Article
Oncology
Esther Schoutrop, Ibrahim El-Serafi, Thomas Poiret, Ying Zhao, Okan Gultekin, Rui He, Lidia Moyano-Galceran, Joseph W. Carlson, Kaisa Lehti, Moustapha Hassan, Isabelle Magalhaes, Jonas Mattsson
Summary: The study demonstrates the therapeutic potential of MSLN-CAR T cells against ovarian cancer, despite challenges in achieving persistent tumor control. The findings highlight the importance of immune checkpoint pathways in limiting CAR T-cell persistence in the ovarian tumor microenvironment.
Article
Biochemistry & Molecular Biology
Haruhiko Fujihira, Daisuke Takakura, Atsushi Matsuda, Masaaki Abe, Michiyo Miyazaki, Tomomi Nakagawa, Kazunori Kajino, Kaori Denda-Nagai, Miki Noji, Okio Hino, Tatsuro Irimura
Summary: Mesothelioma is a highly aggressive tumor associated with asbestos exposure, with no effective targeted therapy available. This study focused on analyzing the differential glycosylation of ERC/mesothelin on epithelioid mesothelioma cells compared to normal mesothelial cells, identifying a potential new target for therapeutic antibodies. Lectin microarray and mass spectrometry analysis revealed a unique bisecting-GlcNAc structure on ERC/mesothelin from epithelioid mesothelioma cells, suggesting a promising approach for developing a selective and safe therapy for this type of cancer.
JOURNAL OF BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Andrew R. Haas, Ryan J. Golden, Leslie A. Litzky, Boris Engels, Linlin Zhao, Fangmin Xu, John A. Taraszka, Melissa Ramones, Brian Granda, Wan-Jung Chang, Julie Jadlowsky, Kim-Marie Shea, Adam Runkle, Anne Chew, Emily Dowd, Vanessa Gonzalez, Fang Chen, Xiaojun Liu, Chongyun Fang, Shuguang Jiang, Megan M. Davis, Neil C. Sheppard, Yangbing Zhao, Joseph A. Fraietta, Simon F. Lacey, Gabriela Plesa, J. Joseph Melenhorst, Keith Mansfield, Jennifer L. Brogdon, Regina M. Young, Steven M. Albelda, Carl H. June, Janos L. Tanyi
Summary: Clinical studies have shown limited efficacy of mesothelin (MSLN)-positive solid tumor treatment using MSLN-directed chimeric antigen receptor (CAR) T cells. A phase 1 study observed severe pulmonary toxicity in two patients following high-dose infusion of a fully human anti-MSLN CAR. Autopsy findings revealed lung injury, T cell infiltration, and accumulation of CAR T cells. Low levels of MSLN expression in lung epithelial cells indicate that pulmonary pneumocytes may cause dose-limiting toxicity. Patient enrollment criteria and dosing regimens should consider dynamic expression of MSLN in benign lung and underlying inflammatory or fibrotic conditions.
Review
Oncology
Zhihui Dou, Dapeng Zhao, Xiaohua Chen, Caipeng Xu, Xiaodong Jin, Xuetian Zhang, Yupei Wang, Xiaodong Xie, Qiang Li, Cuixia Di, Hong Zhang
Summary: The study of Bcl-x pre-mRNA splicing reveals its crucial role in cell death regulation and its dysregulation is associated with various human diseases, particularly cancers. Understanding the mechanism and regulation of Bcl-x splicing has provided insights for drug development to enhance cancer cell sensitivity to death, highlighting the significance of aberrant splicing isoforms of Bcl-x as targets for cancer therapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Guozhu Hou, Yujing Jin, Pan Peng, Rong Zheng
Summary: This article reported a rare case of diffuse epithelioid malignant mesothelioma (MM) with ovarian metastasis. A 39-year-old woman was diagnosed with multiple masses in the hepatic hilus through ultrasound examination at an external hospital. FDG PET/CT examination was then recommended to evaluate the nature of the lesions. The results showed two hypodense lesions with intense metabolic activity in the perihepatic space, and an additional metabolic lesion in the right ovary, which was later confirmed as diffuse epithelioid MM with ovarian metastasis by pathological examination.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Medicine, General & Internal
Francesco Fortarezza, Mila Della Barbera, Federica Pezzuto, Francesca Lunardi, Eleonora Faccioli, Giulia Pasello, Federico Rea, Stefania Rizzo, Fiorella Calabrese
Summary: The histological diagnosis of pleural epithelioid mesothelioma can be challenging in cases of rare variants or patients with previous or concomitant tumors. Immunohistochemical reactions play a role in obtaining a sensitive and specific diagnosis of malignant pleural mesothelioma but sometimes the final interpretation remains inconclusive. Ultrastructural examination has historically been a useful tool in defining the mesothelial nature of neoplastic cells.
