Article
Pharmacology & Pharmacy
Masafumi Funamoto, Yoichi Sunagawa, Mai Gempei, Kana Shimizu, Yasufumi Katanasaka, Satoshi Shimizu, Toshihide Hamabe-Horiike, Giovanni Appendino, Alberto Minassi, Andreas Koeberle, Maki Komiyama, Kiyoshi Mori, Koji Hasegawa, Tatsuya Morimoto
Summary: This study investigated the impact of curcumin and its derivatives on cardiomyocyte hypertrophy. It was found that PyrC inhibits cardiomyocyte hypertrophy by suppressing Cdk9 kinase activity, indirectly inhibiting p300-HAT activity and RNA polymerase II transcription elongation activity.
Article
Pharmacology & Pharmacy
Yoichi Sunagawa, Kiyotaka Shimizu, Ayumi Katayama, Masafumi Funamoto, Kana Shimizu, Sari Nurmila, Satoshi Shimizu, Yusuke Miyazaki, Yasufumi Katanasaka, Koji Hasegawa, Tatsuya Morimoto
Summary: The study investigated the potential effects of metformin on cardiac hypertrophy by inhibiting p300-mediated acetylation of histone-H3K9 and hypertrophic responses in cardiomyocytes. Metformin was shown to suppress PE-induced and p300-mediated hypertrophic responses, suggesting its potential therapeutic use in patients with diabetes and heart failure.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Microbiology
Ahai Chen, Yifan Zhou, Yiyi Ren, Chao Liu, Xingmin Han, Jing Wang, Zhonghua Ma, Yun Chen
Summary: In this study, it was found that E3 ligase Tom1 and deubiquitinating enzyme Ubp14 regulated the ubiquitination and deubiquitination of Gcn5, respectively, in the important plant pathogenic fungus Fusarium graminearum. This finding highlights the important role of the Tom1-Gcn5-Ubp14 circuit in fungal virulence.
Article
Chemistry, Medicinal
Zhiqin Ji, Richard F. Clark, Vikram Bhat, T. Matthew Hansen, Loren M. Lasko, Kenneth D. Bromberg, Vlasios Manaves, Mikkel Algire, Ruth Martin, Wei Qiu, Maricel Torrent, Clarissa G. Jakob, Hong Liu, Philip A. Cole, Ronen Marmorstein, Edward A. Kesicki, Albert Lai, Michael R. Michaelides
Summary: p300 and CBP play essential roles in cellular processes and dysregulation of their histone acetyltransferase activity is linked to various human diseases. The novel drug-like compound 21 is a selective orally bioavailable inhibitor of p300/CBP histone acetyltransferase, more potent than A-485 and lacking off-target inhibition of dopamine and serotonin transporters.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Hong Ding, Yuan Pei, Yuanqing Li, Wen Xu, Lianghe Mei, Zeng Hou, Yiman Guang, Liyuan Cao, Peizhuo Li, Haijing Cao, Jinlei Bian, Kaixian Chen, Cheng Luo, Bing Zhou, Ting Zhang, Zhiyu Li, Yaxi Yang
Summary: This study modified the p300/CBP HAT domain inhibitor and obtained a highly active small molecule that showed significant anti-proliferation activity on ovarian cancer cells. The discovery provides a novel idea for the application of epigenetic inhibitors in the treatment of ovarian cancer.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Hao Hu, Kailiang Zhao, Debao Fang, Zhongyu Wang, Ning Yu, Bo Yao, Kaiyue Liu, Fang Wang, Yide Mei
Summary: The RNA binding protein RALY functions as an oncogenic factor in lung cancer by stabilizing Mdm2 and enhancing its E3 ligase activity toward p53. This leads to increased ubiquitination and degradation of p53, promoting lung tumorigenesis.
