Article
Medicine, General & Internal
Somin Lee, Yong Yeon Jeong, Byung Chan Lee, Sang Soo Shin, Suk Hee Heo, Hyoung Ook Kim, Chan Park, Won Gi Jeong
Summary: This study compared the long-term therapeutic outcomes of drug-eluting bead transarterial chemoembolization (DEB-TACE) with radiofrequency ablation (RFA) for the initial treatment of a single small hepatocellular carcinoma (HCC). The results showed that RFA had superior local tumor progression and progression-free survival rates compared to DEB-TACE, but there was no significant difference in overall survival rates. Therefore, DEB-TACE may be considered as an efficient substitute for RFA in some patients with a single small HCC who are ineligible for RFA.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Oncology
Guangshao Cao, Yuyan Liu, Lupeng Li, Xiaoyang Zhao, Ruiqing Liu, Jian Liu, Jianwen Liu, Huicun Cao
Summary: This study compared the occurrence of adverse events (AEs) among radiofrequency ablation (RFA), conventional transarterial chemoembolization (cTACE), and drug-eluting bead TACE (DEB-TACE) in treating HCC patients. It found that cTACE resulted in the highest incidence of AEs, with male gender, bronchial asthma, and disease duration being independent predictive factors for total AEs risk.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Dong Ik Cha, Min Woo Lee, Dongho Hyun, Soo Hyun Ahn, Woo Kyoung Jeong, Hyunchul Rhim
Summary: The therapeutic outcomes of fluoroscopy-guided transarterial chemoembolization combined with radiofrequency ablation (TACE + RFA) for small hepatocellular carcinomas (HCC) were found to be comparable to those of general ultrasound (US)-guided RFA.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elisabeth Dhondt, Bieke Lambert, Laurens Hermie, Lynn Huyck, Peter Vanlangenhove, Anja Geerts, Xavier Verhelst, Maridi Aerts, Aude Vanlander, Frederik Berrevoet, Roberto Ivan Troisi, Hans Van Vlierberghe, Luc Defreyne
Summary: This study compared the efficacy and safety of Y-90 glass TARE and DEB-TACE for unresectable HCC. The results showed that TARE conferred superior tumor control and overall survival compared to DEB-TACE. Both treatments had similar safety profiles.
Article
Oncology
Wenzhe Fan, Bowen Zhu, Xinlin Zheng, Shufan Yue, Mingjian Lu, Huishuang Fan, Liangliang Qiao, Fuliang Li, Guosheng Yuan, Yanqin Wu, Xinhua Zou, Hongyu Wang, Miao Xue, Jiaping Li
Summary: This study investigated the effectiveness and safety of combining sorafenib and drug-eluting bead transarterial chemoembolization (DEB-TACE) in the treatment of early intrahepatic stage-progressed advanced hepatocellular carcinoma (ISPA-HCC). The results showed that the combination therapy significantly improved tumor response rates, overall survival, and time to progression compared to sorafenib monotherapy. However, the DTS group had a higher incidence of adverse events during treatment.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ahmed Kaml El Dorry, Mohammed Kamal Shaker, Nevien Fouad El-Fouly, Ahmed Hussien, Runia Fouad El-Folly, Amr Hafez El Fouly, Karim Abd El Tawab
Summary: The study discussed the effects of RFA followed by TACE and vice versa on objective response, overall survival, local recurrence, and tumor-free survival in the treatment of hepatic malignant tumors. Results showed that RFA/TACE demonstrated effective complete response, downstaging, disease-free survival, and overall survival.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Oncology
Lei Chen, Weihua Zhang, Tao Sun, Yanqiao Ren, Bo Sun, Licheng Zhu, Huangxuan Zhao, Chuansheng Zheng
Summary: This study compared the efficacy and safety of TACE-P and TACE-R in the treatment of patients with eiHCC. Using the propensity score matching method, it was found that the overall survival and progression-free survival were similar between the TACE-P group and the TACE-R group. Subgroup analysis showed that patients with a single tumor had worse tumor response when treated with TACE-P. There were no significant differences in adverse events between the two groups.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adrian Kobe, Lambros Tselikas, Frederic Deschamps, Charles Roux, Alexandre Delpla, Eloi Varin, Antoine Hakime, Thierry De Baere
Summary: The study aimed to evaluate the safety and efficacy of combining TACE and thermal ablation in patients with liver metastases larger than 3cm in diameter. The results showed that the treatment is safe and achieves a high local control rate in a single session.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2022)
Article
Oncology
Hao Li, Chao Liang, Donglin Kuang, Guohao Huang, Mengfan Zhang, Pengfei Chen, Qingzhu Zheng, Wenze Xu, Jianzhuang Ren, Xinwei Han, Xuhua Duan
Summary: This study evaluated the impact of drug-eluting bead transarterial chemoembolization (DEB-TACE) and conventional transarterial chemoembolization (cTACE) on hepatic fibrosis in hepatocellular carcinoma (HCC) patients. The results showed that DEB-TACE attenuates the progression of hepatic fibrosis and has comparable tolerance to cTACE in treating intermediate- or advanced-stage HCC.
