Article
Biochemistry & Molecular Biology
Caroline Swoboda, Lena Deloch, Claudia von Zimmermann, Tanja Richter-Schmidinger, Bernd Lenz, Johannes Kornhuber, Christiane Muehle
Summary: This study investigated the potential of MIF at genetic, expression, and protein levels as a risk factor and biomarker for diagnosing, monitoring, or predicting MDD. The results suggest a genetic effect of MIF in women but do not provide strong evidence for its utility as a biomarker for MDD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Krishnamoorthi Sumaiya, Charles Solomon Akino Mercy, Gangatharan Muralitharan, Abdurahman Hajinur Hirad, Abdullah A. Alarfaj, Kalimuthusamy Natarajaseenivasan
Summary: This study evaluated the diagnostic value of macrophage migration inhibitory factor (MIF) for leptospirosis. The results showed that serum MIF levels were significantly elevated in leptospirosis patients and correlated with disease severity and progression. Serum MIF exhibited high sensitivity and specificity, making it a potential rapid diagnostic marker for leptospirosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jianbo He, Lin Zheng, Xiaojuan Li, Furong Huang, Sitao Hu, Lei Chen, Manya Jiang, Xianfeng Lin, Haibo Jiang, Yifan Zeng, Tianshen Ye, Dingkun Lin, Qian Liu, Jiake Xu, Kai Chen
Summary: This study aimed to explore the therapeutic potential of Obacunone (OB) on osteoporosis and its rudimentary mechanisms. In vitro and in vivo experiments showed that OB suppressed the formation and function of osteoclasts. Mechanistically, OB interacted with macrophage migration inhibitory factor (MIF), attenuating receptor activator of nuclear factor kappa B (NF-KB) ligand (RANKL)-induced signaling pathways. This led to a decrease in the expression level of the master transcriptional factor of osteoclastogenesis, nuclear factor of activated T cells 1 (NFATc1), and its downstream osteoclast-specific proteins. OB also alleviated estrogen deficiency-induced osteoporosis by targeting MIF and inhibiting hyperactive osteoclasts.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yan-yan Li, Hui Wang, Yang-yang Zhang
Summary: The MIF gene rs755622 G/C polymorphism is significantly associated with CAD, especially in the Chinese population. Individuals carrying the C allele of the MIF gene rs755622 G/C polymorphism may have a higher susceptibility to CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Ni Cui, Hui Li, Yaoshan Dun, Jeffrey W. Ripley-Gonzalez, Baiyang You, Dezhao Li, Yuan Liu, Ling Qiu, Cui Li, Suixin Liu
Summary: This study found that hepatocyte-expressed macrophage migration inhibitory factor (MIF) can limit the occurrence of fatty liver during obesity. Exercise can reduce lipotoxicity and inhibit JNK activation by modulating endogenous hepatic MIF in nonalcoholic fatty liver disease (NAFLD). These findings have important clinical implications for the prevention and intervention of NAFLD induced by immoderate diet.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Xiangwen Shi, Yipeng Wu, Haonan Ni, Mingjun Li, Baochuang Qi, Yongqing Xu
Summary: The expression level of macrophage migration inhibitory factor (MIF) is upregulated in osteomyelitis patients and cell models. MIF inhibits osteogenic differentiation by activating the NF-κB signaling pathway. The study demonstrates that the MIF inhibitor iSO-1 and MIF knockdown can reverse the inhibitory effect of inflammation on osteogenic differentiation, providing a potential target for osteomyelitis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yanyan Wang, Yue Zhang, Jiaqi Mi, Chenchen Jiang, Qiang Wang, Xinwei Li, Menglin Zhao, Zhijun Geng, Xue Song, Jing Li, Lugen Zuo, Sitang Ge, Zining Zhang, Hexin Wen, Zishu Wang, Fang Su
Summary: ANKFN1 is found to be upregulated in hepatocellular carcinoma (HCC) and its overexpression is associated with cirrhosis, high alpha-fetoprotein (AFP) levels, and poor prognosis. Silencing ANKFN1 expression suppresses HCC cell proliferation, migration, invasion, and metastasis, while ANKFN1 overexpression promotes HCC proliferation and metastasis. ANKFN1 activates the MEK1/2-ERK1/2 signaling pathway to promote cell proliferation, migration, and invasion in HCC.
