprehensive understanding of the signals regulating MSC-tumor cross-talk is highly important for the development of MSCs as potential therapeutic vehicles. Thus, the presented review focuses on factors released by MSCs and on the dual role they may have on various stages of tumorigenesis. (C) 2012 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据