期刊
CANCER RESEARCH
卷 73, 期 8, 页码 2400-2406出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-12-4348
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资金
- Cancer Council Victoria Postgraduate Scholarship
- GlaxoSmithKline Postgraduate Award
- Association of International Cancer Research project grant
- National Breast Cancer Foundation Fellowship
Siah ubiquitin ligases play important roles in a number of signaling pathways involved in the progression and spread of cancer in cell-based models, but their role in tumor progression remains controversial. Siah proteins have been described to be both oncogenic and tumor suppressive in a variety of patient cohort studies and animal cancer models. This review collates the current knowledge of Siah in cancer progression and identifies potential methods of translation of these findings into the clinic. Furthermore, key experiments needed to close the gaps in our understanding of the role Siah proteins play in tumor progression are suggested. Cancer Res; 73(8); 2400-6. (C) 2013 AACR.
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