Article
Mathematics
Ilya Slobodnyak, Anatoly Sidorov, Denis Alekseev
Summary: This article discusses the use of mathematical methods for cash deficit probability predictions, addressing the challenges and solutions in this area. By analyzing external and internal factors, it proposes the possibility of predicting cash deficits based on probability theory methods. It emphasizes that the model predicts the probability of deficits rather than specific dates, distinguishing it from common scoring estimates.
Review
Biochemistry & Molecular Biology
Justina Kazokaite-Adomaitiene, Holger M. Becker, Joana Smirnoviene, Ludwig J. Dubois, Daumantas Matulis
Summary: This review presents the design, development, and identification of selective nano-to picomolar CA IX inhibitors VD11-4-2, VR16-09, and VD12-09. Various methods and results were discussed, including compound binding, biophysical techniques, protein cloning and purification strategies, and cancer cell-based assays which confirmed nanomolar activities of lead inhibitors. Novel CA IX inhibitors show promise for in vivo exploration and targeting multiple proteins involved in tumor acidosis may improve cancer management.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Neurosciences
Leo K. Cheng, Nipuni D. Nagahawatte, Recep Avci, Peng Du, Zhongming Liu, Niranchan Paskaranandavadivel
Summary: This review discusses the use of gastric pacing and stimulation strategies in treating motility disorders, as well as targeting nerves in the stomach to modulate stomach function. The article summarizes effective parameters and limitations in existing studies, and explores the use of mathematical models to refine pacing and stimulation protocols. Additionally, future directions and challenges in this field are also discussed.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Oncology
Daniel A. Anaya, Prashant Dogra, Zhihui Wang, Mintallah Haider, Jasmina Ehab, Daniel K. Jeong, Masoumeh Ghayouri, Gregory Y. Lauwers, Kerry Thomas, Richard Kim, Joseph D. Butner, Sara Nizzero, Javier Ruiz Ramirez, Marija Plodinec, Richard L. Sidman, Webster K. Cavenee, Renata Pasqualini, Wadih Arap, Jason B. Fleming, Vittorio Cristini
Summary: The study showed that drug concentration at the tumor site can be used as a reliable biomarker for predicting chemotherapy outcome, and the mathematical modeling approach can be applied in clinical settings to customize treatment design for optimizing results.
Article
Chemistry, Multidisciplinary
Ana C. Puhl, Melina Mottin, Carolina Q. . Sacramento, Tatyana Almeida Tavella, Gabriel Goncalves Dias, Natalia Fintelman-Rodrigues, Jairo R. . Temerozo, Suelen S. G. Dias, Paulo Ricardo Pimenta da Silva Ramos, Eric M. Merten, Kenneth H. Pearce, Fabio Trindade Maranha Costa, Lakshmanane Premkumar, Thiago Moreno L. Souza, Carolina Horta Andrade, Sean Ekins
Summary: Finding antivirals for SARS-CoV-2 remains a major challenge, and vaccines play a crucial role in controlling the pandemic. This study identified a potential drug for targeting SARS-CoV-2 through computational and experimental techniques, showing antiviral activity in vitro and in vivo.
