Article
Radiology, Nuclear Medicine & Medical Imaging
Leo L. Tsai, Rupal S. Bhatt, Meaghan F. Strob, Opeyemi A. Jegede, Maryellen R. M. Sun, David C. Alsop, Paul Catalano, David McDermott, Philip M. Robson, Michael B. Atkins, Ivan Pedrosa
Summary: Tumor perfusion measured by ASL MRI may help identify responders to VEGFR TKIs in metastatic RCC patients. Perfusion decreases during treatment but is not correlated with ORR or PFS, while increases significantly at disease progression.
Article
Oncology
Cora N. Sternberg, Ian D. Davis, Jozef Mardiak, Cezary Szczylik, Eunsik Lee, John Wagstaff, Carlos H. Barrios, Pamela Salman, Oleg A. Gladkov, Alexander Kavina, Juan J. Zarba, Mei Chen, Lauren McCann, Lini Pandite, Debasish F. Roychowdhury, Robert E. Hawkins
Summary: This study evaluated the efficacy and safety of Pazopanib in the treatment of advanced renal cell carcinoma. The results showed significant improvement in progression-free survival and tumor response with Pazopanib compared to placebo.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Immunology
Dag Olav Dahle, Morten Skauby, Carl Wilhelm Langberg, Knut Brabrand, Nicolai Wessel, Karsten Midtvedt
Summary: Kidney transplant recipients (KTRs) have an increased risk of developing renal cell carcinoma (RCC) and may encounter this cancer at different stages of the transplant process. Screening for RCC after transplantation is not cost-effective, and treatment of RCC in KTRs poses challenges in adjusting immunosuppression and oncologic treatments. Excision or nephrectomy is often curative for localized RCC, while recent trials in the nontransplanted population demonstrate that immunotherapy combinations improve survival for metastatic RCC. However, dedicated trials in KTRs are lacking, although case series indicate potential tumor response with immune checkpoint inhibitors at the cost of rejection developing in some patients.
Article
Cell Biology
Roy Elias, Vanina T. Tcheuyap, Akash K. Kaushik, Nirmish Singla, Ming Gao, Oscar Reig Torras, Alana Christie, Aditi Mulgaonkar, Layton Woolford, Christina Stevens, Kavitha Priya Kettimuthu, Andrea Pavia-Jimenez, Lindsey K. Boroughs, Allison Joyce, Marianna Dakanali, Hollis Notgrass, Vitaly Margulis, Jeffrey A. Cadeddu, Ivan Pedrosa, Noelle S. Williams, Xiankai Sun, Ralph J. DeBerardinis, Orhan K. Oz, Hua Zhong, Somasekar Seshagiri, Zora Modrusan, Brandi L. Cantarel, Payal Kapur, James Brugarolas
Summary: By orthotopically implanting tumor samples from ethnically diverse individuals into mice, a resource of 172 independently derived, stably engrafted TG lines has been generated. These lines are characterized histologically and genomically, helping to advance understanding of RCC biology.
Article
Oncology
Minna Kankuri-tammilehto, Laura Perasto, Seppo Pyrhonen, Eeva Salminen
Summary: This study provides long-term follow-up data on the use of IFN-alpha in metastatic renal cell carcinoma (mRCC) patients. The results show that patients with stable and responding disease can benefit from prolonged IFN-alpha treatment, although the 5-year survival rate is low in the high-risk group.
ANTICANCER RESEARCH
(2023)
Article
Oncology
Yuan-Yuan Qu, Hai-Liang Zhang, Hongqian Guo, Hong Luo, Qing Zou, Nianzeng Xing, Shujie Xia, Zhongquan Sun, Xuepei Zhang, Chaohong He, Jinling Cai, Xiao Zhang, Quanren Wang, Ding-Wei Ye
Summary: The combination of camrelizumab and famitinib demonstrated potent and enduring antitumor activity in patients with advanced or metastatic RCC, with a higher objective response rate in treatment-naive patients compared to previously treated patients. The median progression-free survival had not been reached for treatment-naive patients, indicating a promising treatment strategy for this population.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Tushuai Li, Longjiang Xu, Zhe Wei, Shaomei Zhang, Xingyu Liu, Yanzi Yang, Yue Gu, Jie Zhang
Summary: This study found that downregulation of ELF5 and DNA hypermethylation inhibit RCC development through the USP3/WDTC1 axis in RCC.
