Article
Immunology
Lei Chen, Yi Zheng, Changqin Jiang, Cheng Yang, Li Zhang, Chaozhao Liang
Summary: Prostate cancer is a common malignancy among men with poor prognosis, especially in cases of recurrence and advanced disease. A study identified chemokine genes associated with the prognosis of PCa and established a prognostic gene signature. The CRPGS could predict patient responses to anti-androgen and immunotherapies, and was associated with clinical characteristics of PCa patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Deng Wang, Chaping Cheng, Xinyu Chen, Jinming Wang, Kaiyuan Liu, Na Jing, Penghui Xu, Xialian Xi, Yujiao Sun, Zhongzhong Ji, Huifang Zhao, Yuman He, Kai Zhang, Xinxing Du, Baijun Dong, Yuxiang Fang, Pengcheng Zhang, Xueming Qian, Wei Xue, Wei-Qiang Gao, Helen He Zhu
Summary: The activation of androgen receptor (AR) signaling pathway in tumor-associated macrophages (TAMs) promotes the overexpression and secretion of IL-1 beta, inhibiting cytotoxic T cells activation and leading to an immune suppressive microenvironment in advanced prostate cancer (PCa). Combined treatment of androgen deprivation therapy (ADT) with anti-IL-1 beta antibody and immune checkpoint inhibitor anti-PD-1 antibody shows a stronger anticancer effect on castration-resistant PCa.
Article
Multidisciplinary Sciences
Jae-Uk Jeong, Taek-Keun Nam, Ju-Young Song, Mee Sun Yoon, Sung-Ja Ahn, Woong-Ki Chung, Ick Joon Cho, Yong-Hyub Kim, Shin Haeng Cho, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon
Summary: In patients with locally advanced prostate cancer, the addition of long-term A-ADT over 1 year to radiotherapy leads to favorable biochemical failure-free survival and overall survival rates. Achieving a nadir PSA value <= 0.001 ng/mL is a strong clinical predictor of treatment outcomes for prostate cancer patients receiving combination therapy with radiotherapy and A-ADT.
Review
Cell Biology
Ujjwal R. Dahiya, Hannelore Heemers
Summary: The androgen receptor (AR) plays a crucial role in male phenotype development and diseases, including prostate cancer. Therapeutic approaches targeting the interaction between AR and its ligands show promise, but face challenges. Understanding the 3D structure of AR complexes and protein interaction sites is essential for developing effective interventions.
Article
Medicine, General & Internal
Mallika Marar, Qi Long, Ronac Mamtani, Vivek Narayan, Neha Vapiwala, Ravi B. Parikh
Summary: This study investigated the differences in outcomes between African American and non-Hispanic White men with metastatic castration-resistant prostate cancer (mCRPC) who received first-line abiraterone therapy. The results showed that African American men had a higher overall survival when receiving first-line abiraterone compared to non-Hispanic White men. However, there was a difference in outcomes between the two groups for first-line enzalutamide treatment.
Article
Medicine, General & Internal
Gerhardt Attard, Laura Murphy, Noel W. Clarke, William Cross, Robert J. Jones, Christopher C. Parker, Silke Gillessen, Adrian Cook, Chris Brawley, Claire L. Amos, Nafisah Atako, Cheryl Pugh, Michelle Buckner, Simon Chowdhury, Zafar Malik, J. Martin Russell, Clare Gilson, Hannah Rush, Jo Bowen, Anna Lydon, Ian Pedley, Joe M. O'Sullivan, Alison Birtle, Joanna Gale, Narayanan Srihari, Carys Thomas, Jacob Tanguay, John Wagstaff, Prantik Das, Emma Gray, Mymoona Alzoueb, Omi Parikh, Angus Robinson, Isabel Syndikus, James Wylie, Anjali Zarkar, George Thalmann, Johann S. de Bono, David P. Dearnaley, Malcolm D. Mason, Duncan Gilbert, Ruth E. Langley, Robin Millman, David Matheson, Matthew R. Sydes, Louise C. Brown, Mahesh K. B. Parmar, Nicholas D. James
Summary: The combination therapy of abiraterone acetate with prednisolone showed significantly higher rates of metastasis-free survival compared with ADT alone in men with high-risk non-metastatic prostate cancer. This combination therapy may be considered a new standard treatment for this patient population.
