Article
Biochemistry & Molecular Biology
Mengyuan Li, Ping Jiang, Shuhua Wei, Yuhan Yang, Liting Xiong, Junjie Wang, Chunxiao Li
Summary: A recent study revealed that gasdermin D (GSDMD) is upregulated in glioma tissues and is associated with shorter overall survival in patients. Upregulation of GSDMD is also linked to higher tumor mutation burden and PD-1/PD-L1 expression. Furthermore, GSDMD is positively correlated with immune infiltrates, including macrophages and cancer-associated fibroblasts, in an immunosuppressive microenvironment. Knockdown of GSDMD inhibits glioma proliferation, migration, and growth.
Article
Oncology
Yantong Zhou, Peng Nan, Chunxiao Li, Hongnan Mo, Ying Zhang, Haijuan Wang, Dongkui Xu, Fei Ma, Haili Qian
Summary: Upregulation of MTA1 in colorectal cancer drives an immunosuppressive tumor microenvironment by decreasing tumor-associated macrophages and inducing their phenotypic change, which weakens the cytotoxic effect of CD8(+) T cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Martino Maddalena, Giuseppe Mallel, Nishanth Belugali Nataraj, Michal Shreberk-Shaked, Ori Hassin, Saptaparna Mukherjee, Sharathchandra Arandkar, Ron Rotkopf, Abby Kapsack, Giuseppina Lambiase, Bianca Pellegrino, Eyal Ben-Isaac, Ofra Golani, Yoseph Addadi, Emma Hajaj, Raya Eilam, Ravid Straussman, Yosef Yarden, Michal Lotem, Moshe Oren
Summary: Missense p53 mutations in PDAC patients can suppress CD8(+) T cell infiltration into tumors and hinder the immune system’s ability to eliminate cancer cells. Silencing mutp53 can reduce tumor size and fibrotic response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Kai Huang, Wenwu Luo, Jinmei Fang, Changjun Yu, Guangjie Liu, Xiaodong Yuan, Yun Liu, Wenyong Wu
Summary: Our study found that Notch3 is highly expressed in colon tumor tissues and regulates the infiltration of macrophages. The expression of Notch3 is positively correlated with macrophage recruitment-related cytokines in colon tumor tissues. Depletion of Notch3 attenuated colon cancer tumor growth and reduced infiltration of immunosuppressive cells in the tumor microenvironment.
Article
Cell Biology
Qi Zhao, Shuping Gao, Xin Chen, Xiyan Zhu
Summary: This study investigated the expression and prognostic value of POC1A in pan-cancer using data from GTEx and TCGA. It found that high expression of POC1A was associated with poor prognosis in most cancers. POC1A expression was also related to tumor immune infiltration and microenvironment, as well as immune checkpoint genes, TMB, and MSI. GSEA analysis suggested that POC1A may be involved in cell cycle and immune-related pathways. These findings highlight the importance of POC1A as a prognostic biomarker and target for immunotherapy in pan-cancer.
Article
Oncology
Hai-Jun Hu, Xiu Liang, Hai-Lang Li, Huai-Yuan Wang, Jin-Fa Gu, Lan-Ying Sun, Jing Xiao, Jin-Qing Hu, Ai-Min Ni, Xin-Yuan Liu
Summary: The combination therapy of localized ZD55-IL-24 and systemic PD-1 blockade shows a synergistic inhibition of both local and distant established tumors in an immunocompetent mouse model. This synergistic therapeutic effect is associated with the promotion of tumor immune infiltration and recognition, primarily facilitated by ZD55-IL-24 therapy. The study suggests a rationale for further investigation of this combination therapy in clinical settings.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Wendy Bernhard, Kris Barreto, Ayman El-Sayed, John DeCoteau, C. Ronald Geyer
Summary: This study demonstrates the use of a molecule as an imaging agent to determine the recruitment of immune cells to tumors. Non-invasive targeted molecular imaging provides a method to monitor immune response with advantages of whole-body imaging, non-invasiveness, and longitudinal monitoring.
