Article
Biochemistry & Molecular Biology
Sarah Naguib, Jon R. Backstrom, Melanie Gil, David J. Calkins, Tonia S. Rex
Summary: Oxidative stress contributes to degeneration of retinal ganglion cells and their axons in glaucoma, but the NRF2-KEAP1-ARE antioxidant pathway is early activated, helping to slow neurodegeneration in glaucoma.
Article
Medicine, Research & Experimental
Dhananjay Kumar Sah, Yogesh Rai, Ankit Chauhan, Neeraj Kumari, Madan Mohan Chaturvedi, Anant Narayan Bhatt
Summary: SKII has radio-protective effects by alleviating IR-induced oxidative stress and cell death, enhancing antioxidant defense system and DNA repair pathways.
Article
Biochemistry & Molecular Biology
Dorthe Schaue, Ewa D. Micewicz, Josephine A. Ratikan, Keisuke S. Iwamoto, Erina Vlashi, J. Tyson McDonald, William H. McBride
Summary: NRF2 is a master transcription factor that regulates the expression of detoxifying and antioxidant genes. It plays a role in redox regulation, metabolism, inflammation/autoimmune disease, cancer, and radioresistance. Activation of NRF2 pathways by ionizing radiation is delayed and may be critical for immune transition and cellular survival.
Article
Biology
Seishi Aihara, Kumiko Torisu, Yushi Uchida, Noriyuki Imazu, Toshiaki Nakano, Takanari Kitazono
Summary: Kidney metabolism is altered in chronic kidney disease, particularly in unilateral ureteral obstruction (UUO)-induced fibrosis. Arginine metabolism is the most affected, with spermidine being the most increased metabolite. Spermidine is associated with fibrosis in human glomerulonephritis, and it induces Nrf2 in human proximal tubule cells. Activation of the Nrf2 pathway by spermidine protects against fibrotic signals and oxidative stress, and its deficiency exacerbates fibrosis in UUO kidneys.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jacek Grebowski, Paulina Kazmierska-Grebowska, Natalia Cichon, Anna Konarska, Marian Wolszczak, Grzegorz Litwinienko
Summary: This study investigated the radioprotective effect of fullerenol C-60(OH)(36) on human erythrocytes. The results showed that C-60(OH)(36) protected the erythrocyte antioxidant enzymes from radiation-induced damage and reduced erythrocyte microviscosity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shih-Han Wang, Yi-Siao Chen, Kuei-Hung Lai, Chung-Kuang Lu, Hsun-Shuo Chang, Ho-Cheng Wu, Feng-Lin Yen, Lo-Yun Chen, Jin-Ching Lee, Chia-Hung Yen
Summary: The extract of Prinsepiae Nux was identified as a potent NRF2 activator and showed potential in preventing UVB-induced skin damage.
Article
Biochemistry & Molecular Biology
Ethan L. Ostrom, Ana P. Valencia, David J. Marcinek, Tinna Traustadottir
Summary: High intensity exercise significantly impacts Nrf2-ARE binding and Keap1 protein expression in mouse skeletal muscle, while low intensity exercise does not show significant effects on these factors. This suggests that the intensity of exercise plays a role in activating redox signaling pathways in skeletal muscle.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Editorial Material
Oncology
Gourish Mondal, Jayanta Debnath
Summary: Inhibiting autophagy in pancreatic ductal adenocarcinoma cells can activate the NRF2-mediated macropinocytosis pathway, providing an alternate way for tumors to obtain nutrients from the extracellular environment. Therefore, the combined inhibition of autophagy and macropinocytosis may enhance cancer treatment outcomes.
