Article
Biochemistry & Molecular Biology
Juan Carlos Montero, Atanasio Pandiella
Summary: Neuregulins and their ErbB/HER receptors are important in mammalian development and tissue homeostasis, with PDCD4 identified as a novel mediator in neuregulin-ErbB signaling. Phosphorylation of PDCD4 at serine 67 is shown to promote its degradation and regulate important biological functions of neuregulin, such as proliferation, migration, and invasion, through mTORC1 and ERK1/2 pathways.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Christine Hoesl, Thomas Froehlich, Christian Posch, Hermann Kneitz, Matthias Goebeler, Marlon R. Schneider, Maik Dahlhoff
Summary: The incidence of melanoma and nonmelanoma skin cancer has been increasing in recent years. Research has shown that LRIG1 plays a significant role in skin carcinogenesis, with LRIG1-TG mice developing melanocytic tumors during chemical skin carcinogenesis.
MOLECULAR ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sunday Amos Onikanni, Cheng-Ying Yang, Lloyd Noriega, Chih-Hao Wang
Summary: In recent years, thermogenic differentiation and activation in brown and white adipose tissues have been considered as a promising strategy for treating and improving obesity. However, the pharmacological approach to this process has been limited, posing a challenge for obesity treatment. This research examines the effects of U0126 compound on thermogenic differentiation during adipogenesis and suggests it as a potential pharmacological option to enhance thermogenic adipocyte formation and energy expenditure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Meng Nie, Na Chen, Huanhuan Pang, Tao Jiang, Wei Jiang, Panwen Tian, LiAng Yao, Yangzi Chen, Ralph J. DeBerardinis, Weimin Li, Qitao Yu, Caicun Zhou, Zeping Hu
Summary: This study discovered that the neurotransmitter acetylcholine (ACh) specifically accumulates in drug-tolerant persister (DTP) cells in EGFR-mutant non-small cell lung cancer (NSCLC). Manipulating ACh biosynthesis or signaling can predictably regulate the formation of DTP cells. Pharmacologically targeting ACh/M3R signaling with darifenacin, an FDA-approved drug, can delay tumor relapse by activating the WNT signaling pathway. Aberrant ACh metabolism in NSCLC patients may play a role in predicting the response rate and progression-free survival of EGFR-TKI treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Jinhuan Wu, Yuping Chen, Rui Li, Yaping Guan, Mu Chen, Hui Yin, Xiaoning Yang, Mingpeng Jin, Bingsong Huang, Xin Ding, Jie Yang, Zhe Wang, Yiming He, Qianwen Wang, Jian Luo, Ping Wang, Zhiyong Mao, Michael S. Y. Huen, Zhenkun Lou, Jian Yuan, Fanghua Gong
Summary: The study reveals that CDK2 regulates the ERK pathway through USP37, promoting cancer cell proliferation. Additionally, the combination of CDK1/2 and EGFR inhibitors shows a synergistic anticancer effect by reducing the stability and activity of ERK1/2.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
M. Florencia Sanchez, Marina S. Dietz, Ulrike Mueller, Julian Weghuber, Karl Gatterdam, Ralph Wieneke, Mike Heilemann, Peter Lanzerstorfer, Robert Tampe
Summary: Membrane receptor clustering is important for cell-cell communication, but its physiological role in cell signaling is still unclear. In this study, the researchers developed a dynamic platform to induce cluster formation of neuropeptide Y2 hormone receptors (Y2R) and found that receptor clustering enhanced the cell's response to ligands and played a key role in cell signaling.
