Article
Multidisciplinary Sciences
Parvaneh Emami, Masaru Ueno
Summary: Research shows that DIM induces apoptosis and autophagy in fission yeast, which are crucial for cell survival.
Review
Biochemistry & Molecular Biology
Xue-Song Xiang, Peng-Cheng Li, Wen-Quan Wang, Liang Liu
Summary: Pancreatic cancer is the seventh leading cause of cancer death worldwide and novel treatment options for PDAC are urgently needed. The dysregulation of HDACs has been identified in association with PDAC and may represent a therapeutic breakthrough. However, the contributions of HDACs to PDAC remain controversial and pharmacokinetic challenges limit the application of HDACis in PDAC.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Infectious Diseases
Yifat Baruch, Karina Golberg, Qun Sun, Karina Yew-Hoong Gin, Robert S. Marks, Ariel Kushmaro
Summary: This study tested the effect of a natural compound called 3,3'-Diindolylmethane (DIM) on the biofilm of the oral bacterium Streptococcus mutans. The results showed that DIM was able to reduce the formation of S. mutans biofilm and decrease its durability under acidic conditions. This suggests that DIM has potential in reducing biofilm formation and preventing dental caries.
Article
Biochemistry & Molecular Biology
Hongyi Zhou, Huabo Su, Weiqin Chen
Summary: The study reveals that neddylation plays a crucial role in myoblast differentiation by regulating class IIa and III histone deacetylases. This provides new insights into the mechanisms of muscle disease and regeneration, highlighting the importance of neddylation in controlling the myogenic program.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yang Ye, Xue Li, Zhihua Wang, Fen Ye, Wenrong Xu, Rongzhu Lu, Haijun Shen, Shuhan Miao
Summary: The natural compound 3,3'-Diindolylmethane (DIM) inhibits proliferation and induces apoptosis and autophagy in gastric cancer cells by activating the STIM1-mediated Store-operated calcium entry (SOCE) pathway. Inhibition of SOCE attenuates DIM-induced effects on apoptosis and autophagy, suggesting SOCE as a potential therapeutic target in gastric cancer. Further research is warranted to explore combination chemotherapy strategies targeting SOCE for clinical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Celine Warnon, Karim Bouhjar, Noelle Ninane, Mathilde Verhoyen, Antoine Fattaccioli, Maude Fransolet, Catherine Lambert de Rouvroit, Yves Poumay, Geraldine Piel, Denis Mottet, Florence Debacq-Chainiaux
Summary: This study reveals that the expression levels of HDACs are significantly altered during the aging process of dermal fibroblasts. Treatment with HDAC inhibitor or specific downregulation of HDAC2 and HDAC7 can induce the appearance of senescence biomarkers. Moreover, re-expression of HDAC7 can extend the proliferative lifespan of cells.
Review
Cardiac & Cardiovascular Systems
Sebastian Guttzeit, Johannes Backs
Summary: This article discusses the importance of epigenetic regulators in cardiovascular disease, particularly the role of class IIa histone deacetylases in cellular homeostasis and response to external stimuli. The review summarizes the reversible post-translational modifications of class IIa HDACs and their impact on transcriptional changes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Microbiology
Yong-Guy Kim, Jin-Hyung Lee, Sunyoung Park, Jintae Lee
Summary: The study investigated the antibacterial and antibiofilm activities of 20 indoles against Cutibacterium acnes, a bacterium that inhabits human skin and is implicated in acne vulgaris formation. The results showed that indole-3-carbinol and 3,3'-diindolylmethane significantly inhibited biofilm formation by C. acnes. Furthermore, 3,3'-diindolylmethane successfully inhibited multispecies biofilm formation by C. acnes, Staphylococcus aureus, and Candida albicans. Transcriptional analyses showed that 3,3'-diindolylmethane inhibited the expressions of several biofilm-related genes in C. acnes and inhibited hyphal formation and cell aggregation by C. albicans. These findings suggest that 3,3'-diindolylmethane could be a potential treatment for acne vulgaris and biofilm-associated infections.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Zsofia Kutil, Marat Meleshin, Petra Baranova, Barbora Havlinova, Mike Schutkowski, Cyril Barinka
Summary: In this study, the researchers designed and synthesized a peptide library to investigate the substrate specificity of Class IIa histone deacetylases (HDACs). The results showed a strong preference for aromatic acids flanking the central modified lysine, while positively charged residues and proline were disfavored at specific positions. The chemical nature of amino acid residues N-terminally to the modified lysine had a greater impact on substrate recognition than residues located C-terminally.
Review
Physiology
Zexu Shen, Yun Bei, Haoran Lin, Taofeng Wei, Yunjian Dai, Yangmin Hu, Chao Zhang, Haibin Dai
Summary: Vascular endothelial cells play a crucial role in maintaining homeostasis and are regulated by signaling pathways and epigenetic factors. Dysfunctions in endothelial cells are associated with cardiovascular and cerebrovascular diseases. Histone deacetylases (HDACs), especially Class IIa HDACs, have limited activity and tissue-specific regulation in endothelial cells. In this article, we discuss the functions of HDACs in endothelial cells, including angiogenesis and immune response, and propose potential applications of HDAC inhibitors for the treatment of vascular diseases.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elmira Vagapova, Maxim Kozlov, Timofey Lebedev, Karina Ivanenko, Olga Leonova, Vladimir Popenko, Pavel Spirin, Sergey Kochetkov, Vladimir Prassolov
Summary: The resistance of leukemia and neuroblastoma cells to anticancer therapy remains a challenge, but targeting HDAC with hydrazostat has shown potential in reactivating RTK expression and enhancing the efficacy of RTK inhibitors. This study reveals a promising strategy to overcome drug resistance in these diseases.
