Article
Biochemistry & Molecular Biology
Katsuyoshi Kumagai, Masakatsu Takanashi, Shin-ichiro Ohno, Yuichirou Harada, Koji Fujita, Keiki Oikawa, Katsuko Sudo, Shun-ichi Ikeda, Hirotaka Nishi, Kosuke Oikawa, Masahiko Kuroda
Summary: Cervical cancer development involves HPV infection and estrogen receptor signaling. WAPL plays a crucial role in CIN development by activating MACROD1 to increase ESR1 sensitivity, thereby promoting the expression of MYC and Cyclin D1.
Article
Biochemistry & Molecular Biology
Maite Garcia-Guasch, Lourdes Navarro, Vanessa Rivero, Irmgard Costa, Eduard Escrich, Raquel Moral
Summary: Breast cancer is the most common malignancy in women worldwide, with dietary and environmental factors playing a role in its etiology. The study found that high fat diets have different effects on tumor progression, and metabolic changes play a role in the molecular modulation of different signaling pathways in the context of tumor malignancy.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Engineering, Biomedical
Jensen N. Amens, Gokhan Bahcecioglu, Kiera Dwyer, Xiaoshan S. Yue, M. Sharon Stack, Tyvette S. Hilliard, Pinar Zorlutuna
Summary: This study investigated the effect of multigenerational obesity on epithelial cell migration and invasion in breast tissues. Results showed that offspring from dams fed with high-fat diet had larger adipocytes and curvier collagen fibers, leading to enhanced migration and invasion of breast cancer cells. The curvature of collagen fibers was found to be a critical factor in regulating the migration and invasion of breast cancer cells.
Article
Cardiac & Cardiovascular Systems
Dongze Qin, Xiaotong F. Jia, Anis Hanna, Jaehoon Lee, Ryan Pekson, John W. Elrod, John W. Calvert, Nikolaos G. Frangogiannis, Richard N. Kitsis
Summary: At least seven cell death programs are activated during myocardial infarction (MI), but the importance of each program in causing heart damage is not fully understood. In this study, the researchers focused on the role of BAK, a pro-cell death protein, in cardiomyocyte apoptosis and necrosis during MI/reperfusion (MI/R) and non-reperfused MI. They found that the absence of BAK significantly reduced infarct size and necrosis in vivo and in isolated cardiomyocytes. However, the complete deletion of BAK did not affect acute infarct size or long-term scar size, post-infarct remodeling, cardiac dysfunction, or mortality in non-reperfused MI. These results suggest that BAK may be a potential therapeutic target for MI/R.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Medicine, Research & Experimental
De-Dong Li, Rami Bechara, Kritika Ramani, Chetan Jawale, Yang Li, Jay K. Kolls, Sarah L. Gaffen, Partha S. Biswas
Summary: Antibody-mediated glomerulonephritis (AGN) is a clinical manifestation of many autoimmune kidney diseases, with IL-17 playing a key role in pathogenesis, and Regnase-1 acting as a negative regulator of IL-17 signaling in renal tubular epithelial cells.
Article
Cell Biology
Kazushi Azuma, Mai Sakamoto, Shota Katayama, Atsuka Matsui, Kazuya Nakamichi, Naoki Goshima, Shinya Watanabe, Jun Nakayama, Kentaro Semba
Summary: The dysregulation of homeobox family genes, especially HOXB7, is associated with poor prognosis in various cancers. HOXB7 is involved in cancer progression through promoting epithelial to mesenchymal transition, drug resistance, and angiogenesis. In this study, HOXB7 was found to be coamplified with ERBB2 in a subset of breast cancer patients and its overexpression correlated with poor prognosis in HER2-positive breast cancer. Further experiments revealed that HOXB7 induced cellular transformation, tumorigenesis, and lung metastasis through JAK-STAT signaling activation.
Article
Oncology
Milena Perrone, Claudia Chiodoni, Mara Lecchi, Laura Botti, Barbara Bassani, Annamaria Piva, Elena Jachetti, Matteo Milani, Daniele Lecis, Elda Tagliabue, Paolo Verderio, Sabina Sangaletti, Mario P. Colombo
Summary: Cancer can reprogram the bone marrow niche through the BM mesenchymal stem cells (MSC) and IL-1B/ATF3 signaling pathway, which promotes myeloid cell differentiation and tumor development. The expression of CD11b thorn population in the peripheral blood can be used as a potential biomarker for early diagnosis of breast cancer. This study suggests that targeting IL-1B or ATF3 may have therapeutic benefits for breast cancer patients.