Review
Biochemistry & Molecular Biology
Jeetendra Kumar Nag, Hodaya Malka, Priyanga Appasamy, Shoshana Sedley, Rachel Bar-Shavit
Summary: The essential role of G-protein coupled receptors (GPCRs) in tumor growth is recognized, yet GPCR based drugs in cancer are rare. Understanding the molecular path of a tumor driver gene may lead to the design and development of effective drugs. Several aspects of some cardinal GPCRs in tumor angiogenesis are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Jinming Xu, Yan Wang, Jiahao Jiang, Cong Yin, Bentao Shi
Summary: ADAM12 is significantly upregulated in clear cell renal cell carcinoma (ccRCC) and is associated with poor prognosis. ADAM12 promotes ccRCC cell proliferation, migration, and invasion by activating the EGFR/ERK signaling pathway, inducing epithelial-mesenchymal transition (EMT), and upregulating target genes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Osman Ali, Mazen Tolaymat, Shien Hu, Guofeng Xie, Jean-Pierre Raufman
Summary: Despite the challenges in treating colorectal cancer, targeting muscarinic receptors and MMPs shows promise in inhibiting tumor growth and progression. Selective approaches can help overcome potential off-target effects, allowing clinicians to exploit these pathways for therapeutic purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Santino Blando, Ivana Raffaele, Luigi Chiricosta, Andrea Valeri, Agnese Gugliandolo, Serena Silvestro, Federica Pollastro, Emanuela Mazzon
Summary: This study investigates the effect of cannabidiol (CBD) on neuronal differentiation at different concentrations and reveals a potential correlation between CBD, neurodifferentiation, and retinoic acid receptor-related orphan receptors (RORs).
Article
Microbiology
Bao-Rui Zhao, Xin-Xin Wang, Xian-Wei Wang
Summary: This study found that MjShoc2 in kuruma shrimp interacts with Vibrio anguillarum flagellin A (FlaA) and mediates its induced expression. The study established the Flagellin/MjShoc2/Erk/Stat signaling axis and revealed a new antibacterial strategy in shrimp.
Article
Multidisciplinary Sciences
Daria Zdzalik-Bielecka, Agata Poswiata, Kamila Kozik, Kamil Jastrzebski, Kay Oliver Schink, Marta Brewinska-Olchowik, Katarzyna Piwocka, Harald Stenmark, Marta Miaczynska
Summary: The study identified an interactome of AXL and its associations with proteins regulating actin dynamics. GAS6-mediated AXL activation triggered actin remodeling and macropinocytosis, promoting the survival of cancer cells under glutamine-deprived conditions. AXL activation by GAS6 drove invasion of cancer cells through actin-driven cytoskeletal rearrangements.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Hsin-Yu Ho, Ping-Ju Chen, Yi-Ching Chuang, Yu-Sheng Lo, Chia-Chieh Lin, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: Picrasidine I exerts anticancer effects in nasopharyngeal carcinoma by modulating HO-1 via the ERK and Akt signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Haowei Lu, Hui Wang, Guohua Huang, Xuchao Wang, Xiaolin Bu
Summary: This study found that fisetin can significantly improve the formation of hypertrophic scars by inhibiting the proliferation, activation, and collagen production of fibroblasts induced by mechanical stress. Fisetin achieves this by downregulating the phosphorylation of FAK and ERK induced by mechanical stress and reducing the nuclear localization of ERK.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Zixu Yuan, Xihu Yu, Wenle Chen, Daici Chen, Jian Cai, Yingming Jiang, Xiaoxia Liu, Zhijie Wu, Lei Wang, William M. Grady, Hui Wang
Summary: This study identified HAND2 as a potential epigenetic driver gene in colorectal cancer (CRC). The researchers found a high frequency of HAND2 methylation in CRC patients, and this methylation was negatively correlated with gene silencing and poor survival. Demethylation treatment was able to restore HAND2 expression in CRC cells. Functional experiments showed that HAND2 reconstitution could inhibit cell proliferation, invasion, and migration in vitro. In a tumor xenograft model, HAND2 reconstruction significantly suppressed tumor growth. Furthermore, HAND2 was found to target the ERK signaling pathway and reduce ERK phosphorylation. Overall, this study suggests that HAND2 is a tumor suppressor gene that acts by targeting the ERK signaling pathway and has potential as an epigenetic driver gene in CRC.