Article
Oncology
A. I. Peltomaa, P. Raittinen, K. Talala, K. Taari, T. L. J. Tammela, A. Auvinen, T. J. Murtola
Summary: Statins have been found to improve the prognosis of prostate cancer patients undergoing androgen deprivation therapy, but only when used after the initiation of ADT, not before.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Oncology
Martin R. Stockler, Andrew J. Martin, Ian D. Davis, Haryana M. Dhillon, Stephen D. Begbie, Kim N. Chi, Simon Chowdhury, Xanthi Coskinas, Mark Frydenberg, Wendy E. Hague, Lisa G. Horvath, Anthony M. Joshua, Nicola J. Lawrence, Gavin M. Marx, John McCaffrey, Ray McDermott, Margaret McJannett, Scott A. North, Francis Parnis, Wendy R. Parulekar, David W. Pook, M. Neil Reaume, Shahneen Sandhu, Alvin Tan, Thean Hsiang Tan, Alastair Thomson, Francisco Vera-Badillo, Scott G. Williams, Diana G. Winter, Sonia Yip, Alison Y. Zhang, Robert R. Zielinski, Christopher J. Sweeney
Summary: Enzalutamide improves overall survival in metastatic, hormone-sensitive prostate cancer, but has limited effects on health-related quality of life.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Shabbir M. H. Alibhai, Henriette Breunis, Gregory Feng, Narhari Timilshina, Aaron Hansen, Padraig Warde, Richard Gregg, Anthony Joshua, Neil Fleshner, George Tomlinson, Urban Emmenegger
Summary: This study longitudinally examined cognitive function in older men with metastatic castration-resistant prostate cancer undergoing treatment with docetaxel, abiraterone, enzalutamide, and radium Ra 223. The findings suggest that most older men do not experience significant cognitive decline in attention, executive function, and global cognition regardless of the treatment used.
Review
Biochemistry & Molecular Biology
Tae Jin Kim, Young Hwa Lee, Kyo Chul Koo
Summary: The androgen receptor (AR) plays a crucial role in the development and progression of prostate cancer (PCa), and treatment for hormone-sensitive prostate cancer (HSPC) relies heavily on androgen deprivation therapy (ADT). Despite most patients progressing to castration-resistant prostate cancer (CRPC), studies suggest that manipulating alternative molecular pathways can help improve current treatments and develop novel therapies for CRPC management.
Article
Multidisciplinary Sciences
Wei Tan, Liang Gao, Ye Yuan, Hao Huang, Yadong Li, Yuanqing Gou, Zili Hu
Summary: Research has shown a higher occurrence of bladder cancer in men compared to women, leading researchers to investigate the role of androgen in bladder cancer. A study was conducted with 147 patients diagnosed with primary bladder cancer and 154 non-tumor patients as the control group. The results revealed a significant correlation between serum total testosterone levels and the occurrence of bladder cancer, along with other factors such as hemoglobin, hypertension, diabetes, and smoking.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Sheng-Feng Lin, Hsiu-Chen Lin, Mei-Yu Lee, Joseph Jordan Keller, Li-Hsuan Wang
Summary: This study found a decreased risk of atopic diseases in patients with prostate cancer treated with GnRH analogues. Further studies are warranted to verify the association between testosterone levels and atopic diseases.
