Article
Immunology
Sidi Yang, Qifeng Deng, Lanqing Sun, Yuan Zhu, Kedi Dong, Shuyan Wu, Rui Huang, Yuanyuan Li
Summary: This study characterized the effects of SpvB on the NF-κB signaling pathway, revealing that SpvB inhibits NF-κB activation by targeting IKKβ and involving KEAP1. These findings uncover a novel mechanism by which Salmonella modulates NF-κB activity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Sisi Wang, Dingrong Wan, Wenqi Liu, Xinyi Kang, Xiuteng Zhou, Fatemeh Sefidkon, Mohaddesehossadat Mahmoud Zadeh Hosseini, Ting Zhang, Xin Pan, Xinzhou Yang
Summary: In this study, the anti-throat carcinoma effects of a biflavonoid-rich extract from Selaginella doederleinii (SD-BFRE) were investigated. SD-BFRE exhibited anti-proliferation and pro-apoptotic effects in throat carcinoma cells through the IKK beta/NF-kappa B/COX-2 and Akt/Bad signaling pathways.
Article
Multidisciplinary Sciences
Shasha Yin, Liu Liu, Charles Brobbey, Viswanathan Palanisamy, Lauren E. Ball, Shaun K. Olsen, Michael C. Ostrowski, Wenjian Gan
Summary: AKT is involved in key cellular processes, and arginine methylation by PRMT5 promotes AKT activity and tumorigenesis.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Xin Dong, Jialin Jiang, Zhijun Lin, Ruijia Wen, Ling Zou, Tong Luo, Zhuoji Guan, Xuan Li, Linhai Wang, Lu Lu, Huan Li, Yusheng Huang, Zhongqi Yang, Junyan Wang, Xiaohan Ye, Xiaohua Hong, Lingjun Wang, Shaoxiang Xian, Zixin Chen
Summary: This study demonstrated that Nuanxinkang (NXK) has a protective effect on ischemia/reperfusion (IR)-induced heart failure (HF). NXK modulates the ratio of proinflammatory and anti-inflammatory macrophages, reducing inflammation and improving cardiac function. The results suggest that NXK could be a natural strategy for the anti-inflammatory treatment of HF.
Article
Cell Biology
Yang Nan, Liyun Guo, Yingwei Zhen, Le Wang, Bingcheng Ren, Xingjie Chen, Yalin Lu, Kai Yu, Yue Zhong, Qiang Huang
Summary: The study found that miRNA-451 regulates the NF-kappa B signaling pathway by targeting IKK beta, inhibiting the growth and invasion ability of glioma cells. Overexpression of miRNA-451 decreased the expression of IKK beta and other proteins, leading to reduced cell proliferation and invasion.
Article
Cell Biology
Yuanxin Xing, Yani Lin, Ying Zhang, Jing Hu, Junmei Liu, Yuanyuan Tian, Jian Zhao, Weiwen Chen, Bo Han
Summary: NF-kappa B signaling pathway plays a crucial role in the development and metastasis of lung adenocarcinoma. The lncRNA IKBKBAS acts as a ceRNA by competitively binding miR-4741 and IKK beta mRNA, regulating the activation of NF-kappa B signaling pathway.
CELL DEATH & DISEASE
(2021)
Article
Agriculture, Multidisciplinary
Xizhu Wang, Liu Dong, Yifei Dong, Zhijie Bao, Songyi Lin
Summary: Hyperuricemia (HUA) is a metabolic disease characterized by elevated uric acid levels, posing a risk for premature death. Corn silk flavonoids (CSF) were found to have a protective effect against HUA by reducing inflammation and apoptosis through the down-regulating PI3K/AKT/NF-κB pathway. This study also demonstrated the UA-lowering activity of CSF in vitro and in potassium oxonate-induced HUA in vivo models.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Zhu-Qi Huang, Wu Luo, Wei-Xin Li, Pan Chen, Zhe Wang, Rui-Jie Chen, Yi Wang, Wei-Jian Huang, Guang Liang
Summary: Costunolide (CTD) has anti-atherosclerotic effects by reducing inflammatory responses and oxLDL uptake, and its mechanism involves the inhibition of NF-kappa B signaling pathway through covalent binding to IKKβ.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pharmacology & Pharmacy
Mahesh Kandasamy
Summary: NF-kappa B signaling pathway may play a crucial role in COVID-19, and pharmacological inhibition of this pathway could be a potential approach for treating the disease.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Microbiology
Shuang Jiao, Changyao Li, Hongyang Liu, Mengdi Xue, Qiongqiong Zhou, Longfeng Zhang, Xiaohong Liu, Chunying Feng, Guangqiang Ye, Jia Liu, Jiangnan Li, Li Huang, Tao Xiong, Zhaoxia Zhang, Changjiang Weng
Summary: Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious pathogen that causes significant economic losses to the swine industry worldwide. The nonstructural protein 4 (Nsp4) of PRRSV is shown to inhibit the activation of the nuclear transcription factor kappa B (NF-kappa B) signaling pathway by cleaving the inhibitor kappa B kinase beta (IKK beta). The cleavage of IKK beta by PRRSV Nsp4 is dependent on its 3C-like serine protease activity.
VETERINARY MICROBIOLOGY
(2023)
Article
Plant Sciences
Xiaoqing Shi, Lishi Jie, Peng Wu, Nongshan Zhang, Jun Mao, Peimin Wang, Songjiang Yin
Summary: In this study, the active components of Shaoyao Gancao Decoction (SG-Tang) were analyzed using network pharmacology and UPLC-QTOF-MS analysis to explore their potential therapeutic mechanism in osteoarthritis (OA).
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Dan Li, Ying-ying Guo, Xian-feng Cen, Hong-liang Qiu, Si Chen, Xiao-feng Zeng, Qian Zeng, Man Xu, Qi-zhu Tang
Summary: The study shows that lupeol protects against cardiac hypertrophy via anti-inflammatory mechanisms by inhibiting the TLR4-PI3K-Akt-NF-kappa B signaling pathway.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Immunology
Yilin Li, Tao Jin, Naixin Liu, Junsong Wang, Zihan Qin, Saige Yin, Yingxuan Zhang, Zhe Fu, Yutong Wu, Yinglei Wang, Yixiang Liu, Meifeng Yang, Ailan Pang, Jun Sun, Ying Wang, Xinwang Yang
Summary: In this study, a new non-toxic peptide NP1 was discovered, which exerted neuroprotective effects on cerebral ischemia-reperfusion injury by reducing inflammation via the miR-6328/IKK beta/NF-kappa B axis. The results not only provide candidate drugs for exogenous peptides and endogenous small nucleic acids, but also a new drug target for the treatment of IS.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Yi Hui Yee, Stephen Jun Fei Chong, Li Ren Kong, Boon Cher Goh, Shazib Pervaiz
Summary: The study indicates that a pro-oxidant environment is an upstream effector of oncogenic NF-κB signaling, and sustained NF-κB signaling relies on nitration-mediated inactivation of PP2A. Pro-oxidant-driven NF-κB activation can enhance the invasive potential of cancer cells.