Article
Medicine, Research & Experimental
Sakdiphong Punpai, Audchara Saenkham, Faongchat Jarintanan, Suchada Jongrungruangchok, Kiattawee Choowongkomon, Sunit Suksamrarn, Wanlaya Tanechpongtamb
Summary: The xanthone derivative Cowanin extracted from Garcinia fusca has been found to exhibit antimicrobial, anti-inflammatory, and anticancer activities. It functions as a histone deacetylase inhibitor (HDACi), inhibiting HDAC activity and inducing cancer cell death through apoptosis and autophagy. Cowanin also suppresses the PI3K/AKT/mTOR pathway to inhibit cancer cell growth.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Adriana Celesia, Marzia Franzo, Diana Di Liberto, Marianna Lauricella, Daniela Carlisi, Antonella D'Anneo, Antonietta Notaro, Mario Allegra, Michela Giuliano, Sonia Emanuele
Summary: We previously showed that the HDAC inhibitor ITF2357 targets oncogenic BRAF in melanoma cells. In this study, we found that oncogenic BRAF localizes to the nucleus of these cells and ITF2357 reduces both nuclear and cytosolic BRAF levels. We also observed an interaction between BRAF and oncogenic p53, and ITF2357 decreased levels of both proteins in certain melanoma cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Laura Urwanisch, Michael Stefan Unger, Helene Sieberer, Hieu-Hoa Dang, Theresa Neuper, Christof Regl, Julia Vetter, Susanne Schaller, Stephan M. Winkler, Emanuela Kerschbamer, Christian X. Weichenberger, Peter W. Krenn, Michela Luciano, Lisa Pleyer, Richard Greil, Christian G. Huber, Fritz Aberger, Jutta Horejs-Hoeck
Summary: Epigenetic alterations play a significant role in cancer development, and the reversible nature of epigenetic changes makes them attractive targets for therapy. In this study, the authors investigated the expression of HDAC genes in AML patients and cell lines, and the effects of the HDAC inhibitor TMP269 on AML cells. They found significant overexpression of various HDACs in AML and observed that TMP269 treatment had effects on the proteome and growth of AML cells. Additionally, they demonstrated that the combination of TMP269 and venetoclax resulted in enhanced cell apoptosis. These findings highlight the potential of TMP269 as a therapeutic compound for AML.
Article
Dermatology
Lina Song, Anne Catherine Bretz, Jan Gravemeyer, Ivelina Spassova, Shakhlo Muminova, Thilo Gambichler, Ashwin Sriram, Soldano Ferrone, Juergen C. Becker
Summary: Merkel cell carcinoma is a rare and highly aggressive skin cancer, with immune modulation by immune checkpoint inhibitors showing promise. However, resistance to immunotherapy remains a significant challenge. Histone deacetylase inhibitors like domatinostat have shown potential to reverse low MHC I expression and increase MCC cells' susceptibility to cytotoxic T cell recognition and elimination.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Munevver Yenigul, Emel Basak Gencer Akcok
Summary: Cholangiocarcinoma, a type of biliary tract cancer, is an aggressive adenocarcinoma originating from the epithelial cells of the biliary system. The effects of autophagy modulators and HDAC inhibitors on cholangiocarcinoma are not fully understood. Understanding the molecular mechanisms and effects of HDAC inhibitors in the context of cholangiocarcinoma is essential.
Article
Biochemistry & Molecular Biology
Hsueh-Yun Lee, Di-Wei Tang, Chi-Yuan Liu, Er-Chieh Cho
Summary: This study focuses on the development of benzamide-based compounds as potential HDAC1/2 inhibitors for colorectal cancer treatment. Compound 9 is identified as a selective HDAC inhibitor with significant anticancer activity against colorectal cancer cells. The study also investigates the molecular regulatory mechanisms of compound 9, demonstrating its potential in apoptosis activation, cell cycle arrest induction, DNA damage facilitation, and cancer migration suppression in colorectal cancer cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Cell Biology
Yuki Kanda, Ayami Mizuno, Teruaki Takasaki, Ryosuke Satoh, Kanako Hagihara, Takashi Masuko, Yuichi Endo, Genzoh Tanabe, Reiko Sugiura
Summary: DUSP6 is a key negative regulator of the RAS-ERK MAPK signaling pathway, and its up-regulation may promote growth in cancer cells overexpressing HER2. ACA-28, a novel anticancer compound, down-regulates DUSP6 through proteasome activity to inhibit proliferation and induce apoptosis in HER2-overexpressing cancer cells.
