Article
Cell Biology
Zhaowei Xu, Shuyan Liu, Chun Feng, Fuyi Xu, Demin Kong, Jia Mi, Chunhua Yang, Guilong Zhang, Pengfei Wei, Buyan-Ochir Orgil, Jonas Bergquist, Geng Tian
Summary: This study found that the expression of checkpoint suppressor 1 (CHES1) is highly associated with triple-negative breast cancer (TNBC) and plays a role in promoting the proliferation and metastasis of TNBC. Acetylation of CHES1 enhances its stability and contributes to its high abundance in TNBC. These findings highlight the significance of CHES1 acetylation in breast cancer progression.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Jianbing Hou, Yudong Liu, Pan Huang, Yutao Wang, Dakun Pei, Ruoyue Tan, Yundong Zhang, Hongjuan Cui
Summary: RANBP10 is overexpressed in GBM and correlated with poor patient survival; downregulation of RANBP10 significantly inhibits proliferation, migration, and tumor growth of GBM cells; RANBP10 promotes GBM progression by controlling the FBXW7-c-Myc axis.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Zeyu Xing, Ruojiao Wang, Xin Wang, Jiaqi Liu, Menglu Zhang, Kexin Feng, Xiang Wang
Summary: The study demonstrated that circPDCD11 functions as an oncogene in triple-negative breast cancer (TNBC), promoting metabolic activity and tumor growth. This circRNA serves as a miRNA sponge to upregulate LDHA expression, providing a potential prognostic biomarker for TNBC.
CELL DEATH DISCOVERY
(2021)
Review
Biochemistry & Molecular Biology
Zhaoyou Meng, Xiaoya Wang, Dongmei Zhang, Zhen Lan, Xiaoxia Cai, Chen Bian, Jiqiang Zhang
Summary: The effects of steroid hormones are mediated by their nuclear receptors. The p160 coactivator family interacts with nuclear receptors to enhance their transcriptional activities. SRC-1, predominantly localized in the central nervous system, is regulated by steroids and non-steroidal factors. It plays important roles in normal function and pathophysiology, but its mechanisms are not fully understood.
Article
Cell Biology
Marcel Rose, Katrin Domsch, Jakob Bartle-Schultheis, Ingolf Reim, Christoph Schaub
Summary: The genesis of syncytial muscles is typically considered an irreversible developmental process, and the mesodermal master regulator Twist plays a key role in the reprogramming process by regulating the activity of the Hippo pathway effector Yorkie. This study provides evidence that Twist is required for the initiation of syncytial muscle dedifferentiation and fragmentation, and fibroblast growth factor receptor (FGFR) Ras-mitogen-activated protein kinase (MAPK) signaling maintains Twist expression in resulting mononucleated myoblasts.
Article
Cell Biology
Anfei Liu, Yunting Li, Sitong Lu, Chunqing Cai, Fei Zou, Xiaojing Meng
Summary: Lung metastasis is a major cause of breast cancer-related death. Tumor microenvironment and secreted factors, such as STC1, play important roles in promoting the metastasis. STC1 enhances cancer cell invasiveness, promotes angiogenesis and lung fibroblast activation in the metastatic microenvironment. Mechanistically, STC1 mediates its effects through the upregulation of S100A4 via EGFR and ERK signaling. Knockdown of S100A4 diminishes STC1-induced lung metastasis. Additionally, JNK signaling pathway activates STC1 expression in breast cancer cells with lung-tropism.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Jianing Tang, Zeyu Wu, Zelin Tian, Wei Chen, Gaosong Wu
Summary: This study identified OTUD7B as a deubiquitylase of ER alpha in breast cancer, which is positively correlated with ER alpha expression and associated with poor prognosis. Depletion of OTUD7B decreased ER alpha protein level and suppressed breast cancer cell proliferation and migration. Overexpression of ER alpha could rescue the suppressive effect induced by OTUD7B depletion, suggesting the essential role of ER alpha in the function of OTUD7B in breast carcinogenesis.
CELL DEATH & DISEASE
(2021)
Article
Endocrinology & Metabolism
Rebecca J. Watters, Kostas Verdelis, Peter C. Lucas, Shiming Jiang, Yuqing Chen, Feiqi Lu, Benjamin M. Martin, Lyuda Lukashova, Geoffrey Pecar, Alejandro Morales-Restrepo, Margaret Hankins, Li Zhu, Peter Mittwede, Ryan J. Hartmaier, Peter G. Alexander, George C. Tseng, Kurt R. Weiss, Deborah L. Galson, Adrian Lee, Brendan Lee, Steffi Oesterreich
Summary: The SNP P1272S in the SRC-1 gene affects estrogen receptor activity and is associated with the effect of SERMs on bone density, possibly promoting breast cancer bone metastasis.
