Article
Oncology
Harald Krenzlin, Mykola Zdioruk, Michal O. Nowicki, Tomer Finkelberg, Naureen Keric, Niels Lemmermann, Magdalena Skubal, E. Antonio Chiocca, Charles H. Cook, Sean E. Lawler
Summary: The study suggests that the CMV-induced upregulation of c-MET may be a potential mechanism involved in the effects of CMV on GBM growth.
Article
Cell Biology
Xiangpeng Dai, Xiaoling Zhang, Qing Yin, Jia Hu, Jianping Guo, Yang Gao, Aidan H. Snell, Hiroyuki Inuzuka, Lixin Wan, Wenyi Wei
Summary: This study reveals that the acetyltransferase p300 activates BRAF kinase by promoting BRAF K601 acetylation, which plays a significant role in melanoma and is associated with resistance to BRAF(V600E) inhibitors.
Article
Agriculture, Multidisciplinary
Xizhu Wang, Liu Dong, Yifei Dong, Zhijie Bao, Songyi Lin
Summary: Hyperuricemia (HUA) is a metabolic disease characterized by elevated uric acid levels, posing a risk for premature death. Corn silk flavonoids (CSF) were found to have a protective effect against HUA by reducing inflammation and apoptosis through the down-regulating PI3K/AKT/NF-κB pathway. This study also demonstrated the UA-lowering activity of CSF in vitro and in potassium oxonate-induced HUA in vivo models.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Plant Sciences
Xiaoqing Shi, Lishi Jie, Peng Wu, Nongshan Zhang, Jun Mao, Peimin Wang, Songjiang Yin
Summary: In this study, the active components of Shaoyao Gancao Decoction (SG-Tang) were analyzed using network pharmacology and UPLC-QTOF-MS analysis to explore their potential therapeutic mechanism in osteoarthritis (OA).
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Dan Li, Ying-ying Guo, Xian-feng Cen, Hong-liang Qiu, Si Chen, Xiao-feng Zeng, Qian Zeng, Man Xu, Qi-zhu Tang
Summary: The study shows that lupeol protects against cardiac hypertrophy via anti-inflammatory mechanisms by inhibiting the TLR4-PI3K-Akt-NF-kappa B signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Shun He, Wen-Long Ye, Yu-Juan Zhang, Xiao-Qin Yang, Feng Liu, Jing-Ru Wang, Xiao-Lu Ding, Yun Yang, Ruo-Nan Zhang, Yuan-Yuan Zhao, Hai-Xia Bi, Ling-Chuan Guo, Wen-Juan Gan, Hua Wu
Summary: In this study, we found that BEST4 promotes cell proliferation and metastasis in colorectal cancer. It activates the Akt signaling pathway by binding to the regulatory subunit p85 alpha of PI3K, leading to the expression of critical regulators such as MYC and CCND1. Additionally, high expression of BEST4 is associated with poor prognosis in patients.
Article
Pharmacology & Pharmacy
Yingying Chen, Yueyue Xi, Milu Li, Yaling Wu, Wei Yan, Jun Dai, Mingfu Wu, Wenjun Ding, Jinjin Zhang, Fang Zhang, Su Zhou, Shixuan Wang
Summary: There is evidence to suggest that maternal exposure to ambient PM2.5 negatively affects ovarian function in offspring. This study found that exposure to PM2.5 reduced the size of the primordial follicle pool and impaired its development in mice. It also activated primordial follicles and increased oxidative stress-related genes in offspring mice. The findings suggest a link between maternal PM2.5 exposure and ovarian reserve in offspring.
Article
Cell Biology
Yan-Lin Chen, De-Yi Yan, Chen-Yu Wu, Jiang-Wei Xuan, Chen-Qiang Jin, Xin-Li Hu, Guo-Dong Bao, Yu-Jie Bian, Zhi-Chao Hu, Zhong-Hai Shen, Wen-Fei Ni
Summary: OA is characterized by destruction of articular cartilage and inflammation plays a key role in its progression. Maslinic acid (MA) from olive fruit has been shown to have anti-inflammatory effects. In in vitro and in vivo experiments, MA was found to attenuate inflammatory mediators and inhibit the progression of OA disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Immunology
LuLu Qian, Jun-Zhao Li, XueMei Sun, Jie-Bin Chen, Ying Dai, Qiu-Xiang Huang, Ying-Ji Jin, Qing-Ning Duan
Summary: The study demonstrates that safinamide can inhibit the production of pro-inflammatory cytokines by macrophages, reduce the release of inflammatory mediators, prevent leukocyte migration, and decrease the generation of related enzymes. These effects are mainly achieved through safinamide's inhibition of the TLR4/NF-kappa B signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Virology
Andrew J. McNamara, Austin D. Brooks, Pranav Danthi
Summary: This study reveals that mammalian reovirus can block the function of NF-κB, an important protein family for the host cell's response to viral infection, through the expression of a viral protein called sigma 3. The expression of sigma 3 diminishes the host's response to infection and promotes viral replication. The differences in NF-κB target gene expression following infection with different reovirus strains are controlled by polymorphisms in the amino acid sequence of sigma 3.