Article
Oncology
Ryohei Kufukihara, Eiji Kikuchi, Koichiro Ogihara, Keisuke Shigeta, Yoshinori Yanai, Kimiharu Takamatsu, Hiroki Ide, Masafumi Oyama, Hirotaka Asakura, Ryuichi Mizuno, Mototsugu Oya
Summary: The study suggests that a previous history of non-urothelial malignancy may result in worse clinical outcomes for patients with NMIBC, especially for current smokers.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Fatima Karzai, Stephanie M. Walker, Scott Wilkinson, Ravi A. Madan, Joanna H. Shih, Maria J. Merino, Stephanie A. Harmon, David J. VanderWeele, Lisa M. Cordes, Nicole Carrabba, John R. Bright, Nicolas T. Terrigino, Guinevere Chun, Marijo Bilusic, Anna Couvillon, Amy Hankin, Monique N. Williams, Rosina T. Lis, Huihui Ye, Peter L. Choyke, James L. Gulley, Adam G. Sowalsky, Baris Turkbey, Peter A. Pinto, William L. Dahut
Summary: For patients with localized intermediate- or high-risk prostate cancer, baseline mpMRI can help predict pathologic response, with low relative tumor burden at initial scan being most predictive of minimal residual disease or pathologic complete response. Tailoring patient selection based on these metrics may lead to improved outcomes in high-risk disease.
CLINICAL CANCER RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Masaki Shiota, Miho Ushijima, Shigehiro Tsukahara, Shohei Nagakawa, Leandro Blas, Dai Takamatsu, Satoshi Kobayashi, Takashi Matsumoto, Junichi Inokuchi, Masatoshi Eto
Summary: This study explored the cellular mechanisms involved in steroidogenesis that lead to resistance to the antiandrogen agent darolutamide in prostate cancer. The overexpression of HSD3B1 and its upstream regulator NR5A2 were found in darolutamide-resistant cells, and they were induced by darolutamide treatment and AR knockdown. Inhibiting the NR5A2/HSD3B1 pathway can increase cellular sensitivity to darolutamide, suggesting it as a potential therapeutic strategy to overcome resistance.
DRUG RESISTANCE UPDATES
(2023)
Article
Gastroenterology & Hepatology
Yongfeng Song, Chune Liu, Xia Liu, Jocelyn Trottier, Michele Beaudoin, Li Zhang, Chad Pope, Guangyong Peng, Olivier Barbier, Xiaobo Zhong, Linheng Li, Li Wang
Article
Biochemistry & Molecular Biology
Marine S. Da Silva, Pierre Julien, Jean-Francois Bilodeau, Olivier Barbier, Iwona Rudkowska
Article
Gastroenterology & Hepatology
Anna Cieslak, Jocelyn Trottier, Melanie Verreault, Piotr Milkiewicz, Marie-Claude Vohl, Olivier Barbier
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Gastroenterology & Hepatology
Martin Perreault, Ewa Wunsch, Andrzej Bialek, Jocelyn Trottier, Melanie Verreault, Patrick Caron, Guy G. Poirier, Piotr Milkiewicz, Olivier Barbier
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2018)
Article
Gastroenterology & Hepatology
Fernando F. Anhe, Renato T. Nachbar, Thibault V. Varin, Jocelyn Trottier, Stephanie Dudonne, Melanie Le Barz, Perrine Feutry, Genevieve Pilon, Olivier Barbier, Yves Desjardins, Denis Roy, Andre Marette
Article
Gastroenterology & Hepatology
Ewa Wunsch, Joanna Raszeja-Wyszomirska, Olivier Barbier, Malgorzata Milkiewicz, Marcin Krawczyk, Piotr Milkiewicz
JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
(2018)
Article
Endocrinology & Metabolism
Mathilde Mouchiroud, Etienne Camire, Manal Aldow, Alexandre Caron, Eric Jubinville, Laurie Turcotte, Ines Kaci, Marie-Josee Beaulieu, Christian Roy, Sebastien M. Labbe, Thibault V. Varin, Yves Gelinas, Jennifer Lamothe, Jocelyn Trottier, Patricia L. Mitchell, Frederic Guenard, William T. Festuccia, Philippe Joubert, Christopher F. Rose, Constantine J. Karvellas, Olivier Barbier, Mathieu C. Morissette, Andre Marette, Mathieu Laplante
MOLECULAR METABOLISM
(2019)
Article
Biochemistry & Molecular Biology
Lais R. Perazza, Patricia L. Mitchell, Farah Lizotte, Benjamin A. H. Jensen, Philippe St-Pierre, Jocelyn Trottier, Olivier Barbier, Patrick Mathieu, Pedro M. Geraldes, Andre Marette
Summary: The study shows that dietary intake of Omega-3 polyunsaturated fatty acids can prevent ESRD and cardiac dysfunction in diabetic mice, while PDX offers a potential new therapeutic strategy against ESRD by protecting against renal failure and cardiac dysfunction.
