Article
Fisheries
Shanshan Zeng, Meifeng Li, Xining Cheng, Shina Lu, Zhiqing Feng, Zeyin Jiang, Zhichao Sun, Xiaowen Xu, Huiling Mao, Chengyu Hu
Summary: In this study, it was found that grass carp DYRK2 induces cell apoptosis by increasing the phosphorylation level of p53.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Cell Biology
Lian Zhang, Yujiao He, Yi Jiang, Qi Wu, Yanchen Liu, Qingqiang Xie, Yuxiu Zou, Jiaqian Wu, Chundong Zhang, Zhongjun Zhou, Xiu-Wu Bian, Guoxiang Jin
Summary: This study reveals the dual role of PRMT1-mediated RIP3 methylation in necroptotic cancer cell death and tumor immune escape. PRMT1 methylates RIP3 and inhibits its interaction with RIP1, thereby suppressing necrosome complex formation and necroptosis activation. The protein levels of PRMT1 and RIP3(ADMA) are positively correlated in cancer tissues and both serve as valuable prognostic markers for colon cancer.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Xingyan Zhang, Yaoyao Zhou, Zhenyu Shi, Zhenfeng Liu, Hao Chen, Xiaochen Wang, Yiming Cheng, Lishan Xi, Xuanyuan Li, Chunze Zhang, Li Bao, Chenghao Xuan
Summary: ATP-dependent chromatin remodelers (ATPCRs) play a crucial role in cancer, particularly in colorectal cancer, where several genes involved in chromatin organization and regulation are frequently mutated. One of these genes, chromodomain helicase DNA-binding protein 7 (CHD7), is shown to promote the growth of colorectal cancer cells by maintaining chromatin accessibility and facilitating transcription. Additionally, a CHD7-AK4-AMPK-p53 axis is identified, which plays an oncogenic role in colorectal cancer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Xiuyuan Zhang, Qijian Zheng, Xiuying Yue, Zhanna Yuan, Jiming Ling, Yanzhi Yuan, Yanying Liang, Aihua Sun, Yuchen Liu, Hui Li, Kaikun Xu, Fuchu He, Jian Wang, Jin Wu, Chunling Zhao, Chunyan Tian
Summary: This study reveals that ZNF498 is highly expressed in hepatocellular carcinoma (HCC) and is associated with advanced pathological grade and poor prognosis. ZNF498 promotes HCC initiation and progression by inhibiting p53 transcriptional activation and phosphorylation. ZNF498 also inhibits p53-mediated apoptosis and ferroptosis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Gang Wang, Li Ma, Bowen Wang, Fentang Gao, Jianfeng Li, Hongyi Cai, Juan Wang, Tiancheng Zhang, Hao Guo, Ping Xie, Yi Li
Summary: Tanshinone IIA can counteract radiation-induced myocardial injury by regulating the p38/p53 pathway, restoring cardiomyocyte proliferation and reducing cell apoptosis.
MEDIATORS OF INFLAMMATION
(2022)
Article
Chemistry, Medicinal
Jingbo Qin, Boning Niu, Xiaohui Chen, Cheng Hu, Sheng Lu, Hongsheng Li, Weihao Liu, Jiayi Li, Zihao Teng, Yinghuang Yang, Hongyu Hu, Yang Xu, Shuaidong Huo, Zhen Wu, Yingkun Qiu, Hu Zhou, Meijuan Fang
Summary: The orphan nuclear receptor Nur77 has been validated as a potential drug target for treating breast cancer. In this study, the compound ja showed improved binding capability to Nur77 and exhibited excellent antiproliferative activities against breast cancer cell lines, specifically triple-negative breast cancer cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Jia-yi Yin, Xin-tong Lu, Meng-ling Hou, Ting Cao, Zhen Tian
Summary: SIRT1 is a crucial protein that plays key roles in maintaining genome stability, gene regulation, cell proliferation, and apoptosis. It deacetylates p53 and inhibits its transcriptional activity, exerting its action on pathways related to tissue homeostasis and pathological states. The SIRT1-p53 axis is important in tumorigenesis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yei-Jin Kang, Dae-Won Kim, Xiangguo Che, Je-Yong Choi, Seong-Gon Kim
Summary: This study demonstrates that 4HR has the potential to restore the loss of function in mutant p53 cancer cells through acetylation and phosphorylation of p53 and inhibition of HDAC4.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Savinee Chanvijit, Suttinee Phuagkhaopong, Panupong Mahalapbutr, Methus Klaewkla, Warinthorn Chavasiri, Piyanuch Wonganan
Summary: The study found that Mansonone G (MG) and its derivatives exhibited concentration-dependent cytotoxicity on CRC cell lines, with allyl ether mansonone G (MG7) being the most toxic. MG7 induced ROS generation and apoptosis, and modulated protein expression and signaling pathways related to cell survival and proliferation. Molecular docking analysis revealed the potential binding of MG7 to ATP-binding pockets of AKT and ERK1 proteins.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Jinghui Liu, Yue Zhao, Daheng He, Katelyn M. Jones, Shan Tang, Derek B. Allison, Yanquan Zhang, Jing Chen, Qiongsi Zhang, Xinyi Wang, Chaohao Li, Chi Wang, Lang Li, Xiaoqi Liu
Summary: Enzalutamide (ENZA), a second-generation androgen receptor antagonist, enhances the efficacy of treatment for metastatic prostate cancer (PCa), but resistance remains a challenge. Through a CRISPR-Cas9 knockout screen, casein kinase 1a (CK1a) has been identified as a therapeutic target to overcome ENZA resistance. Inhibition of CK1a stabilizes ATM and restores DNA-damage response signaling, leading to increased cell death and growth arrest.
