Review
Immunology
Ellen N. Scott, Angela M. Gocher, Creg J. Workman, Dario A. A. Vignali
Summary: Regulatory T cells utilize multiple suppressive mechanisms to hinder effector immune responses within the tumor microenvironment, creating a physical and biological barrier that results in immune exclusion or limitation within the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Mikhail Salnikov, Martin A. A. Prusinkiewicz, Sherman Lin, Farhad Ghasemi, Matthew J. J. Cecchini, Joe S. S. Mymryk
Summary: EBVaGCs exhibit a T cell-inflamed phenotype with increased T and NK cell infiltration, immune checkpoint marker expression, and T cell effector molecules compared to EBVnGCs. Six EBV-encoded miRNAs are strongly negatively correlated with the expression of immune checkpoint receptors and markers of anti-tumor immunity. These differences may explain the divergent pathological and clinical outcomes between EBVaGCs and EBVnGCs.
Article
Immunology
Ti Zhang, Mengmeng Wang, Jiaxun Zhang, Xiaopian Feng, Zhengzhao Liu, Zhen Cheng
Summary: In patients with lupus nephritis, the number of tubulointerstitial CD8+T cells correlates with clinicohistologic impairment, and levels exceeding 130/mm(2) are independently associated with an unfavorable kidney outcome.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kuo-Ti Peng, Jiun-Liang Chen, Liang-Tseng Kuo, Pei-An Yu, Wei-Hsiu Hsu, Chiang-Wen Lee, Pey-Jium Chang, Tsung-Yu Huang
Summary: The study found that GMI, a fungal immunomodulatory peptide isolated from Ganoderma microsporum, suppresses MDSC expansion and promotes the proliferation of cytotoxic T cells by increasing the expression of IL-6 and TNF-alpha and reducing ROS expression. This suggests that GMI may be potentially useful for treating Staphylococcus aureus-induced PJIs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ina N. Eckert, Eliana Ribechini, Katja J. Jarick, Sandra Strozniak, Sarah J. Potter, Andreas Beilhack, Manfred B. Lutz
Summary: The study discovered that the adhesion of VLA-1 integrin to collagen IV plays a critical role in extending the contact time between MDSCs and T cells, which is necessary for suppression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Julia Strandmark, Alansana Darboe, Joann Diray-Arce, Rym Ben-Othman, Sofia M. Vignolo, Shun Rao, Kinga K. Smolen, Geert Leroux-Roels, Olubukola T. Idoko, Guzman Sanchez-Schmitz, Al Ozonoff, Ofer Levy, Tobias R. Kollmann, Arnaud Marchant, Beate Kampmann, EPIC Consortium
Summary: The study shows that a single birth dose of Hepatitis B vaccine can induce antigen-specific polyfunctional CD4(+) T-cells, and the frequency of polyfunctional T-cells increases after completing the vaccine schedule. The production of these polyfunctional T-cells is positively correlated with serum antibody titres.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Najmeh Bozorgmehr, Isobel Okoye, Olaide Oyegbami, Lai Xu, Amelie Fontaine, Nanette Cox-Kennett, Loree M. Larratt, Mark Hnatiuk, Andrei Fagarasanu, Joseph Brandwein, Anthea C. Peters, Shokrollah Elahi
Summary: The study found that CD160 was the most upregulated co-inhibitory receptor in patients with CLL, and its expression was associated with an exhausted T cell phenotype. EVs were identified as a source of CD160 in the plasma of CLL patients. Additionally, a dominantly proinflammatory cytokine profile, especially elevated interleukin-16, was observed in CLL patients' plasma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Najmeh Bozorgmehr, Mark Hnatiuk, Anthea C. Peters, Shokrollah Elahi
Summary: This study found that CD26(+)CD8(+) T cells are reduced in chronic lymphocytic leukemia (CLL), but they possess polyfunctionality and durability, making them potential candidates for immunotherapy. Additionally, malignant B cells induce apoptosis of CD26(+)CD8(+) T cells through the release of Galectin-9.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Immunology
Jatin Machhi, Pravin Yeapuri, Yaman Lu, Emma Foster, Rupesh Chikhale, Jonathan Herskovitz, Krista L. Namminga, Katherine E. Olson, Mai Mohamed Abdelmoaty, Ju Gao, Rolen M. Quadros, Tomomi Kiyota, Liang Jingjing, Bhavesh D. Kevadiya, Xinglong Wang, Yutong Liu, Larisa Y. Poluektova, Channabasavaiah B. Gurumurthy, R. Lee Mosley, Howard E. Gendelman
Summary: Alzheimer's disease is characterized by pathological deposition of misfolded self-protein amyloid beta, leading to neuroinflammation. Effector T cells induced by self-antigens accelerate disease progression, suggesting a potential therapeutic target in controlling AD pathology.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Likai Tan, Alina Suzann Fichtner, Elena Bruni, Ivan Odak, Inga Sandrock, Anja Bubke, Alina Borchers, Christian Schultze-Florey, Christian Koenecke, Reinhold Foerster, Michael Jarek, Constantin von Kaisenberg, Ansgar Schulz, Xiaojing Chu, Bowen Zhang, Yang Li, Ulf Panzer, Christian F. Krebs, Sarina Ravens, Immo Prinz
Summary: The study reveals distinct waves of human innate-like effector gamma delta T cells in early fetal thymus, with semi-invariant V gamma 9V delta 2(+) TCR. High heterogeneity of gamma delta T cells in neonatal and adult blood is correlated with TCR usage. Effector gamma delta T cells with type 1 and type 3 innate T cell signatures were detected in embryonic thymus organogenesis.
