Article
Endocrinology & Metabolism
Hongyun Zhao, Da Teng, Lifeng Yang, Xincheng Xu, Jiajia Chen, Tengjia Jiang, Austin Y. Feng, Yaqing Zhang, Dennie T. Frederick, Lei Gu, Li Cai, John M. Asara, Marina Pasca di Magliano, Genevieve M. Boland, Keith T. Flaherty, Kenneth D. Swanson, David Liu, Joshua D. Rabinowitz, Bin Zheng
Summary: This study reveals that itaconate, produced by myeloid-derived suppressor cells (MDSCs), acts as an immune checkpoint metabolite to suppress CD8(+) T cells. Inhibition of IRG1 may enhance anti-tumour immunity and improve the efficacy of immune checkpoint blockade. These findings have implications for understanding immune surveillance and developing new strategies for cancer treatment.
Article
Allergy
Cory A. Perugino, Naoki Kaneko, Takashi Maehara, Hamid Mattoo, Jesper Kers, Hugues Allard-Chamard, Vinay S. Mahajan, Hang Liu, Emanuel Della-Torre, Samuel J. H. Murphy, Musie Ghebremichael, Zachary S. Wallace, Marcy B. Bolster, Liam M. Harvey, Geetha Mylvaganam, Yesim Tuncay, Lloyd Liang, Sydney B. Montesi, Xiuwei Zhang, Akira Tinju, Keita Mochizuki, Ryusuke Munemura, Mizuki Sakamoto, Masafumi Moriyama, Seiji Nakamura, Nir Yosef, John H. Stone, Shiv Pillai
Summary: In IgG(4)-related disease, CD4(+)CTLs and CD8(+)CTLs may induce apoptotic cell death in tissues by preferentially targeting nonendothelial, nonimmune cells of mesenchymal origin.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Cell Biology
Vandana Kalia, Yevgeniy Yuzefpolskiy, Adithya Vegaraju, Hanxi Xiao, Florian Baumann, Shashank Jatav, Candice Church, Martin Prlic, Abhishek Jha, Paul Nghiem, Stanley Riddell, Surojit Sarkar
Summary: The inhibitory role of PD-1 signaling in CD8 T cells has been well established in chronic viral infections and cancers, but its impact on the development of long-lived antigen-independent T cell memory remains unclear. Studies have shown that PD-1 expression on antigen-specific CD8 T cells is essential for the formation of a durable CD8 T cell memory pool, with loss of T cell-specific PD-1 signaling leading to increased apoptosis and a defect in antigen-independent renewal of memory CD8 T cells.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Hemapriyadarshini Vadarevu, Ridhima Juneja, Zachary Lyles, Juan L. Vivero-Escoto
Summary: The use of nanoparticle-based materials in photodynamic therapy for cancer treatment is a growing area of research, with Polysilsesquioxane nanoparticles showing promise in enhancing PDT effectiveness. This study focused on a Protroporphyrin IX-based PSilQ platform, revealing that cell death pathways during PDT were regulated by both apoptosis and ferroptosis.
Article
Multidisciplinary Sciences
Xinwei Liu, Jing Hao, Peng Wei, Xiaohong Zhao, Qiuyan Lan, Lu Ni, Yongzhen Chen, Xue Bai, Ling Ni, Chen Dong
Summary: In this study, the researchers found that SMAD4 plays a critical role in promoting CD8(+) T cell function in both tumor and infection models. SMAD4-mediated transcriptional regulation enhances CD8(+) T cell activation and cytotoxicity through the T cell receptor (TCR) signaling pathway. Furthermore, SMAD4 is directly phosphorylated by ERK following TCR activation.
