Article
Oncology
Ichiro Yajima, Akira Tazaki, Nobutaka Ohgami, Masashi Kato
Summary: Chronic arsenic exposure can lead to various diseases, including skin cancer. However, there is limited information on key molecules and prevention methods for arsenic-promoted carcinogenesis. A study found that calcitriol can inhibit arsenic uptake and carcinogenesis in the skin by suppressing aquaporin gene expressions.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Gabriela Morales-Guadarrama, Edgar A. Mendez-Perez, Janice Garcia-Quiroz, Euclides Avila, Fernando Larrea, Lorenza Diaz
Summary: The study suggests that low doses of calcitriol may be a suitable candidate to synergize the effects of AZD4547 in luminal B breast tumors, allowing for dose reduction and minimizing adverse effects.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Sida Peng, Qingqing Yang, Huan Li, Yuhang Pan, Jiani Wang, Pan Hu, Nana Zhang
Summary: CTSB mRNA is upregulated in AML patients, and its overexpression is associated with poor prognosis in terms of both OS and DFS. Inhibition of CTSB expression in HL-60 cells suppresses cell proliferation and tumorigenesis, possibly through inactivation of the AKT signaling pathway.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Oncology
Hyunsoo Cho, Ji Eun Jang, Ju-In Eom, Hoi-Kyung Jeung, Haerim Chung, Jin Seok Kim, June-Won Cheong, Yoo Hong Min
Summary: The study demonstrated the synergistic effects of venetoclax and arsenic trioxide on AML leukemia stem cells, suggesting a potential combination therapy for acute leukemia treatment. Venetoclax efficiently induced apoptosis and impaired cell viability when combined with ATO, showing promising antileukemic effects.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qun Lou, Meichen Zhang, Yanmei Yang, Yanhui Gao
Summary: Long term low dose exposure to arsenic can lead to cell proliferation and malignant transformation. In this study, it was found that low dose exposure to arsenic trioxide increased glucose uptake and promoted cell viability and DNA synthesis. The activation of AKT induced by arsenic trioxide upregulated the expression of GLUT1 on the plasma membrane, enhancing glucose uptake and cell proliferation.
Article
Oncology
Xin Zhang, Bo Hu, Yun-Fan Sun, Xiao-Wu Huang, Jian-Wen Cheng, Ao Huang, Hai-Ying Zeng, Shuang-Jian Qiu, Ya Cao, Jia Fan, Jian Zhou, Xin-Rong Yang
Summary: Differentiation-inducing therapy using arsenic trioxide (ATO) was shown to effectively induce differentiation of hepatocellular carcinoma (HCC) cancer stem cells (CSCs) by downregulating CSC-related genes and suppressing tumorigenicity. Combinatorial treatment with ATO and 5-fluorouracil/cisplatin enhanced therapeutic effects through synergistic inhibition of the LIF/JAK1/STAT3 and NF-kB signaling pathways in HCC cells. These findings provide new insights for clinical treatment of HCC.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Toxicology
Prakash Binu, Reshma Soman, Omar Zakhariah Hisham, Sunilkumar Puthenpurackal Narayanan, Raveendran Harikumaran Nair
Summary: The study found that at physiological pH, eugenol can protect cardiomyocytes from the destructive effects of As2O3 without compromising its anti-cancer properties on leukemia cells. Meanwhile, there is no interaction between the two at acidic pH, allowing As2O3 to exhibit its anti-cancer effects. Therefore, the antioxidant molecule eugenol is an effective protective agent against the adverse effects of As2O3 on cardiomyocytes.
TOXICOLOGY MECHANISMS AND METHODS
(2021)
Article
Genetics & Heredity
Yahui Li, Yingjie Feng, Xiaohui Si, Chenjin Zhao, Fanping Wang, Xinqing Niu
Summary: ATO shows anti-tumor effects in AML treatment, especially regulating proliferation, apoptosis, and cell cycle in KG-1a cells, offering potential to enhance its efficacy.
