Article
Environmental Sciences
Zhiyuan Cheng, Xichi Zhang, Bryan Bassig, Russ Hauser, Theodore R. Holford, Elizabeth Zheng, Dian Shi, Yong Zhu, Stephen Marc Schwartz, Chu Chen, Kunchong Shi, Bo Yang, Zhengmin Qian, Peter Boyle, Tongzhang Zheng
Summary: The study found no association between total serum levels of PCBs and the overall risk of TGCT, but a strong positive association was observed between total serum levels of Wolff's Group 1 PCBs and the risk of TGCT overall as well as its subtypes.
ENVIRONMENTAL POLLUTION
(2021)
Review
Biochemistry & Molecular Biology
Marco De Martino, Paolo Chieffi, Francesco Esposito
Summary: Testicular germ cell tumors are the leading form of solid cancer and death among males aged 20 to 40. The deregulation of miRNAs plays a key role in TGCTs, making them potential diagnostic and prognostic markers for testicular tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dennis M. Timmerman, Thomas F. Eleveld, Ad J. M. Gillis, Carlijn C. Friedrichs, Sanne Hillenius, Tessa L. Remmers, Sruthi Sriram, Leendert H. J. Looijenga
Summary: Germ cell tumors (GCTs) have varying responses to platinum-based chemotherapy depending on their anatomical origin, with mediastinal GCTs showing resistance compared to testicular GCTs. TP53 mutations may play a role in causing cisplatin resistance in mediastinal GCTs, suggesting a potential target for treatment. The study provides insights into the underlying mechanisms of TP53 mutant and mediastinal GCTs for alternative treatment approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Kira Kirchner, Christoph Seidel, Finn-Ole Paulsen, Bianca Sievers, Carsten Bokemeyer, Davor Lessel
Summary: The CHEK2 gene is associated with susceptibility to testicular germ cell tumors (TGCT) and has moderate penetrance. The frequency of CHEK2 gene variants was found to be significantly higher in TGCT cases compared to the control group, and patients with CHEK2 variants developed TGCT at a younger age. Additionally, another CHEK2 variant related to TGCT susceptibility was identified.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Ruijing Sun, Eun Joo Lee, Seonock Lee, Gamin Kim, Jungho Kim
Summary: This study demonstrates that the Pin1 inhibitor KPT6566 has significant antiproliferative and antitumor effects in TGCT cells, suggesting its potential as a therapeutic approach for TGCTs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Developmental Biology
Nicholas J. Webster, Rebecca L. Maywald, Susan M. Benton, Emily P. Dawson, Oscar D. Murillo, Emily L. LaPlante, Aleksandar Milosavljevic, Denise G. Lanza, Jason D. Heaney
Summary: NANOS2 plays a crucial role in coordinating the differentiation of germ cells, and its absence may increase susceptibility to tumors. Developmental phenotypes necessary for tumorigenesis typically occur in germ cells failing to express NANOS2.
Review
Biochemistry & Molecular Biology
Milena Urbini, Sara Bleve, Giuseppe Schepisi, Cecilia Menna, Giorgia Gurioli, Caterina Gianni, Ugo De Giorgi
Summary: Cisplatin-based chemotherapy combinations have greatly improved the outcome of metastatic testicular germ cell tumor patients. However, predicting the prognosis of patients who relapse after first-line therapy remains complex. Molecular selection of patients and validated biomarkers are needed to improve risk stratification and identify novel therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Nianyu Xue, Guoyao Wang, Shengmin Zhang, Yijun Lu
Summary: Unlike younger patients, seminoma is not common in patients with primary testicular tumors over the age of 50. The diagnostic value of conventional ultrasonography and contrast-enhanced ultrasonography (CEUS) in these patients was compared. The CEUS method showed higher accuracy in distinguishing between germ cell tumors and non-germ cell tumors.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Anne-Laure Hermann, Aurore L'Hermine-Coulomb, Sabine Irtan, Georges Audry, Liesbeth Cardoen, Herve J. Brisse, Saskia Vande Perre, Hubert Ducou Le Pointe
Summary: Pediatric testicular tumors are rare and most are benign, but those that occur after puberty are more likely to be malignant. Imaging plays a crucial role in the diagnosis, staging, and follow-up of testicular tumors. Pre- and post-pubertal tumors have different characteristics in terms of epidemiology, diagnosis, and treatment.
Review
Environmental Sciences
Xin Gao, Di Yan, Guangying Li, Yu Wei, Huan He, Jinxia Zhai
Summary: This meta-analysis explored the relationship between polychlorinated biphenyls (PCBs) and metabolic syndrome (MetS). The results suggested that PCBs may not be a risk factor for MetS, but their high heterogeneity indicates that they are under-represented. Furthermore, total PCBs were found to be a protective factor against diabetes. Subgroup analysis revealed that different types and congerners of PCBs have varying effects on the risk of MetS and diabetes. Therefore, more high-quality research is needed to further understand the role of different species and congerners of PCBs in MetS and diabetes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Oncology
Tim Nestler, Justine Schoch, Gazanfer Belge, Klaus-Peter Dieckmann
Summary: miR371 is a more sensitive and specific biomarker for testicular germ cell cancer than conventional serum markers. It shows potential for initial diagnosis, treatment monitoring, and follow-up. However, miR371 is not expressed in teratoma. Further studies are needed to determine its importance in detecting testicular tumor recurrences and residual tumors after chemotherapy.
Review
Oncology
Saeideh Nakhaei-Rad, Zahra Soleimani, Saeedeh Vahedi, Zahra Gorjinia
Summary: This article summarizes the genetic risk factors for testicular germ cell tumors (TGCTs) and their association with chemotherapy resistance, as well as the impact of epigenetic changes on TGCT progression. It also proposes a model for RAS-dependent signaling networks in TGCTs.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Francesco Donato, Marco Moneda, Nazario Portolani, Angelo Rossini, Sarah Molfino, Silvia Ministrini, Giovanni Battista Contessi, Silvia Pesenti, Giuseppe De Palma, Alice Gaia, Elena Zanardini, Claudio Vito Sileo, Michele Magoni
Summary: This study investigated the association between PCB serum levels and hepatocellular carcinoma (HCC) in a PCB-polluted area. The results suggest that PCBs may play a role in the development of HCC.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Cezanne D. Kooij, Annelies M. C. Mavinkurve-Groothuis, Idske C. L. Kremer Hovinga, Leendert H. J. Looijenga, Tuula Rinne, Jacques C. Giltay, Laetitia M. O. de Kort, Aart J. Klijn, Ronald R. de Krijger, Annemarie A. Verrijn Stuart
Summary: This study reports the development of malignant testicular germ cell tumors in two young adult males with familial male-limited precocious puberty (FMPP) due to LHCGR pathogenic variants. The study also investigates the potential link between FMPP and testicular tumors. The results suggest that FMPP might increase the risk of developing testicular GCTs in early adulthood.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biology
Marco Barchi, Pamela Bielli, Susanna Dolci, Pellegrino Rossi, Paola Grimaldi
Summary: Testicular germ cell tumors (TGCTs) are commonly seen in adolescent and young men, and recent genome-wide studies have shown that aberrant regulation of RNA metabolism can drive tumorigenesis and affect chemotherapeutic response. Understanding the role of different RNA species, including non-coding RNAs and splicing variants, in cancer development is crucial for diagnosis, prognosis, and therapy of TGCTs. Additionally, the misregulation of R-loop in TGCTs affects genomic stability.