Article
Chemistry, Medicinal
Raghad Al-Jarf, Alex G. C. de Sa, Douglas E. Pires, David B. Ascher
Summary: The development of a novel predictive tool, pdCSM-cancer, provides an accurate way to predict molecules likely to be active against one or multiple cancer cell lines by using graph-based chemical structure signatures. This tool includes trained and validated models on data from over 18,000 compounds on 9 tumor types and 74 distinct cancer cell lines, achieving successful predictive performance.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Biochemistry & Molecular Biology
Umberto Attanasio, Flora Pirozzi, Remo Poto, Alessandra Cuomo, Antonio Carannante, Michele Russo, Alessandra Ghigo, Emilio Hirsch, Carlo Gabriele Tocchetti, Gilda Varricchi, Valentina Mercurio
Summary: Redox abnormalities play a significant role in cardiovascular diseases, cancer, and cardiotoxicity from anticancer treatments. Increased oxidative stress is a key mechanism of action for anthracyclines and is also responsible for the toxic cardiovascular effects of antineoplastic targeted drugs and radiotherapy.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Medicine, General & Internal
Jinyun Wang, Dingwei Liu, Qixuan Wang, Yong Xie
Summary: This study identified six BM-related genes and developed a prognostic model for gastric cancer. It was found that activated CD4+ T cells and follicular T cells infiltrated more widely in the low-risk group, which also had higher TMB levels and better prognosis, favoring immunotherapy.
Article
Chemistry, Multidisciplinary
Haojie Liu, Shiyi Xu, Tuying Yong, Zhaohan Wei, Nana Bie, Xiaoqiong Zhang, Xin Li, Jianye Li, Shiyu Li, Sheng Wang, Yanbing Zhao, Xiangliang Yang, Lu Gan
Summary: This study presents a simple and effective strategy for improving the delivery of anticancer drugs using hydrophobicity-adaptive polymers anchored to tumor-cell-derived microparticles (MPs). These polymers switch to hydrophobicity in the tumor acidic microenvironment, promoting the fission of MPs into small vesicles, facilitating drug accumulation, deep penetration into tumors, and efficient intracellular uptake.
ADVANCED MATERIALS
(2023)
Article
Environmental Sciences
Guido Cavaletti, Alessia D'Acunti, Alessandro Porcu, Gabriella Masiello, Laura Del Campo, Gianfranca Traclo, Francesco De Lorenzo, Davide Paolo Bernasconi
Summary: Chemotherapy-induced neurotoxicity is a well-known complication of effective anticancer treatments, causing cognitive impairment and peripheral neuropathy. The social and economic effects of this condition on patients' lifestyles and relationships are under-investigated and largely unknown.
Article
Chemistry, Multidisciplinary
Junyi Chen, Yahan Zhang, Yadan Zhang, Liang Zhao, Longming Chen, Yao Chai, Zhao Meng, Xueshun Jia, Qingbin Meng, Chunju Li
Summary: The study demonstrated the successful loading of PMX using WP6A and formation of host-guest inclusion to reduce its cytotoxicity on cells for improved chemotherapy efficacy. This supramolecular strategy effectively blocked efflux pump and released PMX simultaneously, resulting in synergistic enhancement of anticancer performance.
CHINESE CHEMICAL LETTERS
(2021)
Article
Cell Biology
Jiefu Tang, Fan Yao, Zhiyong Yao, Xiao-Liang Xing
Summary: Cuproptosis is identified as a new therapeutic target for RCC, and four differentially expressed lncRNAs are found to be potential biomarkers for this cancer. The study also reveals significant differences in immune status, immunotherapy, and chemotherapy drug sensitivity between high-risk and low-risk RCC patients.