CANCER BIOLOGY & THERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lei Zhang, Jun-Hui Sun, Jian-Song Ji, Bin-Yan Zhong, Guan-Hui Zhou, Jing-Jing Song, Zhong-Heng Hou, Peng Huang, Shen Zhang, Zhi Li, Xiao-Li Zhu, Cai-Fang Ni
Summary: In the treatment of unresectable HCC patients, DEB-TACE was associated with higher rates of hepatobiliary injury and severe abdominal pain compared to cTACE, while local tumor disease control rates did not differ significantly between the two approaches.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Oncology
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-Hsiang Huang, Jia- Liao, Chien-Wei Su, Ming-Chih Hou, Teh-Ia Huo
Summary: Tumor burden score (TBS), estimated by the diameter and number of tumor nodules, is a feasible prognostic marker for HCC patients within the Milan criteria. Among patients with low TBS, radiofrequency ablation (RFA) should be considered the priority treatment modality.
Article
Radiology, Nuclear Medicine & Medical Imaging
P. Hendriks, D. R. Sudiono, J. J. Schaapman, M. J. Coenraad, M. E. Tushuizen, R. B. Takkenberg, T. T. M. Oosterveer, L. F. de Geus-Oei, O. M. van Delden, M. C. Burgmans
Summary: In this retrospective cohort study, the efficacy of using thermal ablation (TA) with neoadjuvant transarterial chemoembolization (TACE) versus adjuvant TACE in the treatment of hepatocellular carcinoma (HCC) lesions was compared. The results showed no statistical differences in overall survival (OS), time to progression (TTP), and local tumor progression (LTP) between the two treatment sequences.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zachary J. Brown, D. Brock Hewitt, Timothy M. Pawlik
Summary: Unfortunately, some HCC patients are not eligible for curative treatments, making locoregional treatments like TACE crucial. Systemic therapy has advanced in the past decade, with combination atezolizumab and bevacizumab now the standard for advanced disease. Combination therapies with TACE, including systemic therapies, locoregional therapies, and immunotherapies, show promise for the management of intermediate stage HCC.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2022)
Article
Pharmacology & Pharmacy
Guangsheng Zhao, Song Liu, Songbai Chen, Zhizhong Ren, Chuang Li, Jie Bian, Jianlin Wu, Jun Zhou, Yuewei Zhang
Summary: In short-term efficacy, CalliSpheres group showed significantly higher objective response rate and disease control rate compared to the HepaSpheres group; however, there were no significant differences between the two groups in terms of long-term efficacy and safety.
Article
Oncology
Tan-Yang Zhou, Sheng-Qun Chen, Hong-Liang Wang, Sheng-Ming Weng, Guan-Hui Zhou, Yue-Lin Zhang, Chun-Hui Nie, Tong-Yin Zhu, Bao-Quan Wang, Zi-Niu Yu, Li Jing, Feng Chen, Jun-Hui Sun
Summary: This study evaluated the safety and efficacy of DEB-TACE with CSM in HCC patients with PVTT and found that higher Child-Pugh classification and tumor burden were significant prognostic factors for poor OS.