CELL REPORTS MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Fabiola N. Velazquez, Jeffrey L. Stith, Leiqing Zhang, Amira M. Allam, John Haley, Lina M. Obeid, Ashley J. Snider, Yusuf A. Hannun
Summary: This study suggests that targeting sphingosine kinase 1 (SK1), a key enzyme upregulated in various types of cancer, can effectively decrease tumor growth in lymphoma without functional p53. This positions SK1 as a potential therapeutic target for tumors that lack functional p53.
Article
Cell Biology
Ying-chen Xia, Jian-hua Zha, Yong-Hua Sang, Hui Yin, Guo-qiu Xu, Jie Zhen, Yan Zhang, Ben-tong Yu
Summary: Activation of AMPK by ASP4132 effectively inhibits NSCLC cell growth in vitro and in vivo, inducing apoptosis, causing mitochondrial dysfunction and autophagy. AMPK activation also leads to downstream events including mTORC1 inhibition, receptor tyrosine kinase degradation, Akt inhibition, and programmed necrosis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Lei Sun, Arpad V. Patai, Tara L. Hogenson, Martin E. Fernandez-Zapico, Bo Qin, Frank A. Sinicrope
Summary: Depletion of PD-L1 enhances JNK activity, leading to increased apoptosis and reduced chemotherapy resistance. Degradation of CYLD mRNA by EXOSC10 promotes JNK signaling pathway activation.
Article
Medicine, Research & Experimental
Francesca Benedetti, Sabrina Curreli, Robert C. Gallo, Davide Zella
Summary: Studies on tumor cell signaling mechanisms have highlighted the crucial role of kinases in carcinogenesis and cancer progression. Mycoplasmas, components of the normal human microbiota, have been associated with certain cancers and are found in the tumor microenvironment. Research indicates that Mycoplasmas can impact kinase activity, leading to dysregulation of signaling pathways involved in cancer progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Medicinal
Yun Wu, Ziping Qi, Beilei Wang, Junjie Wang, Qingwang Liu, Aoli Wang, Chenliang Shi, Bin Zhou, Qianmao Liang, Wenliang Wang, Fengming Zou, Shuang Qi, Zuowei Wang, Li Wang, Wenchao Wang, Jing Liu, Qingsong Liu
Summary: A novel, potent, and selective MST1 inhibitor 19 was discovered, which protected ss cells from inflammatory cytokines in vitro and showed potential in treating diabetes in animal models.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Yuta Imaizumi, Saishu Yoshida, Yumi Kanegae, Ken Eto, Kiyotsugu Yoshida
Summary: In colorectal cancer, the expression of DYRK2 is decreased, affecting clinical prognosis. Overexpression of DYRK2 through adenovirus-mediated gene transfer can inhibit cell proliferation and induce apoptosis, providing a potential therapy for colorectal cancer.
Review
Gastroenterology & Hepatology
Kohji Yamada, Kiyotsugu Yoshida
Summary: Protein kinase C delta (PKC delta) is a member of the PKC family and plays important roles in various biological and cancerous processes. Its function is regulated by factors such as phosphorylation and subcellular localization. Recent studies have found its unique extracellular localization and growth factor-like function in liver cancer cells, contributing to our understanding of its involvement in liver cancer progression.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Kohji Yamada, Ryusuke Kizawa, Ayano Yoshida, Rei Koizumi, Saya Motohashi, Yuya Shimoyama, Yoshito Hannya, Saishu Yoshida, Tsunekazu Oikawa, Masayuki Shimoda, Kiyotsugu Yoshida
Summary: PKC delta is secreted from liver cancer cells and binds to the epidermal growth factor receptor (EGFR), activating the EGFR signaling pathway and promoting cell proliferation and tumor growth in liver cancer.
Article
Cell Biology
Akira Kawamura, Saishu Yoshida, Katsuhiko Aoki, Yuya Shimoyama, Kohji Yamada, Kiyotsugu Yoshida
Summary: This study reveals that dual-specificity tyrosine-regulated kinase 2 (DYRK2) is a novel regulator of neddylation, promoting neddylation through forming a complex with NEDD8-activating enzyme E1 component NAE1, and thus maintaining genome stability.
