期刊
CANCER SCIENCE
卷 103, 期 1, 页码 150-153出版社
WILEY
DOI: 10.1111/j.1349-7006.2011.02106.x
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类别
资金
- New Energy and Industrial Technology Development Organization (NEDO)
- Grants-in-Aid for Scientific Research [22790370] Funding Source: KAKEN
A patient with pulmonary metastasis of colon cancer was treated with artificially synthesized helper/killer-hybrid epitope long peptide (H/K-HELP) of MAGE-A4 cancer antigen. The patient was vaccinated with MAGE-A4-H/K-HELP combined with OK432 and Montanide ISA-51. There were no severe side-effects except for a skin reaction at the injection site. MAGE-A4-H/K-HELP induced MAGE-A4-specific Th1 and Tc1 immune responses and the production of MAGE-A4-specific complement-fixing IgG antibodies. Tumor growth and carcinoembryonic antigen tumor marker were significantly decreased in the final diagnosis. This is the first report that artificially synthesized MAGE-A4-H/K-HELP induces Th1-dependent cellular and humoral immune responses in a human cancer patient. (Cancer Sci 2012; 103: 150-153)
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