Article
Chemistry, Multidisciplinary
Emanuele Panizon, Andrea Silva, Xin Cao, Jin Wang, Clemens Bechinger, Andrea Vanossi, Erio Tosatti, Nicola Manini
Summary: The understanding of nano-scale friction, governed by atomic arrangements, is incomplete. This study provides a unified understanding of friction by researching the potential energy of contacting surfaces and categorizing contacts into three types based on geometrical features. These types include structurally lubricated contacts, corrugated and interlocked contacts, and a newly discovered directionally structurally lubricated contact. The findings have implications for a wide range of materials in contact.
Article
Engineering, Civil
Jun Zeng, Haijiang Liu
Summary: In this study, an improved analytical solution for studying swash hydrodynamics was deduced by considering a parameter k-controlled seaward boundary condition. The solution was found to be applicable to different stages of the swash process, but may slightly overestimate water depth and flow velocity in certain cases.
COASTAL ENGINEERING
(2022)
Article
Chemistry, Physical
Wen Cheng, Xinyu Wang, Ze Xiong, Jun Liu, Zhuangjian Liu, Yunxia Jin, Haicheng Yao, Tak-Sing Wong, John S. Ho, Benjamin C. K. Tee
Summary: The authors designed a pressure sensor that utilizes solid-liquid-liquid-gas multiphasic interfaces and a trapped air layer to modulate capacitance changes with pressure, achieving near-friction-free contact line motions and near-ideal pressure sensing performance. The sensor possesses outstanding linearity, ultralow hysteresis, and very high sensitivity, making it suitable for operation in complex fluid environments.
Article
Dermatology
Yang-Yi Chen, Shu-Mei Huang, Yu-Wen Cheng, Meng-Chi Yen, Ya-Ling Hsu, Cheng-Che E. Lan
Summary: This study investigated the role of human epidermal keratinocytes (HEKs) in diabetic wound healing. By culturing HEKs in normal and high-glucose environments and conducting RNA sequencing, the researchers identified key overexpressed genes and signaling pathways associated with impaired wound healing in diabetes. The findings provide insights into the molecular basis of diabetic wounds and have implications for personalized therapies.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2023)
Article
Mathematics, Interdisciplinary Applications
Myung-Jin Choi, Sven Klinkel, Roger A. Sauer
Summary: This paper presents an isogeometric finite element formulation for nonlinear beams with impenetrability constraints. The paper introduces a surface-to-surface contact algorithm combined with an active set strategy and a penalty method for frictionless lateral beam-to-beam contact. Several numerical examples are used to verify the accuracy and efficiency of the proposed beam contact formulation.
COMPUTATIONAL MECHANICS
(2022)
Article
Computer Science, Interdisciplinary Applications
Erdal Oner
Summary: This study investigates the receding contact problem between a homogeneous orthotropic coating and isotropic substrate under various parameters, utilizing theory of elasticity and Fourier integral transformation techniques to derive governing equations. Numerical solutions for contact stresses and contact widths are obtained using Gauss-Chebyshev integration formulas.
COMPUTERS AND CONCRETE
(2021)
Article
Immunology
Weichen Wang, Zhichao Lu, Maoyu Wang, Zongheng Liu, Bing Wu, Chengkai Yang, He Huan, Peipei Gong
Summary: By analyzing cuproptosis-related genes, a cuproptosis-based signature was constructed, revealing that patients with high CuproptosisScore had worse prognosis and higher gene mutation frequency. CuproptosisScore could serve as an independent prognostic factor, providing predictive value for glioma patients and potentially guiding personalized treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jessica K. Holien, Lachlan Coff, Andrew J. Guy, Jennifer C. Boer
Summary: During the COVID-19 lockdowns, online learning activities were developed for undergraduate and master's students. An integrative, industry-based research assignment was designed to guide students through a drug discovery project. This assignment allowed students to apply diverse bioinformatic principles to analyze biological and chemical data and make meaningful predictions. It served as the final assessment of the students' knowledge.
