Article
Biology
Xi Xu, Weiwei Ma, Guo Qiu, Li Xuan, Chong He, Tian Zhang, Jian Wang, Qifa Liu
Summary: In this study, we analyzed the genetic characteristics of sorafenib-resistant AML cells and found that they can promote BCL2 transcription by activating STAT3. By introducing the BCL2 inhibitor venetoclax, the chemotherapy sensitivity of AML cells to sorafenib can be enhanced.
Letter
Oncology
Yunxin Zeng, Xinyu Zhang, Dongjun Lin, Xiaohui Feng, Yuye Liu, Zhengwen Fang, Weijian Zhang, Yu Chen, Meng Zhao, Jun Wu, Linjia Jiang
Summary: This study revealed that hypoxia environment increases lysosomes in leukemia cells, which in turn reduces the effectiveness of chemotherapy drugs. By developing a novel nanomedicine targeting lysosomes, the researchers were able to enhance the chemotherapy outcome in leukemia. This new approach shows promising results in overcoming chemoresistance in myeloid leukemia.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Review
Oncology
Sreoshee Rafiq, Sharon L. McKenna, Sylviane Muller, Mario P. Tschan, Magali Humbert
Summary: Lysosomes, traditionally known for degrading cellular macromolecules, have emerged as crucial regulators of cell homeostasis. Their involvement in cellular trafficking, nutrient signaling, energy metabolism, and immune regulation has sparked interest in targeting lysosomes for novel disease treatments, particularly cancer. This review highlights the diverse functions of lysosomes and their importance in malignant disease, with a focus on potential targeting strategies in acute myeloid leukemia (AML).
Article
Biochemistry & Molecular Biology
Emeline Bollaert, Melissa Claus, Virginie Vandewalle, Sandrine Lenglez, Ahmed Essaghir, Jean-Baptiste Demoulin, Violaine Havelange
Summary: The study found that miR-15a-5p induces chemoresistance in AML cells by inhibiting daunorubicin-induced autophagy, suggesting that this miRNA could be a promising therapeutic target for chemoresistant AML patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Jie Sun, Fan Xia, Shaoqi Zhang, Bo Zhang, Yunan Guan, Xi Hu, Pengpeng Xue, Shengfei Yang, Yan Zhou, Daishun Ling, Fangyuan Li
Summary: Cell cycle checkpoint activation promotes DNA damage repair and is associated with the chemoresistance of various cancers. This study reports a selective nano cell cycle checkpoint inhibitor (NCCI) that can inhibit the cell cycle checkpoint of acute myeloid leukemia (AML) to enhance the chemotherapeutic efficacy. NCCI can selectively accumulate in AML cells and degrade proteins involved in the G2/M checkpoint, resulting in the revitalization of the anti-AML efficacy of cytarabine. This study provides new insights into designing selective cell cycle checkpoint inhibitors for biomedical applications.
Article
Oncology
Aleksandra Olszewska, Agata Borkowska, Monika Granica, Justyna Karolczak, Bartosz Zglinicki, Claudine Kieda, Halina Was
Summary: The study aimed to investigate the role of autophagy in the senescence-related chemoresistance of lung cancer cells. The results showed that hypoxia facilitates cancer cells to escape from CIS-induced senescence, which could be overcome by autophagy inhibition with HCQ.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Chendi Xie, Hui Zhou, Dongmei Qin, Huijian Zheng, Yuanfang Tang, Wenjuan Li, Jie Zhou, Long Liu, Xinxin Yu, Hongpeng Duan, Yong Zhou, Zhifeng Li, Zhihong Fang, Yiming Luo, Bing Z. Carter, Bing Xu, Jie Zha
Summary: This study found that the combination of Bcl-2 inhibitor venetoclax and PPARa agonist chiglitazar can effectively eliminate LSCs of acute myeloid leukemia (AML) without damaging normal cells. This combination therapy also significantly inhibits AML progression in mouse models.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Jinbao Chen, Jian Xu, Jiahua Yang, Yueping Zhan, Sen Li, Linlin Jia, Wentao Wu, Xianke Si, Die Zhang, Kun Yu, Peihao Yin, Yijun Cao, Wanli Deng, Ke Xu, Wei Li
Summary: Chemoresistance is a significant challenge for patients with colorectal cancer (CRC), and hypoxia is associated with poor prognosis and therapeutic resistance in cancer patients. Alpha-hederin has shown antitumour effects and can inhibit hypoxia-mediated drug resistance in CRC, but the underlying mechanism is still unclear. This study reveals that alpha-hederin inhibits drug resistance in hypoxic CRC cells by reducing AKT phosphorylation and Bcl2 expression, promoting apoptosis. These findings suggest that alpha-hederin may be a promising adjuvant for reversing drug resistance in CRC.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Mashima Naksawat, Chosita Norkaew, Kantorn Charoensedtasin, Sittiruk Roytrakul, Dalina Tanyong
Summary: This study revealed the anti-leukemic effects and underlying mechanisms of menthol in NB4 and Molt-4 leukemic cell lines, including induction of apoptosis and autophagy through activating the caspase cascade, regulating BAX and p53/MDM2, and modulating autophagy via the ATG3/mTOR signaling pathway.