FRONTIERS IN GENETICS
(2021)
Article
Pharmacology & Pharmacy
Amandda Evelin Silva-Carvalho, Nakaly Natiely de Oliveira, Julia Viana Lafeta Machado, Daniel Carneiro Moreira, Guilherme Dotto Brand, Jose Roberto S. A. Leite, Alexandra Placido, Peter Eaton, Felipe Saldanha-Araujo
Summary: The antioxidant peptide Salamandrin-I, isolated from the skin secretion of the fire salamander, has been found to exhibit anticancer activity in human leukemia cell line HL-60, resulting in reduced cell proliferation and cell cycle arrest. The cellular toxicity of Salamandrin-I may be related to pyroptosis, as indicated by loss of mitochondrial membrane potential and hyperexpression of inflammasome components. This study provides the first evidence of the anticancer potential of Salamandrin-I peptide and offers valuable insights for cancer therapy and drug design.
Article
Food Science & Technology
Robert A. Freeborn, Allison P. Boss, Luca M. Kaiser, Elizabeth M. Gardner, Cheryl E. Rockwell
Summary: This study found that arsenic has long-term effects on human T cell immune function, including reducing cell viability, altering cell activation, decreasing memory cell population, and reducing IFN gamma and granzyme B production. These findings contribute to a better understanding of the impact of arsenic on influenza immune response.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yan Shen, Ruihong Zhang, Xiangrui Li
Summary: eIF6 is found to be overexpressed in lung adenocarcinoma (LUAD), which is associated with advanced clinical stages and poor prognosis. Overexpression of eIF6 promotes LUAD cell proliferation, migration, and invasion, while inhibition of eIF6 induces cell cycle arrest and apoptosis. eIF6 expression is positively correlated with the expression of stemness-associated genes in LUAD cells. Targeting eIF6 can delay tumor growth and improve prognosis in mice.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Yilin Wang, Jiandong Sun, Dong Xie, Ren Zhong, Shaoyong Si, Xiaotong Liu, Zhenghai Qu, Lirong Sun, Lingzhen Wang
Summary: This study investigated the effect of UV LED on leukemia cells under hypoxia and found that UV LED exacerbated apoptosis and proliferation inhibition in HL-60 cells through the regulation of caspase 3/9 and the Bcl-2/Bax ratio-dependent pathway. The application of UV LEDs in hypoxia conditions may be a promising approach to eliminate residual drug-resistant leukemia cells in autologous grafts.
JOURNAL OF ONCOLOGY
(2022)
Article
Oncology
Francesco Autore, Patrizia Chiusolo, Federica Sora, Sabrina Giammarco, Luca Laurenti, Idanna Innocenti, Elisabetta Metafuni, Nicola Piccirillo, Livio Pagano, Simona Sica
Summary: Acute promyelocytic leukemia is a variant of acute myeloid leukemia characterized by t(15;17) and PML/RAR alfa fusion gene. Treatment with a combination of all-trans retinoic acid and arsenic trioxide has shown high efficacy and tolerability, providing an alternative to chemotherapy for selected patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Integrative & Complementary Medicine
Dandan Zheng, Yongming Zhou, Yong Liu, Lihai Ma, Lingzhan Meng
Summary: This study investigates the effective efficacy of traditional Chinese medicine Dingqing Tablet in treating acute myeloid leukemia. The key component kaempferol in Dingqing Tablet is found to bind with the core target gene AKT1, reducing the level of P-AKT and promoting leukemia cell apoptosis.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Oncology
Yu-Sheng Wang, Ji-Zhong Yin, Xiao-Qian Shi, Xue-Wei Zhao, Bing Li, Meng-Hang Yang
Summary: This study demonstrated that As2O3 could inhibit the growth and metastasis of SCLC cells by degrading mutant p53 protein via binding to MDM2.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)