Article
Oncology
Jiang Zhu, Lingjing Chen, Qiaoli Zheng, Rui Han, Xianzhen Chen, Qiang Zhou, Hao Cheng
Summary: This study aimed to establish a reliable protocol for immunohistochemistry stains to detect HPV16 E7 protein and found a positive correlation between HPV16 E7 protein expression and malignancy grade.
Article
Biochemistry & Molecular Biology
Katsuyoshi Kumagai, Masakatsu Takanashi, Shin-ichiro Ohno, Yuichirou Harada, Koji Fujita, Keiki Oikawa, Katsuko Sudo, Shun-ichi Ikeda, Hirotaka Nishi, Kosuke Oikawa, Masahiko Kuroda
Summary: Cervical cancer development involves HPV infection and estrogen receptor signaling. WAPL plays a crucial role in CIN development by activating MACROD1 to increase ESR1 sensitivity, thereby promoting the expression of MYC and Cyclin D1.
Article
Virology
Sebastian O. Wendel, Avanelle Stoltz, Xuan Xu, Jazmine A. Snow, Nicholas Wallace
Summary: A subset of human papillomaviruses (HPVs), particularly HPV16, play a crucial role in the development of cervical cancer. The HPV16 E7 oncogene destabilizes RB and facilitates viral replication, while HPV16 E6 degrades p53 to mitigate replication stress. This study shows that cervical cancer cells activate the translesion synthesis (TLS) pathway to prevent replication fork collapse caused by stress. Increased expression of TLS genes is more common in cervical cancer than in other cancer types, and is associated with improved survival rates.
Article
Oncology
Giorgio Bogani, Francesco Sopracordevole, Andrea Ciavattini, Enrico Vizza, Paolo Vercellini, Fabio Ghezzi, Giovanni Scambia, Violante Di Donato, Andrea Giannini, Francesco Raspagliesi
Summary: HPV is the primary cause of cervical dysplasia and cervical cancer, and efforts are needed to better categorize patients with HPV to provide useful information.
CANCER CYTOPATHOLOGY
(2023)
Article
Microbiology
Ramon Antano-Arias, Oscar Del Moral-Hernandez, Julio Ortiz-Ortiz, Luz Del Carmen Alarcon-Romero, Jorge Adan Navor-Hernandez, Marco Antonio Leyva-Vazquez, Marco Antonio Jimenez-Lopez, Jorge Organista-Nava, Berenice Illades-Aguiar
Summary: This study identified specific E7 variants associated with the highest risk of cervical cancer, with E6/E7 bicistron analysis revealing even greater risk potential for specific variants. These findings underscore the importance of analyzing combinations of E6/E7 variants in HPV 16 infection for predicting cervical cancer development.
Article
Immunology
Lina Zhang, Xinyi Shi, Qing Zhang, Zhilei Mao, Xiaoyu Shi, Jun Zhou, Aili Jian, Renying Zhu, Shisong Jiang, Wenshu Lu
Summary: High-risk human papillomavirus (HPV) infection is the main cause of cervical cancer, and the specific T cell response to HPV16 E7 in peripheral blood mononuclear cells is related to HPV16 clearance and protection against malignant development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Barbara Simas Chagas, Elias Tiburcio Junior, Ruany Cristyne de Oliveira Silva, Daffany Luana dos Santos, Marconi Rego Barros Junior, Rita de Cassia Pereira de Lima, Maria da Conceicao Viana Invencao, Vanessa Emanuelle Pereira Santos, Pedro Luiz Franca Neto, Antonio Humberto Silva Junior, Jacinto Costa Silva Neto, Marcus Vinicius de Aragao Batista, Antonio Carlos de Freitas
Summary: This study evaluated the genetic variability and structural effects of the E7 oncogene of HPV58 in cervical scraping samples from Brazilian women. Several mutations in the E7 protein were found to reduce its stability, and one variant of HPV58-E7 was associated with decreased NF-kB pathway activity.
Article
Oncology
Luz Eugenia Alcantara-Quintana, Martha Esmeralda Gonzalez-Perez, Alejandra Loyola-Leyva, Yolanda Teran-Figueroa
Summary: This study examined the effect of exosomes obtained from self-taken vaginal samples on the viability of HeLa cells. It found that exosomes have a protective effect on cells from patients without injury, but promote cell viability in injured patients. This suggests that exosomes can potentially serve as biomarkers for the early diagnosis of cervical cancer and as a treatment option.