Article
Gastroenterology & Hepatology
Aldo J. Montano-Loza, Vincenzo Ronca, Maryam Ebadi, Bettina E. Hansen, Gideon Hirschfield, Saleh Elwir, Mohamad Alsaed, Piotr Milkiewicz, Maciej K. Janik, Hanns-Ulrich Marschall, Maria Antonella Burza, Cumali Efe, Ali Riza Caliskan, Murat Harputluoglu, Gokhan Kabacam, Debora Terrabuio, Fernanda de Quadros Onofrio, Nazia Selzner, Alan Bonder, Albert Pares, Laura Llovet, Murat Akyildiz, Cigdem Arikan, Michael P. Manns, Richard Taubert, Anna-Lena Weber, Thomas D. Schiano, Brandy Haydel, Piotr Czubkowski, Piotr Socha, Natalia Oldak, Nobuhisa Akamatsu, Atsushi Tanaka, Cynthia Levy, Eric F. Martin, Aparna Goel, Mai Sedki, Irena Jankowska, Toru Ikegami, Maria Rodriguez, Martina Sterneck, Christina Weiler-Normann, Christoph Schramm, Maria Francesca Donato, Ansgar Lohse, Raul J. Andrade, Vilas R. Patwardhan, Bart van Hoek, Maaike Biewenga, Andreas E. Kremer, Yoshihide Ueda, Mark Deneau, Mark Pedersen, Marlyn J. Mayo, Annarosa Floreani, Patrizia Burra, Maria Francesca Secchi, Benedetta Terziroli Beretta-Piccoli, Marco Sciveres, Giuseppe Maggiore, Syed-Mohammed Jafri, Dominique Debray, Muriel Girard, Florence Lacaille, Ellina Lytvyak, Andrew L. Mason, Michael Heneghan, Ye Htun Oo
Summary: Recurrence of autoimmune hepatitis (AIH) is common after liver transplantation, and it is associated with younger age at transplantation, the use of mycophenolate mofetil post-transplant, sex mismatch, and high pre-transplant IgG levels. Recurrent AIH is associated with impaired graft and overall survival. Better characterization, prevention, and treatment strategies are needed for the management of recurrent AIH.
JOURNAL OF HEPATOLOGY
(2022)
Article
Nutrition & Dietetics
Maryam Ebadi, Stephen Ip, Ellina Lytvyak, Somayyeh Asghari, Elora Rider, Andrew Mason, Aldo J. Montano-Loza
Summary: This study aims to investigate the prevalence of vitamin D deficiency in patients with primary biliary cholangitis (PBC) and its impact on treatment response to ursodeoxycholic acid (UDCA), development of cirrhosis, and liver-related events (mortality and liver transplantation).
Article
Surgery
Nghiem B. Ha, Aldo J. Montano-Loza, Elizabeth J. Carey, Shezhang Lin, Amy M. Shui, Chiung-Yu Huang, Michael A. Dunn, Jennifer C. Lai
Summary: This study aims to investigate the association between sarcopenic visceral obesity (SVO) and post-transplant mortality. Through analysis of patients with cirrhosis, it was found that SVO is significantly associated with increased post-transplant mortality.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Oncology
Navesh K. Sharma, S. Cheenu Kappadath, Michael Chuong, Michael Folkert, Peter Gibbs, Salma K. Jabbour, D. Rohan Jeyarajah, Andrew Kennedy, David Liu, Joshua E. Meyer, Justin Mikell, Rahul S. Patel, Gary Yang, Firas Mourtada
Summary: This article aims to develop a multidisciplinary consensus for the high-quality implementation of Yttrium-90 (90Y) microsphere brachytherapy for primary and metastatic liver cancer using transarterial radioembolization (90Y TARE). The guidelines are based on the most recent literature and clinical experience, covering indications for 90Y TARE, quality management, treatment dosimetry, and follow-up management.