Article
Immunology
Nuo Xu, Douglas C. Palmer, Alexander C. Robeson, Peishun Shou, Hemamalini Bommiasamy, Sonia J. Laurie, Caryn Willis, Gianpietro Dotti, Benjamin G. Vincent, Nicholas P. Restifo, Jonathan S. Serody
Summary: The study demonstrates that enhancing CAR T cell therapy targeting solid tumors with STING agonists, specifically DMXAA, can greatly improve tumor control by promoting CAR T cell trafficking and persistence in the tumor microenvironment. The single-cell RNA sequencing results show that DMXAA generates a chemokine milieu that facilitates CART cell recruitment and modulates the immunosuppressive TME.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Vineet K. Maurya, Maria M. Szwarc, David M. Lonard, Ramakrishna Kommagani, San Pin Wu, Bert W. O'Malley, Francesco J. DeMayo, John P. Lydon
Summary: The role of steroid receptor coactivator-2 (SRC-2) in the implantation process and the development of uterine receptivity has been investigated. The study found that SRC-2 is essential for embryo attachment and adherence to the luminal epithelium. It also plays a role in the plasma membrane transformation (PMT) state required for uterine receptivity.
Article
Oncology
Derek Dustin, Guowei Gu, Amanda R. Beyer, Sarah K. Herzog, David G. Edwards, Hangqing Lin, Thomas L. Gonzalez, Sandra L. Grimm, Cristian Coarfa, Doug W. Chan, Beom-Jun Kim, O. Jean-Paul De La, Matthew J. Ellis, Dan Liu, Shunqiang Li, Alana L. Welm, Suzanne A. W. Fuqua
Summary: This study identified hyperactivation of RON in ESR1 mutant cells and its association with acquired palbociclib-resistant models. The interaction between RON and IGF-1R was demonstrated, and combination therapy of endocrine therapy with a RON inhibitor effectively decreased organoid growth in ESR1 mutant models. Additionally, the combination therapy also reduced metastasis in an ESR1 Y537S mutant PDX model, suggesting RON/PI3K pathway inhibition as a potential treatment strategy for ESR1 mutant and PalbR MBC patients.
BRITISH JOURNAL OF CANCER
(2021)
Article
Cell Biology
Yunhe Zhao, Dezhen Peng, Yanyun Liu, Qian Zhang, Bin Liu, Yanran Deng, Wenhao Ding, Zizhang Zhou, Qingxin Liu
Summary: The Usp8-Tak1-JNK axis promotes tumor cell migration, and knocking down USP8 suppresses breast cancer cell migration, providing a potential target for cancer treatment.
CELL DEATH & DISEASE
(2022)
Article
Endocrinology & Metabolism
Parama Dey, Alexander Wang, Yvonne Ziegler, Sandeep Kumar, Shunchao Yan, Sung Hoon Kim, John A. Katzenellenbogen, Benita S. Katzenellenbogen
Summary: Triple-negative breast cancer (TNBC) is a challenging subtype of breast cancer, but the study has identified ER beta 1 as a potential therapeutic target. The research shows that ER beta 1 can reduce tumor growth and metastasis, regulate gene expression, and inhibit cancer cell invasiveness and metastasis. Additionally, the use of ER beta-selective agonist ligand can enhance the suppressive activity of ER beta 1, offering potential improvements in TNBC treatment.
Article
Oncology
Sang Jun Han, Nuri Sung, Jin Wang, Bert W. O'Malley, David M. Lonard
Summary: SRC-3 plays a critical role in modulating the tumor immune microenvironment in breast cancer, promoting tumor progression. Inhibiting SRC-3 or reducing its expression can enhance the antitumor immune response by increasing the number of cytotoxic immune cells, thus suppressing breast cancer growth.