Article
Engineering, Chemical
Yingqian Zhou, Haoshui Yu, Xiao Feng, Minbo Yang
Summary: In this study, a simplified structure for optimal design of hydrogen networks is developed, and an algorithm based on heuristics is proposed. The algorithm significantly reduces computational time and achieves better hydrogen network designs.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Eliska Waloschkova, Ana Gonzalez-Ramos, Apostolos Mikroulis, Jan Kudlacek, My Andersson, Marco Ledri, Merab Kokaia
Summary: The transplantation of GABAergic interneuron precursors derived from human embryonic stem cells into the hippocampi of epileptic rats showed their maturation into functional GABAergic interneurons in the host brain, which reduced the rate of epileptiform discharges and decreased seizure frequency in vivo, demonstrating the potential therapeutic effect of this approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Huan Wang, Qi Cheng, Kaikai Chang, Lingjie Bao, Xiaofang Yi
Summary: This study examined the diagnostic, prognostic, and therapeutic value of ferroptosis-related genes in ovarian cancer using transcriptomic data. A reliable ferroptosis signature for ovarian cancer diagnosis was identified. A prognostic signature and a risk score model based on three genes were constructed and validated. The results suggested a potential crosstalk between ferroptosis and immunity in ovarian cancer, with implications for prognosis and treatment decision-making.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Donlin Lai, Lin Tan, Xiaojia Zuo, DingSheng Liu, Deyi Jiao, Guoqing Wan, Changlian Lu, Dongjie Shen, Xuefeng Gu
Summary: This study investigates the combined effects of ferroptosis and lncRNAs on the prognosis and therapy of stomach cancer. A prognostic model consisting of 10 ferroptosis-related lncRNAs was constructed and validated. The model had guiding significance for prognosis and personalized therapy, helping to identify stomach cancer patients who might benefit from immunotherapy and guiding the selection of personalized chemotherapeutic drugs. The study also revealed differences in immune response and sensitivity to certain chemotherapy drugs among different risk groups.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Gloria Echeverria, Shirong Cai, Yizheng Tu, Jiansu Shao, Emily Powell, Abena B. Redwood, Yan Jiang, Aaron McCoy, Amanda L. Rinkenbaugh, Rosanna Lau, Alexander J. Trevarton, Chunxiao Fu, Rebekah Gould, Elizabeth E. Ravenberg, Lei Huo, Rosalind Candelaria, Lumarie Santiago, Beatriz E. Adrada, Deanna L. Lane, Gaiane M. Rauch, Wei T. Yang, Jason B. White, Jeffrey T. Chang, Stacy L. Moulder, W. Fraser Symmans, Susan G. Hilsenbeck, Helen Piwnica-Worms
Summary: This study established 369 orthotopic PDX models of breast cancer and found that treatment-resistant cancers were more likely to be successfully engrafted. The molecular subtype of breast cancer was not associated with engraftment rate. A statistical model predictive of engraftment was developed based on clinical indicators. These breast cancer models are valuable for clinical treatment and biomarker research.
Review
Pharmacology & Pharmacy
Mohammad Fawad Ansari, Huzaifa Yasir Khan, Sartaj Tabassum, Farukh Arjmand
Summary: Metal-based complexes have been at the forefront of treating chronic diseases, particularly different types of cancers. While cisplatin has been successful, few metallo-drugs are currently used in cancer chemotherapy due to toxic effects and limited efficacy. However, research in medicinal inorganic chemistry has been growing rapidly, focusing on novel drug design strategies to improve outcomes and reduce side effects. Natural products, such as alkaloids, have become key elements in anticancer drug development. Metal complexes of natural alkaloids have shown promise in inhibiting tumor progression through various pathways. Despite unclear targets, these complexes have exhibited anticancer potency both in vitro and in vivo. Advances have been made in the development of natural alkaloid-based metallo-drugs for cancer chemotherapy.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Rui Zhou, Lingbo Li, Shaoyan Xi, Yue Zhang, Zhihong Liu, Dongqiang Zeng, Huiying Sun, Jianhua Wu, Ling Wang, Min Shi, Jianping Bin, Yulin Liao, Wangjun Liao
Summary: This study identified the tumor heterogeneity related to secretory cell signature expression patterns in colon cancer. A scoring model, SCS score, was developed to guide personalized therapeutic strategies for colon cancer patients.
