Article
Oncology
Jiajia Zhang, Zhenzhen Yan, Yukun Wang, Yaguang Wang, Xin Guo, Ju Jing, Xiangnan Dong, Shasha Dong, Xiuhua Liu, Xiaochun Yu, Chen Wu
Summary: The study examined mutations in the TP53 binding protein 1 (53BP1) gene in various human cancers, revealing that these mutations may disrupt the DNA damage repair function of 53BP1 and impact genomic stability.
Article
Neurosciences
Feifei Luo, Yifu Liao, Endong Cao, Yong Yang, Kai Tang, Dexiang Zhou, Dong Zhou, Haiping Cai
Summary: This study found that HIC2 gene is hypermethylated and expressed at low levels in glioma. Hypermethylation and low expression of HIC2 predict poor prognosis. Further experiments showed that HIC2 inhibits glioma proliferation in vitro and in vivo by interacting with RNF44 and PTPRN2.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Oncology
Nancy Issa, Hassan Bjeije, Elisabeth R. Wilson, Aishwarya Krishnan, Wangisa M. B. Dunuwille, Tyler M. Parsons, Christine R. Zhang, Wentao Han, Andrew L. Young, Zhizhong Ren, Kai Ge, Eunice S. Wang, Andrew P. Weng, Amanda Cashen, David H. Spencer, Grant A. Challen
Summary: T-ALL is an aggressive hematopoietic neoplasm driven by NOTCH1 mutations and overexpression of KDM6B. KDM6B is crucial for the development and maintenance of T-ALL, making it a potential therapeutic target.
Article
Medicine, Research & Experimental
Sharmila Nair, Luciano Mazzoccoli, Arijita Jash, Jennifer Govero, Sachendra S. Bais, Tong Hu, Camila R. Fontes-Garfias, Chao Shan, Hideho Okada, Sujan Shresta, Jeremy N. Rich, Pei-Yong Shi, Michael S. Diamond, Milan G. Chheda
Summary: Zika virus targets GBM stem cells and prevents tumor growth by recruiting CD8(+) T cells and myeloid cells. While anti-PD-1 antibody alone moderately improves survival, combining it with ZIKV treatment significantly increases survival rate. Immune-sensitized ZIKV strain shows promise for safe and effective combination therapy with immunotherapies for GBM patients.
Article
Immunology
Yuan Jiang, Qiankun Ji, Xiaoyan Long, Peng Wang, Zewei Tu, Xian Zhang, Xingen Zhu, Kai Huang, Jingying Li
Summary: The expression level of CLCF1 is related to the prognosis of glioma and is associated with the response to immunotherapy, suggesting that it may be a promising therapeutic target.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Lorna S. Thorne, Garret Rochford, Timothy D. Williams, Andrew D. Southam, Giovanny Rodriguez-Blanco, Warwick B. Dunn, Nikolas J. Hodges
Summary: Cytoglobin plays a crucial role in the progression of oral squamous cell carcinoma by mediating changes in gene expression related to stress response and metabolism, protecting cells from cisplatin-induced apoptosis and oxidative stress. Lipidomic analysis revealed up-regulation of cardiolipin in cells expressing cytoglobin, suggesting a potential mechanism for cancer cells to exploit phenotypic changes and facilitate disease progression.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Naser Ansari-Pour, Mehmet Samur, Erin Flynt, Sarah Gooding, Fadi Towfic, Nicholas Stong, Maria Ortiz Estevez, Konstantinos Mavrommatis, Brian Walker, Gareth Morgan, Nikhil Munshi, Herve Avet-Loiseau, Anjan Thakurta
Summary: Large-scale analysis of relapsed/refractory multiple myeloma (rrMM) shows significant genomic variation compared to newly diagnosed multiple myeloma (ndMM). This variation may be associated with therapeutic exposures and clonal structure. Genomic aberrations associated with resistance to immunomodulatory agent (IMiD) therapy are identified and their role in therapy evasion should be further evaluated.
