Article
Endocrinology & Metabolism
Jinhua Xu, Jingjing Li, Guofeng Wu, Yajun Ren, Xue Wang, Qianyun Zhang
Summary: The study evaluated the effects of pemetrexed combined with cisplatin on the immune system of NSCLC patients. The results showed that patients treated with pemetrexed plus cisplatin had higher levels of interferon-γ and tumor necrosis factor-alpha, and lower levels of CD4+ T cells and tumor markers compared to those treated with docetaxel plus cisplatin.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Cell Biology
Ravi Danielsson, Hakan Eriksson
Summary: Aluminium salts have been used in vaccines as adjuvants for almost a century, but the mechanisms behind the immune stimulating properties are still not fully understood. A persistent intracellular presence of aluminium ions over an extended time may affect the functionality of sentinel cells of the innate immune system, inducing polarization and activation. The immune stimulating properties of aluminium adjuvants are presumably mediated by several discrete events, with a persistent intracellular presence of aluminium ions being a key factor.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Quentin Devalloir, Clementine Fritsch, Yara Alchammas, Francis Raoul, Vincent Driget, Caroline Amiot, Shinji Ozaki, Nico van den Brink, Renaud Scheifler
Summary: Cadmium and lead exposure enhances immune cell damage and reduces immunity, while selenium plays a crucial role in immune response. This study found that animals exposed to highly polluted environments showed higher inflammatory response to immune challenge, whereas animals with low exposure had faster recovery when fed a standard diet. Additionally, selenium played a functional role in the inflammatory response.
ENVIRONMENTAL POLLUTION
(2023)
Article
Engineering, Environmental
Li Wang, Yinghui Zhong, Qianqian Wu, Yu Wang, Ruoqi Tang, Silu Zhou, Jingde Yang, Qiming Liu, Guoxin Shi, Yanan Tang, Xianglong Meng, Kexin Chen, Xianqiang Yan, Xuelei Liu, Jing Zhan, Thomas M. Roberts, Song Liang, Jiaao Yu, Zhenning Liu
Summary: Two types of spermidine-functionalized biomaterials have been fabricated and shown to inhibit inflammatory responses and promote wound healing through in vitro and in vivo experiments. The findings of the proteomic analysis suggest possible mechanisms underlying these effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cell Biology
Michael K. Fasseas, Manish Grover, Florence Drury, Clara L. Essmann, Eva Kaulich, William R. Schafer, Michalis Barkoulas
Summary: This study reveals the recognition and response mechanisms of Caenorhabditis elegans to oomycetes, demonstrating that the nematode can enhance its immune response by sensing substances derived from animals infected with oomycetes. Neuron-to-epidermis communication plays a crucial role in shaping animal hosts' responses to oomycete recognition.
Article
Nutrition & Dietetics
Barbara Wroblewska, Ewa Kubicka, Ewelina Semenowicz, Anna Ogrodowczyk, Anita Mikolajczyk, Dagmara Zlotkowska
Summary: Barley proteins are similar to wheat proteins and can cause allergic reactions. The 15-kDa fraction (B-FrVI) of barley proteins showed the strongest immune response. In a mouse model, B-FrVI protein significantly enhanced specific immune responses and stimulated lymphocyte proliferation.
