Article
Medicine, Research & Experimental
Cho-Won Kim, Hong Kyu Lee, Min-Woo Nam, Gabsang Lee, Kyung-Chul Choi
Summary: This study found that KiSS1 overexpression increases the growth and migration of metastatic prostate cancer cells, as well as promoting tumor metastasis and angiogenesis. These findings highlight the critical role of KiSS1 in prostate cancer progression.
Article
Biochemistry & Molecular Biology
Cho-Won Kim, Hong Kyu Lee, Min-Woo Nam, Youngdong Cho, Kyung-Chul Choi
Summary: KiSS1 promotes the proliferation, migration, and metastasis of liver cancer cells, which is associated with changes in the expressions of epithelial mesenchymal transition-related genes and increased angiogenic capacity.
MOLECULES AND CELLS
(2022)
Article
Biochemistry & Molecular Biology
Lucas Trevisan Franca de Lima, Fernando Augusto de Oliveira Ganzella, Gabriela Casani Cardoso, Veronica dos Santos Pires, Andressa Chequin, Giulia Luiza Santos, Karin Braun-Prado, Claudia Martins Galindo, Odair Braz Braz Junior, Marcelo Beltrao Molento, Alexandra Acco, Eliana Rezende Adami, Erico Tosoni Costa, Celia Regina Cavichiolo Franco, Giseli Klassen, Edneia Amancio de Souza Ramos
Summary: The monoterpene L-carvone (CRV) found in spearmint has been shown to inhibit adhesion, migration, and invasion of breast cancer cells in vitro and suppress tumor growth in mice. Mechanistic studies revealed that CRV disrupts focal adhesion by modulating the beta 1-integrin/FAK signaling pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Oncology
Hongyu Yuan, Zitong Zhao, Jing Xu, Ruiping Zhang, Liying Ma, Jing Han, Weihong Zhao, Mingzhou Guo, Yongmei Song
Summary: This study elucidated the molecular mechanism of TMTC3 in regulating tumor angiogenesis and identified the potential therapeutic combination of TMTC3 inhibitor and cisplatin, providing a promising strategy for the treatment of esophageal squamous cell carcinoma (ESCC).
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Tanyaporn Keratibumrungpong, Warunee Srisuthtayanont, Orawan Wanachewin, Jeerawan Klangjorhor, Thanyaluck Phitak, Peraphan Pothacharoen, Thuzar Hla Shwe, Prachya Kongtawelert
Summary: This study investigates the effect of sesame seed phytochemical sesamin on physiological and pathological angiogenesis. Sesamin significantly inhibits VEGFA-induced pathological angiogenesis and reduces vascular branching, endothelial cell proliferation, and migration. It also inhibits the activation of Src and FAK signaling proteins and reduces the expression of angiogenesis-related genes, suggesting its potential use in the prevention or treatment of diseases with excessive angiogenesis.
Article
Pharmacology & Pharmacy
Chen Zhao, Hio-Tong Kam, Yan Chen, Guiyi Gong, Maggie Pui-Man Hoi, Krystyna Skalicka-Wozniak, Alberto Carlos Pires Dias, Simon Ming-Yuen Lee
Summary: The study revealed that crocetin was more effective than crocin in inhibiting angiogenesis by regulating the VEGF/VEGFR2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Developmental Biology
Yuko Yoshida, Atsushi Yamada, Yoshihiro Akimoto, Kyoko Abe, Sachie Matsubara, Junri Hayakawa, Junichi Tanaka, Mitsuhiro Kinoshita, Tadashi Kato, Hiroaki Ogata, Akiko Sakashita, Kenji Mishima, Yoshiaki Kubota, Hayato Kawakami, Ryutaro Kamijo, Takehiko Iijima
Summary: Cdc42 plays a critical role in blood vessel formation in vascular endothelial cells, as shown by the abnormal vascular phenotypes in Cdc42 cKO mice and reduced vascular sprouting induced by VEGF-A. Electron microscopy revealed detachment of endothelial cells and macrophage-induced phagocytosis of dead endothelial cells in Cdc42 cKO mice.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Nehal Gupta, Sanjay K. Srivastava
Summary: Atovaquone shows anti-metastatic effects on triple-negative breast cancer by inducing apoptosis and reducing the expression of genes related to metastatic potential. In vivo experiments demonstrate that atovaquone significantly suppresses the growth of metastatic tumors in the lungs, liver, and brain, suggesting its potential as a treatment for breast cancer metastasis.
Article
Cell Biology
Ming-Jen Hsu, Han-Kun Chen, Jin-Cherng Lien, Yu-Han Huang, Shiu-Wen Huang
Summary: This study evaluated the anti-angiogenic properties of a new naphthoquinone derivative, PPE8, and explored its mechanisms of action. The results showed that PPE8 reduced proliferation, migration, invasion, and tube formation in human umbilical vein endothelial cells (HUVECs) induced by VEGF-A. It also inhibited micro vessel sprouting and angiogenesis in vivo. Additionally, PPE8 suppressed phosphorylation of VEGFR-2, Src, FAK, ERK1/2, and AKT in HUVECs exposed to VEGF-A, and exhibited significant decline in xenograft tumor growth. These findings suggest that PPE8 may target VEGF-A-VEGFR-2 signaling to reduce angiogenesis, making it a potential drug candidate for angiogenesis-related diseases.
