Article
Physiology
Badr Khbouz, Francois Lallemand, Arianna Cirillo, Pascal Rowart, David Legouis, Nor Eddine Sounni, Agnes Noel, Pascal De Tullio, Sophie de Seigneux, Francois Jouret
Summary: This study investigates the protective effects and mechanisms of kidney-centered irradiation against renal ischemia-reperfusion injury (I/R). Kidney irradiation increased vascular surface in the renal parenchyma and conferred resistance against renal I/R damage. These findings suggest potential strategies for the treatment of ischemic acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Immunology
Hongtao Liu, Ye Shen
Summary: The exosomes extracted from splenic ischemic preconditioning models have a protective effect on renal ischemia-reperfusion injury, reducing inflammation and apoptosis. Additionally, they can modulate the levels of cytokines in the exosomes.
Article
Urology & Nephrology
Tuna Till Mut, Omer Acar, Ayse Armutlu, Said Incir, Annemarie Uhlig, Lale A. Ertuglu, Melis Ozel, Ali Cihan Taskin, Dilek Ertoy Baydar, Mehmet Kanbay, Tarik Esen
Summary: The study found that while RIPC failed to mitigate the detrimental effects of PN under warm ischemia on renal function in a solitary kidney animal model, there were marginal histological findings supportive of RIPC's renoprotective potential.
Review
Biochemistry & Molecular Biology
Juan Antonio Ortega-Trejo, Norma A. A. Bobadilla
Summary: Acute kidney injury (AKI) is a global health problem and has recently been recognized as a risk factor for developing chronic kidney disease (CKD). Ischemic preconditioning (IPC) has emerged as a promising strategy to prevent renal tissue damage from AKI. Several studies have shown the effectiveness of IPC in reducing renal damage and efforts are being made to find the best strategy to activate reparative mechanisms. Remote IPC, inducing ischemia in distant tissues before renal ischemia-reperfusion, is also being studied. This review provides a comprehensive overview of existing studies on IPC strategies for AKI and their impact on renal function and structure in animal models and humans, as well as the prospects and challenges for clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jan Rossaint, Melanie Meersch, Katharina Thomas, Sina Mersmann, Martin Lehmann, Jennifer Skupski, Tobias Tekath, Peter Rosenberger, John A. Kellum, Hermann Pavenstaedt, Alexander Zarbock
Summary: Remote ischemic preconditioning (RIPC) provides renal protection by modulating HMGB1 levels. In mice, RIPC reduces renal ischemia-reperfusion injury and improves kidney function. This protection is mediated by activation of AMPKa and NF-.B, which leads to the upregulation of Sema5b.
Review
Cardiac & Cardiovascular Systems
Zigang Liu, Yongmei Zhao, Ming Lei, Guancong Zhao, Dongcheng Li, Rong Sun, Xian Liu
Summary: A meta-analysis evaluating the efficacy of remote ischemic preconditioning (RIPC) in preventing acute kidney injury (AKI) after cardiac surgery showed that RIPC significantly reduced the incidence of AKI, particularly for mild-to-moderate cases that did not require renal replacement therapy. The results suggest that RIPC is an effective strategy for AKI prevention after cardiac surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yang Du, Rui Qiu, Lei Chen, Yuewen Chen, Zhifeng Zhong, Peng Li, Fangcheng Fan, Yong Cheng
Summary: This study investigated the potential molecular mechanism of remote ischemic preconditioning (RIPC)-mediated neuroprotection. By analyzing the differential metabolites and proteins in the serum exosomes of RIPC participants and control subjects, it was found that these differentially expressed substances were related to pathways associated with neurodegenerative diseases. The results suggest that serum exosomal metabolites can serve as promising biomarkers for RIPC and provide a rich dataset and framework for future analyses of cerebral ischemia-reperfusion injury under ischemia/reperfusion conditions.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Min Suk Chae, Jung-Woo Shim, Hoon Choi, Sung Hoo Hong, Ji Youl Lee, Woohyung Jeong, Bongsung Lee, Eunji Kim, Sang Hyun Hong
Summary: Robot-assisted laparoscopic partial nephrectomy (RALPN) may provide benefits in preserving renal function and minimizing postoperative complications in patients with renal cell carcinoma (RCC). Combining remote ischemic preconditioning (RIPC) and intrathecal morphine block (ITMB) as a bundle strategy can enhance the preservation of renal function. Swift adjustment of modifiable variables postoperatively is crucial for renal recovery. The combined RIPC and ITMB bundle therapy may serve as a safe and efficient method for improving renal outcomes in RCC patients undergoing RALPN.
