Article
Oncology
Jessica Amaru, Federica Barbieri, Marica Arvigo, Agnese Solari, Adriana Bajetto, Federica Nista, Claudia Campana, Gabriele Gaggero, Alessandro Prior, Diego Criminelli Rossi, Gianluigi Zona, Diego Ferone, Tullio Florio, Federico Gatto
Summary: The first-generation somatostatin receptor ligands (fg-SRLs), like octreotide, and the second-generation ligand, pasireotide, act mainly through SST2 in somatotroph tumor cells, and their combination does not show any additional benefits.
Review
Endocrinology & Metabolism
Giovanni Tulipano, Andrea Giustina
Summary: Autophagy is an important cellular process involved in degradation and recycling, regulated by various stimuli and having complex roles in tumor cells. Research on autophagy in the pituitary gland and pituitary tumors is still relatively limited, but gaining attention for its potential implications.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Endocrinology & Metabolism
Jiun-Lin Yan, Mao-Yu Chen, Yao-Liang Chen, Chi-Cheng Chuang, Peng-Wei Hsu, Kuo-Chen Wei, Chen-Nen Chang
Summary: This study evaluated the outcomes of the endoscopic transsphenoidal approach as the primary treatment for somatotroph adenomas and investigated patients with suboptimal surgical results. Factors such as tumor size, preoperative GH level, and residual tumors were found to be associated with surgical failure. Octreotide showed good outcomes for treating DGSA patients, while SRS/EXRT generated good results for patients receiving secondary treatments when remission could not be reached after 6 months of TSA operation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Daniela Modena, Maria Luisa Moras, Giovanni Sandrone, Andrea Stevenazzi, Barbara Vergani, Pooja Dasgupta, Andrea Kliever, Sebastian Gulde, Alessandro Marangelo, Mathias Schillmaier, Raul M. Luque, Stephen Baeuerle, Natalia S. Pellegata, Stefan Schulz, Christian Steinkuehler
Summary: Therapy for nonfunctioning pituitary adenomas (NFPAs) is an unmet medical need. We discovered that ITF2984, a molecule originally developed as a pan-SSTR agonist, is a full agonist of SSTR3 and showed significant antitumor activity in an in vivo model. ITF2984 may provide a new therapeutic option for NFPA patients.
Article
Endocrinology & Metabolism
Federico Gatto, Richard A. Feelders, Peter M. van Koetsveld, Fadime Dogan, Sebastian J. C. M. M. Neggers, Aart-Jan van der Lelij, Jessica Amaru, Diego Ferone, Leo J. Hofland
Summary: Cabergoline (CAB) is an off-label medical therapy for acromegaly, but it is overshadowed by first-generation somatostatin receptor ligands like octreotide (OCT). In this study, OCT was found to be slightly more effective than CAB in inhibiting growth hormone (GH) secretion in vitro. Additionally, the response to CAB treatment was shown to be better in GH/prolactin (PRL) co-secreting tumors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yi Fang, He Wang, Ming Feng, Wentai Zhang, Lei Cao, Chenyu Ding, Hongjie Chen, Liangfeng Wei, Shuwen Mu, Zhijie Pei, Jun Li, Heng Zhang, Renzhi Wang, Shousen Wang
Summary: Accurate predictive models for hormonal prognosis in NFPA were lacking. Machine learning models were developed to assess pituitary hormonal outcomes post-surgery, showing significant changes in hormone levels and the effectiveness of ML in predicting outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Jie Liu, Yamei Yang, Lian Duan, Xiaofeng Chai, Huijuan Zhu, Kan Deng, Xiaolan Lian, Yong Yao
Summary: This study found that the octreotide suppression test can be used as an efficient tool to predict the decline of thyroid-stimulating hormone in patients with thyrotrophin-secreting pituitary adenomas. The 24-hour and 72-hour timepoints were particularly effective in guiding the use of somatostatin analogs.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Oncology
Sebastian Gulde, Tobias Wiedemann, Mathias Schillmaier, Isabel Valenca, Amelie Lupp, Katja Steiger, Hsi-Yu Yen, Stephen Baeuerle, Johannes Notni, Raul Luque, Herbert Schmid, Stefan Schulz, Donna P. Ankerst, Franz Schilling, Natalia S. Pellegata
Summary: There is currently a lack of effective medical therapy for residual/recurrent nonfunctioning pituitary tumors (NFPTs). Pasireotide may be an effective treatment, especially for female NFPTs patients. Female NFPTs patients have higher levels of Sstr3 expression, which may also be present in human NFPTs patients.