JOURNAL OF VIROLOGY
(2022)
Article
Fisheries
Junya Wang, Zhao Jia, Huifeng Dang, Jun Zou
Summary: This study identified two Meteorin-like (Metrnl) homologues in grass carp, with CiMetrnl-a being constitutively expressed in healthy fish tissues and CiMetrnl-b transcripts being undetectable. CiMetrnl-a was inducible by certain pathogens and was able to up-regulate pro-inflammatory cytokines, potentially through the NF-kappa B dependent pathway.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhen Ye, Yuzheng Li, Yingqi She, Mingquan Wu, Yu Hu, Kaihua Qin, Linzhen Li, Han Yu, Qian Zhao, Zhao Jin, Fating Lu, Qiaobo Ye
Summary: This study investigated the potential active components and molecular mechanisms of Renshen Baidu powder (RSBDP) for the treatment of ulcerative colitis. Results showed that RSBDP could ameliorate disease activity index, colon weight, colon shortening, and histology in TNBS-induced colitis rats. Furthermore, RSBDP inhibited the PI3K/Akt/NF-kappa B signaling pathway to effectively alleviate colitis in rats.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Shuaibing Hou, Xiaomin Wang, Tengxiao Guo, Yanjie Lan, Shengnan Yuan, Shuang Yang, Fei Zhao, Aizhong Fang, Na Liu, Wanzhu Yang, Yajing Chu, Erlie Jiang, Tao Cheng, Xiaojian Sun, Weiping Yuan
Summary: This study reveals that PHF6 plays a significant role in myeloid leukemia by inhibiting NF-κB signaling pathway to suppress cell proliferation and induce apoptosis. The authors also discovered that PHF6 acts as a tumor suppressor gene in lymphocytic leukemia but as an oncogene in myeloid leukemia.
Article
Agriculture, Dairy & Animal Science
Haokun Liu, Ying Zhao, Yanfang Wu, Yutong Yan, Xiaoe Zhao, Qiang Wei, Baohua Ma
Summary: Mastitis is a common and important clinical disease in ruminants, which may lead to inflammatory fibrosis if not promptly treated. This study found that Snail plays a critical role in LPS-induced EMT in GMECs, and the mechanism is dependent on the activation of the TLR4/NF-kappa B signaling pathway.
Article
Oncology
Tom Walsh, Suleyman Gulsuner, Ming K. Lee, Melissa A. Troester, Andrew F. Olshan, H. Shelton Earp, Charles M. Perou, Mary-Claire King
Summary: The Carolina Breast Cancer Study (CBCS) identified pathogenic variants in BRCA1, BRCA2, PALB2, or TP53 in a subset of breast cancer patients. The study found a significant association between BRCA1, BRCA2, and PALB2 with triple-negative breast cancer (TNBC) among African-American patients compared to European-American patients.