Article
Oncology
Andrew J. Armstrong, Andrew B. Nixon, Andrea Carmack, Qian Yang, Tim Eisen, Walter M. Stadler, Robert J. Jones, Jorge A. Garcia, Ulka N. Vaishampayan, Joel Picus, Robert E. Hawkins, John D. Hainsworth, Christian K. Kollmannsberger, Theodore F. Logan, Igor Puzanov, Lisa M. Pickering, Christopher W. Ryan, Andrew Protheroe, Daniel J. George, Susan Halabi
Summary: In patients with metastatic NC-RCC, several poor prognosis angiokines and immunomodulatory chemokines were identified during treatment with sunitinib or everolimus, particularly OPN.
CLINICAL CANCER RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Xuelian Gong, Ling Jiang, Wei Li, Qingbin Liang, Zhen Li
Summary: The study showed that curcumin effectively inhibited cell viability of renal cell carcinoma, induced apoptosis and autophagy by suppressing the AKT/mTOR pathway. Using curcumin to target the AKT/mTOR pathway could be a promising alternative treatment for RCC.
Article
Oncology
Stephanie Chow, Oliver Dorigo
Summary: Adoptive cell transfer of IFN-activated monocytes administered intraperitoneally showed antitumor effects and acceptable tolerability in patients with platinum-resistant ovarian cancer. Exposure of monocytes to IFN-α and IFN-γ upregulated TRAIL, leading to caspase 8 activation and direct cell-to-cell contact-dependent apoptosis of ovarian cancer cells.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Abhenil Mittal, Esmail Al-Ezzi, Xuan Li, Brian Moloney, Brooke Wilson, Pavlina Spiliopoulou, Srikala Sridhar, Nazanin Fallah-Rad, Peter Chung, Robert James Hamilton, Martin O'malley, Aaron R. Hansen
Summary: This study found that the addition of cytoreductive nephrectomy (CN) to systemic therapy (ST) improved outcomes for patients with metastatic renal cell carcinoma (mRCC) and tumor thrombus.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Song Chen, Yejinpeng Wang, Yaoyi Xiong, Tianchen Peng, Mengxin Lu, Lian Zhang, Zhongqiang Guo
Summary: The study found that wild-type IDH1 could inhibit the proliferation and migration of RCC cells, as well as promote apoptosis, while the mutant IDH1 lacked this biological function. Additionally, the study verified the correlation between IDH1 and hypoxia signal-related proteins, and the potential role of α-KG in RCC treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Editorial Material
Oncology
Elizabeth P. Henske, Liang Cheng, A. Ari Hakimi, Toni K. Choueiri, David A. Braun
Summary: Chromophobe renal cell carcinoma (ChRCC) is the second most common variant of non-clear cell renal cell carcinoma. ChRCC differs from clear cell RCC (ccRCC) in terms of genetics, genomics, metabolism, cell of origin, and response to targeted and immune therapies. The pathogenesis of ChRCC is not well understood, but current evidence suggests two potential mechanisms: mTORC1 hyperactivation through PTEN pathway mutations and mitochondrial dysfunction leading to oxidative stress.
Review
Urology & Nephrology
Alexandre Ingels, Riccardo Campi, Umberto Capitanio, Daniele Amparore, Riccardo Bertolo, Umberto Carbonara, Selcuk Erdem, Onder Kara, Tobias Klatte, Maximilian C. Kriegmair, Michele Marchioni, Maria C. Mir, Idir Ouzaid, Nicola Pavan, Angela Pecoraro, Eduard Roussel, Alexandre de la Taille
Summary: The standard treatment for renal cell carcinoma relies on surgery for low-risk localized tumors and systemic treatment for poor-prognosis metastatic disease. However, there is a grey area for the treatment of high-risk localized tumors and metastatic disease with a good-to-intermediate prognosis. Recent practice-changing trials have transformed the therapeutic options for metastatic renal cell carcinoma. Treatments targeting vascular endothelial growth factor have been the mainstay, but immune checkpoint inhibitors have revolutionized the treatment landscape. The potential benefits of these therapies in the neoadjuvant and adjuvant settings have been investigated. The role of surgery for metastatic disease has been redefined, and there is growing interest in deferred surgery for residual tumors or metastases after checkpoint inhibitor treatment.