Review
Medicine, General & Internal
Alexandru Dan Popescu, Mara Carsote, Ana Valea, Andreea Gabriela Nicola, Ionela Teodora Dascalu, Tiberiu Tirca, Jaqueline Abdul-Razzak, Mihaela Jana Tuculina
Summary: Acromegaly-related sub/infertility is associated with suboptimal disease control, hyperprolactinemia, hypogonadotropic hypogonadism, and glucose profile anomalies. This review explores the impact of acromegaly on pregnancy outcomes and discusses management strategies. The level of disease control, family history of diabetes, and body mass index are important predictors of maternal complications. Pharmacotherapy has been shown to be safe and effective in improving pregnancy outcomes.
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonella Giampietro, Federica Mirra, Federico Donfrancesco, Tommaso Tartaglione, Pier Paolo Mattogno, Flavia Angelini, Lauretti Liverana, Marco Gessi, Anile Carmelo, Guido Rindi, Andrea Giustina, Maria Fleseriu, Alfredo Pontecorvi, Laura De Marinis, Antonio Bianchi
Summary: The study investigated predictors of response to Pegvisomant and Pasireotide LAR in acromegaly patients, finding that factors such as tumor extension, Ki67-Li levels, and IGF-I levels may impact treatment efficacy.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Mujdat Kara, Meltem Yilmaz, Meric Sengoz, Selcuk Peker
Summary: The study showed that GKRS was effective for patients with NFPA whether used as an adjuvant or primary treatment. Lower radiation doses were associated with lower tumor control rates, while larger tumor volumes were associated with higher rates of hypopituitarism and tumor progression.
BRITISH JOURNAL OF NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Runsheng Zhao, Kaiyu Fan, Weiqing Wan
Summary: A retrospective study found that short-term preoperative octreotide treatment does not improve the surgical outcome of TSHoma patients, and the duration of octreotide treatment needs to be extended to fully benefit from the tumor-shrinking effects of SSAs.
BMC ENDOCRINE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Mehmet Sozen, Busra Yaprak Bayrak, Alev Selek, Harun Emre Sen, Berrin cetinarslan, Zeynep Canturk, Aziz Hakki Civriz, Sibel Balci, Emre Gezer, Damla Koksalan, Savas Ceylan
Summary: This study analyzed the features and outcomes of TSHomas, aiming to determine the factors influencing remission. A total of 41 cases were retrospectively analyzed, and it was found that endoscopic transsphenoidal surgery achieved remission in 75.6% of patients. Preoperative use of antithyroid drugs was significantly associated with surgical cure.
