Article
Oncology
Mihaela Chivu-Economescu, Vlad Herlea, Simona Dima, Andrei Sorop, Catalin Pechianu, Alexandru Procop, Shuji Kitahara, Laura Necula, Lilia Matei, Denisa Dragu, Ana-Iulia Neagu, Coralia Bleotu, Carmen C. Diaconu, Irinel Popescu, Dan G. Duda
Summary: In this study, the researchers compared the expression of PD-L1 in primary tissue samples and sPD-L1 concentration in preoperative plasma samples from gastric cancer patients. They found that sPD-L1 levels were associated with tissue PD-L1 expression, greater inflammatory cell infiltration, disease progression, and poor overall survival. The study suggests that sPD-L1 may serve as a useful minimally invasive diagnostic and prognostic biomarker in gastric cancer patients.
Article
Medicine, Research & Experimental
Jialiang Zheng, Fenglin Miao, Zhao Wang, Yuan Ma, Zhenhang Lin, Yaqin Chen, Xu Kong, Yue Wang, Aobo Zhuang, Ting Wu, Wengang Li
Summary: This study conducted a comprehensive analysis of the role of MDM2 in human cancer and found that MDM2 is a reliable prognostic biomarker closely related to cancer immunity, providing a potential immunotherapeutic target for breast cancer, bladder cancer, and ovarian cancer.
Article
Oncology
Yuehong Cui, Qian Li, Wei Li, Yan Wang, Fang Lv, Xinying Shi, Zhaoqing Tang, Zhenbin Shen, Yingyong Hou, Henghui Zhang, Beibei Mao, Tianshu Liu
Summary: The study uncovered a new mechanism by which NOTCH3 participates in immune tolerance in GC, indicating its potential as a therapeutic target or predictive marker for GC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yunfei Wang, Jiadong Pan, Fangmei An, Ke Chen, Jiawei Chen, He Nie, Yanping Zhu, Zhengtao Qian, Qiang Zhan
Summary: In this study, the expression, prognostic value, and immune-correlations of guanylate-binding protein 2 (GBP2) in gastric cancer were investigated. The results showed that GBP2 was highly expressed in tumor tissues and associated with poor prognosis. It was also found that GBP2 was related to the immune-hot phenotype and had positive correlations with immuno-modulators, tumor-infiltrating immune cells, immunotherapy biomarkers, and immunotherapeutic response. Additionally, GBP2 was expected to be an indicator of high immunogenicity in most cancer types. Importantly, GBP2 could predict the immunotherapeutic responses in at least four different cancer types.
Article
Oncology
Jun-Yan Liu, Jing Yao, Jia-Jia Liu, Tao He, Fang-Jie Wang, Tian-Yu Xie, Jian-Xin Cui, Xiao-Dong Yang
Summary: In this study, a novel survival-related ferroptosis-related lncRNA (FRlncRNA), LASTR, was identified in gastric cancer (GC). High expression of LASTR was associated with shorter overall survival and progression-free survival of GC patients. Knocking down LASTR had a significant effect on reducing the proliferation of GC cells. Additionally, the expression of LASTR was negatively associated with certain immune cells. These findings suggest that LASTR may serve as a novel prognostic biomarker for predicting response to cancer immunotherapy and therapeutic target for GC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Jiannan Xu, Songyao Chen, Jianming Liang, Tengfei Hao, Huabin Wang, Guangyao Liu, Xinghan Jin, Huan Li, Junchang Zhang, Changhua Zhang, Yulong He
Summary: The SLFN gene family is highly expressed in gastric cancer patients and is associated with lymph node metastasis, tumor stage, tumor grade, and poor prognosis. The genetic alterations of the SLFN family in gastric cancer are frequent, including mutations and amplifications. The SLFN family interacts with multiple genes and proteins and may be involved in immune response and immune cell infiltration in gastric cancer. Additionally, the SLFN family may regulate T cell activation and contribute to immune evasion in gastric cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Biao Fan, Ke Ji, Zhaode Bu, Ji Zhang, Heli Yang, Jialin Li, Xiaojiang Wu
Summary: The study found that ARHGAP11A is elevated in various cancers, including gastric cancer. In gastric cancer, high expression of ARHGAP11A is significantly correlated with better prognosis. The expression of ARHGAP11A is negatively associated with infiltration levels of CD8(+) T cells, CD4(+) T cells, macrophages and dendritic cells.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Nutrition & Dietetics
Jianping Xiong, Yunzi Wu, Haitao Hu, Wenzhe Kang, Yang Li, Peng Jin, Xinxin Shao, Weikun Li, Yibin Xie, Yantao Tian
Summary: This study evaluated the prognostic impact of Peking prognostic score (PPS) on patients with gastric cancer liver metastases (GCLM) who underwent hepatectomy. PPS was found to be associated with age, body mass index (BMI), and liver metastasis number. Furthermore, PPS was found to be an independent predictor of overall survival (OS) and recurrence-free survival (RFS) for these patients.