Article
Biochemistry & Molecular Biology
Katharina Feige, Sebastian Roth, Rene M'Pembele, Anna Galow, Sarah Koenig, Martin Stroethoff, Annika Raupach, Giovanna Lurati Buse, Alexander M. Mathes, Markus W. Hollmann, Ragnar Huhn, Carolin Torregroza
Summary: The adverse impact of common diseases like diabetes mellitus and acute hyperglycemia on morbidity and mortality from myocardial infarction (MI) has been well documented. The relationship between blood glucose and mortality appears linear, and this seems to be independent of a diagnosis of diabetes. This study investigates the influence of acute and prolonged hyperglycemia on the protective effect of transferred human RIPC-plasma and suggests that hyperglycemia might obstruct translation into the clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Lars Hummitzsch, Karina Zitta, Lena Fritze, Jonas Monnens, Patrick Vollertsen, Matthias Lindner, Rene Rusch, Katharina Hess, Matthias Gruenewald, Markus Steinfath, Fred Fandrich, Rouven Berndt, Martin Albrecht
Summary: Remote ischemic preconditioning (RIPC) and chronic remote ischemic conditioning (cRIPC) have been shown to protect the heart against ischemia/reperfusion injury through promoting in-vitro angiogenesis and altering cell surface characteristics of circulating monocytes, potentially mediated by a combination of humoral and cellular factors. Interindividual variations may also play a significant role in the mechanisms associated with RIPC and cRIPC.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Cell Biology
Martin Donato, Eliana P. Bin, Veronica D'Annunzio, Ricardo J. Gelpi
Summary: Remote ischemic preconditioning (rIPC) can protect the heart from ischemia/reperfusion injury by activating different signaling pathways. Factors such as age, comorbidities, medication, and anesthetic protocol may weaken the subcellular mechanisms of rIPC in patients. Further carefully designed studies are necessary to develop a clearer understanding of the pathways and mechanisms of early and late rIPC.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Marco Moscarelli, Gianni D. Angelini, Costanza Emanueli, Saadeh Suleiman, Martino Pepe, Gaetano Contegiacomo, Prakash P. Punjabi
Summary: The study, based on multiple studies, confirmed the cardioprotective effect of RIPC on patients undergoing valve intervention, but did not observe improvement in post-operative clinical outcomes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cell Biology
Eliana P. Bin, Tamara Zaobornyj, Mariana Garces, Veronica D'Annunzio, Bruno Buchholz, Timoteo Marchini, Pablo Evelson, Ricardo J. Gelpi, Martin Donato
Summary: The rupture of the plasma membrane is the key point in cell death, which can be prevented by remote ischemic preconditioning through inhibiting MMP-2 activity. Besides, remote ischemic preconditioning also improves mitochondrial function, increasing membrane potential, ATP production and respiratory control.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Gal Yaniv, Arik Eisenkraft, Lilach Gavish, Linn Wagnert-Avraham, Dean Nachman, Jacob Megreli, Gil Shimon, Daniel Rimbrot, Ben Simon, Asaf Berman, Matan Cohen, David Kushnir, Ruth Shaylor, Baruch Batzofin, Shimon Firman, Amir Shlaifer, Michael Hartal, Yuval Heled, Elon Glassberg, Yitshak Kreiss, S. David Gertz
Summary: This study investigated the effects of limb remote ischemic preconditioning (RIPC) in a controlled hemorrhage model on survival rate and physiological status of pigs. The results showed that animals in the RIPC group had faster recovery of mean arterial pressure, higher heart rates, less decrease in bicarbonate, higher global oxygen delivery, and lower tissue oxygen extraction ratio after hemorrhage.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Usman Khalid, Robert H. Jenkins, Robert Andrews, Gilda Pino-Chavez, Benjamin C. Cossins, Rafael Chavez, Timothy Bowen, Donald J. Fraser
Summary: Ischemic preconditioning (IPC) provides optimal protection against subsequent ischemic acute kidney injury through short, repetitive sequences of preconditioning insult. Molecular analysis identified a unique profile of microRNA changes related to ischemia-reperfusion injury (IRI), predominantly localized in glomeruli and proximal tubules in the rat kidney. Pulsatile IPC reduces kidney damage post-IRI and attenuates the microRNA signal, highlighting potential candidate microRNAs as biomarkers and therapeutic targets.
SCIENTIFIC REPORTS
(2021)