Article
Endocrinology & Metabolism
Huijia Fu, Wang Tan, Zhi Chen, Zi Ye, Yuhan Duan, Jiayu Huang, Hongbo Qi, Xiru Liu
Summary: The abnormal expression of DNA topoisomerase II alpha (TOP2A) in the endometrium is found to play a crucial role in recurrent implantation failure (RIF). TOP2A affects the process of decidualization and the window of implantation in RIF patients. It functions through the NF-kappa B pathway and is involved in decidualization and embryo implantation processes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Johnny E. Elguero, Guangmei Liu, Katherine Tiemeyer, Shruthi Bandyadka, Heena Gandevia, Lauren Duro, Zhenhao Yan, Kimberly Mccall
Summary: This study found that Drosophila mutants lacking the phagocytic receptor Draper have phagocytic defects leading to neurodegenerative diseases. The study also discovered that phagocytic defects cause neurodegeneration through increased immune signaling.
Article
Reproductive Biology
Xiao-hua Xia, Ning Liang, Xiao-yu Ma, Lu Qin, Song-yun Wang, Zhong-jie Chang
Summary: In recent years, sex-controlled breeding has been proven to be effective in enhancing the yields and economic benefits of aquaculture. This study used the large-scale loach as a research model and investigated the impacts of inhibiting the NF-KB signaling pathway on gonadal differentiation and reproduction. The results showed that the inhibition of the NF-KB signaling pathway influenced gene expression related to gonad development, and affected the gonadal differentiation and sex ratio of the large-scale loach. Additionally, high concentrations of the NF-KB inhibitor affected the reproductive capabilities of adult loaches and inhibited the growth of offspring. This study provides a research basis for sex control in fish and contributes to the sustainable development of the aquaculture industry.
Review
Biochemistry & Molecular Biology
Qingfang Li, Yan Tie, Aqu Alu, Xuelei Ma, Huashan Shi
Summary: Head and neck cancer is a malignant and genetically complex disease that is difficult to treat. It is the sixth most common cancer, with tobacco, alcohol, and human papillomavirus as major risk factors. HNC is heterogeneous and treatment remains challenging. Despite current therapies, recurrence and metastasis are common, and resistance to chemotherapy and targeted therapies is a problem. Therefore, it is urgent to explore more effective and tolerable targeted therapies to improve outcomes for HNC patients.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Medicine, Research & Experimental
Amira A. Abdellatef, Yue Zhou, Akane Yamada, Sahar A. Elmekkawy, Aki Kohyama, Satoru Yokoyama, Meselhy R. Meselhy, Yuji Matsuya, Hiroaki Sakurai, Yoshihiro Hayakawa
Summary: The synthetic derivative GSD-1 strongly inhibits NF-kappa B activation, preventing nuclear translocation and cell-intrinsic activation, showing potential for treating breast cancer growth and metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Clinical Neurology
Jian Mao, Haorun Huang, Fan Liu, Yiying Mai, Xixian Liao, Binghui Qiu, Fen Mei, Yun Bao
Summary: The study revealed the presence of pituitary fibrosis in elderly individuals, which could be alleviated by reducing proinflammatory cytokine levels and increasing GH secretion.
WORLD NEUROSURGERY
(2022)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Article
Pharmacology & Pharmacy
Guangxia Yang, Kai Wang, Hua Song, Rujie Zhu, Shuai Ding, Hui Yang, Jian Sun, Xin Wen, Lingyun Sun
Summary: This study investigated the effect of celastrol on osteoarthritis (OA) and identified the mechanisms involved. The results showed that celastrol delayed cartilage damage, reduced osteophyte formation and bone resorption in an OA rat model. In vitro experiments also demonstrated that celastrol suppressed the production of inflammatory factors and inhibited matrix degradation. Furthermore, celastrol inhibited the TLR2/NF-kappa B signaling pathway. These findings suggest that celastrol could be a potential therapy for OA by targeting this signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Jing Zhang, Yu-Jing Wu, Xiao-Xi Hu, Wei Wei
Summary: Lck and nuclear factor-kappa B play crucial roles in the development and progression of autoimmune diseases and malignancies, and understanding their signaling pathways may lead to the identification of new therapeutic targets and approaches.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Danhui Liu, Zhenyu Zhong, Michael Karin
Summary: Inflammation is an important physiological process that removes pathogens, cellular debris, and promotes tissue repair. NF-kappa B transcription factor family plays a key role in inflammation, both promoting inflammatory response and tissue repair. Recent studies have shown that the NF-kappa B pathway also has inhibitory effects to temper inflammation.