FRONTIERS IN NUTRITION
(2022)
Article
Pathology
Samir Abdullazade, Hans-Michael Behrens, Sandra Krueger, Jochen Haag, Christoph Roecken
Summary: The study validated gene amplification, protein expression, and tumor biological function of MDM2 in gastric cancer, and found a significant correlation between MDM2 amplification and protein expression. However, MDM2 amplification and expression were not associated with patient survival.
Article
Anatomy & Morphology
Deqin Li, Tiantian Qi, Jian Chen
Summary: This study found that SAMD4A is highly expressed in gastric cancer and is associated with poor prognosis in patients. SAMD4A promotes the proliferation, invasion, and migration abilities of gastric adenocarcinoma cells. This indicates that SAMD4A plays an important role in the occurrence and development of gastric cancer and could be an effective indicator for the diagnosis and prognosis evaluation of gastric cancer.
Article
Biotechnology & Applied Microbiology
Yuan-Jie Liu, Jie-Pin Li, Ying Zhang, Meng-Jun Nie, Yong-Hua Zhang, Shen-Lin Liu, Xi Zou
Summary: The study found that FSTL3 expression is upregulated in gastric cancer patients and is significantly associated with cancer stage, pathological tumor grade, and survival prognosis. Functional enrichment analysis indicated that FSTL3 overexpression can activate epithelial-mesenchymal transition and promote the proliferation of M2 macrophages.
ONCOTARGETS AND THERAPY
(2021)
Article
Medicine, Research & Experimental
Jing Liu, Xingwu Zhu, Meinan Yan, Hui Li
Summary: In this study, a predictive model named circPanel was established based on two highly expressed circRNAs (hsa_circ_0005092 and hsa_circ_0002647) in gastric cancer patients with good prognoses, showing potential as a prognostic biomarker with greater accuracy than single circRNAs and traditional tumor markers. Functional analysis and network prediction were also performed for these circRNAs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Hirotaka Hasegawa, Kohei Shitara, Shuji Takiguchi, Noriaki Takiguchi, Seiji Ito, Mitsugu Kochi, Hidehito Horinouchi, Takahiro Kinoshita, Takaki Yoshikawa, Kei Muro, Hiroyoshi Nishikawa, Hideaki Suna, Yasuhiro Kodera
Summary: Neoadjuvant nivolumab monotherapy is feasible and safe for resectable gastric cancer, and can induce a major pathologic response in certain patients.