Article
Cell Biology
Elena A. Matveeva, Hejer Dhahri, Yvonne Fondufe-Mittendorf
Summary: The elongation of RNA polymerase along the gene body is tightly regulated, and PARP1 has been shown to regulate it by binding to IntS3. The physical presence of PARP1 affects the recruitment of IntS3 and other elongation factors, rather than its PARylation activity.
Article
Biochemistry & Molecular Biology
Laura Mannarino, Lara Paracchini, Federica Pezzuto, Gheorghe Emilian Olteanu, Laura Moracci, Luca Vedovelli, Irene De Simone, Cristina Bosetti, Monica Lupi, Rosy Amodeo, Alessia Inglesi, Maurizio Callari, Serena Penpa, Roberta Libener, Sara Delfanti, Antonina De Angelis, Alberto Muzio, Paolo Andrea Zucali, Paola Allavena, Giovanni Luca Ceresoli, Sergio Marchini, Fiorella Calabrese, Maurizio D'Incalci, Federica Grosso
Summary: This study identified distinct transcriptional profiles and immune features in long-term survivors of epithelioid pleural mesothelioma. Differences in B cell infiltration and TLS formation were observed between long and short-term survivors, suggesting the importance of B cell infiltration in modulating disease aggressiveness and providing a potential pathway for novel immunotherapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Erhan Aptullahoglu, Carmela Ciardullo, Jonathan P. Wallis, Helen Marr, Scott Marshall, Nick Bown, Elaine Willmore, John Lunec
Summary: This study investigates the effects of splicing modulation on key proteins in the p53 signaling pathway. The results show that splicing modulation by E7107 reduces full-length MDM2 production and increases p53 expression in TP53(WT) cells. Additionally, a novel isoform of p21(WAF1) with compromised kinase inhibitory activity is produced due to intron retention. E7107 synergizes with the MDM2 inhibitor RG7388, leading to greater p53 stabilization and apoptosis. This study provides evidence for a novel combination therapy of MDM2 and spliceosome inhibitors for the treatment of CLL and other hematological malignancies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Hans-Peter Rihs, Swaantje Casjens, Irina Raiko, Jens Kollmeier, Martin Lehnert, Kerstin Noefer, Kerstin May-Taube, Nina Kaiser, Dirk Taeger, Thomas Behrens, Thomas Bruening, Georg Johnen
Summary: Mesothelin is a biomarker for malignant mesothelioma, and its concentration is influenced by genetic variants. This study found that four genetic variants were associated with increased mesothelin concentrations, providing useful insight into high values of mesothelin protein in healthy individuals and improving diagnostic procedures.
Article
Multidisciplinary Sciences
Yung-Hsuan Wu, Shu-Ting Mo, I. -Ting Chen, Fu-Yi Hsieh, Shie-Liang Hsieh, Jinake Zhang, Ming-Zong Lai
Summary: Inhibition of Caspase-8 leads to inflammasome assembly and production of IL-10 and IL-18 in Toll-like receptor (TLR)-primed myeloid cells. Autophagy and cathepsin-B play important roles in the activation of inflammasomes when apoptosis and necroptosis are blocked and Caspase-8 is inhibited.
Article
Multidisciplinary Sciences
Jiankang Wang, Ryuichiro Nakato
Summary: Chromatin organization is controlled by cohesin and its dysfunction can cause various diseases, including cancer. Aberrant cohesin binding in cancer cells, which has not been comprehensively surveyed, is found to be responsible for dysregulated chromatin structure and transcription. CASs, identified as cancer-aberrant binding sites of cohesin, represent tissue-specific epigenomic signatures enriched for dysregulated genes and play a functional and clinical role in cancer. Cohesin depletion data suggests that cohesin binding at CASs actively regulates dysregulated genes in cancer cells.
