Article
Multidisciplinary Sciences
Purnima Singh, Liting Zhou, Disheet A. Shah, Romina B. Cejas, David K. Crossman, Mariam Jouni, Tarek Magdy, Xuexia Wang, Noha Sharafeldin, Lindsey Hageman, Donald E. McKenna, Steve Horvath, Saro H. Armenian, Frank M. Balis, Douglas S. Hawkins, Frank G. Keller, Melissa M. Hudson, Joseph P. Neglia, A. Kim Ritchey, Jill P. Ginsberg, Wendy Landier, Paul W. Burridge, Smita Bhatia
Summary: Investigation found an association between genome-wide differential methylation at CpG sites in peripheral blood DNA and anthracycline-induced cardiomyopathy. Several genes associated with cardiac dysfunction were also identified. This suggests that differential DNA methylation of certain genes could play a role in the pathogenesis of anthracycline-induced cardiomyopathy.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Garrett L. Jensen, Gabriel Axelrud, David Fink, Kendall Hammonds, Kimberly Walker, Marcus Volz, Alan Gowan, Arundhati Rao, Niloyjyoti Deb, Sameer G. Jhavar
Summary: The study found that patients with oropharyngeal and oral cavity squamous cell carcinoma who are p16- and MGMT+ have significantly better local control with definitive CRT than those who are p16- and MGMT-. Prospective studies are needed to verify these findings.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Akiko Tonoike, Ken-Ichi Otaki, Go Terauchi, Misato Ogawa, Maki Katayama, Hikari Sakata, Fumina Miyasako, Kazutaka Mogi, Takefumi Kikusui, Miho Nagasawa
Summary: Research on ancient dog breeds reveals that they exhibit differences in social cognitive abilities compared to other European breeds. Gene polymorphisms associated with the tasks indicate the involvement of glucocorticoid functions in the cognitive skills acquired during dog domestication.
SCIENTIFIC REPORTS
(2022)
Article
Agronomy
Jinqiong Shan, Xi Sun, Ran Li, Bin Zhu, Pei Liang, Xiwu Gao
Summary: Overexpression of certain genes in the ABCG subfamily is implicated in the resistance of Plutella xylostella to chlorantraniliprole. These findings could provide a foundation for further exploration of the role of ABC transporters in chlorantraniliprole resistance in Plutella xylostella and other insect pests.
PEST MANAGEMENT SCIENCE
(2021)
Article
Oncology
Yoshikuni Inokawa, Masamichi Hayashi, Shahnaz Begum, Maartje G. Noordhuis, Daivd Sidransky, Joseph Califano, Wayne Koch, Mariana Brait, William H. Westra, Mohammad O. Hoque
Summary: AGTR1 and FHIT methylation can serve as suitable detection markers for OPSCCs derived from the HPV-infected field, showing associations with p16-positive and RB-negative phenotypes. These markers have high sensitivity and are linked to better overall survival outcomes.
Article
Oncology
Shaelene Standing, Son Tran, Luis Murguia-Favela, Olga Kovalchuk, Pinaki Bose, Aru Narendran
Summary: Cancer, especially in children, is a major cause of disease-related mortality, and there is a correlation between primary immunodeficiencies (PID) genes and the development of pediatric cancers. This study used a bioinformatics framework to analyze the expression differences, gene ontology enrichment, protein-protein interaction, and prognostic impacts of PID-related genes in pediatric cancers, revealing the connection between multiple PID-related genes and the development of PID and cancer.
Article
Biotechnology & Applied Microbiology
Antonio M. Burgos-Molina, Silvia Mercado-Saenz, Casimiro Cardenas, Beatriz Lopez-Diaz, Francisco Sendra-Portero, Miguel J. Ruiz-Gomez
Summary: This study aimed to select a cisplatin-resistant Saccharomyces cerevisiae strain to identify new molecular markers of resistance and mechanisms involved. The resistant strain showed higher resistance to cisplatin and multiple deregulated proteins in various metabolic pathways, suggesting a complex process of resistance involving growth, metabolism, structure, and stress response proteins.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kwun Wah Wen, Linlin Wang, Joshua R. Menke, Blossom Damania
Summary: EBV and KSHV, both human gammaherpesviruses with oncogenic properties, are associated with various lymphoproliferative diseases and plasmacytic/plasmablastic neoplasms. These viruses can also infect epithelial cells and cause carcinomas. The pathogenesis of these two viruses is closely linked to the expression of viral proteins.