Article
Biochemistry & Molecular Biology
Zhi Nie, Shan Cai, Zhimin Wei, Yanxi Li, Li Bian, Chenyang Wang, Chunyan Wang
Summary: SH3BGRL2 is weakly expressed in GBM and IDH1 wildtype GBM, and its ectopic expression inhibits GBM cell growth, migration, and GSCs self-renewal both in vitro and in vivo, by suppressing key regulators like SOX2 and CD133. This suggests SH3BGRL2 has potential as a biomarker and therapeutic target for glioma patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Mathieu Paquette, Ming Yan, Josue M. J. Ramirez-Reyes, Leeanna El-Houjeiri, Marco Biondini, Catherine R. Dufour, Hyeonju Jeong, Alain Pacis, Vincent Giguere, Jennifer L. Estall, Peter M. Siegel, Etienne Audet-Walsh, Arnim Pause
Summary: FLCN protein activity could be a promising target for small molecule drugs to treat liver fibrosis by specifically activating autophagy, promoting the degradation of intracellular lipid stores, ultimately resulting in reduced hepatocellular damage and inflammation. These results show an unexpected role for Flcn in fatty liver disease progression and highlight new potential treatment strategies.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Tadas K. Rimkus, Austin B. Arrigo, Dongqin Zhu, Richard L. Carpenter, Sherona Sirkisoon, Daniel Doheny, Angelina T. Regua, Grace L. Wong, Sara Manore, Calvin Wagner, Hui-Kuan Lin, Guangxu Jin, Jimmy Ruiz, Michael Chan, Waldemar Debinski, Hui-Wen Lo
Summary: The study found that TUSC2 protein expression is reduced in glioblastoma compared to normal brain due to protein destabilization. NEDD4-mediated polyubiquitination is a novel mechanism for TUSC2 degradation in glioblastoma. TUSC2 loss promotes glioblastoma progression through upregulation of Bcl-xL and its knockout gene signature predicts poor patient survival.
Article
Biochemistry & Molecular Biology
Livia E. Clarke, Allyson Cook, Sabateeshan Mathavarajah, Amit Bera, Jayme Salsman, Elias Habib, Carter Van Iderstine, Moamen Bydoun, Stephen M. Lewis, Graham Dellaire
Summary: PRP4K is an essential gene that when reduced is associated with aggressive breast and ovarian cancer phenotypes, leading to increased cell migration and invasion. These effects suggest that PRP4K functions as a haploinsufficient tumor suppressor.
Article
Multidisciplinary Sciences
Abdul S. Qadir, Jean Philippe Guegan, Christophe Ginestier, Assia Chaibi, Alban Bessede, Emmanuelle Charafe-Jauffret, Manon Macario, Vincent Lavoue, Thibault de la Motte Rouge, Calvin Law, Jacob Vilker, Hongbin Wang, Emily Stroup, Matthew J. Schipma, Bryan Bridgeman, Andrea E. Murmann, Zhe Ji, Patrick Legembre, Marcus E. Peter
Summary: The apoptosis inducing receptor CD95/Fas has tumorigenic activities and its expression in tumor cells can suppress NK cell immunity, providing a new target for immune therapy.
Article
Biotechnology & Applied Microbiology
Benxia Zhang, Min Hu, Qizhi Ma, Kai Li, Xue Li, Xia He, Pei Shu, Yue Chen, Ge Gao, Diyuan Qin, Fuchun Guo, Jian Zhao, Ning Liu, Kexun Zhou, Mingyang Feng, Weiting Liao, Dan Li, Xin Wang, Yongsheng Wang
Summary: HFRT can improve the major challenge of poor intratumoral infiltration in CAR-T cell therapy for solid tumors by inducing the activation and proliferation of MDSCs in the tumor microenvironment. Therefore, combining HFRT with MDSCs blockade can significantly enhance the intratumoral infiltration and treatment efficacy of CAR-T cells in solid tumor patients.
Article
Biotechnology & Applied Microbiology
Benxia Zhang, Min Hu, Qizhi Ma, Kai Li, Xue Li, Xia He, Pei Shu, Yue Chen, Ge Gao, Diyuan Qin, Fuchun Guo, Jian Zhao, Ning Liu, Kexun Zhou, MingYang Feng, Weiting Liao, Dan Li, Xin Wang, Yongsheng Wang
Summary: Poor intratumoral infiltration is a challenge for CAR-T cell therapy in solid tumors. HFRT induces activation and proliferation of tumor-infiltrated MDSCs, mediated by chemokines and receptors. When combined with HFRT, CXCR2 blockade enhances intratumoral infiltration and treatment efficacy of CAR-T cells, promising for CAR-T cell therapy optimization in solid tumors.