Article
Oncology
Vito Amodio, Simona Lamba, Rosaria Chila, Chiara M. Cattaneo, Benedetta Mussolin, Giorgio Corti, Giuseppe Rospo, Enrico Berrino, Claudio Tripodo, Federica Pisati, Alice Bartolini, Maria Costanza Aquilano, Silvia Marsoni, Gianluca Mauri, Caterina Marchio, Sergio Abrignani, Federica Di Nicolantonio, Giovanni Germano, Alberto Bardelli
Summary: Patients with DNA mismatch repair deficiency (MMRd) in colorectal cancer (CRC) often respond to immune checkpoint blockade therapies, while those with mismatch repair-proficient (MMRp) tumors generally do not. MMRp CRCs with variable fractions of MMRd cells may impact immune surveillance. Modulation of the MMRd fraction in MMR heterogeneous tumors can enhance their immunogenicity.
Correction
Chemistry, Physical
Emanuela Frittoli, Andrea Palamidessi, Fabio Iannelli, Federica Zanardi, Stefano Villa, Leonardo Barzaghi, Hind Abdo, Valeria Cancila, Galina V. Beznoussenko, Giulia Della Chiara, Massimiliano Pagani, Chiara Malinverno, Dipanjan Bhattacharya, Federica Pisati, Weimiao Yu, Viviana Galimberti, Giuseppina Bonizzi, Emanuele Martini, Alexander A. Mironov, Ubaldo Gioia, Flora Ascione, Qingsen Li, Kristina Havas, Serena Magni, Zeno Lavagnino, Fabrizio Andrea Pennacchio, Paolo Maiuri, Silvia Caponi, Maurizio Mattarelli, Sabata Martino, Fabrizio d'Adda di Fagagna, Chiara Rossi, Marco Lucioni, Richard Tancredi, Paolo Pedrazzoli, Andrea Vecchione, Cristiano Petrini, Francesco Ferrari, Chiara Lanzuolo, Giovanni Bertalot, Guilherme Nader, Marco Foiani, Matthieu Piel, Roberto Cerbino, Fabio Giavazzi, Claudio Tripodo, Giorgio Scita
Article
Oncology
Riccardo Ray Colciago, Irene Fischetti, Carlotta Giandini, Eliana La Rocca, Tiziana T. Rancati, Alicia Rejas Mateo, Mario Paolo Colombo, Laura Lozza, Claudia Chiodoni, Elena Jachetti, Maria Carmen De Santis
Summary: Oncological treatments are rapidly changing with the introduction of targeted anticancer drugs and regimens, and radioimmunotherapy is emerging as a promising field. This review provides an overview of the synergistic use of radiotherapy and immunotherapy and addresses important questions about its implementation, the patient selection criteria, and when it becomes standard clinical practice.
EXPERT REVIEW OF ANTICANCER THERAPY
(2023)
Article
Gastroenterology & Hepatology
Rosaria M. Pipitone, Francesco Malvestiti, Grazia Pennisi, Oveis Jamialahmadi, Paola Dongiovanni, Giorgio Bertolazzi, Jussi Pihlajamaeki, Hannele Yki-Jaervinen, Umberto Vespasiani-Gentilucci, Federica Tavaglione, Samantha Maurotti, Cristiana Bianco, Gabriele Di Maria, Marco Enea, Anna L. Fracanzani, Vesa Kaerjae, Giulia Lupo, Ville Maennistoe, Marica Meroni, Roberto Piciotti, Sami Qadri, Rossella Zito, Antonio Craxi, Vito Di Marco, Calogero Camma, Claudio Tripodo, Luca Valenti, Stefano Romeo, Salvatore Petta, Stefania Grimaudo
Summary: The study found that the variation in the PDCD1 gene is associated with liver inflammation and progression to hepatocellular carcinoma (HCC) in patients with nonalcoholic fatty liver disease (NAFLD). The rs13023138 G>C variation was found to be associated with severe steatosis, NASH, and advanced fibrosis in individuals who underwent liver biopsy.
LIVER INTERNATIONAL
(2023)
Article
Cell Biology
Ubaldo Gioia, Sara Tavella, Pamela Martinez-Orellana, Giada Cicio, Andrea Colliva, Marta Ceccon, Matteo Cabrini, Ana C. Henriques, Valeria Fumagalli, Alessia Paldino, Ettore Presot, Sreejith Rajasekharan, Nicola Iacomino, Federica Pisati, Valentina Matti, Sara Sepe, Matilde I. Conte, Sara Barozzi, Zeno Lavagnino, Tea Carletti, Maria Concetta Volpe, Paola Cavalcante, Matteo Iannacone, Chiara Rampazzo, Rossana Bussani, Claudio Tripodo, Serena Zacchigna, Alessandro Marcello, Fabrizio d'Adda di Fagagna
Summary: SARS-CoV-2 causes DNA damage and alters the DNA damage response, leading to inflammation and cellular senescence.