MOLECULAR ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Ziqian Deng, Ting Guo, Jiwang Bi, Gangjian Wang, Ying Hu, Hong Du, Yuan Zhou, Shuqin Jia, Xiaofang Xing, Jiafu Ji
Summary: The prevalent heterogeneity in gastric cancer at various levels poses a challenge to personalized therapies. This study explores the use of patient-derived tumor xenograft (PDTX) models to identify robust ECM-related transcriptomic signatures for improved prognosis prediction and therapy design. The findings suggest that ECM-related signatures may contribute to tumor growth and poor prognosis in gastric cancer, and the PTG score, in combination with age and TNM stage, could serve as a new approach for prognosis prediction.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Amir Ajoolabady, Daolin Tang, Guido Kroemer, Jun Ren
Summary: Hepatocellular carcinoma is a prevalent form of liver cancer, with genetic, environmental, and behavioral factors influencing its development. Ferroptosis, a form of nonapoptotic cell death, has potential for suppressing hepatocellular carcinoma. However, malignant cells can develop mechanisms to resist ferroptosis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Cell Biology
Qian Xue, Ding Yan, Xi Chen, Xiaofen Li, Rui Kang, Daniel J. J. Klionsky, Guido Kroemer, Xin Chen, Daolin Tang, Jinbao Liu
Summary: Ferroptosis is an iron-dependent regulated cell death characterized by lipid peroxidation and membrane damage. Copper promotes ferroptotic cell death by inducing autophagic degradation of GPX4. These findings provide new insights into the connection between metal stress and autophagy-dependent cell death.
Review
Biochemistry & Molecular Biology
Carlos Lopez-Otin, Maria A. Blasco, Linda Partridge, Manuel Serrano, Guido Kroemer
Summary: Aging is driven by hallmarks that manifest with age, accelerate aging when accentuated experimentally, and can be decelerated, stopped, or reversed with therapeutic interventions. The twelve proposed hallmarks of aging include genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. These hallmarks are interconnected with each other and with the recently proposed hallmarks of health.
Review
Cell Biology
Carlos Lopez-Otin, Federico Pietrocola, David Roiz-Valle, Lorenzo Galluzzi, Guido Kroemer
Summary: Both aging and cancer share similar characteristics, known as hallmarks, some of which are common metahallmarks. While some aging hallmarks suppress cancer development, others have context-dependent effects. The relationship between aging-associated nutrient-sensing and cancer-related cellular metabolism alterations is complex. Understanding the interplay between aging and cancer has significant implications for cancer morbidity and mortality in the elderly and for therapeutic strategies.
Article
Cell Biology
Julia Kaellberg, Alexandra Harrison, Valerie March, Santa Berzina, Ivan Nemazanyy, Oliver Kepp, Guido Kroemer, Sophie Mouillet-Richard, Pierre Laurent-Puig, Valerie Taly, Wenjin Xiao
Summary: The high mortality rate in colorectal cancer (CRC) is mainly due to drug resistance caused by intratumor heterogeneity (ITH). This study investigated the interaction between different molecular subtypes of CRC cells and found that coculturing CMS1 and CMS4 cells increased their resistance to the chemotherapeutic agent 5-fluorouracil (5-FU) and promoted cellular invasion. The secretome of CMS1 cells played a protective role for CMS4 cells against 5-FU treatment and mediated the transfer of metabolites between CMS1 and CMS4 cells.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Jing Zhang, Christina Trojel-Hansen, Jianghuang Wang, Zili Zhang, Xing Wang, Yuhui Qiao, Huike Jiao, Mickael Michaud, Oliver Kepp, Marja Jäättelä, Guido Kroemer, Qing Zhong
Summary: An experimental inducer of TNF-independent necrosis, NC1, kills human cancer cells in a non-apoptotic, necrotic manner. The cell death induced by NC1 is not inhibited by apoptosis-related pathways, but depends on reactive oxygen species (ROS) production by mitochondria and elimination of mitochondrial DNA. These findings suggest that inducing regulated necrosis may be a promising approach for anticancer therapy.
CELL DEATH & DISEASE
(2023)
Editorial Material
Oncology
Oliver Kepp, Peng Liu, Laurence Zitvogel, Guido Kroemer
Review
Oncology
Jenny Sprooten, Raquel S. Laureano, Isaure Vanmeerbeek, Jannes Govaerts, Stefan Naulaerts, Daniel M. Borras, Lisa Kinget, Jitka Fucikova, Radek Spisek, Lenka Palova Jelinkova, Oliver Kepp, Guido Kroemer, Dmitri V. Krysko, An Coosemans, Rianne D. W. Vaes, Dirk De Ruysscher, Steven De Vleeschouwer, Els Wauters, Evelien Smits, Sabine Tejpar, Benoit Beuselinck, Sigrid Hatse, Hans Wildiers, Paul M. Clement, Peter Vandenabeele, Laurence Zitvogel, Abhishek D. Garg
Summary: Immunogenic cell death (ICD) is a unique process of regulated cell death that activates the immune system. The effectiveness of ICD relies on the antigenicity of dying cells and their ability to expose immunostimulatory molecules. Certain chemotherapies, such as anthracyclines, paclitaxels, and oxaliplatin, have been validated as potent ICD inducers and can be used in combination with immunotherapies against resistant tumors. This article discusses the integration of ICD-inducing chemotherapy in immuno-oncological paradigms.