Article
Biochemistry & Molecular Biology
Kimberly K. Richardson, Wen Ling, Kimberly Krager, Qiang Fu, Stephanie D. Byrum, Rupak Pathak, Nukhet Aykin-Burns, Ha-Neui Kim
Summary: This study found that exposure to multiple fractions of low-dose radiation or a single exposure to the same total dose of radiation can cause a decrease in trabecular bone mass in male mice. The damaging effect is associated with highly activated bone resorption and increased expression and activity of Sirt3, a protein essential for osteoclast mitochondrial activity. Osteoclast progenitors lacking Sirt3 exhibit impaired resorptive activity when exposed to radiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Alberto Delaidelli, Mette Richner, Lixiang Jiang, Amelia van der Laan, Ida Bergholdt Jul Christiansen, Nelson Ferreira, Jens R. Nyengaard, Christian B. Vaegter, Poul H. Jensen, Ian R. Mackenzie, Poul H. Sorensen, Asad Jan
Summary: The pathological accumulation of alpha-synuclein impairs redox homeostasis in the nervous system, leading to nuclear NRF2 accumulation and alterations in NRF2-responsive genes. Using a transgenic mouse model, it was observed that neuronal populations with phosphorylated aSyn showed increased nuclear NRF2 and abnormal anti-oxidant and inflammatory gene response in the affected neuraxis. Boosting neuronal anti-oxidant response may be a promising strategy to mitigate neurodegeneration in PD and related diseases.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Romaric Magerand, Pascal Rey, Laurence Blanchard, Arjan de Groot
Summary: Deinococcus bacteria exhibit high resistance to radiation and DNA damage, which relies on the metalloprotease IrrE-induced DNA repair gene expression by cleaving transcriptional repressor DdrO. Experimental findings show that reactive oxygen species can stimulate the metalloprotease activity of IrrE in Deinococcus, leading to DdrO cleavage.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Xuerui Lu, Junxiang Li, Yingchun Ma, Israr Khan, Yun Yang, Yuxi Li, YaFei Wang, GuanLan Liu, Zhiming Zhang, Pingrong Yang, Chunjiang Zhang
Summary: This study investigates the effects of fermented Angelica sinensis on aging in mice and explores the potential mechanisms. The results suggest that fermented Angelica sinensis has anti-aging effects and can alleviate hepatic oxidative stress through regulating gut microbiota and metabolism.
Article
Biochemistry & Molecular Biology
Francesca Antonelli, Arianna Casciati, Montserrat Belles, Noemi Serra, Maria Victoria Linares-Vidal, Carmela Marino, Mariateresa Mancuso, Simonetta Pazzaglia
Summary: Radiation therapy is a primary treatment modality for brain tumors, but long-term neurocognitive decline significantly affects quality of life. Recent evidence suggests that modulating the Shh signaling pathway can mitigate hippocampal radiation injury and improve brain repair and functional recovery after radio-induced injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
R. Paul Robertson
Summary: This perspective explores the idea that chronically elevated blood glucose levels in type 2 diabetes (T2D) can harm body tissues by producing reactive oxygen species (ROS) locally. It suggests a feed-forward scenario where the initial dysfunction of beta cells in T2D leads to sustained elevation in blood glucose levels, resulting in abnormally high levels of ROS throughout the body. This review revisits previous experiments to investigate the concept that chronic hyperglycemia can induce oxidative stress in beta cells, specifically focusing on the absence of beta cell glutathione peroxidase (GPx) activity and the potential improvement through genetic enrichment of beta cell GPx and oral antioxidants like ebselen, a GPx mimetic.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Omayma A. R. Abo-Zaid, Fatma S. M. Moawed, Hend A. Hassan, Enas M. Moustafa
Summary: This study found that BPA and IR have harmful effects on lung tissue by inducing oxidative stress and activating signaling pathways related to inflammation and cell growth. These effects lead to severe lung damage and the development of cancer cells.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2022)