JOURNAL OF CELL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Kohji Yamada, Saya Motohashi, Tsunekazu Oikawa, Naoko Tago, Rei Koizumi, Masaya Ono, Toshiaki Tachibana, Ayano Yoshida, Saishu Yoshida, Masayuki Shimoda, Masahiro Oka, Yoshihiro Yoneda, Kiyotsugu Yoshida
Summary: The study reveals the role of E-Syt1 in mediating cytosolic protein secretion at the ER-PM contact sites in liver cancer cells. SEC22B vesicles tethered to the PM via Q-SNAREs for their secretion, while PKC delta secretion and tumorigenicity were regulated by the interaction with E-Syt1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Yuya Shimoyama, Kohji Yamada, Saishu Yoshida, Akira Kawamura, Yoshito Hannya, Yuta Imaizumi, Tomotaka Kumamoto, Yasuhiro Takeda, Masayuki Shimoda, Ken Eto, Kiyotsugu Yoshida
Summary: This study investigates the role of PKC delta in colorectal cancer (CRC) and finds that PKC delta acts as a negative regulator of cellular senescence in p53 wild-type CRC. The activation of p21 via a p53-independent pathway by PKC delta is shown to be essential for its activity. The study also proposes a novel therapeutic strategy for CRC targeting wt-p53.
Article
Biochemistry & Molecular Biology
Kohji Yamada, Kiyotsugu Yoshida
Summary: Unconventional protein secretion (UPS) is a crucial mechanism controlling the localization of cytosolic proteins lacking signal peptides and is implicated in inflammation, neurodegenerative diseases, and cancer. This article provides an overview of UPS mechanisms and categorizes cancer-specific UPS as CUPS due to their distinct features in cancer cells.
DNA AND CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kohji Yamada, Yoshito Hannya, Tsunekazu Oikawa, Ayano Yoshida, Kuniko Katagiri, Saishu Yoshida, Rei Koizumi, Naoko Tago, Yuya Shimoyama, Akira Kawamura, Yuta Mochimaru, Ken Eto, Kiyotsugu Yoshida
Summary: This study demonstrates that E-Syt1 plays a critical role in the tumorigenic potential of liver cancer cells. E-Syt1 depletion inhibits cell proliferation and is associated with a poorer prognosis in hepatocellular carcinoma. Furthermore, E-Syt1 is required for the unconventional secretion of PKCd and the activation of IGF1R and Erk1/2 signaling pathways, which are implicated in liver cancer tumorigenesis.
Review
Biochemistry & Molecular Biology
Saishu Yoshida, Kiyotsugu Yoshida
Summary: The DYRK family, from invertebrates to mammals, plays a crucial role in regulating cell processes such as proliferation, apoptosis, survival, and differentiation. However, limited evidence exists regarding their in vivo roles in mammalian development. This review provides an overview of in vivo studies on Dyrks, shedding light on their roles in mammalian tissue development and congenital diseases.
Article
Oncology
Yasuhiro Takano, Satomi Yogosawa, Yuta Imaizumi, Hiroshi Kamioka, Yumi Kanegae, Ken Eto, Kiyotsugu Yoshida
Summary: DYRK2 expression is associated with chemosensitivity to 5-fluorouracil and oxaliplatin in p53 wild-type colorectal cancer, suggesting its importance as a new marker in therapeutic strategies.
Article
Gastroenterology & Hepatology
Hiroshi Kamioka, Satomi Yogosawa, Tsunekazu Oikawa, Daisuke Aizawa, Kaoru Ueda, Chisato Saeki, Koichiro Haruki, Masayuki Shimoda, Toru Ikegami, Yuji Nishikawa, Masayuki Saruta, Kiyotsugu Yoshida
Summary: DYRK2 has been found to play an anti-tumor role in hepatocellular carcinoma (HCC) by promoting the degradation of Myc and Hras. This study provides new insights into the potential therapeutic approach of using DYRK2 gene transfer for HCC treatment.
Meeting Abstract
Oncology
Yoshimi Imawari, Rei Mimoto, Kiyotsugu Yoshida
Review
Biochemistry & Molecular Biology
Yuta Mochimaru, Kiyotsugu Yoshida
Summary: DYRK2 plays diverse roles in cancer, with controversy regarding its functional conservation. Although studies have been conducted in different types of cancer, the current methods used are not sufficient to fully comprehend the role of DYRK2 in cancer.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Meeting Abstract
Oncology
Kohji Yamada, Tsunekazu Oikawa, Saya Motohashi, Ayano Yoshida, Rei Koizumi, Saishu Yoshida, Kiyotsugu Yoshida
Meeting Abstract
Oncology
Saya Motohashi, Kohji Yamada, Ayano Yoshida, Rei Koizumi, Kiyotsugu Yoshida