Review
Immunology
Jian Yang, Jialuo He, Yiting Feng, Ming Xiang
Summary: Obesity-related hepatocellular carcinoma (HCC) is closely associated with hepatic inflammation. Inflammatory HCC shows immune effector cells infiltration and better survival compared to non-inflammatory HCC. The immunosuppression induced by obesity contributes to HCC progression and viral infection. This review explores the mechanisms of obesity-induced tumor immune microenvironment and immunosuppression in obesity-related HCC, and proposes potential therapeutic strategies based on immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Wei Wu, Xin'an Wang, Wei Le, Chang Lu, Haopeng Li, Yaru Zhu, Xi Chen, Wenbin An, Chengdang Xu, Qiang Wu, Licheng Wang
Summary: In this study, the tumor microenvironment and immune cell infiltration were analyzed in patients with prostate cancer. High immune cell infiltration scores were associated with poor prognosis and decreased expression of immune-related genes. The TGF-beta and WNT-beta signaling pathways were enriched in the high infiltration score subgroup, suggesting a potential mechanism for immune suppression in prostate cancer patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Jing-Lei Wan, Biao Wang, Mei-Lan Wu, Jie Li, Ruo-Mu Gong, Li-Na Song, Han-Shuo Zhang, Gui-Qi Zhu, Shi-Ping Chen, Jia-Liang Cai, Xiao-Xia Xing, Ya-Dong Wang, Yi Yang, Cheng-Zhe Cai, Run Huang, Hua Liu, Zhi Dai
Summary: This research explores the immunoregulatory function of metadherin (MTDH) in hepatocellular cancer (HCC), and demonstrates that MTDH can modulate PD-L1 expression and transcriptional activity through the β-catenin/LEF-1 signaling pathway. Moreover, combining MTDH ASO with PD-1 mAb improves the effectiveness of immune checkpoint blockade therapy and increases infiltration of cytotoxic T cells. MTDH may serve as a potential biomarker for predicting the therapeutic efficacy of immune checkpoint inhibitor treatment.
Article
Immunology
Xin Zhang, Yanlong Zhang, Li Zhao, Jiayu Wang, Jiaxing Li, Xi Wang, Min Zhang, Xiaopeng Hu
Summary: This study identified potential tumor antigens for mRNA vaccines in bladder cancer (BLCA) and defined three immune subtypes in BLCA. It also applied the immcluster package to predict suitable BLCA patients for antitumor therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Dan Liu, Xue Yang, Xiongzhi Wu
Summary: By analyzing immune infiltration patterns and related genes in melanoma, we constructed an ICI score to assess immune characteristics, revealing that patients with high ICI scores had better prognosis and enrichment in immune pathways, thus showing higher response rates to immunotherapy. This comprehensive immune infiltration landscape in melanoma provides insights for understanding the tumor microenvironment and developing new immune therapy strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Olga V. Kurmyshkina, Pavel V. Dobrynin, Pavel I. Kovchur, Tatyana O. Volkova
Summary: This study identified substantial differences in immune-related characteristics and angiogenic properties between early-stage cervical carcinoma and precursor lesions. These differences have implications for the invasion and progression of the tumor and may provide new options for anti-angiogenic and immune-based therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yihao Mao, Yuqiu Xu, Jiang Chang, Wenju Chang, Yang Lv, Peng Zheng, Zhiyuan Zhang, Zhiqiang Li, Qi Lin, Wentao Tang, Dexiang Zhu, Meiling Ji, Guodong He, Qingyang Feng, Jianmin Xu
Summary: This study explores the immune phenotypes and immune escape mechanisms of colorectal cancer (CRC) and provides inspiration for further research on CRC immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Bolun Zhou, Shugeng Gao
Summary: Recent studies have shown that m(6)A modification is closely associated with immune infiltration in early-stage lung adenocarcinoma (LUAD). By establishing m(6)A-predictive score, immunotherapeutic responses of patients can be predicted. Patients in different m(6)A gene-related clusters exhibit significant differences in immune characteristics and overall survival rates.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Charlotte A. Alemao, Kurtis F. Budden, Henry M. Gomez, Saima F. Rehman, Jacqueline E. Marshall, Shakti D. Shukla, Chantal Donovan, Samuel C. Forster, Ian A. Yang, Simon Keely, Elizabeth R. Mann, Emad M. El Omar, Gabrielle T. Belz, Philip M. Hansbro
Summary: The prevalence of chronic immune and metabolic disorders is increasing rapidly, with significant associations found between alterations in the microbiome, diet, and mucous barriers in the onset and progression of these diseases. The interplay between diet, microbiome, and mucous barrier has gained attention in understanding major immune/metabolic disorders.