Article
Oncology
J. Tyson McDonald, Robert Stainforth, Jack Miller, Thomas Cahill, Willian A. Silveira, Komal S. Rathi, Gary Hardiman, Deanne Taylor, Sylvain Costes, Vinita Chauhan, Robert Meller, Afshin Beheshti
Article
Biochemistry & Molecular Biology
Shashank Shrishrimal, Arpita Chatterjee, Elizabeth A. Kosmacek, Paul J. Davis, J. Tyson McDonald, Rebecca E. Oberley-Deegan
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Arpita Chatterjee, Elizabeth A. Kosmacek, Shashank Shrishrimal, J. Tyson McDonald, Rebecca E. Oberley-Deegan
Article
Oncology
Evodie Peperstraete, Clement Lecerf, Jordan Collette, Constance Vennin, Ludivine Raby, Pamela Volkel, Pierre-Olivier Angrand, Marie Winter, Francois Bertucci, Pascal Finetti, Chann Lagadec, Samuel Meignan, Roland P. Bourette, Xuefen Le Bourhis, Eric Adriaenssens
Article
Multidisciplinary Sciences
Eliah G. Overbey, Amanda M. Saravia-Butler, Zhe Zhang, Komal S. Rathi, Homer Fogle, Willian A. da Silveira, Richard J. Barker, Joseph J. Bass, Afshin Beheshti, Daniel C. Berrios, Elizabeth A. Blaber, Egle Cekanaviciute, Helio A. Costa, Laurence B. Davin, Kathleen M. Fisch, Samrawit G. Gebre, Matthew Geniza, Rachel Gilbert, Simon Gilroy, Gary Hardiman, Raul Herranz, Yared H. Kidane, Colin P. S. Kruse, Michael D. Lee, Ted Liefeld, Norman G. Lewis, J. Tyson McDonald, Robert Meller, Tejaswini Mishra, Imara Y. Perera, Shayoni Ray, Sigrid S. Reinsch, Sara Brin Rosenthal, Michael Strong, Nathaniel J. Szewczyk, Candice G. T. Tahimic, Deanne M. Taylor, Joshua P. Vandenbrink, Alicia Villacampa, Silvio Weging, Chris Wolverton, Sarah E. Wyatt, Luis Zea, Sylvain Costes, Jonathan M. Galazka
Summary: With the advancement of transcriptomic technologies, NASA GeneLab and associated working groups have developed a consensus pipeline for analyzing short-read RNA-sequencing data from spaceflight experiments, which is now publicly available. This aims to promote transparency, reproducibility, and reusability of data, provide a template for future data processing, and encourage cross-analysis of data from different databases.
Article
Cell Biology
Marie Winter, Samuel Meignan, Pamela Volkel, Pierre-Olivier Angrand, Valerie Chopin, Nadege Bidan, Robert-Alain Toillon, Eric Adriaenssens, Chann Lagadec, Xuefen Le Bourhis
Summary: The study reveals that TNBC cells become more invasive after chemotherapy, with vimentin potentially playing a role in enhancing tumor aggressiveness.
Review
Biochemistry & Molecular Biology
Afshin Beheshti, J. Tyson McDonald, Megumi Hada, Akihisa Takahashi, Christopher E. Mason, Maddalena Mognato
Summary: The space environment exposes individuals to a mixture of ionizing radiation and altered gravity, which can impact human cells' genetics and epigenetics, potentially leading to radiation carcinogenesis risk. Researchers are working to collect data under real and simulated space conditions to accurately estimate the risk of space exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
J. Tyson McDonald, Francisco J. Enguita, Deanne Taylor, Robert J. Griffin, Waldemar Priebe, Mark R. Emmett, Mohammad M. Sajadi, Anthony D. Harris, Jean Clement, Joseph M. Dybas, Nukhet Aykin-Burns, Joseph W. Guarnieri, Larry N. Singh, Peter Grabham, Stephen B. Baylin, Aliza Yousey, Andrea N. Pearson, Peter M. Corry, Amanda Saravia-Butler, Thomas R. Aunins, Sadhana Sharma, Prashant Nagpal, Cem Meydan, Jonathan Foox, Christopher Mozsary, Bianca Cerqueira, Viktorija Zaksas, Urminder Singh, Eve Syrkin Wurtele, Sylvain Costes, Gustavo Gastao Davanzo, Diego Galeano, Alberto Paccanaro, Suzanne L. Meinig, Robert S. Hagan, Natalie M. Bowman, Matthew C. Wolfgang, Selin Altinok, Nicolae Sapoval, Todd J. Treangen, Pedro M. Moraes-Vieira, Charles Vanderburg, Douglas C. Wallace, Jonathan C. Schisler, Christopher E. Mason, Anushree Chatterjee, Robert Meller, Afshin Beheshti
Summary: The research demonstrates that miR-2392 is associated with SARS-CoV-2 infection, with potential for use in COVID-19 detection and as a target for antiviral therapy. Targeting miR-2392 can significantly reduce SARS-CoV-2 viability, indicating a potential treatment for COVID-19.