Review
Immunology
Zhangyan Jing, Yuan Li, Yumeng Ma, Xiaozhou Zhang, Xin Liang, Xudong Zhang
Summary: This review discusses the recent advances in using biomaterials for immunomodulation in the treatment of type 1 diabetes, which can reduce the side effects of immunosuppressants. The applications include targeted delivery, regulation of autoreactive T cells, and restoration of immune tolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Guillermo Bauza-Mayol, Marcos Quintela, Ava Brozovich, Michael Hopson, Shazad Shaikh, Fernando Cabrera, Aaron Shi, Federica Banche Niclot, Francesca Paradiso, Emma Combellak, Tom Jovic, Paul Rees, Ennio Tasciotti, Lewis W. Francis, Patrick Mcculloch, Francesca Taraballi
Summary: The use of biomimetic scaffolds in cartilage tissue engineering shows promising results in enhancing cartilaginous tissue formation and suppressing host cartilage degeneration. This approach may provide a clinical solution for cartilage tissue repair by modulating the immune environment to favor regenerative processes and suppress cartilage degeneration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Immunology
Yue Lang, Yanan Lyu, Yehui Tan, Zheng Hu
Summary: Hematological malignancy is a serious disease that endangers human health and the research on its pathogenesis and therapies relies on the use of animal models. Recent studies have increasingly utilized mouse models hosting human hematological malignancy, which can better mimic human characteristics. Depending on the construction methods, these models can be categorized into different types with diverse characteristics and application values. Various strategies have also been developed to improve the engraftment and differentiation of human hematological malignant cells in vivo. Additionally, the humanized mouse model with both functional human immune system and autologous human hematological malignancy provides a unique tool for evaluating the efficacy of novel immunotherapeutic drugs/approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Xiaoshen Hu, Weiyang Zhang, Xiang Li, Dongling Zhong, Yuxi Li, Juan Li, Rongjiang Jin
Summary: Studies have shown that chondrocytes tend to dedifferentiate during cell amplification, losing their physiological properties, but recent research has made progress in redifferentiation control. By modulating various factors in cell culture, similar physiological characteristics and functions to human cartilage tissue have been achieved, offering hope for future cartilage repair and treatment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Miriam Filippi, Francesca Garello, Oncay Yasa, Jesil Kasamkattil, Arnaud Scherberich, Robert K. Katzschmann
Summary: The article discusses the applications of magnetic nanoparticles in biomedicine and their combination with polymers to form magnetic nanocomposites. These composites have the potential to modulate various cellular functions and show promise in regenerative medicine and the development of biomedical robots.
Article
Multidisciplinary Sciences
Zexian Zeng, Shengqing Stan Gu, Cheryl J. Wong, Lin Yang, Nofal Ouardaoui, Dian Li, Wubing Zhang, Myles Brown, X. Shirley Liu
Summary: Using a machine learning framework based on syngeneic mouse tumor models, we developed a predictive model for tumor immunity and response to immune checkpoint blockade (ICB) therapy. This model was able to accurately predict ICB response in human immunotherapy trials and identify ICB-responsive/resistant cancer types in The Cancer Genome Atlas. Feature analysis revealed factors associated with ICB response.
Article
Immunology
Weijie Ma, Sixi Wei, Siqi Long, Eddie C. Tian, Bridget Mclaughlin, Maria Jaimes, Dennis J. Montoya, Varun R. Viswanath, Jeremy Chien, Qianjun Zhang, Jonathan E. Van Dyke, Shuai Chen, Tianhong Li
Summary: The use of multicolor spectrum flow cytometry helps identify potential blood immune biomarkers for immune checkpoint inhibitor (ICI) treatment in non-small-cell lung cancer (NSCLC) patients. The frequency of CD4+ central memory cells and CD4-CD8- double-negative (DN) T cells before treatment is associated with progression-free survival (PFS). ICIs significantly change the frequency of cytotoxic CD8+PD1+ T cells, DN T cells, CD16+CD56dim and CD16+CD56- natural killer (NK) cells, and CD14+HLDRhigh and CD11c+HLADR + monocytes. An increase in the frequency of CD16+CD56dim NK cells and CD14+HLADRhigh monocytes after treatment is associated with a longer PFS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Alejandra Escos, Ester Diaz-Mora, Michael Pattison, Pilar Fajardo, Diego Gonzalez-Romero, Ana Risco, Jose Martin-Gomez, Eric Bonneil, Nahum Sonenberg, Seyed Mehdi Jafarnejad, Juan Jose Sanz-Ezquerro, Steven C. Ley, Ana Cuenda
Summary: Evidence implicating p38? and p38d in inflammation is mainly based on experiments using Mapk12/Mapk13-deficient mice. A new mouse model, p38?/dKIKO, with specific depletion of p38? and p38d was generated to study their functions. The results showed reduced inflammation, susceptibility to septic shock, and Candida albicans infection in p38?/dKIKO mice compared to wild-type mice. Gene expression and phosphorylation analyses revealed the involvement of p38?/p38d in regulating innate immune responses through MEF2D phosphorylation and transcriptional activity.
Article
Immunology
Glaivy Batsuli, Jasmine Ito, Elizabeth S. York, Courtney Cox, Wallace Baldwin, Surinder Gill, Pete Lollar, Shannon L. Meeks
Summary: This study analyzed the internalization of FVIII complexed with epitope-mapped FVIII-specific IgG monoclonal antibodies by murine bone marrow-derived dendritic cells (BMDCs) in vitro, as well as the antibody development in hemophilia A (FVIII-/-) mice injected with FVIII-IC over time. The results showed that certain FVIII-IC subsets modulate the humoral response to FVIII in an epitope-dependent manner.
FRONTIERS IN IMMUNOLOGY
(2023)