Article
Biochemistry & Molecular Biology
Shuang Zhang, Masayuki Harada, Takeshi Kimura, Noboru Ashida
Summary: Cancer-associated fibroblasts (CAFs) are important components of the tumor microenvironment and play critical roles in tumorigenesis. In this study, the researchers investigated the role of IKK beta, a key kinase for NF-kappa B activation, in activated CAFs. The results showed that IKK beta has a tumor-suppressing function in activated CAFs, and its deletion leads to enhanced tumor growth and upregulation of tumor-promoting factors.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Gongjian Zhu, Haixiang Su, Caroline H. Johnson, Sajid A. Khan, Harriet Kluger, Lingeng Lu
Summary: This study revealed that cutaneous melanoma patients with low levels of CD8+ T cells have shorter survival times, while the Lachnoclostridium genus in intratumour bacteria showed a positive association with infiltrating CD8+ T cells and was beneficial for patient survival. Manipulating the intratumour gut microbiome may improve patient outcomes during immunotherapy.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Julia Femel, Luuk van Hooren, Melanie Herre, Jessica Cedervall, Falk Saupe, Elisabeth J. M. Huijbers, Danielle R. J. Verboogen, Matthias Reichel, Victor L. Thijssen, Arjan W. Griffioen, Lars Hellman, Anna Dimberg, Anna-Karin Olsson
Summary: Galectin-1 (Gal1) is a glycan-binding protein that promotes tumor progression through various mechanisms. Vaccination against Gal1 can generate high anti-Gal1 antibody levels and significantly impairs the growth of Gal1-expressing melanomas in mice. This is associated with improved tumor vasculature perfusion and increased infiltration of macrophages and cytotoxic T cells. Gal1 vaccination is a promising approach to enhance immunotherapeutic strategies for cancer therapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Rui Li, Walida Ali, Chao Ma, Apratim Bajpai, Ngoc Luu, Aarushi Varshney, Camden Riley Rowe, Weiqiang Chen
Summary: The strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate enhances mechanotransduction and activation of cytotoxic CD8(+) T cells by triggering noncanonical Wnt signaling. This innovative mechanoregulatory ligand platform has broad applications in fundamental mechano-immunology research and the development of novel immunotherapies.
CHEMICAL COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Nikolaj Pagh Kristensen, Christina Heeke, Siri A. Tvingsholm, Annie Borch, Arianna Draghi, Michael D. Crowther, Ibel Carri, Kamilla K. Munk, Jeppe Sejero Holm, Anne-Mette Bjerregaard, Amalie Kai Bentzen, Andrea M. Marquard, Zoltan Szallasi, Nicholas McGranahan, Rikke Andersen, Morten Nielsen, Goran B. Jonsson, Marco Donia, Inge Marie Svane, Sine Reker Hadrup
Summary: This study examined the frequency of neoepitope-specific CD8(+) T cells in tumor-infiltrating lymphocyte (TIL) infusion products and blood samples from melanoma patients who received adoptive cell therapy (ACT). The results showed that the frequency of neoepitope-specific CD8(+) T cells correlated with patient survival, and these cells were unique to responders of TIL-ACT. Additionally, a transcriptional signature for lymphocyte activity within the tumor microenvironment was associated with a higher frequency of neoepitope-specific CD8(+) T cells in the infusion product.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Gastroenterology & Hepatology
Xinhai Zhu, Ke Li, Guichao Liu, Ruan Wu, Yan Zhang, Siying Wang, Meng Xu, Ligong Lu, Peng Li
Summary: Recent studies have shown that gut microbiota and their metabolites can modulate the antitumor immunity of immune cells, but the underlying mechanisms are unclear. This study found that the serum level of butyric acid is correlated with the expression of PD-1 on CD8(+) and V?9 Vd2 T cells in patients with NSCLC. Patients who responded to anti-PD-1 therapy had higher levels of acetic acid, propionic acid, and butyric acid. Depletion of gut microbiota decreased butyrate levels in feces and serum of tumor-bearing mice.
Article
Oncology
Eldar Sovunjov, Zehra Seda Halbutogullari, Gulcin Gacar, Ahmet Ozturk, Goekhan Duruksu, Yusufhan Yazir
Summary: Lung cancer is a major global health problem with various physical, psychological, social, and economic consequences. Activated cytotoxic T cells (ACTC) have been found to improve cancer patient prognosis by positively influencing the tumor microenvironment (TME). Recent studies suggest that ACTC-derived exosomes (ACTC-dExo) inhibit the spread of mesenchymal stem cells in the TME, potentially combating metastasis. Exosomes, which resemble natural liposomes in their characteristics, size, and stability, hold promise as a targeted drug delivery system for cancer cells. This study aimed to investigate the cytotoxic and metastatic inhibitory effects of ACTC-dExo on A549 cells in vitro, demonstrating their ability to reduce cancer cell proliferation and metastatic properties.