Article
Oncology
Aasim N. Maldar, Sanjeev Pattankar, Basant K. Misra, Phulrenu H. Chauhan, Milind Sankhe, Ketan Desai, N. F. Shah
Summary: This study assessed long-term hormonal and imaging outcomes of Gamma Knife Radiosurgery (GKRS) as an adjunctive treatment for non-functioning pituitary adenomas (NFPA). The results showed that GKRS is a safe treatment modality with satisfactory preservation of hormone functions and a high rate of tumor control in NFPA patients.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Byoungjin Park, Yong-Jae Lee
Summary: The study showed that oral administration of pterostilbene significantly increased the time spent in open field and forced swimming tests in mice, elevated BDNF levels, reduced levels of inflammatory markers in the brain, and decreased plasma hormone levels related to stress. Pterostilbene also increased neuron numbers and reduced glial cell and inflammatory marker-labeled cell numbers in the hypothalamus, indicating its potential in modulating stress-related behaviors, neuroinflammation, and HPA axis hyperactivity.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Endocrinology & Metabolism
Nicolas Jullien, Alexandru Saveanu, Julia Vergier, Emeline Marquant, Marie Helene Quentien, Frederic Castinetti, Noemie Galon-Faure, Raja Brauner, Zinet Marrakchi Turki, Maite Tauber, Mohamed El Kholy, Agnes Linglart, Patrice Rodien, Nora Soumeya Fedala, Ignacio Bergada, Christine Cortet-Rudelli, Michel Polak, Marc Nicolino, Chantal Stuckens, Anne Barlier, Thierry Brue, Rachel Reynaud
Summary: The international GENHYPOPIT network studied a cohort of 1213 patients with non-acquired hypopituitarism, finding that 49 patients experienced progression of pituitary hormonal deficiencies during adulthood. Growth Hormone deficiency was the most common defect, and pituitary Magnetic Resonance Imaging abnormalities were common, with ophthalmological abnormalities being the most prevalent in extrapituitary malformations.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Oncology
Corinne Gerard, Marie Lagarde, Flora Poizat, Sandrine Oziel-Taieb, Vincent Garcia, Catherine Roche, Patricia Niccoli, Anne Barlier, David Romano
Summary: Despite the increasing incidence of neuroendocrine neoplasms (NENs), current treatments are limited due to poor understanding of these tumors. NENs exhibit resistance to common treatments, with mechanisms involving hyperactivation of kinases like those from the FGFR family, cyclin-dependent kinases, and PKCs. Identifying and targeting these hyperactivated kinases may provide novel therapeutic strategies for NENs.
ENDOCRINE-RELATED CANCER
(2021)
Article
Endocrinology & Metabolism
Thomas Cuny, Thomas Graillon, Celines Defilles, Rakesh Datta, Shengwen Zhang, Dominique Figarella-Branger, Henry Dufour, Gregory Mougel, Thierry Brue, Tanya Landsman, Heather A. Halem, Michael D. Culler, Anne Barlier, Alexandru Saveanu
Summary: The chimeric compound TBR-065, a second-generation dopastatin, shows significantly improved efficacy in suppressing GH secretion compared to current therapies, indicating a promising new option for the treatment of acromegaly.
Article
Clinical Neurology
T. Graillon, S. Boissonneau, R. Appay, M. Boucekine, H. Peyriere, M. Meyer, K. Farah, F. Albarel, I Morange, F. Castinetti, T. Brue, S. Fuentes, D. Figarella-Branger, T. Cuny, H. Dufour
Summary: This study aimed to describe the characteristics, outcome, and management of progestin-associated meningiomas. Findings showed favorable outcomes after progestin discontinuation, but outcomes varied by the type of progestin used and tumor location. Long-term follow-up is necessary, with observation recommended in most cases and surgery to be avoided.
Article
Genetics & Heredity
Peter Gergics, Cathy Smith, Hironori Bando, Alexander A. L. Jorge, Denise Rockstroh-Lippold, Sebastian A. Vishnopolska, Frederic Castinetti, Mariam Maksutova, Luciani Renata Silveira Carvalho, Julia Hoppmann, Julian Martinez Mayer, Frederique Albarel, Debora Braslavsky, Ana Keselman, Ignacio Bergada, Marcelo A. Marti, Alexandru Saveanu, Anne Barlier, Rami Abou Jamra, Michael H. Guo, Andrew Dauber, Marilena Nakaguma, Berenice B. Mendonca, Sajini N. Jayakody, A. Bilge Ozel, Qing Fang, Qianyi Ma, Jun Z. Li, Thierry Brue, Maria Ines Perez Millan, Ivo J. P. Arnhold, Roland Pfaeffle, Jacob O. Kitzman, Sally A. Camper
Summary: This study identified new variants that affect transcription and splicing of the POU1F1 gene, which may lead to pituitary hormone deficiency. The research underscores the importance of evaluating the impact of splicing on variants for interpreting unknown significance variants in POU1F1.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Letter