Article
Biochemistry & Molecular Biology
Xue Zhong, Huiwen Deng, Min Long, Honglu Yin, Qiu Zhong, Shilong Zheng, Tao Gong, Ling He, Guangdi Wang, Qiu Sun
Summary: Berberine was discovered as a potent p300/CBP HAT inhibitor and showed inhibition of tumor growth. Novel analog 5d, derived from berberine, demonstrated high selectivity towards p300/CBP HAT and effectively suppressed tumor growth in animal models. Furthermore, liposomes-encapsulated 5d showed increased inhibition of tumor growth with good absorption properties in vivo.
BIOORGANIC CHEMISTRY
(2023)
Article
Cell Biology
Zhangjie Wang, Yuan Xia, Yang Wang, Ruiqiu Zhu, Hongbo Li, Yu Liu, Na Shen
Summary: This study identifies TRIM26 as an E3 ubiquitin ligase of GPX4, which enhances GPX4's protein stability by catalyzing its ubiquitination. Phosphorylation of TRIM26 by PLK1 enhances its interaction with GPX4. Overexpression of TRIM26 is associated with glioma tumorigenesis and poor outcome.
CELL DEATH & DISEASE
(2023)
Article
Nutrition & Dietetics
Yuto Kawase, Yoichi Sunagawa, Kana Shimizu, Masafumi Funamoto, Toshihide Hamabe-Horiike, Yasufumi Katanasaka, Satoshi Shimizu, Philip Hawke, Kiyoshi Mori, Maki Komiyama, Koji Hasegawa, Tatsuya Morimoto
Summary: Hypertrophic stress-induced cardiac remodeling is associated with heart failure. The phytochemical 6-shogaol can suppress hypertrophy and fibrosis, and ameliorate heart failure.
Article
Oncology
Jian Wan, Shunfang Liu, Wanju Sun, Haiyi Yu, Wenlian Tang, Wei Liu, Jing Ji, Bin Liu
Summary: The study revealed that RNF152 is significantly down-regulated in HCC and its down-regulation is associated with patient survival and disease progression. Mechanistically, RNF152 interacts with TSPAN12 to inhibit its ubiquitination and proteasomal degradation, thereby suppressing HCC progression.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Shenyou Nie, Fangrui Wu, Jingyu Wu, Xin Li, Chao Zhou, Yuan Yao, Yongcheng Song
Summary: Acetylation of histone lysine residues by p300 and CBP plays important roles in gene regulation. Compound 29 is a potential inhibitor of p300 HAT with activity against cancer cells.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Shu-Ze Zheng, Xiao-Wen Zhang, Xiao-Min Song, Zhuo Yang, Lu Yao, Peng-Fei Tu, Ke-Wu Zeng
Summary: This study discovered a natural small-molecule compound ECL that inhibits microglia-mediated neuroinflammation by editing the monoubiquitination of histone H2B. ECL modifies the previously undisclosed K46 site in H2B and recruits the E3 ubiquitin ligase to promote H2Bub1 at K120, leading to disruption of AP-1 binding to proinflammatory genes in microglia.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Plant Sciences
Si-Wei Wang, Hao Sheng, Yong-Feng Bai, Yuan-Yuan Weng, Xue-Yu Fan, Fang Zheng, Jing-Qi Fu, Feng Zhang
Summary: The study found that flavanones and phytomedicine rich in flavanones play an important role in protecting pancreatic beta cells in advanced diabetes. Targeting histone acetylation by phytomedicine is a potential strategy to delay the development and progression of diabetes. The inhibition of histone acetylation through regulating AMPK-mediated p300 inactivation is critical for the protective role of naringenin and hesperetin.
Article
Medicine, Research & Experimental
Xingguo Li, Xuenan Wang, Chao Chen, Enyu Zhang, Yuan Zhang, Hongkun Li, Yu Lei, Zhenkai Lou, Fan Zhang
Summary: The study revealed the upregulation of 14 MMPs in aged mice, and 11 MMP gene promoters contained a Runx2 binding site. It was found that Runx2 recruited p300 and NCOA1 to form a complex, promoting MMP expression. The deficiency of HERC3 led to the accumulation of NCOA1 in the inflammatory microenvironment. A small molecule compound SMTNP-191 was identified to inhibit MMP expression and attenuate intervertebral disc degeneration.
