Intermittent chemotherapy can retain the therapeutic potential of anti-CD137 antibody during the late tumor-bearing state

Trial Watch

(2014) Fernando Aranda et al.   OncoImmunology

Combinatorial PD-1 Blockade and CD137 Activation Has Therapeutic Efficacy in Murine Cancer Models and Synergizes with Cisplatin

(2013) Huafeng Wei et al.   PLoS One

Metronomic chemotherapy with low-dose cyclophosphamide plus gemcitabine can induce anti-tumor T cell immunity in vivo

(2012) Miki Tongu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

(2012) Y. Shirota et al.   JOURNAL OF IMMUNOLOGY

Targeting Spatiotemporal Expression of CD137 on Tumor-infiltrating Cytotoxic T Lymphocytes as a Novel Strategy for Agonistic Antibody Therapy

(2012) Shuichi Noji et al.   JOURNAL OF IMMUNOTHERAPY

The HIF-1α Hypoxia Response in Tumor-Infiltrating T Lymphocytes Induces Functional CD137 (4-1BB) for Immunotherapy

(2012) Asís Palazón et al.   Cancer Discovery

Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes

(2011) A. Palazon et al.   CANCER RESEARCH

Low-Dose Metronomic Oral Dosing of a Prodrug of Gemcitabine (LY2334737) Causes Antitumor Effects in the Absence of Inhibition of Systemic Vasculogenesis

(2011) G. Francia et al.   MOLECULAR CANCER THERAPEUTICS

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

(2010) Joris D Veltman et al.   BMC CANCER

Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ

(2010) Juan Dubrot et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunogenic chemotherapy with cyclophosphamide and doxorubicin against established murine carcinoma

(2009) Miki Tongu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cyclophosphamide Augments Antitumor Immunity: Studies in an Autochthonous Prostate Cancer Model

(2009) S. Wada et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

(2009) S. Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Fc-dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies

(2008) W. Lin et al.   BLOOD

Regulatory T Cell-Resistant CD8+ T Cells Induced by Glucocorticoid-Induced Tumor Necrosis Factor Receptor Signaling

(2008) H. Nishikawa et al.   CANCER RESEARCH

Immune regulation and control of regulatory T cells by OX40 and 4-1BB

(2008) Takanori So et al.   CYTOKINE & GROWTH FACTOR REVIEWS

CD4+CD25+ Tregs control the TRAIL-dependent cytotoxicity of tumor-infiltrating DCs in rodent models of colon cancer

(2008) Stephan Roux et al.   JOURNAL OF CLINICAL INVESTIGATION