Review
Immunology
Zilong Wang, Chucun Fang, Mengting Yao, Dongwen Wu, Maga Chen, Tianting Guo, Jianwen Mo
Summary: Venous thromboembolism is a common and costly health problem. Deep-vein thrombosis can cause severe consequences. Inflammatory response is considered an important pathway for triggering venous thromboembolism, and regulating it through the NF-kappa B signaling pathway may provide new solutions for prevention and treatment of thrombosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Md Sahab Uddin, Md Tanvir Kabir, Abdullah Al Mamun, Md Shahid Sarwar, Fatema Nasrin, Talha Bin Emran, Ibtesam S. Alanazi, Abdur Rauf, Ghadeer M. Albadrani, Amany A. Sayed, Shaker A. Mousa, Mohamed M. Abdel-Daim
Summary: NF-κB is a critical transcription factor that is abnormally activated in several cancers, particularly in glioblastoma multiforme (GBM). Despite the use of various treatment modalities for GBM, the survival rate of patients remains low, highlighting the need for new therapeutic approaches.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Xiaoyue Guan, Yani He, Zhichen Wei, Chen Shi, Yingxue Li, Rui Zhao, Lifei Pan, Yue Han, Tiezhou Hou, Jianmin Yang
Summary: The crosstalk between Wnt3a/beta-catenin and NF-kappa B signaling pathways plays a crucial role in the development of apical periodontitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Huibin Yu, Chen Peng, Chi Zhang, Ana M. M. Stoian, Loubna Tazi, Greg Brennan, Stefan Rothenburg
Summary: This study investigates the interaction between the Myxoma virus and the host protein kinase R (PKR). The results show that the MYXV M156 protein inhibits PKR in brush rabbits more strongly than in European rabbits. The moderate inhibition of PKR in European rabbits leads to the activation of the proinflammatory nuclear factor kappa B (NF-kappa B) pathway, which may contribute to the increased virulence of MYXV in European rabbits.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Virology
Andrew J. McNamara, Austin D. Brooks, Pranav Danthi
Summary: This study reveals that mammalian reovirus can block the function of NF-κB, an important protein family for the host cell's response to viral infection, through the expression of a viral protein called sigma 3. The expression of sigma 3 diminishes the host's response to infection and promotes viral replication. The differences in NF-κB target gene expression following infection with different reovirus strains are controlled by polymorphisms in the amino acid sequence of sigma 3.
JOURNAL OF VIROLOGY
(2022)
Article
Cell Biology
Kunihiro Kajiura, Naoki Umemura, Emika Ohkoshi, Takahisa Ohta, Nobuo Kondoh, Satoshi Kawano
Summary: The study demonstrates that shikonin can induce odontoblastic differentiation of dental pulp stem cells through the involvement of the AKT-mTOR signaling pathway and CD44. While CD44 expression is crucial for odontoblastic differentiation of dental pulp stem cells, the relationship between shikonin-induced expression of DSPP and the AKT-mTOR signaling pathway and CD44 expression remains to be fully elucidated.
CONNECTIVE TISSUE RESEARCH
(2021)
Article
Oncology
Linwah Yip, William E. Gooding, Alyaksandr Nikitski, Abigail I. Wald, Sally E. Carty, Esra Karslioglu-French, Raja R. Seethala, Dan P. Zandberg, Robert L. Ferris, Marina N. Nikiforova, Yuri E. Nikiforov
Summary: Risk stratification for patients with differentiated thyroid cancer (DTC) based on genetic profiling is accurate and robust, with molecular risk categories showing strong association with distant metastasis (DM) risk. Preoperative prognostication using molecular assays can help tailor treatment for patients with DTC.
Article
Oncology
Christopher W. Noel, David Forner, David P. Goldstein, Ur Metser, Robert L. Ferris, John Waldron, John R. de Almeida
Summary: The study showed that elective neck dissection (END) is a cost-effective strategy compared to PET-CT in patients with node-negative oral cancer. While PET-CT may become the preferred strategy with improved diagnostic performance, its cost effectiveness is still uncertain due to potential increase in false positive results.
Article
Chemistry, Medicinal
Mohamed A. A. Orabi, Hiroshi Sakagami, Naoki Umemura, Hamad S. Alyami, Tsutomu Hatano
Summary: Investigation into tannins found in Lawsonia inermis leaves led to the discovery of two new C-glycosidic ellagitannins, along with several known ellagitannins and a polyphenolic constituent. These compounds showed cytotoxic effects on human oral squamous cell carcinoma cell lines, with tellimagrandin II exhibiting the highest tumor-specific cytotoxicity.
Article
Medicine, Research & Experimental
Meghan T. Turner, Mathew N. Geltzeiler, Jad Ramadan, Jessica M. Moskovitz, Robert L. Ferris, Eric W. Wang, Seungwon Kim
Summary: The study demonstrated the feasibility of using the nasoseptal flap to reconstruct lateral transoral robotic surgery oropharyngectomy defects, with controlled operative times and complications. Preoperative imaging analysis can help determine the likelihood of surgical success in patients.
Article
Cell Biology
Kenichi Nonaka, Masanao Saio, Naoki Umemura, Arizumi Kikuchi, Takao Takahashi, Shinji Osada, Kazuhiro Yoshida
Summary: This study found that in a Th1-polarized tumor microenvironment, the maturation and activation of tumor-associated macrophages (TAMs) is affected, with TAMs potentially exhibiting immunosuppressive functions similar to myeloid-derived suppressor cells.