Article
Biochemistry & Molecular Biology
Hyunsik Kim, Soo-Yeon Park, Soo Yeon Lee, Jae-Hwan Kwon, Seunghee Byun, Mi Jeong Kim, Sungryul Yu, Jung-Yoon Yoo, Ho-Geun Yoon
Summary: Liver fibrosis is a result of chronic liver damage and the abnormal accumulation of extracellular matrix. A novel p300 inhibitor (A6) was validated to improve liver fibrosis in two mouse models. A6 treatment significantly reduced pathological hallmarks of liver fibrosis and gene expression of matricellular proteins. Further studies showed that A6 treatment improved liver fibrosis by destabilizing p300 protein through disruption of p300 binding to AKT. Targeting p300 with A6 has potential as a major therapeutic avenue for treating liver fibrosis.
Article
Cell Biology
Szymon J. Szymura, Jacob P. Zaemes, David F. Allison, Sheena H. Clift, Jaclyn M. D'Innocenzi, Lisa G. Gray, Brian D. McKenna, Benjamin B. Morris, Stefan Bekiranov, Robin D. LeGallo, David R. Jones, Marty W. Mayo
CELL COMMUNICATION AND SIGNALING
(2019)
Article
Cardiac & Cardiovascular Systems
Tamar B. Nobel, Michael Curry, Renee Gennarelli, David R. Jones, Daniela Molena
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Giye Choe, Amanda Ghanie, Gregory Riely, Andreas Rimner, Bernard J. Park, Manjit S. Bains, Valerie W. Rusch, Prasad S. Adusumilli, Robert J. Downey, David R. Jones, James Huang
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Marc R. Moon, David R. Jones, David H. Adams, Vaughn A. Starnes
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Mara Antonoff, Leah Backhus, Daniel J. Boffa, Stephen R. Broderick, Lisa M. Brown, Phillip Carrott, James M. Clark, David Cooke, Elizabeth David, Matt Facktor, Farhood Farjah, Eric Grogan, James Isbell, David R. Jones, Biniam Kidane, Anthony W. Kim, Shaf Keshavjee, Seth Krantz, Natalie Lui, Linda Martin, Robert A. Meguid, Shari L. Meyerson, Tim Mullett, Heidi Nelson, David D. Odell, Joseph D. Phillips, Varun Puri, Valerie Rusch, Lawrence Shulman, Thomas K. Varghese, Elliot Wakeam, Douglas E. Wood
ANNALS OF THORACIC SURGERY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
David R. Jones, Hiroshi Date
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Neel P. Chudgar, Shi Yan, Meier Hsu, Kay See Tan, Katherine D. Gray, Daniela Molena, Tamar Nobel, Prasad S. Adusumilli, Manjit Bains, Robert J. Downey, James Huang, Bernard J. Park, Gaetano Rocco, Valerie W. Rusch, Smita Sihag, David R. Jones, James M. Isbell
Summary: The study compared the observed and predicted outcomes after pulmonary resections between SURPAS and NSQIP SRC. Results showed no significant differences in discrimination performance between the two models for most complications, except for renal failure. The NSQIP SRC performed better in discriminating the risk of renal failure compared to SURPAS.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Raul Caso, Gregory D. Jones, Kay See Tan, George J. Bosl, Samuel A. Funt, Joel Sheinfeld, Victor E. Reuter, David Amar, Gregory Fischer, Daniela Molena, Gaetano Rocco, Manjit S. Bains, Darren R. Feldman, David R. Jones
Summary: This study explored the outcomes of thoracic metastasectomy in GCT patients who received first-line chemotherapy alone versus salvage chemotherapy. Patients treated with salvage chemotherapy had more aggressive disease and worse PFS, but achieved encouraging OS. Aggressive thoracic metastasectomy plays an integral role in treating GCT patients with residual thoracic disease after chemotherapy.