Review
Food Science & Technology
Cecilia Castro-Lopez, Hugo S. Garcia, Guillermo Cristian Guadalupe Martinez-Avila, Aaron F. Gonzalez-Cordova, Belinda Vallejo-Cordoba, Adrian Hernandez-Mendoza
Summary: The clinical evidence supporting the beneficial effects of probiotics in consumer's health and wellness has increased over the past two decades, leading to the production of different probiotic foods and strains by the food and pharmaceutical industries. Comprehensive trials are necessary to characterize probiotic candidates, including their resistance to physiological barriers, inhibition of pathogens, adherence to mucus, and other properties. Further research is needed to clarify the metabolic capabilities, adaptation features, physiological functions, safety, and molecular mechanisms underlying the functional activities of probiotics. Genomics-based approaches, such as probiogenomics, have been successfully applied to study current probiotics and identify new potential candidates with health-promoting and safety properties.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Surgery
H. Tibermacine, P. Rouanet, M. Sbarra, R. Forghani, C. Reinhold, S. Nougaret
Summary: The study evaluated and compared different radiomics approaches for predicting disease-free survival in patients with locally advanced rectal cancer. The 3D radiomics model outperformed qualitative analysis and showed good performance in predicting DFS. Radiomics models have the potential to predict DFS more accurately than qualitative analysis.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Acoustics
Cas Smits, Adriana A. Zekveld
Summary: Probabilistic models for quantifying context effects in speech recognition have been found valuable in audiology. Different models have been proposed to quantify the effect of context in sentence recognition, with signal-to-noise ratio-dependent context parameters providing the most accurate fit in Dutch sentence-in-noise tests. The importance of controlling for word recognition probability in isolation when comparing the use of sentence context between different groups of listeners has been demonstrated.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2021)
Review
Medicine, General & Internal
Adam E. Gaweda, Eleanor D. Lederer, Michael E. Brier
Summary: Chronic kidney disease (CKD) leads to severe bone loss, but the incomplete understanding of the pathophysiology and complexity of the disease hampers fracture prevention. This review proposes the use of mathematical modeling and artificial intelligence techniques to accelerate clinical trials and improve understanding of CKD osteoporosis. It also discusses the potential application of individualized precision medical therapy using principles of quantitative systems pharmacology, model predictive control, and reinforcement learning.
FRONTIERS IN MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Hamed Mohammadnejad, Bonnie A. Marion, Anthony A. Kmetz, Keith P. Johnson, Kurt D. Pennell, Linda M. Abriola
Summary: The successful application of nanoparticle-based subsurface technologies heavily relies on the mobility of nanoparticles, with the addition of Gum Arabic showing significant enhancement in nanoparticle mobility. Experiments demonstrated that co-injection of Gum Arabic could increase nanoparticle mobility by up to 2.47-fold. Multi-dimensional model simulations accurately captured the enhanced transport of nanoparticles in the presence of Gum Arabic, with a coefficient of determination (R-2) of 0.82 across all observations.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Computer Science, Information Systems
Mahsasadat Seyedbarhagh, Arash Ahmadi, Majid Ahmadi
Summary: This paper investigates the important role of astrocyte cells in neural networks, proposing a modified neuron-astrocyte interaction model designed using a hardware approach called stochastic computing paradigm. The results show that astrocyte cells can modulate the behavior of neural networks by providing appropriate feedback mechanisms and with lower hardware costs.
Article
Oncology
Helen Salome Keck, Frank-Juergen Weinreich, Ranjita Shegokar, Alfred Koenigsrainer, Marc Andre Reymond, Giorgi Nadiradze
Summary: The study demonstrates the feasibility of using Icodextrin solution as a carrier for pressurized intraperitoneal aerosol chemotherapy with Cisplatin and Doxorubicin. Icodextrin remains stable after aerosolization, significantly affects the adhesion of gastric cancer cells, and does not impair the cytotoxic effects of the chemotherapeutic drugs.
Article
Environmental Sciences
S. Poomagal, R. Sujatha, P. Senthil Kumar, Dai-Viet N Vo
Summary: This study used a mathematical model based on Fuzzy Cognitive Map to analyze the negative effects of Malathion on human health and ecosystems, establishing causal relationships through mathematical simulation. This approach provides an effective method for studying the impact of any pesticide on human health and the environment.
Article
Energy & Fuels
Mohammed-Hichem Benzaama, Farjallah Alassaad, Lala Rajaoarisoa, Karim Touati
Summary: This paper presents the thermal behavior prediction of bio-based walls with Phase Change Materials (PCMs) using artificial neural networks. Long-Short-Term Memory (LSTM) and Convolutional Neural Network (CNN) models are assessed based on in-situ study. The results show that these models can accurately predict heat transfers in bio-based walls with or without phase change materials, with the CNN model being more accurate in predicting processes involving phase shift.