Article
Immunology
Andrea Gaissler, Trine Sundebo Meldgaard, Christina Heeke, Sepideh Babaei, Siri Amanda Tvingsholm, Jonas Bochem, Janine Spreuer, Teresa Amaral, Nikolaus Benjamin Wagner, Reinhild Klein, Friedegund Meier, Claus Garbe, Thomas K. Eigentler, Graham Pawelec, Manfred Claassen, Benjamin Weide, Sine Reker Hadrup, Kilian Wistuba-Hamprecht
Summary: This study investigated the dynamics of tumor antigen-specific T cells in the circulation of metastatic melanoma patients during anti-PD-1 treatment. The researchers identified a correlation between an increase in MAE-specific CD8+ T cell populations and improved overall survival. The study also found an increase in TIM-3+ and LAG-3+ T cells in patients with a dominantly increased MAE-specific CD8+ T cell signature. These findings contribute to a better understanding of biomarkers of response and anti-cancer mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Satu Salmi, Kaisla Halinen, Anton Lin, Sanna Suikkanen, Otto Jokelainen, Eija Rahunen, Hanna Siiskonen, Sanna Pasonen-Seppanen
Summary: In melanoma, CD8+ and GrB+ lymphocytes were found to be more abundant in pT4 melanomas and lymph node metastases compared to primaries. A low GrB/CD8 ratio was associated with better recurrence-free survival in primary melanomas, suggesting that GrB+ lymphocytes may represent activated immunosuppressive lymphocytes.
Article
Oncology
Tian-Yu Zhang, Hong-Yan Ren, Ning Pan, Hui-Xia Dong, Si-Min Zhao, Zhi-Fa Wen, Xu-Ru Wang, Li-Xin Wang
Summary: DRibble-loaded B cells are found to play a crucial role in priming naive CD8(+) T cell responses and controlling tumors, potentially offering an important therapeutic strategy for tumor immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Cell Biology
Pieter Goossens, Juan Rodriguez-Vita, Anders Etzerodt, Marion Masse, Olivia Rastoin, Victoire Gouirand, Thomas Ulas, Olympia Papantonopoulou, Miranda Van Eck, Nathalie Auphan-Anezin, Magali Bebien, Christophe Verthuy, Thien Phong Vu Manh, Martin Turner, Marc Dalod, Joachim L. Schultze, Toby Lawrence
Article
Immunology
Connie B. Gilfillan, Chensu Wang, Mona O. Mohsen, Nathalie Rufer, Michael Hebeisen, Mathilde Allard, Gregory Verdeil, Darrell J. Irvine, Martin F. Bachmann, Daniel E. Speiser
EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Anders Etzerodt, Morgane Moulin, Thomas Koed Doktor, Marcello Delfini, Noushine Mossadegh-Keller, Marc Bajenoff, Michael H. Sieweke, Soren Kragh Moestrup, Nathalie Auphan-Anezin, Toby Lawrence
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Review
Immunology
Claire Imbratta, Hind Hussein, Fabienne Andris, Gregory Verdeil
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Oncology
Marine M. Leblond, Laure Tille, Sina Nassiri, Connie B. Gilfillan, Claire Imbratta, Martina Schmittnaegel, Carola H. Ries, Daniel E. Speiser, Gregory Verdeil
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Biology
Jennifer Bintz, Analia Meilerman Abuelafia, Francois Gerbe, Elodie Baudoin, Nathalie Auphan-Anezin, Emmanuelle Sidot, Philippe Jay, Juan Iovanna
Letter
Immunology
Alejandra Gomez-Cadena, Laurie Spehner, Marie Kroemer, Myriam Ben Khelil, Kevin Bouiller, Gregory Verdeil, Sara Trabanelli, Christophe Borg, Romain Loyon, Camilla Jandus
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Paul Oster, Laurie Vaillant, Erika Riva, Brynn McMillan, Christina Begka, Caroline Truntzer, Corentin Richard, Marine M. Leblond, Meriem Messaoudene, Elisavet Machremi, Emeric Limagne, Francois Ghiringhelli, Bertrand Routy, Gregory Verdeil, Dominique Velin
Summary: This study revealed that Helicobacter pylori infection may reduce the efficacy of cancer immunotherapies, as demonstrated in mouse models and human clinical studies.