Article
Gastroenterology & Hepatology
Annika Bergquist, Tobias J. Weismueller, Cynthia Levy, Christian Rupp, Deepak Joshi, Jeremy Shanika Nayagam, Aldo J. Montano-Loza, Ellina Lytvyak, Ewa Wunsch, Piotr Milkiewicz, Roman Zenouzi, Christoph Schramm, Nora Cazzagon, Annarosa Floreani, Ingalill Friis Liby, Miriam Wiestler, Heiner Wedemeyer, Taotao Zhou, Christian P. Strassburg, Eirini Rigopoulou, George Dalekos, Manasa Narasimman, Xavier Verhelst, Helena Degroote, Mette Vesterhus, Andreas E. Kremer, Bennet Buendgens, Fredrik Rorsman, Emma Nilsson, Kristin Kaasen Jorgensen, Erik von Seth, Martin Cornillet Jeannin, Nils Nyhlin, Harry Martin, Stergios Kechagias, Kristine Wiencke, Marten Werner, Benedetta Terziroli Beretta-Piccoli, Marco Marzioni, Helena Isoniemi, Johanna Arola, Agnes Wefer, Jonas Soderling, Martti Farkkila, Henrike Lenzen
Summary: This study compares different follow-up strategies in patients with PSC and finds that scheduled imaging can improve survival. There are considerable variations in follow-up strategies across centers, but multiple factors may contribute to this result.
LIVER INTERNATIONAL
(2023)
Article
Surgery
David M. Liu, Thomas W. T. Leung, Pierce K. H. Chow, David C. E. Ng, Rheun-Chuan Lee, Yun Hwan Kim, Yilei Mao, Yu-Fan Cheng, Gao-Jun Teng, Wan Yee Lau
Summary: This study provides guidance and perspectives on the use of selective internal radiation therapy (SIRT) for hepatocellular carcinoma (HCC) in Asia. Through a systematic literature review and consensus approach, experts developed guidelines and recommendations for the use of SIRT in HCC patients in Asia. The study also highlights the need for further clinical trials to define the role of SIRT in managing HCC among Asian populations.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Review
Cell Biology
Maryam Ebadi, Cynthia Tsien, Rahima A. Bhanji, Abha R. Dunichand-Hoedl, Elora Rider, Maryam Motamedrad, Vera C. Mazurak, Vickie Baracos, Aldo J. Montano-Loza
Summary: Myosteatosis, or pathological excess fat accumulation in muscle, is common in patients with cirrhosis and may be associated with reduced survival and increased complications. The mechanisms behind myosteatosis, such as hyperammonemia, insulin resistance, and impaired mitochondrial function, are still not fully understood.
Article
Cell Biology
Maryam Ebadi, Cynthia Tsien, Rahima A. Bhanji, Abha R. Dunichand-Hoedl, Elora Rider, Maryam Motamedrad, Vera C. Mazurak, Vickie Baracos, Aldo J. Montano-Loza
Summary: Myosteatosis is common in patients with cirrhosis and is associated with increased mortality. The concomitant presence of myosteatosis and sarcopenia leads to worse outcomes.
Article
Gastroenterology & Hepatology
Christophe Corpechot, Fabrice Carrat, Farid Gaouar, Frederic Chau, Gideon Hirschfield, Aliya Gulamhusein, Aldo J. Montano-Loza, Ellina Lytvyak, Christoph Schramm, Albert Pares, Ignasi Olivas, John E. Eaton, Karim T. Osman, George Dalekos, Nikolaos Gatselis, Frederik Nevens, Nora Cazzagon, Alessandra Zago, Francesco Paolo Russo, Nadir Abbas, Palak Trivedi, Douglas Thorburn, Francesca Saffioti, Laszlo Barkai, Davide Roccarina, Vicenza Calvaruso, Anna Fichera, Adele Delamarre, Esli Medina-Morales, Alan Bonder, Vilas Patwardhan, Cristina Rigamonti, Marco Carbone, Pietro Invernizzi, Laura Cristoferi, Adriaan van der Meer, Rozanne de Veer, Ehud Zigmond, Eyal Yehezkel, Andreas E. Kremer, Ansgar Deibel, Jerome Dumortier, Tony Bruns, Karsten Grosse, Georges-Philippe Pageaux, Aaron Wetten, Jessica Dyson, David Jones, Olivier Chazouilleres, Bettina Hansen, Victor de Ledinghen
Summary: In the largest ever study of LSM in patients with PBC, LSM assessed by VCTE improves prediction of survival beyond biochemical response, established prognostic scores, and age categories, independent of time. LSM can reasonably be regarded as a useful prognostic marker and a potential surrogate endpoint in PBC clinical trials.