Article
Oncology
Sophia Steinlein, Frank Essmann, Amanda Franceschini Ghilardi, Heike Horn, Julia Schueler, Angelika Hausser, Lijun Sun, German Ott, Claudia Kalla
Summary: In this study, two indolyl-chalcones (CIT-026 and CIT-223) were found to be highly effective in inhibiting the growth and viability of malignant pleural mesothelioma (MPM) cells, while having minimal effects on normal fibroblasts. These compounds induce tumor cell apoptosis by disrupting microtubule assembly and show promising potential as small-molecule therapeutics for MPM, especially in cells resistant to standard therapeutics.
FRONTIERS IN ONCOLOGY
(2023)
Article
Fisheries
Wei Qin, Yang Lu, Hongyu Wang, Beixiang Liu, Zuosheng Jiang, Chengxiang Zhou, Xin Huang, Xiaoling Dai, Qian Ren
Summary: In this study, a clip domain serine protease (MncSP) and its alternative transcript (MncSP-isoform) were identified from Macrobrachium nipponense, which are widely distributed in different tissues. MncSP participated in the synthesis of antimicrobial peptides (AMPs) and the activation of prophenoloxidase, as shown through expression profile analysis and RNAi experiments.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Virology
Samuel J. Resnick, Sho Iketani, Seo Jung Hong, Arie Zask, Hengrui Liu, Sungsoo Kim, Schuyler Melore, Fang-Yu Lin, Manoj S. Nair, Yaoxing Huang, Sumin Lee, Nicholas E. S. Tay, Tomislav Rovis, Hee Won Yang, Li Xing, Brent R. Stockwell, David D. Ho, Alejandro Chavez
Summary: The study developed a simplified cell-based assay for identifying chemical inhibitors of a wide range of coronavirus 3CL proteases, which can be widely used in laboratories. The assay, without the need for live virus, is suitable for high-throughput screening and has identified broad-spectrum inhibitors.
JOURNAL OF VIROLOGY
(2021)
Article
Hematology
Thierry Guillaume, Virginie Dehame, Patrice Chevallier, Pierre Peterlin, Alice Garnier, Marc Gregoire, Edward Pichinuk, Daniel B. Rubinstein, Daniel H. Wreschner
EXPERIMENTAL HEMATOLOGY
(2019)
Article
Nanoscience & Nanotechnology
Joanna Boucard, Tina Briolay, Thibaut Blondy, Mohammed Boujtita, Steven Nedellec, Philippe Hulin, Marc Gregoire, Christophe Blanquart, Elena Ishow
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Oncology
Beatrice Vanbervliet-Defrance, Tiphaine Delaunay, Thomas Daunizeau, Vahan Kepenekian, Olivier Glehen, Kathrin Weber, Yann Estornes, Audrey Ziverec, Leila Djemal, Marion Delphin, Sylvie Lantuejoul, Guillaume Passot, Marc Gregoire, Olivier Micheau, Christophe Blanquart, Toufic Renno, Jean-Francois Fonteneau, Serge Lebecque, Karene Mahtouk
Article
Oncology
Tiphaine Delaunay, Carole Achard, Nicolas Boisgerault, Marion Grard, Tacien Petithomme, Camille Chatelain, Soizic Dutoit, Christophe Blanquart, Pierre-Joseph Royer, Stephane Minvielle, Lisa Quetel, Clement Meiller, Didier Jean, Delphine Fradin, Jaafar Bennouna, Antoine Magnan, Laurent Cellerin, Frederic Tangy, Marc Gregoire, Jean-Francois Fonteneau
JOURNAL OF THORACIC ONCOLOGY
(2020)
Article
Infectious Diseases
Karine Petit, Charlotte Dunoyer, Claude Fischer, Jean Hars, Eric Baubet, Jorge Ramon Lopez-Olvera, Sophie Rossi, Eric Collin, Marie-Frederique Le Potier, Catherine Belloc, Carole Peroz, Nicolas Rose, Jean-Pierre Vaillancourt, Claude Saegerman
TRANSBOUNDARY AND EMERGING DISEASES
(2020)
Article
Oncology
Joelle S. Nader, Jordan Guillon, Coralie Petit, Alice Boissard, Florence Franconi, Stephanie Blandin, Sylvia Lambot, Marc Gregoire, Veronique Verriele, Beatrice Nawrocki-Raby, Philippe Birembaut, Olivier Coqueret, Catherine Guette, Daniel L. Pouliquen