Article
Oncology
Kan Omi, Yoichi Matsuo, Goro Ueda, Yoshinaga Aoyama, Tomokatsu Kato, Yuichi Hayashi, Hiroyuki Imafuji, Kenta Saito, Ken Tsuboi, Mamoru Morimoto, Ryo Ogawa, Hiroki Takahashi, Shuji Takiguchi
Summary: The study confirmed that escin inhibits angiogenesis in pancreatic cancer by reducing the secretion of IL-8 and VEGF through blocking NF-kappa B activity. This suggests that escin could be a novel molecular therapy for pancreatic cancer.
Article
Oncology
Arianna Scagliotti, Laura Capizzi, Marina Elena Cazzaniga, Alice Ilari, Marco De Giorgi, Nicoletta Cordani, Matteo Gallazzi, Antonino Bruno, Giuseppe Pelosi, Adriana Albini, Marialuisa Lavitrano, Emanuela Grassilli, Maria Grazia Cerrito
Summary: The study found that metronomic chemotherapy (mCHT) with 5-Fluorouracil plus Vinorelbine (5-FU+VNR) is more effective than standard treatment (STD) in controlling the proliferation, survival, migration, and invasion of endothelial cells (ECs) and triple-negative breast cancer (TNBC) cells. It also has a strong anti-angiogenic effect. The data suggest that the stabilization of tumor growth observed in TNBC patients treated with mCHT is likely due to its direct cytotoxic effects as well as its anti-metastatic and anti-angiogenic effects.
FRONTIERS IN ONCOLOGY
(2022)
Article
Plant Sciences
Xiaopeng Ai, Peiling Yu, Liuling Luo, Jiayi Sun, Honglin Tao, Xiaobo Wang, Xianli Meng
Summary: This study examined the microvascular protection of water extract of Xiao Bopi against spontaneous retinal damage in db/db mice. The results suggested that Xiao Bopi alleviates angiogenesis and apoptosis by suppressing the HIF-1 alpha/VEGF/DLL-4/Notch-1 pathway, providing new insights into its potential mechanisms in the treatment of diabetic retinopathy.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Yasuko Iwakiri, Jonel Trebicka
Summary: Portal hypertension, a consequence of increased intrahepatic vascular resistance due to the dysregulation of liver sinusoidal endothelial cells and hepatic stellate cells, often arising from chronic liver diseases, is exacerbated by extrahepatic hemodynamic changes. The pathogenic complexity of portal hypertension and the unsuccessful translation of preclinical studies hinder the development of effective therapeutics for patients with cirrhosis.
Review
Biochemistry & Molecular Biology
Akiyoshi Uemura, Yoko Fukushima
Summary: Rho GTPases, especially RhoJ, play essential roles in regulating cell migration and junctions in vascular endothelial cells, affecting vascular formation and permeability. RhoJ, enriched in angiogenic ECs, induces actin depolymerization by competing with Cdc42 for common effector proteins, thus influencing cytoskeletal rearrangements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Seyma Aydinlik, Ayca Uvez, Hulya Tuba Kiyan, Ebru Gurel-Gurevin, Veysel Turan Yilmaz, Engin Ulukaya, Elif Ilkay Armutak
Summary: The palladium (II) complex and thalidomide combination can suppress angiogenesis-mediated cell proliferation, with the complex showing significant growth inhibition in HUVECs in a dose-dependent manner and promoting cell apoptosis. Thalidomide did not have a significant effect on cell viability.
MICROVASCULAR RESEARCH
(2021)
Article
Chemistry, Medicinal
Gao Wei, Yalan Wu, Xiao-Long He, Ting Liu, Mingyao Liu, Jian Luo, Wen -Wei Qiu
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Biochemical Research Methods
Xin Tian, Mingyuan Xin, Jian Luo, Mingyao Liu, Zhenran Jiang
JOURNAL OF COMPUTATIONAL BIOLOGY
(2017)
Article
Cell Biology
Peng Sun, Kunhang Jia, Chunbing Zheng, Xinlei Zhu, Jing Li, Liang He, Stefan Siwko, Feng Xue, Mingyao Liu, Jian Luo
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Correction
Chemistry, Multidisciplinary
Xiaocheng Wang, Fang Lv, Tian Li, Yiming Han, Zhengfang Yi, Mingyao Liu, Jiang Chang, Chengtie Wu
Article
Immunology
Qing Li, Chunlei Feng, Lingyun Li, Guiliang Xu, Haijuan Gu, Shiqiang Li, Dali Li, Mingyao Liu, Shuhua Han, Biao Zheng
Summary: This study demonstrates the important role of Lp-PLA(2) in controlling inflammatory macrophage polarization in autoimmune encephalomyelitis and multiple sclerosis. Lp-PLA(2) affects M1 function through lysophosphatidylcholine-mediated pathways and G2A receptor guidance, which could potentially lead to new therapeutic approaches for MS and other inflammatory disorders.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Fazhi Yu, Chenyu Zhu, Shuyin Ze, Haojie Wang, Xinyu Yang, Mingyao Liu, Qiong Xie, Weiqiang Lu, Yonghui Wang
Summary: Compound 57 demonstrates potential as a novel A(2A) receptor antagonist in cancer immunotherapy, enhancing T cell activation and inhibiting adenosine levels in the tumor microenvironment.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Yufei Chen, Chenfeng Mao, Rui Gu, Rujia Zhao, Weihao Li, Zihan Ma, Yiting Jia, Fang Yu, Jian Luo, Yi Fu, Jinpeng Sun, Wei Kong
Summary: Nidogen-2 is an endogenous ligand of LGR4 that inhibits vascular calcification by activating a specific signaling pathway.