JOURNAL OF HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jules Gregory, Lambros Tselikas, Caroline Allimant, Thierry de Baere, Irene Bargellini, Jon Bell, Jose Ignacio Bilbao, Antoine Bouvier, Julius Chapiro, Carlo Chiesa, Thomas Decaens, Alban Denys, Rafael Duran, Julien Edeline, Etienne Garin, Julien Ghelfi, Thomas Helmberger, Farah Irani, Marnix Lam, Robert Lewandowski, David Liu, Romaric Loffroy, David C. Madoff, Charles Mastier, Riad Salem, Bruno Sangro, Daniel Sze, Valerie Vilgrain, Michael Vouche, Boris Guiu, Maxime Ronot
Summary: This study aimed to define a textbook outcome (TO) for selective internal radiation therapy (SIRT) of hepatocellular carcinoma. The final TO, determined through expert opinions and an international survey, is a multidimensional standardization tool suitable for routine care, clinical round, and research.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Oncology
Pompilia Radu, Maryam Ebadi, Aldo J. Montano-Loza, Jean Francois Dufour
Summary: Recent advances have shown that body mass index is an inaccurate tool for assessing nutritional status, while body composition may serve as a non-invasive prognostic tool for patients with hepatocellular carcinoma. However, due to the heterogeneity of data, lack of prospective studies, absence of a standardized assessment method, and interpopulation variation, body composition assessment is not currently part of the standard pre-therapeutic workup.
Article
Nutrition & Dietetics
Maryam Ebadi, Elora Rider, Catherine Tsai, Sarah Wang, Ellina Lytvyak, Andrew Mason, Aldo J. Montano-Loza
Summary: This study aimed to investigate the association between severe vitamin D deficiency and disease progression, hepatobiliary malignancies, liver-related mortality, and the need for liver transplantation in primary sclerosing cholangitis (PSC). The results showed that severe vitamin D deficiency was related to an increased risk of hepatobiliary malignancies, and a severe deficiency at diagnosis and persistent deficiencies over time were independently associated with poor clinical liver outcomes.
Review
Oncology
Jason K. Wong, Howard J. Lim, Vincent C. Tam, Kelly W. Burak, Laura A. Dawson, Prosanto Chaudhury, Robert J. Abraham, Brandon M. Meyers, Gonzalo Sapisochin, David Valenti, Setareh Samimi, Ravi Ramjeesingh, Amol Mujoomdar, Ilidio Martins, Elijah Dixon, Maja Segedi, David M. Liu
Summary: This article summarizes the consensus recommendations from Canadian experts on the management of intermediate-stage hepatocellular carcinoma (HCC). Through iterative feedback cycles and online surveys, consensus statements were developed in the areas of multidisciplinary treatment, intra-arterial therapy, biologics, radiation therapy, surgical resection and transplantation, and percutaneous ablative therapy. These recommendations reflect an expansion in treatment options, increased therapeutic flexibility, and a shift towards strategies with curative intent.
CANCER TREATMENT REVIEWS
(2023)
Editorial Material
Gastroenterology & Hepatology
Maryam Ebadi, Patrizia Burra, Alberto Zanetto, Aldo J. Montano-Loza
JOURNAL OF HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Aldo J. Montano-Loza, Manuel L. Rodriguez-Peralvarez, George-Philippe Pageaux, Alberto Sanchez-Fueyo, Sandy Feng
Summary: The outcomes of liver transplantation have improved over the years, but long-term survival rates are still lower than the general population. The liver has unique immunological functions and can modulate the recipient's immune system to promote tolerance. Immunosuppressive drugs should be individualized to control alloreactivity while minimizing toxicities.
JOURNAL OF HEPATOLOGY
(2023)
