期刊
CANCER SCIENCE
卷 106, 期 1, 页码 60-68出版社
WILEY
DOI: 10.1111/cas.12566
关键词
Inhibitors of apoptosis proteins; microparticles; multidrug resistance; NFB; P-glycoprotein
类别
资金
- Instituto Nacional de Ciencia e Tecnologia (INCT)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Programa de Oncobiologia
- Fundacao de Amparo a Pesquisa do Rio de Janeiro (FAPERJ)
Multidrug resistance (MDR) is considered a multifactorial event that favors cancer cells becoming resistant to several chemotherapeutic agents. Numerous mechanisms contribute to MDR, such as P-glycoprotein (Pgp/ABCB1) activity that promotes drug efflux, overexpression of inhibitors of apoptosis proteins (IAP) that contribute to evasion of apoptosis, and oncogenic pathway activation that favors cancer cell survival. MDR molecules have been identified in membrane microparticles (MP) and can be transferred to sensitive cancer cells. By co-culturing MP derived from MDR-positive cells with recipient cells, we showed that sensitive cells accumulated Pgp, IAP proteins and mRNA. In addition, MP promoted microRNA transfer and NFB and Yb-1 activation. Therefore, our results indicate that MP can induce a multifactorial phenotype in sensitive cancer cells.
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