Article
Oncology
Tomas Pascual, Aranzazu Fernandez-Martinez, Maki Tanioka, M. Vittoria Dieci, Sonia Pernas, Joaquin Gavila, Valentina Guarnieri, Javier Cortes, Patricia Villagrasa, Nuria Chic, Maria Vidal, Barbara Adamo, Montserrat Munoz, Gaia Griguolo, Antonio Llombart, Pierfranco Conte, Mafalda Oliveira, Benedetta Conte, Laia Pare, Patricia Galvan, Lisa A. Carey, CharlesM. Perou, Aleix Prat
Summary: In HR+/HER2+ breast cancer, the PAM50-based CES score can predict sensitivity to chemo-endocrine therapy and provide additional prognostic information beyond intrinsic subtype and clinicopathologic characteristics. High CES is associated with lower pCR probability and better DFS.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Sung Gwe Ahn, Seon-Kyu Kim, Jonathan H. Shepherd, Yoon Jin Cha, Soong June Bae, Chungyeul Kim, Joon Jeong, Charles M. Perou
Summary: The SP142 PD-L1 assay is a companion diagnostic for atezolizumab in metastatic triple-negative breast cancer (TNBC). Through studying 149 TNBC samples, it was found that PD-L1-positive TNBC samples had higher levels of CD8+ T cells, stromal tumor-infiltrating lymphocytes, and immunomodulatory TNBCtype compared to PD-L1-negative samples. The SP142-guided gene expression signature consisting of 94 immune-related genes was associated with improved response and survival in multiple TNBC cohorts.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Amber N. Hurson, Mustapha Abubakar, Alina M. Hamilton, Kathleen Conway, Katherine A. Hoadley, Michael Love, Andrew F. Olshan, Charles M. Perou, Montserrat Garcia-Closas, Melissa A. Troester
Summary: This study identified breast cancer risk factors associated with RNA-based TP53 and ER, providing a new etiologic schema of interest in breast cancer prevention research.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Achal Patel, Montserrat Garcia-Closas, Andrew F. Olshan, Charles M. Perou, Melissa A. Troester, Michael Love, Arjun Bhattacharya
Summary: This study identifies race-specific genetic associations with breast cancer risk of recurrence scores and suggests mediation of these associations by PAM50 subtype and expression, with implications for clinical interpretation of these scores.
Article
Immunology
Sarah C. Vick, Oleg Kolupaev, Charles M. Perou, Jonathan S. Serody
Summary: Experimental findings showed that PD-1 blockade increases proliferation, protection from apoptosis, and suppressive capabilities of T-regs in the tumor microenvironment, leading to enhanced immunosuppression.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Oncology
Carey K. Anders, Mark G. Woodcock, Amanda E. D. Van Swearingen, Dominic T. Moore, Maria J. Sambade, Sonia Laurie, Alexander Robeson, Oleg Kolupaev, Luz A. Cuaboy, Amy L. Garrett, Karen McKinnon, Kristen Cowens, Dante Bortone, Benjamin C. Calhoun, Alec D. Wilkinson, Lisa Carey, Trevor Jolly, Hyman Muss, Katherine Reeder-Hayes, Rebecca Kaltman, Rachel Jankowitz, Vinay Gudena, Oludamilola Olajide, Charles Perou, E. Claire Dees, Benjamin G. Vincent, Jonathan S. Serody
Summary: This study evaluated the efficacy of using a low dose of cyclophosphamide (Cy) to deplete regulatory T cells (T-regs) before initiating pembrolizumab in patients with triple negative breast cancer (TNBC). The results showed that Cy did not significantly decrease T-regs before pembrolizumab and there was a rapid recovery in T-regs after the first cycle of therapy. Baseline samples with increased B cell gene expression were associated with clinical response and immune-related toxicity (IRT).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Alina M. Hamilton, Amber N. Hurson, Linnea T. Olsson, Andrea Walens, Joseph Nsonwu-Farley, Erin L. Kirk, Yara Abdou, Stephanie M. Downs-Canner, Jonathan S. Serody, Charles M. Perou, Benjamin C. Calhoun, Melissa A. Troester, Katherine A. Hoadley
Summary: The immune microenvironment in breast cancer is closely related to race, age, tumor subtype, and grade. Black and young women have higher immune response, which may be associated with higher recurrence risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Sonam Bhatia, Melissa Kramer, Suzanne Russo, Payal Naik, Gayatri Arun, Kyle Brophy, Peter Andrews, Cheng Fan, Charles M. Perou, Jonathan Preall, Taehoon Ha, Dennis Plenker, David A. Tuveson, Arvind Rishi, John E. Wilkinson, W. Richard McCombie, Karen Kostroff, David L. Spector
Summary: This study developed a diverse biobank of patient-derived organoids of triple-negative breast cancer (TNBC) and provided comprehensive insights into TNBC biology and progression. The organoids successfully recapitulated patient tumor characteristics and identified potential mechanisms of tumorigenesis at the single-cell level.
