Article
Biochemistry & Molecular Biology
Salvatore Pulcrano, Roberto De Gregorio, Claudia De Sanctis, Laura Lahti, Carla Perrone-Capano, Donatella Ponti, Umberto di Porzio, Thomas Perlmann, Massimiliano Caiazzo, Floriana Volpicelli, Gian Carlo Bellenchi
Summary: The development of midbrain dopaminergic neurons requires precise regulation of a specific gene expression program, which is controlled by the Lmx1a-miR-204/211-Nurr1 axis. The miR-204/211 acts as a molecular switch to regulate the timing of Nurr1 expression, ultimately leading to the differentiation of mature midbrain dopaminergic neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Weilin Sun, Gang Ma, Li Zhang, Pengliang Wang, Nannan Zhang, Zizhen Wu, Yinping Dong, Fenglin Cai, Liqiao Chen, Huifang Liu, Han Liang, Jingyu Deng
Summary: ADAMTS9 in gastric cancer cells exerts inhibitory effects, with its decreased expression associated with malignant phenotypes and poor prognosis. Restoration of ADAMTS9 significantly suppressed the viability and motility of GC cells.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Weihong Xu, Yanan Lai, Yunqi Pan, Meiyu Tan, Yanyun Ma, Huiming Sheng, Jiucun Wang
Summary: The study found that NDUFA4 is highly expressed in gastric cancer and is associated with poor prognosis. Inhibition of NDUFA4 can reduce cell proliferation and tumor growth. NDUFA4 promotes glycolysis and mitochondrial fission in gastric cancer cells, and inhibition of glycolysis can suppress tumor growth. Moreover, METTL3 can increase the expression of NDUFA4 by increasing the m6A level of NDUFA4 mRNA.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Mengyu Xie, Long Zhang, Linyu Han, Linying Huang, Yizhou Huang, Ming Yang, Nasha Zhang
Summary: The ASH1L-AS1-ASH1L regulatory axis plays a significant role in histone modification reprogramming and activation of the RAS signaling pathway, making it a potential novel target for gastric cancer therapeutics and diagnosis.
Article
Multidisciplinary Sciences
Buze Chen, Xiaojuan Ding, Ailing Wan, Xin Qi, Xiaoman Lin, Haihong Wang, Wenyu Mu, Gang Wang, Junnian Zheng
Summary: TLX2 plays an important role in multiple tumors and its abnormal expression is associated with a poor overall survival rate in several cancer types. The most common type of alteration in TLX2 is amplification, and it co-occurs with alterations in other genes. TLX2 has high methylation levels in various tumors. Its expression is related to immune infiltration, immune checkpoint genes, and chemoresistance.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Nil Grunberg, Meirav Pevsner-Fischer, Tal Goshen-Lago, Judith Diment, Yaniv Stein, Hagar Lavon, Shimrit Mayer, Oshrat Levi-Galibov, Gil Friedman, Yifat Ofir-Birin, Li-Jyun Syu, Cristina Migliore, Eyal Shimoni, Salomon M. Stemmer, Baruch Brenner, Andrzej A. Dlugosz, David Lyden, Neta Regev-Rudzki, Irit Ben-Aharon, Ruth Scherz-Shouval
Summary: This study used RNA sequencing of CAFs from gastric cancer patients to identify a stromal gene signature associated with aggressive gastric cancer, with HSF1 playing a key regulatory role in this signature. HSF1 upregulates inhibin subunit beta A and thrombospondin 2, which are secreted in CAF-derived extracellular vesicles to promote cancer progression.
Article
Multidisciplinary Sciences
Mihoko Saito-Adachi, Natsuko Hama, Yasushi Totoki, Hiromi Nakamura, Yasuhito Arai, Fumie Hosoda, Hirofumi Rokutan, Shinichi Yachida, Mamoru Kato, Akihiko Fukagawa, Tatsuhiro Shibata
Summary: This study analyzes the structural rearrangement landscape of 170 gastric cancer genomes and identifies six rearrangement signatures. Specific rearrangement signatures are associated with driver events and epidemiological backgrounds. Additionally, 27 structural variant hotspots potentially linked to gastric cancer driver genes are discovered.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Jiaying Li, Miaomiao Pei, Wushuang Xiao, Xuehua Liu, Linjie Hong, Zhen Yu, Ying Peng, Jieming Zhang, Ping Yang, Jianjiao Lin, Xiaosheng Wu, Zhizhao Lin, Weimei Tang, Fachao Zhi, Guoxin Li, Li Xiang, Aimin Li, Side Liu, Ye Chen, Jide Wang
Summary: Long non-coding RNA PAXIP1-AS1 plays a suppressive role in gastric cancer by inhibiting tumor progression and EMT through destabilizing PABPC1. The HOXD9/PAXIP1-AS1/PABPC1/PAK1 signaling axis may be involved in the progression of gastric cancer.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Linqing Sun, Yuqi Chen, Lu Xia, Jiayu Wang, Jinghan Zhu, Juntao Li, Kun Wang, Kanger Shen, Dongze Zhang, Guangbo Zhang, Tongguo Shi, Weichang Chen
Summary: TRIM69 regulates the PRKCD/BDNF axis in gastric cancer cells, suppressing the processes of anoikis resistance and metastasis, and may have potential implications for the treatment of metastatic gastric cancer.