NATURE REVIEWS UROLOGY
(2022)
Article
Medicine, Research & Experimental
Yuan-Chin Tsai, Chao-Yuan Huang, Yu-Mei Hsueh, Yu-Ching Fan, Yu-Cin Fong, Shu-Pin Huang, Jiun-Hung Geng, Lih-Chyang Chen, Te-Ling Lu, Bo-Ying Bao
Summary: This study investigated the association of MAPK cascade genes with renal cell carcinoma risk and survival, revealing that a specific single nucleotide polymorphism in the MAPK10 gene is linked to lower RCC risk and metastasis. High MAPK10 expression is associated with a favorable prognosis, and MAPK10 activation can inhibit RCC cell growth.
Article
Physics, Applied
Takayuki Yanagida, Go Okada, Takumi Kato, Daisuke Nakauchi, Satoko Yanagida
APPLIED PHYSICS EXPRESS
(2016)
Article
Physics, Applied
Keiichiro Saeki, Yutaka Fujimoto, Masanori Koshimizu, Takayuki Yanagida, Keisuke Asai
APPLIED PHYSICS EXPRESS
(2016)
Article
Materials Science, Ceramics
Takumi Kato, Go Okada, Takayuki Yanagida
CERAMICS INTERNATIONAL
(2016)
Article
Chemistry, Multidisciplinary
Hiroki Tatsumi, Go Okada, Takayuki Yanagida, Hirokazu Masai
Article
Physics, Applied
Masaki Mori, Go Okada, Noriaki Kawaguchi, Takayuki Yanagida
JAPANESE JOURNAL OF APPLIED PHYSICS
(2017)
Article
Chemistry, Applied
M. Koshimizu, T. Yanagida, Y. Fujimoto, K. Asai
JOURNAL OF RARE EARTHS
(2016)
Article
Chemistry, Applied
Go Okada, Yutaka Fujimoto, Hironori Tanaka, Safa Kasap, Takayuki Yanagida
JOURNAL OF RARE EARTHS
(2016)
Article
Instruments & Instrumentation
Daisuke Nakauchi, Go Okada, Masanori Koshimizu, Takayuki Yanagida
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
(2016)
Article
Materials Science, Multidisciplinary
Makoto Shimizu, Masanori Koshimizu, Yutaka Fujimoto, Takayuki Yanagida, Shingo Ono, Keisuke Asai
Article
Physics, Applied
Keiichiro Saeki, Yutaka Fujimoto, Masanori Koshimizu, Daisuke Nakauchi, Hironori Tanaka, Takayuki Yanagida, Keisuke Asai
JAPANESE JOURNAL OF APPLIED PHYSICS
(2017)
Article
Optics
Narumi Kumamoto, Daisuke Nakauchi, Takumi Kato, Go Okada, Noriaki Kawaguchi, Takayuki Yanagida
Article
Materials Science, Ceramics
Fumiya Nakamura, Takumi Kato, Go Okada, Noriaki Kawaguchi, Kentaro Fukuda, Takayuki Yanagida
CERAMICS INTERNATIONAL
(2017)
Article
Instruments & Instrumentation
Hidehito Nanto, Mizuha Sato, Yuka Miyamoto, Kazuki Hirasawa, Yoshinori Takei, Takayuki Yanagida, Tatsuya Nakamura, Masaki Katagiri
SENSORS AND MATERIALS
(2016)
Article
Instruments & Instrumentation
Yutaka Fujimoto, Takayuki Yanagida, Takahiro Kojima, Masanori Koshimizu, Hironori Tanaka, Keisuke Asai
SENSORS AND MATERIALS
(2016)
Article
Materials Science, Ceramics
Hiroki Tatsumi, Go Okada, Takayuki Yanagida, Hirokazu Masai
JOURNAL OF THE CERAMIC SOCIETY OF JAPAN
(2016)