Article
Cell Biology
Camille Guillerey, Kimberley Stannard, Jason Chen, Sophie Krumeich, Kim Miles, Kyohei Nakamura, Jessica Smith, Yuan Yu, Susanna Ng, Heidi Harjunpaa, Michele W. L. Teng, Christian Engwerda, Gabrielle T. Belz, Mark J. Smyth
Summary: The study found that the growth of multiple myeloma was associated with changes in BM ILC2s, characterized by increased expression of maturation markers and reduced cytokine response. A subset of KLRG1(hi)ILC2s which preferentially accumulated in the liver and spleen was identified.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Cell Biology
Svenja Loering, Guy J. M. Cameron, Nirmal P. Bhatt, Gabrielle T. Belz, Paul S. Foster, Philip M. Hansbro, Malcolm R. Starkey
Summary: Lung innate lymphoid cells (ILCs) show differences in numbers, cell surface antigen expression, and cytokine levels between neonatal and adult mice. Female mice have more lung ILCs with different antigen expression compared to males. Additionally, mouse strain impacts ILC numbers and expression in the lung.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Immunology
Verena Kastele, Johannes Mayer, Edward S. Lee, Natalie Papazian, John J. Cole, Vuk Cerovic, Gabrielle Belz, Michio Tomura, Gerard Eberl, Carl Goodyear, Rose A. Maciewicz, Daniel Wall, Tom Cupedo, David R. Withers, Simon Milling
Summary: ILCs are a type of cells enriched in mucosae and lymph nodes, capable of migrating to lymph nodes and responding to infections. They express different genes and cytokines during migration compared to tissue-resident ILCs.
MUCOSAL IMMUNOLOGY
(2021)
Editorial Material
Immunology
Taylor Adair, Gabrielle T. Belz
TRENDS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Raphael Bernard-Valnet, David Frieser, Xuan-Hung Nguyen, Leila Khajavi, Clemence Queriault, Sebastien Arthaud, Silvia Melzi, Maxime Fusade-Boyer, Frederick Masson, Matthias Zytnicki, Abdelhadi Saoudi, Yves Dauvilliers, Christelle Peyron, Jan Bauer, Roland S. Liblau
Summary: This study reveals that Pandemrix (R) vaccination may induce narcolepsy through immune cross-reactivity with a self-antigen, leading to an immunopathological process. This process relies on the synergy between CD4 and CD8 T cells.
Review
Immunology
Nicolas Jacquelot, Cyril Seillet, Eric Vivier, Gabrielle T. Belz
Summary: Innate lymphoid cells (ILCs) play a role in immune responses and have been found to have pleiotropic effects in various tissues, including both tissue repair and immunopathology toward allergens and promotion of tumorigenesis. Recent studies suggest that non-NK ILCs might be harnessed for anti-tumor responses. Gabrielle Belz and colleagues review the influence of ILCs on cancer immune responses.