Letter
Oncology
Didier Jean, Tiphaine Delaunay, Clement Meiller, Nicolas Boisgerault, Marion Grard, Stefano Caruso, Christophe Blanquart, Emanuela Felley-Bosco, Jaafar Bennouna, Frederic Tangy, Marc Gregoire, Jean-Francois Fonteneau
JOURNAL OF THORACIC ONCOLOGY
(2020)
Article
Veterinary Sciences
M. Brentini, C. Peroz, E. Dagher, S. Labrut, O. Albaric, J. Despres, C. Tesson, P. Bourreau, S. Assie, L. Michelet, M. L. Boschiroli, C. Chartier
PREVENTIVE VETERINARY MEDICINE
(2020)
Article
Oncology
Thibaut Blondy, Senan Mickael d'Almeida, Tina Briolay, Julie Tabiasco, Clement Meiller, Anne-Laure Chene, Laurent Cellerin, Sophie Deshayes, Yves Delneste, Jean-Francois Fonteneau, Nicolas Boisgerault, Jaafar Bennouna, Marc Gregoire, Didier Jean, Christophe Blanquart
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Veterinary Sciences
Antoine Rostang, Carole Peroz, Catherine Fournel, Chantal Thorin, Segolene Calvez
Summary: The use of enrofloxacin in trout farms for the treatment of yersiniosis should be reevaluated, as a single intraperitoneal injection of ENR at 10 mg/kg appears to be more effective than repeated oral administrations. This study suggests the need for revising the oral doses used in trout farms.
Article
Veterinary Sciences
Viviane Henaux, Claire Ponsart, Justine Corre, Florence Etore, Henri-Jean Boulouis, Herve Morvan, Lionel Grisot, Carole Peroz
Summary: The study evaluated the effectiveness of bTB surveillance in high-risk areas in France, finding that increasing monitoring and preventive measures can significantly improve the detection fraction of infected herds.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Respiratory System
Antoine Moui, Stephanie Dirou, Christine Sagan, Renan Liberge, Claire Defrance, Pierre-Paul Arrigoni, Olivier Morla, Christine Kandel-Aznar, Laurent Cellerin, Arnaud Cavailles, Emmanuel Eschapasse, Florent Morio, Pierre-Antoine Gourraud, Thomas Goronflot, Adrien Tissot, Francois-Xavier Blanc
Summary: Our study highlights the additional value of BAL qualitative description in ILD. We suggest incorporating the immune alveolitis profile for the diagnosis and management of ILD, especially in immunocompromised patients, since it guides towards specific diagnoses.
BMC PULMONARY MEDICINE
(2022)
Article
Respiratory System
Agathe Delbove, Thomas Senage, Pierre Gazengel, Adrien Tissot, Philippe Lacoste, Laurent Cellerin, Christian Perigaud, Isabelle Danner-Boucher, Arnaud Cavailles, Thierry Lepoivre, Antoine Mugniot, Johanna Nicolet, Delphine Horeau-Langlard, Nicolas Groleau, Yannick Fedun, Bertrand Rozec, Antoine Magnan, Jean-Christian Roussel, Francois-Xavier Blanc
Summary: Anastomotic complications are common and serious after lung transplantation. This study analyzed the occurrence, risk factors, and impact on survival of symptomatic anastomotic complications in patients between 2010 and 2016. Donor lung infection and age were identified as major factors associated with the occurrence of complications.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
Meeting Abstract
Respiratory System
Thomas Egenod, Nicolas Guibert, Yoann Ammar, Romain Kessler, Benedicte Toublanc, Nicolas Favrolt, Amandine Briault, Herve Dutau, Frederic Wallyn, Armelle Marceau, Laurent Cellerin, Samy Lachkar, Julien Dutilh, Jean-Michel Vergnon, Matthieu Dusselier
EUROPEAN RESPIRATORY JOURNAL
(2020)