Article
Health Care Sciences & Services
Ioannis-Fivos Megas, David Simons, Bong-Sung Kim, Christian Stoppe, Andrzej Piatkowski, Panagiotis Fikatas, Paul Christian Fuchs, Jacqueline Bastiaanse, Norbert Pallua, Jurgen Bernhagen, Gerrit Grieb
Summary: This study observed 26 subjects undergoing microsurgical reconstruction, finding that blood levels of MIF, CRP, and leukocytes increased after surgery. Subjects requiring surgical revision due to microanastomosis thrombosis had significantly higher levels of MIF.
Article
Dermatology
Junhua Qi, Yu Zhang, Lvya Zhang, Gang Nie
Summary: This study conducted a meta-analysis to investigate the relationship between MIF-173G/C polymorphism and psoriasis risk. The results showed that carriers of the C allele and the GC genotype may have a higher risk of developing psoriasis.
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2023)
Article
Agriculture, Multidisciplinary
Shaoshuai Liu, Maria Jose Ladera-Carmona, Minna M. Poranen, Aart J. E. van Bel, Karl-Heinz Kogel, Jafargholi Imani
Summary: The study suggests that MIF genes could be a potential target for insect control, but the application of naked dsRNA to plants for aphid control is inefficient. Focus should be put into developing effective dsRNA formulations for better pest management.
JOURNAL OF PLANT DISEASES AND PROTECTION
(2021)
Article
Clinical Neurology
Felix Neumaier, Christian Stoppe, Anzhela Stoykova, Miriam Weiss, Michael Veldeman, Anke Hoellig, Hussam Aldin Hamou, Yasin Temel, Catharina Conzen, Tobias Philip Schmidt, Rabia Dogan, Martin Wiesmann, Hans Clusmann, Gerrit Alexander Schubert, Roel Hubert Louis Haeren, Walid Albanna
Summary: This study determined the levels of macrophage migration inhibitory factor (MIF) in serum, cerebrospinal fluid (CSF), and cerebral microdialysate (MD) at different time points after aneurysmal subarachnoid hemorrhage (aSAH). The results showed that MIF levels in serum increased during the critical phase, while CSF levels remained relatively stable. MD levels peaked during the early phase, decreased during the critical phase, and increased again during the late phase. Subgroup analyses revealed higher serum and cerebral MIF levels in patients with anterior circulation aneurysms and those with delayed cerebral ischemia (DCI).
FRONTIERS IN NEUROLOGY
(2023)
Review
Endocrinology & Metabolism
Wei Xuan, Wanqing Xie, Fengshi Li, Dan Huang, Ziyu Zhu, Yuxuan Lin, Binwei Lu, Weifeng Yu, Yan Li, Peiying Li
Summary: This review summarizes the regulatory functions of macrophage migration inhibitory factor (MIF) in brain injury and neurodegenerative diseases, including its effects on immune cells, endothelial cells, and neurons, as well as the possible link with the severity of stroke and the development of neurodegenerative diseases.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Chemistry, Multidisciplinary
Zhangping Xiao, Shanshan Song, Deng Chen, Ronald van Merkerk, Petra E. van Der Wouden, Robbert H. Cool, Wim J. Quax, Gerrit J. Poelarends, Barbro N. Melgert, Frank J. Dekker
Summary: The development of a MIF-targeted PROTAC, MD13, is able to induce MIF degradation at low concentrations and suppress the proliferation of inflammatory and cancer cells, demonstrating the potential therapeutic value of PROTACs in cancer treatment.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Huiyuan Zhu, Shaochun Yan, Jingshuo Wu, Zhong Zhang, Xiaolin Li, Zheng Liu, Xing Ma, Lina Zhou, Lin Zhang, Mingming Feng, Yiwei Geng, Aixin Zhang, Sabina Janciauskiene, Aiguo Xu
Summary: Serum MIF levels were found to be associated with the pathophysiology of allergic asthma in patients, and may serve as a potential biomarker for evaluating therapeutic response.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Biochemistry & Molecular Biology
Yejin Zhang, Lin Zheng, Jiawei Fang, Kainan Ni, Xingyu Hu, Lin Ye, Hehuan Lai, Tao Yang, Zhenzhong Chen, Dengwei He
Summary: This study reveals that migration inhibitory factor (MIF) plays a crucial role in lumbar intervertebral disc degeneration (IDD) and has potential therapeutic value for the treatment of this disease.