Letter
Oncology
Peihong Wang, Xinhua Xiao, Yuyin Zhang, Baoyuan Zhang, Donghe Li, Mingzhu Liu, Xi Xie, Chenxuan Liu, Ping Liu, Ruibao Ren
Summary: Research has identified KX2-391 as a promising FLT3 inhibitor for treating AML patients, especially those with drug-resistant FLT3-ITD-TKD mutations, showing significant efficacy in inhibiting FLT3 phosphorylation and enhancing apoptosis in AML cell lines.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Oncology
Hongdan Dai, Jianming Wang, Zhenglan Huang, Hui Zhang, Xin Wang, Qian Li, Wenli Feng
Summary: The study demonstrated that autophagy is associated with drug resistance in CML cells, and upregulation of OIP5-AS1 enhances autophagy while knockdown of OIP5-AS1 suppresses it and increases sensitivity to IM. OIP5-AS1 regulates ATG12 by competitively binding miR-30e-5p, affecting autophagy-related drug resistance in CML cells.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Article
Oncology
Harshit Shah, Metodi Stankov, Diana Panayotova-Dimitrova, Amir Yazdi, Ramachandramouli Budida, Jan-Henning Klusmann, Georg M. N. Behrens
Summary: Current cancer research shows an interest in exploring lysosomal membrane permeabilization and lysosomal cell death as a targeted therapeutic approach for cancer treatment. Differences in lysosomal biogenesis between cancer and normal cells may provide a therapeutic window. Mefloquine was identified as a selective activator of lysosomal biogenesis in multiple myeloid leukemia (ML) cells, and its combination with mTOR inhibition induced targeted ML cell death without additional toxicity.
FRONTIERS IN ONCOLOGY
(2023)
Article
Hematology
Kaitlyn M. Dykstra, Hannah R. S. Fay, Ashish C. Massey, Neng Yang, Matthew Johnson, Scott Portwood, Monica L. Guzman, Eunice S. Wang
Summary: This passage discusses the role of autophagy in the survival, mitochondrial function, and cell death of AML cells. The study found that inducing apoptosis in AML cells and preventing the maintenance of AML LSCs can be achieved by using autophagy inhibitors, which also reveals the effectiveness of autophagy inhibitors in inducing AML cell death is related to inducing mitochondrial damage and mitophagy simultaneously.
Review
Pharmacology & Pharmacy
Mehrdad Izadirad, Leila Jafari, Alva Rani James, Juan Pablo Unfried, Zhuo-Xun Wu, Zhe-Sheng Chen
Summary: lncRNAs play a crucial role in the development of drug resistance in AML patients, serving as potential molecular markers for diagnosis, predicting response to chemotherapy, and novel therapeutic targets for AML.
DRUG DISCOVERY TODAY
(2021)
Review
Cell Biology
Wenxin Du, Aixiao Xu, Yunpeng Huang, Ji Cao, Hong Zhu, Bo Yang, Xuejing Shao, Qiaojun He, Meidan Ying
Summary: Autophagy plays a crucial role in the development of AML, with studies indicating the potential of modulating autophagy to enhance targeted therapy for AML.
Meeting Abstract
Hematology
Hannah R. S. Fay, Kaitlyn M. Dykstra, Matthew Johnson, Tara L. Cronin, Linda Lutgen-Dunckley, Brandon L. Martens, Joseph R. Moberg, Monica L. Guzman, Eunice S. Wang
Article
Hematology
Kaitlyn M. Dykstra, Hannah R. S. Fay, Ashish C. Massey, Neng Yang, Matthew Johnson, Scott Portwood, Monica L. Guzman, Eunice S. Wang
Summary: This passage discusses the role of autophagy in the survival, mitochondrial function, and cell death of AML cells. The study found that inducing apoptosis in AML cells and preventing the maintenance of AML LSCs can be achieved by using autophagy inhibitors, which also reveals the effectiveness of autophagy inhibitors in inducing AML cell death is related to inducing mitochondrial damage and mitophagy simultaneously.
Article
Cardiac & Cardiovascular Systems
Ankeet S. Bhatt, Anubodh S. Varshney, Erica L. Goodrich, Jingyi Gong, Curtis Ginder, Balimkiz C. Senman, Matthew Johnson, Kayleigh Butler, Ann E. Woolley, James A. de Lemos, David A. Morrow, Erin A. Bohula
Summary: STEMI is a rare but detrimental complication in hospitalized COVID-19 patients, with low rates of coronary angiography and primary reperfusion therapy. Adaptations in treatment systems are needed to ensure timely and modern care for this population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Meeting Abstract
Hematology
Matthew Johnson, Kaitlyn Dykstra, Tara Cronin, Linda Lutgen-Dunckley, Brandon L. Martens, Monica L. Guzman, Eunice S. Wang