SCIENCE IMMUNOLOGY
(2021)
Review
Immunology
Michael L. Dixon, Jonathan D. Leavenworth, Jianmei W. Leavenworth
Summary: Regulatory T-cells, particularly effector Tregs (eTregs), play a crucial role in maintaining self-tolerance and tissue homeostasis, with potential implications in tumor development. Understanding the mechanisms that modulate the stability and suppressive function of tumoral Tregs, such as eTregs and T-FR cells, can lead to the development of more effective cancer immunotherapies that target the tumor microenvironment while minimizing systemic side effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ambily Anna Mathew, Zahara T. Zakkariya, Anusha Ashokan, Maneesh Manohar, Pavithran Keechilat, Shantikumar V. Nair, Manzoor Koyakutty
Summary: The researchers used various strategies to reverse the non-immunogenic character of the cold tumor, including photodynamic therapy, TAM repolarization, immune checkpoint inhibition, and MDSC depletion. Among them, low-dose 5-fluorouracil chemotherapy showed significant anti-tumor effects, primarily due to the increased infiltration of CD8+ cytotoxic T-cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Aenne Harberts, Constantin Schmidt, Joanna Schmid, Daniel Reimers, Friedrich Koch-Nolte, Hans-Willi Mittruecker, Friederike Raczkowski
Summary: IRF4 is essential for the activation and reactivation of CD8(+) memory T cells, but does not affect their overall survival. However, the formation and maintenance of CD8(+) tissue-resident memory T cells appears to depend on IRF4.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Vedika Mehra, Giulia Agliardi, Juliana Dias Alves Pinto, Manar S. Shafat, Amaia Cadinanos Garai, Louisa Green, Alastair Hotblack, Fred Arce Vargas, Karl S. Peggs, Anniek B. van der Waart, Harry Dolstra, Martin A. Pule, Claire Roddie
Summary: This study evaluated the use of AKT inhibitor (VIII) to enrich Tscm/Tcm subsets, aiming to improve the expansion and persistence of AUTO1. The results showed that AUTO1 manufactured with VIII exhibited Tscm/Tcm enrichment, improved expansion, and cytotoxicity in vitro, as well as superior antitumor activity in vivo. Moreover, VIII-induced AUTO1 showed Th1/Th17 skewing, increased polyfunctionality, and had a unique metabolic profile and autophagy signature, supporting enhanced expansion and cytotoxicity. Overall, AUTO1 generated with VIII may help overcome CD19+relapse.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Vivien Koh, Jayati Chakrabarti, Meaghan Torvund, Nina Steele, Jennifer A. Hawkins, Yoshiaki Ito, Jiang Wang, Michael A. Helmrath, Juanita L. Merchant, Syed A. Ahmed, Asim Shabbir, Jimmy Bok Yan So, Wei Peng Yong, Yana Zavros
Summary: The study shows that PD-L1 expression in gastric cancer is mediated by Hh and mTOR signaling pathways. Patient-derived organoid/immune cell co-cultures can be used to study immunosuppressive MDSC function. DSP analysis reveals infiltration of immunosuppressive MDSCs in gastric cancer tissues.
Editorial Material
Geriatrics & Gerontology
Graham Pawelec, Janet McElhaney
Article
Geriatrics & Gerontology
Graham Pawelec, Janet McElhaney
Summary: The rapid development and testing of COVID-19 vaccines have shown high efficacy in older adults, potentially leading to a paradigm shift in understanding the impact of immunosenescence on vaccination against novel infectious diseases.
Article
Cell Biology
Nicola Beucke, Svenja Wingerter, Karin Haehnel, Lisbeth Aagaard Larsen, Kaare Christensen, Graham Pawelec, Kilian Wistuba-Hamprecht
Summary: The study found that latent cytomegalovirus infection affects the differentiation status of alpha beta and gamma delta T cells in humans. Additionally, genetic factors also influence the differentiation of gamma delta and alpha beta T cell subsets.