Article
Multidisciplinary Sciences
Yuhui Wei, Caizhen Yang, Jinmei Wei, Wentao Li, Yuanwen Qin, Guangnan Liu
Summary: This study analyzed the expression profile of microtubule-associated genes (MAGs) in lung adenocarcinoma (LUAD) and explored their therapeutic value and impact on prognosis. By constructing a prognostic signature and identifying hub genes, high-value MAGs related to LUAD treatment and prognosis were identified. These findings contribute to the development of personalized treatment strategies for LUAD.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Frederick S. Vizeacoumar, Hongyu Guo, Lynn Dwernychuk, Adnan Zaidi, Andrew Freywald, Fang-Xiang Wu, Franco J. Vizeacoumar, Shahid Ahmed
Summary: This study identified leading differentially expressed genes in GE cancers that can potentially serve as biomarkers. By constructing a co-expression network and performing complex network analysis, the importance of these genes as biomarkers was confirmed.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Xi Sun, Shuning Ding, Shuangshuang Lu, Zheng Wang, Xiaosong Chen, Kunwei Shen
Summary: Our study identified genes associated with tamoxifen resistance, especially those involved in the cell cycle pathway. These genes were validated to be up-regulated in tamoxifen-resistant patients and associated with poor prognosis in ER-positive patients. Targeting these genes may improve efficacy of endocrine therapy in breast cancer.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Margaretha A. Skowron, Christoph Oing, Felix Bremmer, Philipp Stroebel, Matthew J. Murray, Nicholas Coleman, James F. Amatruda, Friedemann Honecker, Carsten Bokemeyer, Peter Albers, Daniel Nettersheim
Summary: This study identified three resistance groups based on the developmental origin of tumor tissue, each exhibiting specific mechanisms underlying resistance to cisplatin. Group 1 (endodermal origin) showed NRF2-pathway activation, Group 2 (mesodermal origin, primordial germ cells) had elevated DNA repair mechanisms and decreased apoptosis induction, and Group 3 (ectodermal and paraxial mesodermal origin) commonly presented deregulated apoptosis induction and alternating pathways as the main cisplatin-induced resistance mechanisms.
Article
Endocrinology & Metabolism
Ting Liu, Yan Xue, Ping-Ping Guo, Qi Wang, Shu Lin
Summary: This study utilized gene expression analysis and bioinformatics methods to identify the key role of collagen type-IV alpha 1 (COL4A1) in the formation of ADR resistance in breast cancer cells and its close association with poor prognosis. Targeting COL4A1 may help improve the prognosis of breast cancer patients with ADR resistance.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Simona Laurino, Mariarita Brancaccio, Tiziana Angrisano, Giovanni Calice, Sabino Russi, Pellegrino Mazzone, Giuseppina Di Paola, Michele Aieta, Vitina Grieco, Gabriella Bianchino, Geppino Falco, Tiziana Notarangelo
Summary: Gastric cancer, a leading cause of death globally, is difficult to treat with chemotherapy due to multidrug resistance. This study investigated the role of STAT3 in gastric cancer drug efficiency through gene expression analysis. The study found that gastric cancer cells become resistant to chemotherapy by activating alternative signaling pathways. However, inhibiting IL-6/STAT3 in combination with cisplatin treatment prevented STAT3 activation and increased lethality compared to single-agent treatment. This suggests that IL-6/STAT3 axis blockage may be a strategy to overcome resistance.
Article
Chemistry, Multidisciplinary
Ying Li, Ya-ping Dong, You-wen Qian, Le-xing Yu, Wen Wen, Xiu-liang Cui, Hong-yang Wang
Summary: Identifying the functional impact of mutated and altered genes in cancer is crucial for precision oncology and drug repurposing. Through multidimensional analysis of multiomics data, it was found that survival-associated genes differ in their position in biological networks and enrich in different pathways, providing important insights for gene identification and drug development.
ACTA PHARMACOLOGICA SINICA
(2021)