BREAST CANCER RESEARCH
(2022)
Article
Cell Biology
Xiaohong Xia, Chuyi Huang, Yuning Liao, Yuan Liu, Jinchan He, Zhenlong Shao, Tumei Hu, Cuifu Yu, Lili Jiang, Jinbao Liu, Hongbiao Huang
Summary: The study highlights the importance of deubiquitinase USP15 in preventing ERα degradation and promoting breast cancer progression. Knockdown of USP15 enhances the antitumor activities of tamoxifen on breast cancer cells. These findings provide a new approach to overcoming resistance to endocrine therapy and targeting the USP15-ERα axis for therapeutic strategies on ERα degradation.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Xian Chen, Li Qin, Zhaoliang Liu, Lan Liao, James F. Martin, Jianming Xu
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2015)
Article
Multidisciplinary Sciences
Xianzhou Song, Chengwei Zhang, Mingkun Zhao, Hui Chen, Xing Liu, Jianwei Chen, David M. Lonard, Li Qin, Jianming Xu, Xiaosong Wang, Feng Li, Bert W. O'Malley, Jin Wang
Article
Oncology
Li Qin, Yan Xu, Yixiang Xu, Gang Ma, Lan Liao, Yelin Wu, Yi Li, Xian Wang, Xiaosong Wang, Jun Jiang, Jin Wang, Jianming Xu
Article
Biochemistry & Molecular Biology
Y. Xu, L. Qin, T. Sun, H. Wu, T. He, Z. Yang, Q. Mo, L. Liao, J. Xu
Article
Oncology
Hongmei Wu, Jiong Bi, Yan Peng, Lei Huo, Xiaobin Yu, Zhihui Yang, Yunyun Zhou, Li Qin, Yixiang Xu, Lan Liao, Yang Xie, Orla M. Conneely, Jos Jonkers, Jianming Xu
Article
Oncology
Li Qin, Yixiang Xu, Xiaobin Yu, Michael J. Toneff, Dabing Li, Lan Liao, Jarrod D. Martinez, Yi Li, Jianming Xu
Article
Pathology
Yan Xu, Yixiang Xu, Lan Liao, Niya Zhou, Sarah M. Theissen, Xin-Hua Liao, Hoang Nguyen, Thomas Ludwig, Li Qin, Jarrod D. Martinez, Jun Jiang, Jianming Xu
AMERICAN JOURNAL OF PATHOLOGY
(2013)
Article
Oncology
Li Qin, Ye-Lin Wu, Michael J. Toneff, Dabing Li, Lan Liao, Xiuhua Gao, Fiona T. Bane, Jean C. -Y. Tien, Yixiang Xu, Zhen Feng, Zhihui Yang, Yan Xu, Sarah M. Theissen, Yi Li, Leonie Young, Jianming Xu
Article
Oncology
Claire A. Walsh, Jarlath C. Bolger, Christopher Byrne, Sinead Cocchiglia, Yuan Hao, Ailis Fagan, Li Qin, Aoife Cahalin, Damian McCartan, Marie McIlroy, Peadar O'Gaora, Jianming Xu, Arnold D. Hill, Leonie S. Young
Article
Biochemistry & Molecular Biology
Zhen Xing, Aifu Lin, Chunlai Li, Ke Liang, Shouyu Wang, Yang Liu, Peter K. Park, Li Qin, Yongkun Wei, David H. Hawke, Mien-Chie Hung, Chunru Lin, Liuqing Yang
Article
Biochemistry & Molecular Biology
Yan Xu, Baoquan Hu, Li Qin, Lianhua Zhao, Qiang Wang, Qingliang Wang, Yixiang Xu, Jun Jiang
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2014)
Article
Biology
Yosi Gilad, Yossi Eliaz, Yang Yu, Adam M. Dean, San Jung Han, Li Qin, Bert W. O'Malley, David M. Lonard
Summary: SRC-3 is a key regulator in breast cancer tumorigenesis with its inhibitor SI-12 showing anti-proliferative activity in various cancer types. A genome-scale CRISPR-Cas9 screen was used to identify gene targets that enhance BC cell cytotoxicity in the presence of SI-12, and a parallel screen with an ER inhibitor was conducted to compare the activities of SRC-3 and ER alpha inhibition.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Li Qin, Jianwei Chen, Dong Lu, Prashi Jain, Yang Yu, David Cardenas, Xiaohui Peng, Xiaobin Yu, Jianming Xu, Jin Wang, Bert W. O. Malley, David M. Lonard
Summary: SI-10 and SI-12 are promising therapeutic agents that effectively inhibit the progression and metastasis of breast cancer by suppressing the viability, migration, and invasion of cancer cells.
ENDOCRINE-RELATED CANCER
(2021)
Article
Multidisciplinary Sciences
Ramesh Singh, Huan Meng, Tao Shen, Lance Edward V. Lumahan, Steven Nguyen, Hong Shen, Subhamoy Dasgupta, Li Qin, Dileep Karri, Bokai Zhu, Feng Yang, Cristian Coarfa, Bert W. O'Malley, Ping Yi
Summary: Castration-resistant prostate cancer (CRPC) is a major clinical challenge, and the androgen receptor (AR) is a critical oncogenic player. This study identifies TRAF4 as a key mediator of AR-regulated transcriptional reprogramming in CRPC, promoting its development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Ziqing Wang, Feng Zhang, Jingquan He, Ping Wu, Li Wei Rachel Tay, Ming Cai, Weiqi Nian, Yuanyuan Weng, Li Qin, Jeffrey T. Chang, Laura B. McIntire, Gilbert Di Paolo, Jianming Xu, Junmin Peng, Guangwei Du
DEVELOPMENTAL CELL
(2017)