Article
Cell Biology
Li Chen, Ping Bai, Xiangyi Kong, Shaolong Huang, Zhongzhao Wang, Xiangyu Wang, Yi Fang, Jing Wang
Summary: The study showed that the PNI value can predict survival and disease progression in breast cancer patients receiving neoadjuvant chemotherapy, with patients having a higher PNI experiencing significantly better DFS and OS. Additionally, PNI has predictive value for both early-stage and advanced breast cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Ozan Yazici, Mutlu Dogan, Guze Ozal, Sedef Hande Aktas, Ahmet Demirkazik, Gungor Utkan, Filiz Cay Senler, Fikri Icli, Hakan Akbulut
Summary: The study indicates that higher serum OPN levels are associated with shorter survival time in patients with advanced gastric cancer. Patients who respond to DCF treatment have lower plasma OPN levels, with performance status and plasma OPN levels being significant factors in overall survival.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Oncology
Weiyou Zhu, Oluf Dimitri Roe, Chen Wu, Wei Li, Renhua Guo, Yanhong Gu, Yiqian Liu, Yongqian Shu, Xiaofeng Chen
JOURNAL OF CHEMOTHERAPY
(2015)
Article
Medicine, General & Internal
Maria Markaki, Ioannis Tsamardinos, Arnulf Langhammer, Vincenzo Lagani, Kristian Hveem, Oluf Dimitri Roe
Article
Cardiac & Cardiovascular Systems
Hailong Cao, Jinfu Zhu, Lei Xi, Oluf Dimitri Roe, Yijiang Chen, Dongjin Wang
Article
Cardiac & Cardiovascular Systems
Hailong Cao, Ying Wu, Qingguo Li, Yanhu Wu, Qing Zhou, Oluf Dimitri Roe, Yijiang Chen, Ruxing Wang, Dongjin Wang
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2014)
Article
Gastroenterology & Hepatology
Yefei Huang, Weimin Wang, Yansu Chen, Yulin Huang, Jianbing Zhang, Song He, Yongfei Tan, Fulin Qiang, Aiping Li, Oluf Dimitri Roe, Shouyu Wang, Yan Zhou, Jianwei Zhou
JOURNAL OF GASTROENTEROLOGY
(2014)
Article
Multidisciplinary Sciences
Xiaofeng Chen, Quan Zhu, Yiqian Liu, Ping Liu, Yongmei Yin, Renhua Guo, Kaihua Lu, Yanhong Gu, Lianke Liu, Jinghua Wang, Zhaoxia Wang, Oluf Dimitri Roe, Yongqian Shu, Lingjun Zhu
Article
Multidisciplinary Sciences
Hailong Cao, Qing Zhou, Rongfang Lan, Oluf Dimitri Roe, Xin Chen, Yijiang Chen, Dongjin Wang
Article
Oncology
Konstantinos Kerkentzes, Vincenzo Lagani, Ioannis Tsamardinos, Mogens Vyberg, Oluf Dimitri Roe
FRONTIERS IN ONCOLOGY
(2014)
Review
Biochemistry & Molecular Biology
Vasiliki Panou, Oluf Dimitri Roe
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Thomas Ringgaard Petersen, Vasiliki Panou, Christos Meristoudis, Ulla Moller Weinreich, Oluf Dimitri Roe
Summary: The study found that survival rates were higher in patients with malignant pleural mesothelioma who received anti-tumor treatment, with good performance score and female gender being positive prognostic factors for patients receiving best supportive care.
Article
Environmental Sciences
Sofie Buenemann Dalsgaard, Else Toft Wuertz, Johnni Hansen, Oluf Dimitri Roe, Oyvind Omland
Summary: This study found that childhood exposure to environmental asbestos is associated with an increased risk of cancer of the corpus uteri and malignant mesothelioma in women.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Sofie Buenemann Dalsgaard, Else Toft Wuertz, Johnni Hansen, Oluf Dimitri Roe, Oyvind Omland
Summary: This study confirms the strong association between environmental asbestos exposure and malignant mesothelioma and suggests that environmental asbestos exposure in childhood may increase the overall cancer risk later in life.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Respiratory System
Oluf Dimitri Roe
BMJ OPEN RESPIRATORY RESEARCH
(2020)
Article
Respiratory System
Oluf Dimitri Roe, Maria Markaki, Ioannis Tsamardinos, Vincenzo Lagani, Olav Toai Duc Nguyen, Jesper Holst Pedersen, Zaigham Saghir, Haseem Gary Ashraf
BMJ OPEN RESPIRATORY RESEARCH
(2019)
Review
Respiratory System
Oluf Dimitri Roe, Giulia Maria Stella
EUROPEAN RESPIRATORY REVIEW
(2015)