Article
Biochemical Research Methods
Kevin A. Murgas, Yanlin Ma, Lidea K. Shahidi, Sayan Mukherjee, Andrew S. Allen, Darryl Shibata, Marc D. Ryser
Summary: A Bayesian hierarchical model was developed to decompose variances of methylation levels on different levels, which successfully identified functionally relevant genomic loci in tumors. The model demonstrated its ability to identify preferentially conserved genes in colorectal cancer patients, suggesting potential novel gene targets for cancer treatment. Pathway analysis revealed several relevant pathways in CRC tumorigenesis, indicating the versatile and powerful application of the model in analyzing complex multi-sample data structures.
Article
Cell Biology
Xiaolong Tang, Yahang Liang, Guorui Sun, Qingsi He, Zhenyu Hou, Xingzhi Jiang, Peng Gao, Hui Qu
Summary: In this study, the researchers identified the protein CRABP2 as a potential target for reversing oxaliplatin resistance in gastric cancer patients. They found that CRABP2 was significantly upregulated in chemoresistant tumor tissues and played a role in promoting oxaliplatin resistance through inhibiting BAX-dependent cell apoptosis. The study suggests that targeting CRABP2 could be a new strategy to overcome chemotherapy resistance in gastric cancer.
CELL DEATH & DISEASE
(2022)
Article
Plant Sciences
Xiao-jie Chen, Qi-xiao Cui, Guo-li Wang, Xiao-li Li, Xiao-lin Zhou, Hui-jie Zhao, Ming-qian Zhang, Min-jing Li, Xiao-juan He, Qiu-sheng Zheng, Yu-liang Wang, Defang Li, Pan Hong
Summary: Sanggenon C inhibits proliferation, induces apoptosis and inhibits mitochondrial fission in gastric cancer cells, achieving these effects by blocking the ERK signaling pathway.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Min Xiao, Yan Zheng, Kuo-Hsiang Huang, Shanhe Yu, Wenbi Zhang, Yanping Xi, Yan Dou, Xiaoxi Sun, Caixia Lei, Huiqian Yu
Summary: Non-syndromic sensorineural hearing loss (NSHL) is a genetically heterogeneous condition with no curative treatment. A rare frameshift variant in LMX1A was found in a Chinese family with autosomal dominant NSHL. The mutation led to variable auditory phenotypes and upregulated HL-associated genes. The C-terminal domain of LMX1A was found to be important for transcriptional regulation and apoptosis in cochlear hair cells.
HUMAN MOLECULAR GENETICS
(2023)
Article
Cell Biology
Shushu Song, Bo Liu, Xiaoqing Zeng, Yingying Wu, Hao Chen, Hao Wu, Jianxin Gu, Xiaodong Gao, Yuanyuan Ruan, Hongshan Wang
Summary: This study found that reticulon 2 (RTN2) is highly expressed in gastric cancer and is associated with patient prognosis. Further experiments revealed that RTN2 promotes the proliferation, migration, and invasion of gastric cancer cells by activating the ERK signaling pathway through regulating calcium release from the endoplasmic reticulum, leading to epithelial-to-mesenchymal transition.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Takuya Shirakihara, Hideki Yamaguchi, Tadashi Kondo, Masakazu Yashiro, Ryuichi Sakai
Summary: The study reveals that in diffuse-type gastric cancer cells, transferrin receptor 1 (TfR1) binds and phosphorylates with fibroblast growth factor receptor 2 (FGFR2), promoting cell proliferation and tumorigenicity. This suggests that controlling TfR1 function could serve as a therapeutic target in diffuse-type gastric cancer with activated FGFR2.