Article
Cell Biology
David Frieser, Aurora Pignata, Leila Khajavi, Danielle Shlesinger, Carmen Gonzalez-Fierro, Xuan-Hung Nguyen, Alexander Yermanos, Doron Merkler, Romana Hoftberger, Virginie Desestret, Katharina M. Mair, Jan Bauer, Frederick Masson, Roland S. Liblau
Summary: This study reveals the important role of tissue-resident memory T cells, particularly pathogenic CD8(+) T cells, in chronic autoimmune diseases of the central nervous system. These cells are crucial for sustaining chronic inflammation and progressive loss of neurons, and they exhibit phenotypic and functional heterogeneity. The presence and functional output of tissue-resident CD8(+) T cells depend critically on CD4(+) T cells. Therefore, therapies targeting this compartmentalized autoreactive T cell subset may be effective for treating CNS autoimmune diseases.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Doron Merkler, Ilena Vincenti, Frederick Masson, Roland S. Liblau
Summary: Tissue-resident memory T cells (T-RM) are a subset of T cells that are retained in tissues and play important roles in protection against reinfection and antitumor responses. The increased density of CD8 T-RM in the central nervous system (CNS) of patients with neuroinflammatory diseases suggests its potential contribution to the pathogenesis of these diseases.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Editorial Material
Immunology
Sophie Curio, Gabrielle T. Belz
Summary: In a new study, researchers discovered that the expression of transcription factor ZBTB46 in ILC3s in the mouse colon plays a crucial role in regulating inflammatory responses.
TRENDS IN IMMUNOLOGY
(2022)
Review
Immunology
Huiyang Yu, Nicolas Jacquelot, Gabrielle T. Belz
Summary: This article reviews the critical role of innate lymphoid cells in tissue protection and immunity in animals, and discusses their metabolic pathways and adaptability to changing conditions. Reprogramming immune cell metabolism may offer new strategies for modulating immune cell behavior and treating various diseases.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Editorial Material
Immunology
Wang Cao, Gabrielle Belz
Summary: Pain is a characteristic symptom of intestinal inflammation. Two articles published in Cell by Zhang et al. and by Yang et al. reveal how gut sensory neurons identify bacterial pathogens, modulate gut microbiome composition, and activate immune regulatory mechanisms.
TRENDS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Susanne Heinzel, Hochan Cheon, Gabrielle T. Belz, Philip D. Hodgkin
Summary: Memory T cells and naive T cells have similarities in maintenance and response dynamics, but may differ in cellular fate programs. Resting memory T cells show heightened sensitivity to homeostatic cytokines and undergo controlled proliferation and return to quiescence similar to naive T cells. However, memory T cells may have reduced expansion capacity in response to activating signals compared to naive T cells.
IMMUNOLOGY AND CELL BIOLOGY
(2023)
Review
Oncology
Chun Ki Ng, Gabrielle T. Belz
Summary: Innate lymphoid cells (ILCs) are a group of immune cells that can respond rapidly to changing microenvironmental cues. They can either protect against tumor development or promote tumor progression and resistance to immunotherapy. This review discusses the regulation of ILCs and the potential for using their functional plasticity to develop therapeutic strategies to enhance immune responses and improve patient outcomes.
Article
Cell Biology
Weldy Bonilla, Nicole Kirchhammer, Anna-Friederike Marx, Sandra M. Kallert, Magdalena A. Krzyzaniak, Min Lu, Stephanie Darbre, Sarah Schmidt, Josipa Raguz, Ursula Berka, Ilena Vincenti, Mindaugas Pauzuolis, Romy Kerber, Sabine Hoepner, Stephan Guenther, Carsten Magnus, Doron Merkler, Klaus K. Orlinger, Alfred Zippelius, Daniel D. Pinschewer
Summary: This study engineered two distantly related arenaviruses for therapeutic cancer vaccination and demonstrated that a prime-boost regimen with these viruses induced tumor-specific CTL responses and eliminated established solid tumors in mice. The findings suggest that combining two genealogically distantly related arenaviruses allows reshuffling of immunodominance hierarchies and breaking self-directed tolerance for effective tumor control.
CELL REPORTS MEDICINE
(2021)