Article
Allergy
T. Fulop, A. Larbi, G. Pawelec, A. Khalil, A. A. Cohen, K. Hirokawa, J. M. Witkowski, C. Franceschi
Summary: The concept of inflammaging introduced by Prof. Franceschi in 2000 revolutionized the understanding of immune changes in response to lifelong stress. It highlights the dichotomy of the proinflammatory process, influenced by genetics and the environment, leading to either beneficial or detrimental consequences. Moreover, it elucidates the complex and systemic nature of aging, opening avenues for studying counter-processes in addition to the process itself. This concept also paves the way for potential multimodal interventions to optimize aging towards healthy longevity.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)
Article
Immunology
Nicola Herold, Anna Schollhorn, Adrian Feile, Andrea Gaissler, Anne Mohrholz, Graham Pawelec, Markus W. Loeffler, Stoyan Dimitrov, Cecile Gouttefangeas, Kilian Wistuba-Hamprecht
Summary: This study investigates the applicability of m24 antibody in the detection of gamma delta T cell activation. The results show that m24 antibody staining is associated with cytokine expression and allows for rapid assessment of activation, eliminating the need for intracellular staining or protein trafficking inhibitors.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Nikolaus Buchmann, Jens Fielitz, Dominik Spira, Maximilian Koenig, Kristina Norman, Graham Pawelec, David Goldeck, Ilja Demuth, Elisabeth Steinhagen-Thiessen
Summary: The study found that inflammation is associated with lower muscle mass, particularly in individuals with Metabolic syndrome (MetS). Controlling MetS may help prevent sarcopenia.
Editorial Material
Geriatrics & Gerontology
Graham Pawelec
Editorial Material
Immunology
Stephanie E. B. McArdle, Graham Pawelec, Alan Graham Pockley, Pal Johansen
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Jonas Bochem, Henning Zelba, Janine Spreuer, Teresa Amaral, Andrea Gaissler, Oltin T. Pop, Karolin Thiel, Can Yurttas, Daniel Soffel, Stephan Forchhammer, Tobias Sinnberg, Heike Niessner, Friedegund Meier, Patrick Terheyden, Alfred Koenigsrainer, Claus Garbe, Lukas Flatz, Graham Pawelec, Thomas K. Eigentler, Markus W. Loeffler, Benjamin Weide, Kilian Wistuba-Hamprecht
Summary: This study found that the initial presence of NY-ESO-1- or Melan-A-reactive T cells in the circulation, which became undetectable during PD-1 immune-checkpoint blockade treatment, correlated with prolonged progression-free survival and overall survival in metastatic melanoma patients. Additionally, the presence of tumor-resident NY-ESO-1- and Melan-A-reactive T cells was associated with disease control, suggesting that PD-1 blockade may lead to the infiltration of melanoma-reactive T cells from the periphery into the tumor, contributing to effective treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Geriatrics & Gerontology
Emilie Picard, Sarah Armstrong, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, George A. Kuchel, Janet E. McElhaney, Chris P. Verschoor
Summary: The study found a significant association between systemic inflammation levels and antibody responses to the seasonal influenza vaccine, particularly in older adults receiving high vaccine doses.
Editorial Material
Medicine, General & Internal
Graham Pawelec
Review
Immunology
Tamas Fulop, Anis Larbi, Graham Pawelec, Alan A. Cohen, Guillaume Provost, Abedelouahed Khalil, Guy Lacombe, Serafim Rodrigues, Mathieu Desroches, Katsuiku Hirokawa, Claudio Franceschi, Jacek M. Witkowski
Summary: Organismal ageing is associated with changes in the immune system, which can lead to age-related diseases and decreased vaccine responses. However, recent advances in vaccine technology and understanding of immune ageing have contributed to the development of vaccines that can protect the health of older adults as well as younger individuals.
Article
Immunology
Andrea Gaissler, Trine Sundebo Meldgaard, Christina Heeke, Sepideh Babaei, Siri Amanda Tvingsholm, Jonas Bochem, Janine Spreuer, Teresa Amaral, Nikolaus Benjamin Wagner, Reinhild Klein, Friedegund Meier, Claus Garbe, Thomas K. Eigentler, Graham Pawelec, Manfred Claassen, Benjamin Weide, Sine Reker Hadrup, Kilian Wistuba-Hamprecht
Summary: This study investigated the dynamics of tumor antigen-specific T cells in the circulation of metastatic melanoma patients during anti-PD-1 treatment. The researchers identified a correlation between an increase in MAE-specific CD8+ T cell populations and improved overall survival. The study also found an increase in TIM-3+ and LAG-3+ T cells in patients with a dominantly increased MAE-specific CD8+ T cell signature. These findings contribute to a better understanding of biomarkers of response and anti-cancer mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Chris P. Verschoor, Daniel W. Belsky, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, Janet E. McElhaney, George A. Kuchel
Summary: Biological age was found to be associated with improved antibody responses to influenza vaccination, depending on vaccine dose and cytomegalovirus (CMV) serostatus.
Article
Geriatrics & Gerontology
Johanna Drewelies, Gizem Hueluer, Sandra Duezel, Valentin Max Vetter, Graham Pawelec, Elisabeth Steinhagen-Thiessen, Gert G. Wagner, Ulman Lindenberger, Christina M. Lill, Lars Bertram, Denis Gerstorf, Ilja Demuth
Summary: Biological age, calculated based on parameters from standard laboratory blood tests, is an important indicator of aging, as it is associated with physician-observed morbidity and mortality risk beyond the effects of other biomarkers.