Article
Nutrition & Dietetics
Ariane Therien, Anna Cieslak, Melanie Verreault, Martin Perreault, Jocelyn Trottier, Stephane Gobeil, Marie-Claude Vohl, Olivier Barbier
Summary: The study found that combining n-3 PUFAs with UDCA can significantly improve the response to the drug, allowing the lowest dose of UDCA to produce effects comparable to or even better than the highest dose. This pharmaco-nutraceutical approach may be used to expand the narrow therapeutic dose of UDCA in cholestatic liver diseases.
Article
Biochemical Research Methods
Valerie Brousseau, Patrick Caron, Jocelyn Trottier, Therese Di Paolo, Piotr Milkiewicz, Olivier Barbier
Summary: This study developed a method for quantification of 24S-hydroxycholesterol and its derivatives in human plasma and validated its clinical applications. The results indicate the accumulation of cerebrosterol and its conjugates in the plasma of cholestatic patients.
JOURNAL OF MASS SPECTROMETRY
(2022)
Article
Biology
Laurent Grosse, Sarah Chouinard, Sophie Paquet, Melanie Verreault, Jocelyn Trottier, Alain Belanger, Olivier Barbier
Summary: This study found that organs and enzymes from mice have the ability to transform androgens into glucuronide derivatives, similar to the metabolism mechanism in humans. Androgens are conjugated in a substrate- and tissue-specific manner by Ugt2b enzymes in mice.
Article
Nutrition & Dietetics
William Gagnon, Veronique Garneau, Jocelyn Trottier, Melanie Verreault, Charles Couillard, Denis Roy, Andre Marette, Jean-Philippe Drouin-Chartier, Marie-Claude Vohl, Olivier Barbier
Summary: This study analyzed the impact of dietary supplementation with blueberry powder on the composition of fecal bile acids (BA). The results showed that the consumption of blueberry powder led to significant increases in glycine-conjugated BAs, glycochenodeoxycholic acid, and glycoursodeoxycholic acid, as well as a significant reduction in secondary BA levels.
Article
Nutrition & Dietetics
Atena Mahdavi, Jocelyn Trottier, Olivier Barbier, Michel Lebel, Iwona Rudkowska
Summary: This study examined the effects of high dairy intake on bile acid profiles, lipid and glycemic markers, and their correlation with proteins. The results showed that higher dairy consumption increased the levels of 7alpha-hydroxy-4-cholesten-3-one (7AC4), a biomarker for bile acid synthesis, and its correlation with proteins involved in cholesterol metabolism. Therefore, higher dairy intake may have a positive effect on cholesterol metabolism in individuals at risk of type 2 diabetes.
Article
Medicine, Research & Experimental
Mathilde Mouchiroud, Etienne Camire, Manal Aldow, Alexandre Caron, Eric Jubinville, Laurie Turcotte, Ines Kaci, Marie-Josee Beaulieu, Christian Roy, Sebastien M. Labbe, Thibault V. Varin, Yves Gelinas, Jennifer Lamothe, Jocelyn Trottier, Patricia L. Mitchell, Frederic Guenard, William T. Festuccia, Philippe Joubert, Christopher F. Rose, Constantine J. Karvellas, Olivier Barbier, Mathieu C. Morissette, Andre Marette, Mathieu Laplante
Article
Endocrinology & Metabolism
Fernando F. Anhe, Thibault V. Varin, Melanie Le Barz, Genevieve Pilon, Stephanie Dudonne, Jocelyn Trottier, Philippe St-Pierre, Cory S. Harris, Michel Lucas, Melanie Lemire, Eric Dewailly, Olivier Barbier, Yves Desjardins, Denis Roy, Andre Marette