Editorial Material
Oncology
Sarah Asad, Kathryn Kananen, Kurt R. Mueller, W. Fraser Symmans, Yujia Wen, Charles M. Perou, James S. Blachly, James Chen, Benjamin G. Vincent, Daniel G. Stover
JCO CLINICAL CANCER INFORMATICS
(2022)
Article
Oncology
Youli Xia, Xiaping He, Lorna Renshaw, Carlos Martinez-Perez, Charlene Kay, Mark Gray, James Meehan, Joel S. Parker, Charles M. Perou, Lisa A. Carey, J. Michael Dixon, Arran Turnbull
Summary: This study identified molecular mechanisms underlying endocrine therapy resistance (ETR) in hormone receptor-positive breast cancer through in-depth genomic analysis. The results showed that ETR involves diverse changes in somatic genetic and transcriptomic profiles, including mutations, gene expression changes, and activation of signaling pathways. Overcoming resistance will require an individualized approach utilizing genomic and genetic biomarkers and drugs tailored to each patient.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Audrey Y. Jung, Thomas U. Ahearn, Sabine Behrens, Pooja Middha, Manjeet K. Bolla, Qin Wang, Volker Arndt, Kristan J. Aronson, Annelie Augustinsson, Laura E. Beane Freeman, Heiko Becher, Hermann Brenner, Federico Canzian, Lisa A. Carey, Cts Consortium, Kamila Czene, A. Heather Eliassen, Mikael Eriksson, D. Gareth Evans, Jonine D. Figueroa, Lin Fritschi, Marike Gabrielson, Graham G. Giles, Pascal Guenel, Andreas Hadjisavvas, Christopher A. Haiman, Niclas Hakansson, Per Hall, Ute Hamann, Reiner Hoppe, John L. Hopper, Anthony Howell, David J. Hunter, Anika Huesing, Rudolf Kaaks, Veli-Matti Kosma, Stella Koutros, Peter Kraft, James Lacey, Loic Le Marchand, Jolanta Lissowska, Maria A. Loizidou, Arto Mannermaa, Tabea Maurer, Rachel A. Murphy, Andrew F. Olshan, Hakan Olsson, Alpa Patel, Charles M. Perou, Gad Rennert, Rana Shibli, Xiao-Ou Shu, Melissa C. Southey, Jennifer Stone, Rulla M. Tamimi, Lauren R. Teras, Melissa A. Troester, Therese Truong, Celine M. Vachon, Sophia S. Wang, Alicja Wolk, Anna H. Wu, Xiaohong R. Yang, Wei Zheng, Alison M. Dunning, Paul D. P. Pharoah, Douglas F. Easton, Roger L. Milne, Nilanjan Chatterjee, Marjanka K. Schmidt, Montserrat Garcia-Closas, Jenny Chang-Claude
Summary: Reproductive factors are differentially associated with risk of breast cancer subtypes, and triple-negative breast cancer has a distinct reproductive risk factor profile.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Aatish Thennavan, Susana Garcia-Recio, Siyao Liu, Xiaping He, Charles M. Perou
Summary: Ductal carcinoma in situ (DCIS) of the breast is a precursor of invasive ductal carcinoma (IDC). This study utilizes mouse models and human samples to identify features associated with DCIS progression. The analysis reveals malignant cells and tumor microenvironmental changes in DCIS and IDC, and suggests the existence of intrinsic subtype unique DCIS features. The findings may contribute to the identification and treatment of progression-prone DCIS in human basal-like breast cancers.
Article
Oncology
Frederick M. Howard, James Dolezal, Sara Kochanny, Galina Khramtsova, Jasmine Vickery, Andrew Srisuwananukorn, Anna Woodard, Nan Chen, Rita Nanda, Charles M. Perou, Olufunmilayo I. Olopade, Dezheng Huo, Alexander T. Pearson
Summary: Gene expression-based recurrence assays are recommended for guiding chemotherapy in hormone receptor-positive, HER2-negative breast cancer, but their high cost and limited availability pose challenges. This study presents a deep learning model that utilizes digital histology and clinical risk factors to predict recurrence assay results and the risk of recurrence, surpassing the performance of established clinical nomograms. The model can identify patients with excellent prognoses who may not require further genomic testing.
Article
Oncology
Feng Bai, Shiqin Liu, Xiong Liu, Daniel P. Hollern, Alexandria Scott, Chuying Wang, Lihan Zhang, Cheng Fan, Li Fu, Charles M. Perou, Wei-Guo Zhu, Xin-Hai Pei
Summary: The study found that PDGFR beta-PKC alpha signaling is repressed by BRCA1, which establishes PDGFR beta-PKC alpha signaling as a therapeutic target for BRCA1-deficient breast cancers. Targeted deletion of Pdgfr beta in Brca1-deficient tumor cells promoted cell death, induced mesenchymal-to-epithelial transition, and suppressed tumor progression, providing potential new therapeutic strategies for this aggressive breast cancer subtype.
BREAST CANCER RESEARCH
(2021)