CIRCULATION RESEARCH
(2022)
Article
Cell Biology
Chunyang Yi, Jiacheng He, Dan Huang, Yumiao Zhao, Chan Zhang, Xiyun Ye, Ying Huang, Ruth Nussinov, Junke Zheng, Mingyao Liu, Weiqiang Lu
Summary: Activation of the orphan GPCR GPR132 induces cell differentiation in acute myeloid leukemia (AML) and the natural product 8-gingerol is found to be a potential GPR132 agonist, promoting differentiation and reducing colony formation in AML cell lines.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Ying Chen, Jinyi Zhang, Yuan Weng, Yueming Xu, Weiqiang Lu, Wei Liu, Mingyao Liu, Tian Hua, Gaojie Song
Summary: This study presents the structures of the human adenosine A2B receptor (A2BR) bound to its agonists NECA and BAY60-6583, elucidating the orthosteric binding pockets and their subtle differences. Selectivity is mainly determined by regions extended from the orthosteric pocket, and the key determinants for BAY60-6583's selectivity against A2BR are identified. This study provides a better understanding of ligand selectivity in the adenosine receptor family and offers a structural template for the development of A2BR ligands for related diseases.
Letter
Oncology
Haiping Song, Hector Manuel Arredondo Carrera, Alexandria Sprules, Ying Ji, Tongsong Zhang, Jiepei He, Eleanor Lawrence, Alison Gartland, Jian Luo, Ning Wang
CANCER COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Peng He, Juanjuan Feng, Xinting Xia, Yue Sun, Jia He, Tian Guan, Yangrui Peng, Xueli Zhang, Mingyao Liu, Xiufeng Pang, Yihua Chen
Summary: HP661 is a highly effective OXPHOS inhibitor that can inhibit mitochondrial oxygen consumption in high OXPHOS lung cancer cells. It also shows significant sensitivity in MEK inhibitor-resistant lung cancer cells and has therapeutic efficacy against high OXPHOS lung cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Chenyu Zhu, Shuyin Ze, Ronghui Zhou, Xinyu Yang, Haojie Wang, Xiaolei Chai, Meimiao Fang, Mingyao Liu, Yonghui Wang, Weiqiang Lu, Qiong Xie
Summary: Recent studies and clinical evidence have shown that adenosine A2A receptor (A2AR) antagonists have great potential as novel approaches for cancer immunotherapy. Through the screening of a compound library, a pyridinone hit compound with weak A2AR antagonistic activity was identified, and further studies led to the discovery of a series of pyridinone derivatives with strong potency. Compound 38 demonstrated potent A2AR antagonistic activity, good metabolic stability, and excellent oral bioavailability, and also effectively enhanced the activation and killing ability of T cells. In addition, it exhibited excellent in vivo antitumor activity, making it a promising candidate for cancer immunotherapy.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Chenyu Zhu, Shuyin Ze, Ronghui Zhou, Xinyu Yang, Haojie Wang, Xiaolei Chai, Meimiao Fang, Mingyao Liu, Yonghui Wang, Weiqiang Lu, Qiong Xie
Summary: Recent studies and clinical evidence have shown that adenosine A2A receptor (A2AR) antagonists have great potential in cancer immunotherapy. Through screening, compound 38, a pyridinone derivative, was identified as a potent A2AR antagonist with good stability and high bioavailability. Furthermore, compound 38 effectively enhanced the activation of T cells in vitro and demonstrated excellent antitumor activity in vivo, making it a promising candidate for cancer immunotherapy.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Cell & Tissue Engineering
Jian Luo, Peng Sun, Stefan Siwko, Mingyao Liu, Jianru Xiao
Article
Pharmacology & Pharmacy
Shijie Chen, Yang Bai, Zhen Li, Kunhang Jia, Yunyun Jin, Bei He, Wen-Wei Qiu, Changsheng Du, Stefan Siwko, Huaqing Chen, Mingyao Liu, Jian Luo
BIOCHEMICAL PHARMACOLOGY
(2017)