CANCER MANAGEMENT AND RESEARCH
(2022)
Review
Oncology
Laura Downham, Iman Jaafar, Mary Luz Rol, Victoria Nyawira Nyaga, Joan Valls, Armando Baena, Li Zhang, Marc J. Gunter, Marc Arbyn, Maribel Almonte
Summary: This study evaluated the accuracy of HPV-E6/E7 oncoprotein tests in detecting cervical precancer and cancer through a systematic review and meta-analysis. The results showed that oncoprotein tests have high specificity and can be used for triaging HPV-positive women. However, further follow-up is needed for oncoprotein-negative women.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Giorgio Bogani, Francesco Sopracordevole, Andrea Ciavattini, Enrico Vizza, Paolo Vercellini, Andrea Giannini, Fabio Ghezzi, Giovanni Scambia, Francesco Raspagliesi, Violante Di Donato
Summary: The duration of HPV persistence is an important factor in predicting the risk of recurrent CIN2+. Patients with HPV persistence at 12 months have a significantly higher risk of recurrence, while persistence beyond 12 months does not correlate with increased risk.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Virology
Sadhana M. Gupta, Himangi Warke, Hemangi Chaudhari, Padmaja Mavani, Rajshree D. Katke, Shilpa C. Kerkar, Jayanti Mania-Pramanik
Summary: This study aimed to evaluate HPV E6/E7 oncogene expression as markers for early identification of cervical cancer risk in women with minor cytological abnormalities and negative cytology. The results showed that E6 and E7 transcripts could serve as sensitive early predictors of cervical cancer risk.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Medicine, General & Internal
Boram Choi, Yoojin Na, Min Yeop Whang, Jung Yoon Ho, Mi-Ryung Han, Seong-Woo Park, Heekyoung Song, Soo Young Hur, Youn Jin Choi
Summary: In this study, the association between MGMT methylation and persistent HPV infection was examined using cervical cytology samples and a public database. The results showed that MGMT methylation was associated with HPV infection and downregulated MGMT mRNA expression correlated with poor overall survival. MGMT methylation level could potentially serve as a prognostic indicator for the transition from atypical squamous cells/low-grade squamous intraepithelial lesion to cervical cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Jennifer Margaret Roberts, Dorothy A. Machalek, Bethan C. Butler, Joanne Crescini, Suzanne M. Garland, Annabelle Farnsworth
Summary: In Australia's HPV-based cervical screening program, the risk of histological high-grade abnormality decreased with age in women with oncogenic HPV. This study followed HPV16/18 positive women aged 55 years and over for up to 3 years to determine the proportion with histological high-grade abnormality and its correlation with liquid-based cytology result and prior screening history. The results showed that age, screening history, and cytology result are important factors to consider in managing screen-detected abnormalities in HPV-based cervical screening programs.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Immunology
Giorgio Bogani, Luca Lalli, Francesco Sopracordevole, Andrea Ciavattini, Alessandro Ghelardi, Tommaso Simoncini, Francesco Plotti, Jvan Casarin, Maurizio Serati, Ciro Pinelli, Alice Bergamini, Barbara Gardella, Andrea Dell'Acqua, Ermelinda Monti, Paolo Vercellini, Innocenza Palaia, Giorgia Perniola, Margherita Fischetti, Giusi Santangelo, Alice Fracassi, Giovanni D'Ippolito, Lorenzo Aguzzoli, Vincenzo Dario Mandato, Luca Giannella, Cono Scaffa, Francesca Falcone, Chiara Borghi, Mario Malzoni, Andrea Giannini, Maria Giovanna Salerno, Viola Liberale, Biagio Contino, Cristina Donfrancesco, Michele Desiato, Anna Myriam Perrone, Giulia Dondi, Pierandrea De Iaco, Simone Ferrero, Giuseppe Sarpietro, Maria G. Matarazzo, Antonio Cianci, Stefano Cianci, Sara Bosio, Simona Ruisi, Lavinia Mosca, Raffaele Tinelli, Rosa De Vincenzo, Gian Franco Zannoni, Gabriella Ferrandina, Marco Petrillo, Giampiero Capobianco, Salvatore Dessiole, Annunziata Carlea, Fulvio Zullo, Barbara Muschiato, Stefano Palomba, Stefano Greggi, Arsenio Spinillo, Fabio Ghezzi, Nicola Colacurci, Roberto Angioli, Pierluigi Benedetti Panici, Ludovico Muzii, Giovanni Scambia, Francesco Raspagliesi, Violante Di Donato
Summary: In this study, a prognostic nomogram was developed to assess the risk of cervical dysplasia persistence/recurrence after primary conization. Variables such as diagnosis of CIN3, presence of high-risk HPV types, positive endocervical margins, HPV persistence, and omission of HPV vaccination after conization were found to significantly increase the risk of cervical dysplasia persistence/recurrence. The nomogram can be a useful tool for counseling women about their risk and the importance of HPV vaccination after conization.
Article
Biotechnology & Applied Microbiology
Xianhuang Li, Mingming Guo, Bei Hou, Bin Zheng, Zhiyun Wang, Mengqian Huang, Yanan Xu, Jin Chang, Tao Wang
Summary: A nanoeditor was designed to knockout two key oncogenes associated with drug resistance in cervical cancer, effectively reactivating signaling pathways that inhibit tumor cell growth. When combined with chemotherapy drugs, the nano system successfully inhibits drug tolerance in cancer cells and improves therapeutic outcomes.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)