CELL COMMUNICATION AND SIGNALING
(2022)
Meeting Abstract
Oncology
Amber Budmark, Michael Catalano, Tyrel Haley, Brady Hicks, Maria Koenen, Thea Patrick, Tyler Larson, Tyler Wagner, Clark Butler, Joshua Feiner, Rebecca Frick, Sierra Haage, James Miller, Mackayla Nohr, Dillon Stadlman, Dillon Turner, Sara Husher, Nicholas Woslum, Nathan Stadem, John Dosch, Tyler Fortuna, Chandler Fredrich, Elise Hadley, Brooklynn Oehlerking, Delayna Paulson, Cal Wiese, Paula Mazzer, Tim Mullican, Cynthia Anderson, Mark Larson, Elena Paryiskaya, Alexandra Kharazova, Paola Vermeer, Samuel Milanovich, Alexei Savinov, John Collins, Alexander Kofman
Article
Multidisciplinary Sciences
Marianna Madeo, Paul L. Colbert, Daniel W. Vermeer, Christopher T. Lucido, Jacob T. Cain, Elisabeth G. Vichaya, Aaron J. Grossberg, DesiRae Muirhead, Alex P. Rickel, Zhongkui Hong, Jing Zhao, Jill M. Weimer, William C. Spanos, John H. Lee, Robert Dantzer, Paola D. Vermeer
NATURE COMMUNICATIONS
(2018)
Review
Oncology
Paola D. Vermeer
Article
Oncology
Christopher T. Lucido, Emily Wynja, Marianna Madeo, Caitlin S. Williamson, Lauren E. Schwartz, Brittney A. Imblum, Ronny Drapkin, Paola D. Vermeer
GYNECOLOGIC ONCOLOGY
(2019)
Article
Immunology
Aaron J. Grossberg, Elisabeth G. Vichaya, Phillip S. Gross, Bianca G. Ford, Kiersten A. Scott, Darlene Estrada, Daniel W. Vermeer, Paola Vermeer, Robert Dantzer
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Biochemistry & Molecular Biology
Joseph A. Westrich, Daniel W. Vermeer, Paul L. Colbert, William C. Spanos, Dohun Pyeon
MOLECULAR CARCINOGENESIS
(2020)
Article
Anesthesiology
Matthew J. Heussner, Joseph K. Folger, Christina Dias, Noura Massri, Albert Dahdah, Paola D. Vermeer, Geoffroy Laumet
Summary: A novel syngeneic model of head and neck cancer pain was established in immunocompetent mice. Contrary to previous beliefs, the study found that pain in head and neck cancer patients is independent of interleukin-1 signaling.
ANESTHESIA AND ANALGESIA
(2021)
Article
Cell Biology
Jeffrey L. Barr, Allison Kruse, Anthony C. Restaino, Natalia Tulina, Sarah Stuckelberger, Samuel J. Vermeer, Caitlin S. Williamson, Daniel W. Vermeer, Marianna Madeo, Jillian Stamp, Maria Bell, Mark Morgan, Ju-Yoon Yoon, Marilyn A. Mitchell, Anna Budina, Dalia K. Omran, Lauren E. Schwartz, Ronny Drapkin, Paola D. Vermeer
Summary: Tumor innervation is associated with cancer progression and prognosis, with limited understanding of the specific contributions and influences of nerves in ovarian cancer. Neuro-tracing techniques can help identify and map nerve sources to study tumor innervation mechanisms in ovarian cancer.
Article
Oncology
Juan L. Callejas-Valera, Daniel W. Vermeer, Christopher T. Lucido, Caitlin Williamson, Marisela Killian, Paola D. Vermeer, William C. Spanos, Steven F. Powell
Summary: Blocking the PD-1/L1 interaction represents a breakthrough in the treatment of head and neck squamous cell carcinoma (HNSCC), with improved efficacy when combined with chemoradiotherapy. While this therapy decreases PD-1-expressing T cells, it may also lead to an increase in populations contributing to immune exhaustion.