NATURE CELL BIOLOGY
(2023)
Article
Oncology
Caterina Cascini, Chiara Ratti, Laura Botti, Beatrice Parma, Valeria Cancila, Adriana Salvaggio, Cristina Meazza, Claudio Tripodo, Mario P. Colombo, Claudia Chiodoni
Summary: Osteosarcoma (OS) is the most common primary bone tumor in children and adolescent. In this study, it was found that intralesional administration of a TLR9 agonist can effectively inhibit tumor growth and also have therapeutic effects on untreated contralateral lesions. The findings suggest that TLR9 agonist can act as an in situ anti-tumor vaccine, activating innate and adaptive immune responses to suppress tumor growth.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
S. Cortellino, V. Quagliariello, G. Delfanti, O. Blazevits, C. Chiodoni, N. Maurea, A. Di Mauro, F. Tatangelo, F. Pisati, A. Shmahala, S. Lazzeri, V. Spagnolo, E. Visco, C. Tripodo, G. Casorati, P. Dellabona, V. D. Longo
Summary: This study explores the use of periodic cycles of a fasting-mimicking diet (FMD) to reduce the side effects caused by immunotherapy in cancer treatment. The combination of FMD cycles with immunotherapy shows promising results in delaying cancer growth and reducing cardiotoxicity.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Camilla Tombari, Alessandro Zannini, Rebecca Bertolio, Silvia Pedretti, Matteo Audano, Luca Triboli, Valeria Cancila, Davide Vacca, Manuel Caputo, Sara Donzelli, Ilaria Segatto, Simone Vodret, Silvano Piazza, Alessandra Rustighi, Fiamma Mantovani, Barbara Belletti, Gustavo Baldassarre, Giovanni Blandino, Claudio Tripodo, Silvio Bicciato, Nico Mitro, Giannino Del Sal
Summary: Mutant p53 stimulates serine/glycine synthesis and essential amino acid uptake to promote breast cancer growth. Under amino acid restriction, mutant p53 is stabilized and activates a transcriptional program that sustains a metabolic adaptive response promoting cancer cell proliferation.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Oncology
Giovanna Talarico, Mara Lecchi, Massimo Costanza, Claudia Chiodoni, Vera Cappelletti, Paolo Verderio, Massimo Di Nicola, Francesco Bertolini, Mario Paolo Colombo, Sabina Sangaletti
Meeting Abstract
Oncology
Roberto Ferrara, Giuseppe Lo Russo, Chiara Maura Ciniselli, Annamaria Piva, Barbara Bassani, Elena Jachetti, Giuseppina Calareso, Valeria Duroni, Settimio Di Gregorio, Claudia Proto, Arsela Prelaj, Alessandro De Toma, Mario Occhipinti, Marta Brambilla, Sara Manglaviti, Laura Mazzeo, Arturo Rinaldi, Teresa Beninato, Monica Ganzinelli, Filippo De Braud, Marina Chiara Garassino, Paolo Verderio, Mario Paolo Colombo, Sabina Sangaletti
Article
Cell Biology
Annamaria Aprile, Laura Raggi, Simona Bolamperti, Isabella Villa, Mariangela Storto, Gaia Morello, Sarah Marktel, Claudio Tripodo, Maria Domenica Cappellini, Irene Motta, Alessandro Rubinacci, Giuliana Ferrari
Summary: Clinical evidence suggests a relationship between blood and bone, but the underlying mechanism is not fully understood. A study using beta-thalassemia as a model found that increased fibroblast growth factor 23 (FGF23) levels in patients and mice with beta-thalassemia were induced by erythropoietin via ERK1/2 and STAT5 pathways. Inhibiting FGF23 signaling with carboxyl-terminal FGF23 peptide rescued bone defects and restored hematopoietic stem cell function in mice with beta-thalassemia. FGF23 may serve as a molecular link connecting anemia, bone, and the hematopoietic stem cell niche.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Grazia Pennisi, Rosaria Maria Pipitone, Francesco Malvestiti, Oveis Jamialahmadi, Paola Dongiovanni, Giorgio Bertolazzi, Jussi Pihlajamaki, Hannele Yki-Jarvinen, Umberto Vespasiani Gentilucci, Federica Tavaglione, Samantha Maurotti, Cristiana Bianco, Gabriele Di Maria, Marco Enea, Anna Ludovica Fracanzani, Vesa Karja, Giulia Lupo, Ville Mannisto, Marica Meroni, Roberto Piciotti, Sami Qadri, Rossella Zito, Antonio Craxi, Vito Di Marco, Calogero Camma, Claudio Tripodo, Luca Valenti, Stefano Romeo, Salvatore Petta, Stefania Grimaudo
JOURNAL OF HEPATOLOGY
(2023)