Article
Oncology
Julie Le Naour, Guido Kroemer
Summary: Accumulating evidence suggests that TLR agonists have favorable immune-activating effects and can be used as immunological adjuvants for cancer immunosurveillance. Several TLR agonists have been approved for oncological applications and extensively investigated. Clinical trials are ongoing to evaluate the combination of TLR agonists with other cancer treatments. Antibodies targeting tumor-enriched surface proteins conjugated with TLR agonists are also being developed to stimulate anticancer immune response within the tumor microenvironment. This review summarizes recent preclinical and clinical advances in TLR agonists for anticancer immunotherapy.
Article
Oncology
Vincent Carbonnier, Julie Le Naour, Thomas Bachelot, Erika Vacchelli, Fabrice Andre, Suzette Delaloge, Guido Kroemer
Summary: Formyl peptide receptor-1 (FPR1) is involved in pathogen recognition, inflammation control and cancer immunosurveillance. A single nucleotide polymorphism (SNP), rs867228, in FPR1 accelerates age at diagnosis of specific carcinomas, including luminal B breast cancer, by 4.9 years. Genetic analysis of 215 patients with metastatic luminal B breast cancer confirmed that rs867228 accelerates age of diagnosis by 6.3 years. Detection of rs867228 may be useful in breast cancer screening to start examinations at a younger age.
Article
Cell Biology
Safae Terrisse, Laurence Zitvogel, Guido Kroemer
Summary: Recent observations show that hormone-receptor breast cancer is influenced by immune and microbial factors. The immune system retards the development of hormone-positive breast cancer and affects the efficacy of hormone therapy. The gut microbiota modulates the anticancer immune response, tumor microenvironment, and estrogen metabolism. Understanding these mechanisms is still in its early stages and requires further analysis.
Article
Oncology
Laurence Zitvogel, Lisa Derosa, Guido Kroemer
Summary: In patients with multiple myeloma, mRNA-based vaccination schemes failed to generate detectable SARS-CoV-2 Omicron-neutralizing antibodies in approximately 60% of the cases and S1-RBD-specific CD8+ T cells in 80% of the cases. Patients who experienced breakthrough infections had very low levels of live-virus neutralizing antibodies and lacked follicular T helper cells.
BLOOD CANCER DISCOVERY
(2023)
Review
Cell Biology
Lea Montegut, Mahmoud Abdellatif, Omar Motino, Frank Madeo, Isabelle Martins, Victor Quesada, Carlos Lopez-Otin, Guido Kroemer
Summary: Acyl coenzyme A binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an ancient protein that plays a role in fatty acid metabolism and has been found to have anti-aging effects. Inhibition of ACBP can extend lifespan and improve healthspan in multiple species.
Review
Health Care Sciences & Services
Celine Chapelle, Edouard Ollier, Paul Bonjean, Clara Locher, Paul Jacques Zufferey, Michel Cucherat, Silvy Laporte
Summary: This study provides an overview of the overlap in systematic reviews (SRs) evaluating direct oral anticoagulants and characterizes these reviews in terms of bias and methodological quality. The results show a large number of replication reviews, with a fifth being excessive replications. Compared to the original SRs, the replication reviews did not improve the overall methodological quality.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Microbiology
Karsten Meier, Lana H. Jachmann, Goezde Tuerkoez, Mohammed Rizwan Babu Sait, Lucia Perez, Oliver Kepp, Raphael H. Valdivia, Guido Kroemer, Barbara S. Sixt
Summary: This study revealed the key role of CpoS protein from Chlamydia trachomatis in the modulation of inclusion membrane and membrane trafficking, as well as its ability to suppress interferon response through interaction with Rab GTPases. These findings advance our understanding of how intracellular bacteria shape and protect their growth niche.