Article
Oncology
Yang Ye, Xue Li, Guoquan Feng, Ying Ma, Fen Ye, Haijun Shen, Kang Sun, Rongzhu Lu, Shuhan Miao
Summary: The study investigated the effect of 3,3'-diindolylmethane (DIM) on ferroptosis against gastric cancer and found that DIM could induce ferroptosis in BGC-823 gastric cancer cells by upregulating lipid-ROS levels and decreasing GSH generation. DIM also reduced the protein levels of SLC7A11 and GPX4 while increasing BAP1 and IP3R levels. The findings suggest that DIM exerts anti-cancer effects through the BAP1-IP3R axis and has therapeutic potential in gastric cancer.
Article
Chemistry, Medicinal
Izabela Szymczak-Pajor, Jozef Drzewoski, Ewa Swiderska, Justyna Strycharz, Anna Gabryanczyk, Jacek Kasznicki, Marta Bogdanska, Agnieszka Sliwinska
Summary: Accumulating evidence suggests that metformin has anticancer properties by inducing apoptosis and inhibiting the growth and proliferation of cancer cells. However, its effect on histone acetylation status remains unclear. Therefore, this study aimed to evaluate the impact of metformin on HATs and HDACs in human pancreatic cancer cell lines.
Article
Chemistry, Medicinal
Linda Schaeker-Huebner, Reza Haschemi, Thomas Buech, Fabian B. Kraft, Birke Brumme, Andrea Schoeler, Robert Jenke, Jens Meiler, Achim Aigner, Gerd Bendas, Finn K. Hansen
Summary: In this study, we investigated the structure-activity and structure-physicochemical property relationships of a series of compounds targeting HDAC1 and HDAC2. We identified a potent and selective inhibitor, LSH-A54, which showed favorable physicochemical properties and exhibited inhibitory effects on breast cancer cells by tightly binding to HDAC1.
Article
Cell Biology
Daniela Marinho, Ildete Luisa Ferreira, Ricardo Lorenzoni, Sandra M. Cardoso, Isabel Santana, A. Cristina Rego
Summary: This study evaluates the efficacy of inhibiting or reducing histone deacetylases (HDACs) in Alzheimer's disease (AD) models by modifying gene transcription. The results show that inhibiting class I HDACs can ameliorate ER-mitochondria cross-talk in AD by normalizing calcium signaling between the two organelles. The selective HDAC inhibitor, Tacedinaline (Tac), counteracted the impaired ER-mitochondria communication and reduced amyloid beta levels in AD cells and animal models. These findings suggest that transcriptional regulation of ER-mitochondria communication could be a promising target for innovative therapeutics in AD.
Meeting Abstract
Oncology
Shaneabbas Raza, Jared Schommer, Megan Meyer, Bin Guo, Kimberly Hammer, Othman Ghribi
Article
Biochemistry & Molecular Biology
Raushan K. Singh, Kyongshin Cho, Satish K. R. Padi, Junru Yu, Manas Haldar, Tanmay Mandal, Changhui Yan, Gregory Cook, Bin Guo, Sanku Mallik, D. K. Srivastava
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Xiaoyu Yang, Yi Xu, Amanda Brooks, Bin Guo, Keith W. Miskimins, Steven Y. Qian
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Yi Xu, Xiaoyu Yang, Pinjing Zhao, Zhongyu Yang, Changhui Yan, Bin Guo, Steven Y. Qian
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Article
Oncology
Shaneabbas Raza, Megan Meyer, Jared Schommer, Kimberly D. P. Hammer, Bin Guo, Othman Ghribi
Article
Oncology
Meiyan Sun, Qunshu Zhang, Xiaoyu Yang, Steven Y. Qian, Bin Guo
MOLECULAR CANCER THERAPEUTICS
(2016)
Article
Biotechnology & Applied Microbiology
Daniel W. Binzel, Yi Shu, Hui Li, Meiyan Sun, Qunshu Zhang, Dan Shu, Bin Guo, Peixuan Guo
Review
Biochemistry & Molecular Biology
Liye Wang, Kwang Bog Cho, Yan Li, Gabriel Tao, Zuoxu Xie, Bin Guo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Liye Wang, Shuang Zhou, Bin Guo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Xiang Gao, Jingwen Liu, Kwang Bog Cho, Samanthreddy Kedika, Bin Guo
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Satya Prakash Shukla, Kwang Bog Cho, Vineeta Rustagi, Xiang Gao, Xinping Fu, Shaun Xiaoliu Zhang, Bin Guo, D. Gomika Udugamasooriya
Summary: The study identified two ACE2-binding peptoid compounds that effectively block the entry of SARS-CoV-2 into human cells. These compounds also showed efficacy against a mutant virus and were found to be safe without reducing ACE2 expression or enzyme activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Shaneabbas Raza, Megan Meyer, Casey Goodyear, Kimberly D. P. Hammer, Bin Guo, Othman Ghribi
CANCER CELL INTERNATIONAL
(2017)
Review
Biochemistry & Molecular Biology
Meiyan Sun, Bin Guo
CURRENT MEDICINAL CHEMISTRY
(2017)
Article
Chemistry, Multidisciplinary
Fataneh Karandish, Manas K. Haldar, Seungyong You, Amanda E. Brooks, Benjamin D. Brooks, Bin Guo, Yongki Choi, Sanku Mallik
Article
Cell Biology
Q. Zhang, M. Sun, S. Zhou, B. Guo
CELL DEATH DISCOVERY
(2016)