Article
Oncology
Xuan Dai, Wenjun Ding, Yongshan He, Shiyong Huang, Yun Liu, Tingyu Wu
Summary: In this study, the efficacy and safety of regorafenib combined with PD-1 inhibitor in refractory MSS CRC were evaluated. The results showed that this combination treatment regimen is feasible and well-tolerated. ERBB2/ERBB3 mutation was identified as a potential predictive factor for treatment response.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Medicinal
Ki-Back Chu, Hae-Ahm Lee, Marc Pflieger, Fabian Fischer, Yodita Asfaha, Leandro A. Alves Avelar, Alexander Skerhut, Matthias U. Kassack, Finn K. Hansen, Andrea Schoeler, Thomas Kurz, Min-Jeong Kim, Eun-Kyung Moon, Fu-Shi Quan
Summary: Acanthamoeba is a pathogen causing severe corneal infection, and the drug-based treatment for this infection has been challenging. Recently, histone deacetylase inhibitors (HDACi) were found to have strong amoebicidal effects on Acanthamoeba trophozoites and can inhibit their encystation process. This discovery highlights the potential of HDACi for further development in treating Acanthamoeba keratitis.
ACS INFECTIOUS DISEASES
(2022)
Article
Cell Biology
Dongjie Zhou, Ming-Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song-Hee Lee, Geun Heo, Jungseok Choi, Kwan-Suk Kim, Xiang-Shun Cui
Summary: In this study, the mRNA level of YME1L1 was knocked down in pig embryos and the expression patterns of YME1L1 and related proteins were examined. It was found that YME1L1 is localized in the punctate structures of mitochondria and highly expressed from the 4-cell stage. Knocking down YME1L1 led to decreased blastocyst rate and quality, mitochondrial fragmentation, excessive ROS production, lower mitochondrial membrane potential and ATP levels. Moreover, YME1L1 knockdown induced OPA1 cleavage and cytochrome c release. These findings demonstrate that YME1L1 is crucial for regulating mitochondrial fission, function, and apoptosis during porcine embryo preimplantation development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yue Hu, Yao-Dong Dong, Yan-Chao Wu, Qiu-Xu Wang, Xiang Nan, Da-Li Wang
Summary: The study investigated the protective effects of AMPK inhibitor BML-275 on cerebral ischemia/reperfusion injury and found that BML-275 could alleviate cerebral infarction, neurological deficit, and neuronal apoptosis induced by occlusion. The inhibitor also induced anti-apoptosis and decreased the expression of apoptosis markers, suggesting that anti-apoptosis may be a potential neuroprotective strategy for stroke treatment.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Hongwei Zhang, Fenqing Chi, Keru Qin, Xiuli Mu, Lieyang Wang, Bin Yang, Yanli Wang, Min Bai, Zhenhua Li, Liping Su, Baofeng Yu
Summary: The study found that Chidamide induces apoptotic death of DLBCL cells by promoting cellular apoptosis, decreasing Bcl-2 expression, and reducing the levels of STAT3 and its phosphorylation. These results support the potential of Chidamide as an effective therapeutic agent for treating DLBCL.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Dong-Lin Yang, Yong Li, Shui-Qing Ma, Ya-Jun Zhang, Jiu-Hong Huang, Liu-Jun He
Summary: In this study, a novel compound, termed compound 275#, was synthesized and found to suppress the proliferation and growth of colorectal cancer cell lines by inducing mitochondria-mediated apoptosis and autophagy activation. The mechanism of action was attributed to an increase in intracellular accumulation of reactive oxygen species (ROS) in colorectal cancer cells. These findings highlight the potential of compound 275# as a novel therapeutic agent for the treatment of colorectal cancer.
Article
Cell Biology
Yanli Bi, Longyuan Gong, Pengyuan Liu, Xiufang Xiong, Yongchao Zhao
Summary: This study reveals a novel mechanism in which nuclear ErbB2 represses the transcription of DEPTOR, leading to activation of the PI3K/AKT/mTOR pathway to inhibit autophagy.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Hui Li, Mridul Roy, Long Liang, Wenjie Cao, Bin Hu, Yanan Li, Xiaojuan Xiao, Haiqin Wang, Mao Ye, Shuming Sun, Bin Zhang, Jing Liu
Summary: This study identified the deubiquitylase USP12 plays an important role in pro-survival autophagy and drug resistance in multiple myeloma by stabilizing HMGB1 protein. The USP12/HMGB1 axis might be a potential diagnostic and therapeutic target in human MM.