Review
Oncology
Marine M. Leblond, Hana Zdimerova, Emma Desponds, Gregory Verdeil
Summary: Tumor-associated macrophages (TAMs) are abundant in solid tumors and their accumulation promotes tumor progression. Targeting TAMs may improve treatment efficacy and survival outcomes for bladder cancer patients.
Article
Immunology
Ghita Ghislat, Ammar S. Cheema, Elodie Baudoin, Christophe Verthuy, Pedro J. Ballester, Karine Crozat, Noudjoud Attaf, Chuang Dong, Pierre Milpied, Bernard Malissen, Nathalie Auphan-Anezin, Thien P. Vu Manh, Marc Dalod, Toby Lawrence
Summary: Through single-cell transcriptomics, it was discovered that nuclear factor kappa B (NF-kappa B) and interferon (IFN) pathways are highly enriched in a subset of functionally mature conventional type 1 dendritic cells (cDC1s). The dynamic reprogramming of tumor-infiltrating cDC1s by NF-kappa B and IFN signaling pathways affects the recruitment and activation of antitumoral CD8(+) T cells. Activation of the NF-kappa B/IRF1 axis in cDC1s is associated with improved clinical outcomes for patients with melanoma, suggesting it may be a key focal point for new diagnostic and therapeutic approaches in cancer immunotherapy.
SCIENCE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sara Trabanelli, Giuseppe Ercolano, Tania Wyss, Alejandra Gomez-Cadena, Maryline Falquet, Daniela Cropp, Claire Imbratta, Marine M. Leblond, Valentina Salvestrini, Antonio Curti, Olivier Adotevi, Camilla Jandus, Gregory Verdeil
Summary: The transcription factor c-Maf is found to be indispensable for optimal type 2 cytokine production and proper memory-like responses in group-2 innate lymphoid cells (ILC2s).
Article
Immunology
Laure Tille, Daniela Cropp, Melanie Charmoy, Patrick Reichenbach, Massimo Andreatta, Tania Wyss, Gabrielle Bodley, Isaac Crespo, Sina Nassiri, Joao Lourenco, Marine M. Leblond, Cristina Lopez-Rodriguez, Daniel E. Speiser, George Coukos, Melita Irving, Santiago J. Carmona, Werner Held, Gregory Verdeil
Summary: Persistent exposure to antigen during chronic infection or cancer can cause dysfunction in T cells. NFAT5, a type of transcription factor, plays a crucial role in tumor-induced CD8(+) T cell exhaustion but not in exhaustion caused by chronic infection. Overexpression of NFAT5 weakens tumor control, while deletion of NFAT5 improves tumor control and promotes the accumulation of exhausted CD8(+) T cells.
Article
Multidisciplinary Sciences
Franca Cassol, Loriane Portal, Sylvie Richelme, Mathieu Dupont, Yannick Boursier, Maria Arechederra, Nathalie Auphan-Anezin, Lionel Chasson, Caroline Laprie, Samantha Fernandez, Laure Balasse, Fabienne Lamballe, Rosanna Dono, Benjamin Guillet, Toby Lawrence, Christian Morel, Flavio Maina
Article
Oncology
Kaat de Jonge, Laure Tille, Joao Lourenco, Helene Maby-El Hajjami, Sina Nassiri, Julien Racle, David Gfeller, Mauro Delorenzi, Gregory Verdeil, Petra Baumgaertner, Daniel E. Speiser
Summary: The role of B cells in solid tumor patients is insufficiently understood. Research suggests that B cells may promote tumor growth by producing inflammatory cytokines, affecting treatment response and overall survival. Different subsets of B cells may have varying impacts on tumor development, necessitating further study for identification and characterization.
Article
Oncology
Nicolas Gestermann, Damien Saugy, Christophe Martignier, Laure Tille, Silvia A. Fuertes Marraco, Markus Zettl, Inigo Tirapu, Daniel E. Speiser, Gregory Verdeil