Article
Cell Biology
Simona Pellecchia, Marco De Martino, Francesco Esposito, Cristina Quintavalle, Alfredo Fusco, Pierlorenzo Pallante
Summary: GBM is classified into four subtypes based on molecular signature genes, with MPPED2 downregulation found in malignant neoplasias and being associated with poor prognosis. This study showed that restoring MPPED2 expression in GBM cell lines decreased cell growth, migration, and increased sensitivity to chemotherapy, suggesting a potential innovative therapy for GBM.
Letter
Oncology
Robert L. Bowman, Qianghu Wang, Angel Carro, Roel G. W. Verhaak, Massimo Squatrito
Article
Multidisciplinary Sciences
Barbara Oldrini, Wan-Ying Hsieh, Hediye Erdjument-Bromage, Paolo Codega, Maria Stella Carro, Alvaro Curiel-Garcia, Carl Campos, Maryam Pourmaleki, Christian Grommes, Igor Vivanco, Daniel Rohle, Craig M. Bielski, Barry S. Taylor, Travis J. Hollmann, Marc Rosenblum, Paul Tempst, John Blenis, Massimo Squatrito, Ingo K. Mellinghoff
NATURE COMMUNICATIONS
(2017)
Article
Oncology
Linda Pudelko, Pegah Rouhi, Kumar Sanjiv, Helge Gad, Christina Kalderen, Andreas Hoglund, Massimo Squatrito, Alberto J. Schuhmacher, Steven Edwards, Daniel Hagerstrand, Ulrika Warpman Berglund, Thomas Helleday, Lars Brautigam
Article
Multidisciplinary Sciences
Barbara Oldrini, Alvaro Curiel-Garcia, Carolina Marques, Veronica Matia, Ozge Uluckan, Osvaldo Grana-Castro, Raul Torres-Ruiz, Sandra Rodriguez-Perales, Jason T. Huse, Massimo Squatrito
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Nan Zhao, Vittorio Sebastiano, Natasha Moshkina, Nacho Mena, Judd Hultquist, David Jimenez-Morales, Yixuan Ma, Alex Rialdi, Randy Albrecht, Romain Fenouil, Maria Teresa Sanchez-Aparicio, Juan Ayllon, Sweta Ravisankar, Bahareh Haddad, Jessica Sook Yuin Ho, Diana Low, Jian Jin, Vyacheslav Yurchenko, Rab K. Prinjha, Alexander Tarakhovsky, Massimo Squatrito, Dalila Pinto, Kimaada Allette, Minji Byun, Melissa Laird Smith, Robert Sebra, Ernesto Guccione, Terrence Tumpey, Nevan Krogan, Benjamin Greenbaum, Harm van Bakel, Adolfo Garcia-Sastre, Ivan Marazzi
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2018)
Article
Multidisciplinary Sciences
A. G. de Lucas, A. J. Schuhmacher, M. Oteo, E. Romero, J. A. Camara, A. de Martino, A. G. Arroyo, M. A. Morcillo, M. Squatrito, J. L. Martinez-Torrecuadrada, F. Mulero
Article
Multidisciplinary Sciences
Monica Pascual-Garcia, Ester Bonfill-Teixidor, Ester Planas-Rigol, Carlota Rubio-Perez, Raffaella Ludaro, Alexandra Arias, Isabel Cuartas, Ada Sala-Hojman, Laura Escudero, Francisco Martinez-Ricarte, Isabel Huber-Ruano, Paolo Nuciforo, Leire Pedrosa, Carolina Marques, Irene Brana, Elena Garralda, Maria Vieito, Massimo Squatrito, Estela Pineda, Francesc Graus, Carmen EspejoH, Juan Sahuquillo, Josep Tabernero, Joan Seoane
NATURE COMMUNICATIONS
(2019)
Review
Biochemistry & Molecular Biology
Anders M. Lindroth, Yoon Jung Park, Veronica Matia, Massimo Squatrito
HUMAN MOLECULAR GENETICS
(2020)
Article
Multidisciplinary Sciences