Article
Biotechnology & Applied Microbiology
Hu Zhao, Xiaofeng Lai, Wei Zhang, Hehuan Zhu, Shenhang Zhang, Weizhen Wu, Shuiliang Wang, Minying Tang, Zhen Deng, Jianming Tan
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2019)
Article
Multidisciplinary Sciences
Ping Wang, Zengli Zhang, Yuji Ma, Jun Lu, Hu Zhao, Shuiliang Wang, Jianming Tan, Bingyan Li
Review
Biochemical Research Methods
Xiaolong Liu, Shuang Liu, Hui Lyu, Adam I. Riker, Yamin Zhang, Bolin Liu
BIOLOGICAL PROCEDURES ONLINE
(2019)
Article
Cell Biology
Hu Zhao, Junqiu Chen, Jin Chen, Xuhui Kong, Hehuan Zhu, Yongping Zhang, Huiyue Dong, Jie Wang, Qun Ren, Qinghua Wang, Shushang Chen, Zhen Deng, Zhan Chen, Qiang Cui, Junqiong Zheng, Jun Lu, Shuiliang Wang, Jianming Tan
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Oncology
Tingting Lin, Qun Ren, Weimin Zuo, Ruxue Jia, Linhui Xie, Rong Lin, Hu Zhao, Jin Chen, Yan Lei, Ping Wang, Huiyue Dong, Lianghu Huang, Jinquan Cai, Yonghai Peng, Zongyang Yu, Jianming Tan, Shuiliang Wang
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Yuanming Cai, Ruxue Jia, Haozhe Xiong, Qun Ren, Weimin Zuo, Tingting Lin, Rong Lin, Yan Lei, Ping Wang, Huiyue Dong, Hu Zhao, Ling Zhu, Yunfeng Fu, Zhiyong Zeng, Wei Zhang, Shuiliang Wang
CANCER MANAGEMENT AND RESEARCH
(2019)
Article
Medicine, Research & Experimental
Wencui Kong, Xiaoming Ling, Ying Chen, Xiaoli Wu, Zhongquan Zhao, Wenwu Wang, Shuiliang Wang, Guoxiang Lai, Zongyang Yu
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2020)
Article
Medicine, Research & Experimental
Jun Lu, Zhan Chen, Hu Zhao, Huiyue Dong, Ling Zhu, Yi Zhang, Jie Wang, Hehuan Zhu, Qiang Cui, Chuang Qi, Shuiliang Wang, Shushang Chen, Jichun Shao
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Cell & Tissue Engineering
Jin Chen, Junqiu Chen, Yuanhang Cheng, Yunfeng Fu, Hongzhou Zhao, Minying Tang, Hu Zhao, Na Lin, Xiaohua Shi, Yan Lei, Shuiliang Wang, Lianghu Huang, Weizhen Wu, Jianming Tan
STEM CELL RESEARCH & THERAPY
(2020)
Article
Oncology
Ping Wang, Jiming Xu, Weijing You, Yongfeng Hou, Shuiliang Wang, Yujie Ma, Jianming Tan, Zengli Zhang, Wentao Hu, Bingyan Li
FRONTIERS IN ONCOLOGY
(2020)
Article
Cell Biology
Wencui Kong, Ying Chen, Zhongquan Zhao, Lei Zhang, Xiandong Lin, Xingguang Luo, Shuiliang Wang, Zhengbo Song, Xiangwu Lin, Guoxiang Lai, Zongyang Yu
Summary: DNA methylation of EXT1 gene is associated with lung cancer prognosis, affecting cell proliferation and migration through the WNT signaling pathway. Targeting EXT1 may have therapeutic potential in lung cancer.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Shuang Liu, Erik Polsdofer, Lukun Zhou, Sanbao Ruan, Hui Lyu, Defu Hou, Hao Liu, Ann D. Thor, Zhimin He, Bolin Liu
Summary: Metformin increases TRAIL expression and induces apoptosis in TNBC and NSCLC cells, showcasing potent antitumor activity by activating the death receptor signaling pathway.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Chemistry, Analytical
Huimin Niu, Shumei Cai, Xueke Liu, Xiaoming Huang, Juan Chen, Shuiliang Wang, Shenghang Zhang
Summary: A new sandwich-like electrochemical immunosensing platform has been developed using C-Ti3C2Tx MXene and RhB/Au/Gr, which shows great potential for the detection of Listeria monocytogenes and other analytes with a very low limit of detection.
ANALYTICAL METHODS
(2022)
Article
Biochemical Research Methods
Hao Liu, Sanbao Ruan, Margaret E. Larsen, Congcong Tan, Bolin Liu, Hui Lyu
Summary: Resistance to HER2-targeted therapies is a challenge in the treatment of HER2-positive breast cancer. In a tumor xenograft model, tumors derived from SKBR3-pool2 and BT474-HR20 cells respond differently to lapatinib treatment, with BT474-HR20 tumors showing resistance.
BIOLOGICAL PROCEDURES ONLINE
(2023)
Article
Oncology
Jie Wang, Hu Zhao, Huiyue Dong, Ling Zhu, Shuiliang Wang, Ping Wang, Qun Ren, Hehuan Zhu, Junqiu Chen, Zhijie Lin, Yuanhang Cheng, Benjiang Qian, Yi Zhang, Ruxue Jia, Weizheng Wu, Jun Lu, Jianming Tan