CELLULAR IMMUNOLOGY
(2021)
Letter
Oncology
Robert L. Ferris, Barbara Burtness, Yael Flamand
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Robert L. Ferris, Yael Flamand, Gregory S. Weinstein, Shuli Li, Harry Quon, Ranee Mehra, Joaquin J. Garcia, Christine H. Chung, Maura L. Gillison, Umamaheswar Duvvuri, Bert W. O'Malley, Enver Ozer, Giovana R. Thomas, Wayne M. Koch, Neil D. Gross, R. Bryan Bell, Nabil F. Saba, Miriam Lango, Eduardo Mendez, Barbara Burtness
Summary: This study aimed to investigate the efficacy and safety of primary transoral surgery (TOS) and reduced postoperative radiation therapy (RT) in intermediate-risk patients with human papillomavirus-associated oropharynx cancer (HPV+ OPC). The results showed that TOS and reduced RT achieved favorable oncologic outcomes and functional outcomes in intermediate-risk HPV+ OPC patients.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Chloe S. Lalonde, Yong Teng, Barbara A. Burtness, Robert L. Ferris, Rafi Ahmed, Nabil F. Saba
Summary: This article provides an overview of the necessary elements to eliminate oropharyngeal squamous cell carcinoma, including improved vaccine uptake, universal vaccination effort, and implementation of novel therapeutics to cure existing disease.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Huaibin Ge, Robert L. Ferris, Jing H. Wang
Summary: This study analyzed the dynamic changes of T-cell receptor (TCR) repertoire in peripheral blood and tumor tissue of patients with cetuximab-treated HNSCC. The expansion of top TCR clonotypes in responder PBMC and TIL samples may serve as predictive markers for cetuximab response in HNSCCs. Data normalization is important for TCR repertoire analysis.
CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Koichi Murakami, Naoki Umemura, Makoto Adachi, Masahiro Motoki, Emika Ohkoshi
Summary: By studying the resistance of head and neck squamous cell carcinoma cells to cisplatin, this study found that CD44, SOX9, and ABCG2 play important roles in maintaining the characteristics of cancer stem cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Oncology
Michael B. Atkins, Hamzah Abu-Sbeih, Paolo A. Ascierto, Michael R. Bishop, Daniel S. Chen, Madhav Dhodapkar, Leisha A. Emens, Marc S. Ernstoff, Robert L. Ferris, Tim F. Greten, James L. Gulley, Roy S. Herbst, Rachel W. Humphrey, James Larkin, Kim A. Margolin, Luca Mazzarella, Suresh S. Ramalingam, Meredith M. Regan, Brian Rini, Mario Sznol
Summary: The activity of agents blocking PD-(L)1 axis has revolutionized oncology, but not all patients benefit from these therapies. Many drug development programs have combined anti-PD-(L)1 with other therapies, but there is a lack of predictive biomarkers and optimized clinical trial designs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Marco A. Mascarella, Tolani F. Olonisakin, Purva Rumde, Varun Vendra, Melonie A. Nance, Seungwon Kim, Mark W. Kubik, Shaum S. Sridharan, Robert L. Ferris, Moon J. Fenton, Daniel R. Clayburgh, James P. Ohr, Sonali C. Joyce, Malabika Sen, James G. Herman, Jennifer R. Grandis, Dan P. Zandberg, Umamaheswa Duvvuri
Summary: A study investigated the relationship between response to neoadjuvant therapy and survival in patients with head and neck squamous cell carcinoma. The analysis showed that patients who received targeted therapy had lower pathological stage migration and higher overall survival. The study also found a correlation between downstage migration and decreased levels of circulating tumor markers SOX17 and TAC1.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Robert I. Haddad, Kevin Harrington, Makoto Tahara, Robert L. Ferris, Maura Gillison, Jerome Fayette, Amaury Daste, Piotr Koralewski, Bogdan Zurawski, Miren Taberna, Nabil F. Saba, Milena Mak, Andrzej Kawecki, Gustavo Girotto, Miguel Angel Alvarez Avitia, Caroline Even, Joaquin Gabriel Reinoso Toledo, Alexander Guminski, Urs Muller-Richter, Naomi Kiyota, Mustimbo Roberts, Tariq Aziz Khan, Karen Miller-Moslin, Li Wei, Athanassios Argiris
Summary: In patients with recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN), first-line nivolumab plus ipilimumab did not show a significant difference in overall survival compared to the standard treatment. However, there may be some advantages in certain populations, and it has a better safety profile.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Ayana T. Ruffin, Housaiyin Li, Lazar Vujanovic, Dan P. Zandberg, Robert L. Ferris, Tullia C. Bruno
Summary: Targeted immunotherapy has improved survival in head and neck squamous cell carcinoma (HNSCC), but new immunotherapies considering the entire HNSCC tumour microenvironment are needed to enhance T cell responses. Recent advancements have provided a comprehensive understanding of the cellular constituents and interactions within the complex HNSCC microenvironment.
NATURE REVIEWS CANCER
(2023)