ANNALS OF THORACIC SURGERY
(2021)
Article
Oncology
Joshua E. Reuss, Valsamo Anagnostou, Tricia R. Cottrell, Kellie N. Smith, Franco Verde, Marianna Zahurak, Mara Lanis, Joseph C. Murray, Hok Yee Chan, Caroline McCarthy, Daphne Wang, James R. White, Stephen Yang, Richard Battafarano, Stephen Broderick, Errol Bush, Malcolm Brock, Jinny Ha, David Jones, Taha Merghoub, Janis Taube, Victor E. Velculescu, Gary Rosner, Peter Illei, Drew M. Pardoll, Suzanne Topalian, Jarushka Naidoo, Ben Levy, Matthew Hellmann, Julie R. Brahmer, Jamie E. Chaft, Patrick M. Forde
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Cardiac & Cardiovascular Systems
Neel Chudgar, Shi Yan, Meier Hsu, Kay See Tan, Katherine D. Gray, Daniela Molena, David R. Jones, Valerie W. Rusch, Gaetano Rocco, James M. Isbell
Summary: The NSQIP SRC can reasonably predict postoperative complications in patients undergoing pulmonary resection, except for certain calibration issues.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Surgery
Gregory D. Jones, Whitney S. Brandt, Ronglai Shen, Francisco Sanchez-Vega, Kay See Tan, Axel Martin, Jian Zhou, Michael Berger, David B. Solit, Nikolaus Schultz, Hira Rizvi, Yuan Liu, Ariana Adamski, Jamie E. Chaft, Gregory J. Riely, Gaetano Rocco, Matthew J. Bott, Daniela Molena, Marc Ladanyi, William D. Travis, Natasha Rekhtman, Bernard J. Park, Prasad S. Adusumilli, David Lyden, Marcin Imielinski, Marty W. Mayo, Bob T. Li, David R. Jones
Summary: The integration of genomic and clinicopathologic features can better predict recurrence in early-stage LUAD patients after surgical resection, potentially enhancing accrual to clinical trials.
Article
Cardiac & Cardiovascular Systems
Nicolas Zhou, Matthew Bott, Bernard J. Park, Eric Vallieres, Candice L. Wilshire, Kazuhiro Yasufuku, Jonathan D. Spicer, David R. Jones, Boris Sepesi
Summary: The study highlights the survival benefit of adjuvant chemotherapy in limited-stage SCLC, but did not find a statistically significant influence from mediastinal PORT or PCI in the cohort. Larger prospective studies are needed to determine the benefits of PORT or PCI in a surgically resected limited-stage SCLC population.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
David R. Jones, Yi-Long Wu, Masahiro Tsuboi, Roy S. Herbst
Summary: The ADAURA trial demonstrated significant benefits of receiving the third-generation EGFR-tyrosine kinase inhibitor osimertinib after lung cancer resection. The results are expected to impact clinical practice and future directions in adjuvant therapy for lung cancer. The role of thoracic surgeons becomes more crucial in ensuring genetic profiling, appropriate adjuvant therapy, and patient participation in future trials studying targeted therapies.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Oncology
Gregory D. Jones, Harry B. Lengel, Meier Hsu, Kay See Tan, Raul Caso, Amanda Ghanie, James G. Connolly, Manjit S. Bains, Valerie W. Rusch, James Huang, Bernard J. Park, Daniel R. Gomez, David R. Jones, Gaetano Rocco
Summary: Surgical resection of the primary tumor in patients with oligometastatic non-small cell lung cancer can lead to encouraging long-term survival, especially in those who undergo neoadjuvant therapy and have limited intrathoracic disease.
Article
Obstetrics & Gynecology
Sarah Ehmann, Emeline M. Aviki, Yukio Sonoda, Thomas Boerner, Dib Sassine, David R. Jones, Bernard Park, Murray Cohen, Norman G. Rosenblum, Dennis S. Chi
Summary: Over 80% of patients with epithelial ovarian cancer present with advanced disease requiring extensive upper abdominal surgery. A rare but serious complication post-surgery is diaphragmatic hernia, which may result in various symptoms and require prompt surgical correction.
GYNECOLOGIC ONCOLOGY REPORTS
(2021)