Article
Oncology
Sarah Trouvilliez, Julien Cicero, Romain Leveque, Leo Aubert, Cyril Corbet, Alexandre Van Outryve, Karolin Streule, Pierre-Olivier Angrand, Pamela Volkel, Romain Magnez, Guillaume Brysbaert, Caroline Mysiorek, Fabien Gosselet, Roland Bourette, Eric Adriaenssens, Xavier Thuru, Chann Lagadec, Jerome de Ruyck, Veronique Orian-Rousseau, Xuefen Le Bourhis, Robert-Alain Toillon
Summary: Our study revealed that CD44v3 forms a complex with TrkA in response to NGF stimulation in breast cancer, and a CD44v3 mimetic peptide can inhibit tumor growth and metastasis, suggesting a potential therapeutic option for triple-negative breast cancers.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Angelina Kasprowicz, Groux-Degroote Sophie, Chann Lagadec, Philippe Delannoy
Summary: GD3 synthase is crucial for the biosynthesis of gangliosides, and targeting it can reduce malignant properties of tumors associated with gangliosides, such as migration, invasion, sternness, and epithelial-mesenchymal transition.
Article
Multidisciplinary Sciences
J. Tyson McDonald, Luisel J. Ricks-Santi
Summary: The implementation of genetic sequencing has led to an increase in the discovery of genetic variants. However, patients with African ancestry may receive inconclusive genetic testing results, which limits the utility of genetic screening in disease management and prevention.
Article
Biochemistry & Molecular Biology
Dorthe Schaue, Ewa D. Micewicz, Josephine A. Ratikan, Keisuke S. Iwamoto, Erina Vlashi, J. Tyson McDonald, William H. McBride
Summary: NRF2 is a master transcription factor that regulates the expression of detoxifying and antioxidant genes. It plays a role in redox regulation, metabolism, inflammation/autoimmune disease, cancer, and radioresistance. Activation of NRF2 pathways by ionizing radiation is delayed and may be critical for immune transition and cellular survival.
Review
Oncology
Sarah Trouvilliez, Chann Lagadec, Robert-Alain Toillon
Summary: This review summarizes the failures of targeted therapies against TrkA, focusing on non-genomic resistance. It highlights that overexpression of TrkA can lead to ligand-independent activation, bypassing the effect of kinase inhibitors, resulting in treatment failures. These observations suggest that genetics alone cannot explain all therapeutic failures, and new hypotheses are needed to understand these failures.
Article
Biochemical Research Methods
Marie Denoulet, Mathilde Brule, Francois Anquez, Audrey Vincent, Julie Schnipper, Eric Adriaenssens, Robert-Alain Toillon, Xuefen Le Bourhis, Chann Lagadec
Summary: The study develops a new R-based tool called ABSP for analyzing CpG methylation levels in bisulfite sequencing PCR data. The tool can process both direct-BSP and cloning-BSP data, and provides an automated analysis process and user-friendly interface.
Article
Medicine, Research & Experimental
Francisco J. Enguita, Ana Lucia Leitao, J. Tyson McDonald, Viktorija Zaksas, Saswati Das, Diego Galeano, Deanne Taylor, Eve Syrkin Wurtele, Amanda Saravia-Butler, Stephen B. Baylin, Robert Meller, D. Marshall Porterfield, Douglas C. Wallace, Jonathan C. Schisler, Christopher E. Mason, Afshin Beheshti
Summary: This study identifies a transcriptional up-regulation pattern of lncRNAs in SARS-CoV-2 infection and explores their interaction with RNA-binding proteins. A lncRNA signature composed of six elements is associated with the regulation of SARS-CoV-2 infection. The findings suggest a competition mechanism between viral RNA genome and regulatory lncRNAs in modulating the interferon response and RNA surveillance.