Siobhan S. Pattwell, Sonali Arora, Patrick J. Cimino, Tatsuya Ozawa, Frank Szulzewsky, Pia Hoellerbauer, Tobias Bonifert, Benjamin G. Hoffstrom, Norman E. Boiani, Hamid Bolouri, Colin E. Correnti, Barbara Oldrini, John R. Silber, Massimo Squatrito, Patrick J. Paddison, Eric C. Holland
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Barbara Oldrini, Nuria Vaquero-Siguero, Quanhua Mu, Paula Kroon, Ying Zhang, Marcos Galan-Ganga, Zhaoshi Bao, Zheng Wang, Hanjie Liu, Jason K. Sa, Junfei Zhao, Hoon Kim, Sandra Rodriguez-Perales, Do-Hyun Nam, Roel G. W. Verhaak, Raul Rabadan, Tao Jiang, Jiguang Wang, Massimo Squatrito
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Matthias Juergen Schmitt, Carlos Company, Yuliia Dramaretska, Iros Barozzi, Andreas Goehrig, Sonia Kertalli, Melanie Grossmann, Heike Naumann, Maria Pilar Sanchez-Bailon, Danielle Hulsman, Rainer Glass, Massimo Squatrito, Michela Serresi, Gaetano Gargiulo
Summary: The study utilizes synthetic genetic tracing to investigate the heterogeneity of glioblastoma, revealing that mesenchymal glioblastoma is an adaptive and unstable cell state driven by inflammatory cues, differentiation signals, and DNA damage. It is discovered that immune cells can induce a proneural-to-mesenchymal transition in glioblastoma cells, contributing to therapeutic resistance.
Article
Cell Biology
Yuan Liu, Neel Chudgar, Brooke Mastrogiacomo, Di He, Manendra B. Lankadasari, Samhita Bapat, Gregory D. Jones, Francisco Sanchez-Vega, Kay See Tan, Nikolaus Schultz, Semanti Mukherjee, Kenneth Offit, Yongde Bao, Matthew J. Bott, Natasha Rekhtman, Prasad S. Adusumilli, Bob T. Li, Marty W. Mayo, David R. Jones
Summary: This study reveals the role of BRMS1 gene mutation in the metastasis of lung adenocarcinoma. The BRMS1v2(A273V/A273V) mutation activates c-fos-mediated gene transcriptional regulation, promoting tumor cell invasion and metastasis. This finding offers a potential therapeutic strategy for patients with lung adenocarcinoma.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Jungyoon Choi, Andreana N. Holowatyj, Mengmeng Du, Zhishan Chen, Wanqing Wen, Nikolaus Schultz, Loren Lipworth, Xingyi Guo
Summary: This study investigated distinct somatic mutation patterns among early-onset and late-onset endometrial cancer patients. The findings revealed unique genomic landscapes in early-onset EC, suggesting potential clinical implications for targeted treatment modalities in younger patients.
JCO PRECISION ONCOLOGY
(2022)
Article
Oncology
Leire Bejarano, Alberto J. Schuhmacher, Marinela Mendez, Diego Megias, Carmen Blanco-Aparicio, Sonia Martinez, Joaquin Pastor, Massimo Squatrito, Maria A. Blasco
Article
Oncology
Qianghu Wang, Baoli Hu, Xin Hu, Hoon Kim, Massimo Squatrito, Lisa Scarpace, Ana C. deCarvalho, Sali Lyu, Pengping Li, Yan Li, Floris Barthel, Hee Jin Cho, Yu-Hsi Lin, Nikunj Satani, Emmanuel Martinez-Ledesma, Siyuan Zheng, Edward Chang, Charles-Etienne Gabriel Sauve, Adriana Olar, Zheng D. Lan, Gaetano Finocchiaro, Joanna J. Phillips, Mitchel S. Berger, Konrad R. Gabrusiewicz, Guocan Wang, Eskil Eskilsson, Jian Hu, Tom Mikkelsen, Ronald A. DePinho, Florian Muller, Amy B. Heimberger, Erik P. Sulman, Do-Hyun Nam, Roel G. W. Verhaak