JOURNAL OF CHEMICAL EDUCATION
(2023)
Article
Multidisciplinary Sciences
Peipei Zuo, Chunchun Ye, Zhongren Jiao, Jian Luo, Junkai Fang, Ulrich S. Schubert, Neil B. McKeown, T. Leo Liu, Zhengjin Yang, Tongwen Xu
Summary: The development of efficient ion-transport membranes is crucial for improving separation processes and electrochemical technologies. We have designed synthetic membranes with covalently bonded polymer frameworks that achieve near-frictionless ion flow through rigidly confined ion channels. These membranes have the potential to greatly enhance the performance of electrochemical devices and molecular separation.
Article
Physics, Fluids & Plasmas
Martin Trulsson
Summary: In this study, we found a new fragility in frictionless ellipses suspensions during shear reversals, where particles can flow indefinitely in one direction but jam in the other direction. This new fragility is related to the directional order of elongated particles at steady shear and its reorientation at shear stress reversal, leading to a more disordered state with an increased number of contacts and possible arrest.
Editorial Material
Biochemical Research Methods
Benjamin J. Heil, Michael M. Hoffman, Florian Markowetz, Su-In Lee, Casey S. Greene, Stephanie C. Hicks
Summary: By adhering to standards based on data, model and code publication, programming best practices and workflow automation, researchers in the life sciences can enhance the computational reproducibility of machine-learning analyses and ensure their trustworthiness.
Article
Biochemistry & Molecular Biology
Chuanqi Jiang, Guangying Wang, Jing Zhang, Siyu Gu, Xueyan Wang, Weiwei Qin, Kai Chen, Dongxia Yuan, Xiaocui Chai, Mingkun Yang, Fang Zhou, Jie Xiong, Wei Miao
Summary: Researchers developed an integrated Genome Decontamination Pipeline (iGDP) to filter contaminated ciliate genome assemblies from wild specimens, resulting in high-quality ciliate genomes. iGDP showed good performance in filtering contaminants and can be applied to other microeukaryotes.
MOLECULAR ECOLOGY RESOURCES
(2023)
Article
Multidisciplinary Sciences
Scarlet S. Bliss, Eve A. Abraha, Erica R. Fuhrmeister, Amy J. Pickering, Carol A. Bascom-Slack
Summary: COVID-19 has led to the adoption of online learning in STEM education, which has posed challenges for professors in providing laboratory experiences. As a solution, many instructors have turned to online alternatives, which have been found to empower students from historically underrepresented backgrounds in STEM fields. This study presents PARE-Seq, a virtual bioinformatics activity focused on antimicrobial resistance research, and demonstrates that it can lead to significant learning gains and increased STEM identity. Factors such as gender, race/ethnicity, and extracurricular work hours can influence these gains, with female-identifying students and underrepresented minority students potentially benefiting more. The findings highlight the potential of online curricula like PARE-Seq to improve outcomes for all students in STEM, but support should be provided to students with extracurricular commitments.
Article
Public, Environmental & Occupational Health
Muntinee Lertpanprom, Atit Silsirivanit, Patcharaporn Tippayawat, Tanakorn Proungvitaya, Sittiruk Roytrakul, Siriporn Proungvitaya
Summary: This study identified a novel and reliable biomarker for diagnosis/prognosis of cholangiocarcinoma (CCA), protein tyrosine phosphatase receptor S (PTPRS), using liquid chromatography-mass spectrometry and tandem mass spectrometry (LC-MS/MS) combined with bioinformatics analysis. The results showed that PTPRS was significantly higher in CCA patients compared to patients with benign biliary disease and healthy controls. Higher serum PTPRS levels were associated with longer overall survival time of CCA patients and PTPRS was found to be an independent prognostic marker for CCA.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Engineering, Multidisciplinary
Gabriele Rovi, Bernhard Kober, Gerhard Starke, Rolf Krause
Summary: This paper examines the dual formulation of the frictionless Signorini problem for a deformable body in contact with a rigid obstacle and proposes a novel and optimal nonlinear multigrid method to solve it. The dual formulation directly solves for the stress variable and is not affected by locking, making it attractive for many engineering applications. However, solving it efficiently poses several challenges, including the stress belonging to the non-Sobolev space H-div, the semi-positive definiteness of the stress-related matrix block in the incompressible limit, and the enforcement of global equality constraints and box-constraints.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING
(2023)