Article
Immunology
Elisabeth G. Vichaya, Josephine K. Darpolor, Phillip S. Gross, Jessica M. Molkentine, Daniel W. Vermeer, Paola D. Vermeer, John H. Lee, Cullen M. Taniguchi, Robert Dantzer
Summary: A study was conducted using a murine model of cancer survivorship to investigate the role of associative learning in the persistence of fatigue. The results showed that re-exposure to a treatment-related olfactory cue could acutely reinstate fatigue. This is the first demonstration that associative processes can modulate the persistence of cancer-related fatigue-like behavior.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Multidisciplinary Sciences
Mohammad Balood, Maryam Ahmadi, Tuany Eichwald, Ali Ahmadi, Abdelilah Majdoubi, Karine Roversi, Katiane Roversi, Christopher T. Lucido, Anthony C. Restaino, Siyi Huang, Lexiang Ji, Kai-Chih Huang, Elise Semerena, Sini C. Thomas, Alexandro E. Trevino, Hannah Merrison, Alexandre Parrin, Benjamin Doyle, Daniel W. Vermeer, William C. Spanos, Caitlin S. Williamson, Corey R. Seehus, Simmie L. Foster, Hongyue Dai, Chengyi J. Shu, Manu Rangachari, Jacques Thibodeau, Sonia Del Rincon, Ronny Drapkin, Moutih Rafei, Nader Ghasemlou, Paola D. Vermeer, Clifford J. Woolf, Sebastien Talbot
Summary: Solid tumors are innervated by nerve fibers that interact with melanoma cells and lead to increased growth and release of neuropeptides. One such neuropeptide, CGRP, directly induces CD8(+) T cell exhaustion, limiting their ability to eliminate melanoma. Inhibition of nerve fibers and CGRP signaling reduces exhaustion and tumor growth, while CD8(+) T cell exhaustion can be rescued by CGRP treatment. Additionally, intratumoral CD8(+) T cells expressing RAMP1 are more exhausted and overexpression of RAMP1 is associated with poorer clinical prognosis. Hence, reducing the release of CGRP from tumor-innervating nerve fibers could improve anti-tumor immunity.
Article
Multidisciplinary Sciences
Anthony C. Restaino, Austin Walz, Samuel J. Vermeer, Jeffrey Barr, Attila Kovacs, Robin R. Fettig, Daniel W. Vermeer, Hunter Reavis, Caitlin S. Williamson, Christopher T. Lucido, Tuany Eichwald, Dalia K. Omran, Euihye Jung, Lauren E. Schwartz, Maria Bell, DesiRae M. Muirhead, Jody E. Hooper, William C. Spanos, Ronny Drapkin, Sebastien Talbot, Paola D. Vermeer
Summary: The functional role of intratumoral nerves in disease is not well understood. Our study demonstrates that these nerves form functional connections within tumors, with significantly higher electrical activity observed in malignancies compared to benign disease or normal tissues. We also show that pharmacologic silencing of tumoral electrical activity is possible, and animals lacking nociceptor neurons exhibit reduced electrical activity in implanted tumors. Furthermore, the presence of the neuropeptide Substance P and its receptor NK1R within tumors promote cellular proliferation and migration. This study reveals a mechanism by which intratumoral nerves contribute to cancer progression.
Review
Biochemistry & Molecular Biology
Anthony C. Restaino, Paola D. Vermeer
Summary: The identification of nerves in the tumor microenvironment has opened up a new area of research in cancer biology. Studies show that various types of peripheral nerves are present in the tumor microenvironment, and an increased nerve density correlates with poorer prognosis. Nerve-mediated alterations impact disease through processes like direct communication with cancer cells, modifying immune populations, and changing stromal components.
Article
Neurosciences
Elisabeth G. Vichaya, Daniel W. Vermeer, David Budac, Anna Lee, Aaron Grossberg, Paola D. Vermeer, John H. Lee, Robert Dantzer
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2019)
Meeting Abstract
Chemistry, Multidisciplinary
Peter Sanchez, Paul Colbert, Marianna Madeo, Paola Vermeer
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)