Endocrinology & Metabolism
Frederic Castinetti, Vincent Amodru, Thierry Brue
Summary: This short manuscript reports three cases of atypical adrenal insufficiency with osilodrostat, which is highly effective in blocking cortisol secretion but also carries the risk of adrenal insufficiency.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Genetics & Heredity
Laurene Ben Aim, Eamonn R. Maher, Alberto Cascon, Anne Barlier, Sophie Giraud, Tonino Ercolino, Pascal Pigny, Roderick J. Clifton-Bligh, Delphine Mirebeau-Prunier, Amira Mohamed, Judith Favier, Anne-Paule Gimenez-Roqueplo, Francesca Schiavi, Rodrigo A. Toledo, Patricia L. Dahia, Mercedes Robledo, Jean Pierre Bayley, Nelly Burnichon
Summary: The international effort led to the classification of 223 SDHB variants into 23 benign/likely benign, 149 pathogenic/likely pathogenic, and 51 variants of unknown significance. The accurate classification of SDHB genetic variants will assist geneticists in diagnosing hereditary PPGL and improving clinical care for patients and their relatives.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Endocrinology & Metabolism
Jean d'Artigues, Thomas Graillon, Sebastien Boissonneau, Kaissar Farah, Vincent Amodru, Thierry Brue, Stephane Fuentes, Henry Dufour
Summary: This study retrospectively reported 17 cases of SAC surgery in Timone University Hospital, Marseille, France. The surgical procedure was homogeneous and consisted in endonasal fully endoscopic surgical obliteration. The technique provided improvement for a high percentage of patients, but with a high complication rate.
Review
Medicine, General & Internal
Nicolas Sahakian, Frederic Castinetti, Thierry Brue, Thomas Cuny
Summary: This article reviews the current medical therapies used in the field of pituitary tumors, discusses the advantages and limitations of each treatment method, and specifies their positioning in the treatment algorithm for each phenotype. Furthermore, it provides insight into the future of medical therapies for pituitary tumors based on recent studies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Thomas Cuny, Peter M. van Koetsveld, Gregoire Mondielli, Fadime Dogan, Wouter W. de Herder, Anne Barlier, Leo J. Hofland
Summary: The treatment of pancreatic neuroendocrine neoplasms (PNEN) is challenging due to metastasis at diagnosis and resistance to treatment in some patients. This study explores the role of stromal fibroblasts in the growth of PNEN and their response to the mTOR inhibitor everolimus. The findings suggest that fibroblasts in the tumor microenvironment of PNEN could be a promising therapeutic target.
Article
Biochemistry & Molecular Biology
Jessica Resta, Yohan Santin, Mathieu Roumiguie, Elodie Riant, Alexandre Lucas, Bettina Couderc, Claudia Binda, Philippe Lluel, Angelo Parini, Jeanne Mialet-Perez
Summary: Bladder cancer cells undergo a metabolic shift towards glucose-dependent metabolism, which is regulated by the inhibition of monoamine oxidases (MAOs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Mirela-Diana Ilie, Antoine Tabarin, Alexandre Vasiljevic, Jean-Francois Bonneville, Lucile Moreau-Grange, Franck Schillo, Brigitte Delemer, Anne Barlier, Dominique Figarella-Branger, Segolene Bisot-Locard, Alexandre Santos, Philippe Chanson, Gerald Raverot
Summary: This study aimed to explore the factors related to SRLs in the treatment of acromegaly and confirmed that SST2A and adenoma granularity are good predictors of response to octreotide. In addition, the optimization of MRI sequences is important for using T2WSI as a predictor of treatment response.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Gregoire Mondielli, Gregory Mougel, Florent Darriet, Catherine Roche, Adeline Querdray, Christophe Lisbonis, Romain Appay, Henry Dufour, Olivier Chinot, Thomas Graillon, Anne Barlier
Summary: Recurrent or high-grade meningiomas are a medical need that has not been met. Studies have shown the potential therapeutic efficacy of mTor inhibitors in controlling the growth of meningiomas. However, the positive feedback on the AKT oncogenic pathway from these drugs may explain their modest success. Our aim was to target the Pi3kinase upstream mTor and MAP kinase pathway, which are overactivated in meningiomas, alone or in combination, and compare them to mTor targeting. Our in vitro results on meningioma cell lines and a large series of fresh human meningiomas showed that co-targeting Pi3kinase and MAP kinase appeared promising, opening up new therapeutic strategies for these tumors.