JOURNAL OF ENERGY STORAGE
(2023)
Review
Pharmacology & Pharmacy
Vijayalakshmi Chelliah, Georgia Lazarou, Sumit Bhatnagar, John P. Gibbs, Marjoleen Nijsen, Avijit Ray, Brian Stoll, R. Adam Thompson, Abhishek Gulati, Serguei Soukharev, Akihiro Yamada, Jared Weddell, Hiroyuki Sayama, Masayo Oishi, Sabine Wittemer-Rump, Chirag Patel, Christoph Niederalt, Rolf Burghaus, Christian Scheerans, Joerg Lippert, Senthil Kabilan, Irina Kareva, Natalya Belousova, Alex Rolfe, Anup Zutshi, Marylore Chenel, Filippo Venezia, Sylvain Fouliard, Heike Oberwittler, Alix Scholer-Dahirel, Helene Lelievre, Dean Bottino, Sabrina C. Collins, Hoa Q. Nguyen, Haiqing Wang, Tomoki Yoneyama, Andy Z. X. Zhu, Piet H. van der Graaf, Andrzej M. Kierzek
Summary: Drug development in oncology often uses molecular biology tools to reprogram cellular responses for therapeutic benefits. In immuno-oncology, the goal is to mobilize the patient's immune system against cancer. While successful with antibodies targeting specific receptors, the trend has shifted towards combination therapies, which presents challenges in efficiency and sustainability.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Microbiology
Xin Zhu, Anshan Shan, Zhi Ma, Wei Xu, Jiajun Wang, Shuli Chou, Baojing Cheng
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Behavioral Sciences
Angela Allen, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2013)
Article
Behavioral Sciences
Taylor Hatchard, Jaimee J. Ting, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2014)
Article
Cell Biology
Darren J. Yip, Chelsea P. Corcoran, Matias Alvarez-Saavedra, Adriana DeMaria, Stephen Rennick, Alan J. Mears, Michael A. Rudnicki, Claude Messier, David J. Picketts
DEVELOPMENTAL CELL
(2012)
Article
Developmental Biology
Federica De Angelis, Antonietta Bernardo, Valerio Magnaghi, Luisa Minghetti, Ada Maria Tata
DEVELOPMENTAL NEUROBIOLOGY
(2012)
Article
Neurosciences
Andra M. Smith, Claude Messier
FRONTIERS IN HUMAN NEUROSCIENCE
(2014)
Article
Geriatrics & Gerontology
Delyana Miller, Michle Gagnon, Vincent Talbot, Claude Messier
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2013)
Review
Geriatrics & Gerontology
Delyana I. Miller, Vanessa Taler, Patrick S. R. Davidson, Claude Messier
NEUROBIOLOGY OF AGING
(2012)
Article
Neurosciences
Reno M. Gandhi, Cary S. Kogan, Claude Messier, Lindsey S. MacLeod
Review
Neurosciences
J. J. Boulanger, C. Messier
Article
Health Care Sciences & Services
Delyana Ivanova Miller, France Aube, Vincent Talbot, Michele Gagnon, Claude Messier
TELEMEDICINE AND E-HEALTH
(2014)
Article
Neurosciences
Reno M. Gandhi, Cary S. Kogan, Claude Messier
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Article
Neurosciences
Alexandria Beland-Millar, Masaki Takimoto, Taku Hamada, Claude Messier
Article
Behavioral Sciences
Jenna J. Boulanger, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Psychology, Educational
Delyana I. Miller, Patrick S. R. Davidson, Dwayne Schindler, Claude Messier
JOURNAL OF PSYCHOEDUCATIONAL ASSESSMENT
(2013)