Article
Oncology
Junhao Liu, Zexuan Liu, Mengxing Li, Weiwei Tang, Uday P. Pratap, Yiliao Luo, Kristin A. Altwegg, Xiaonan Li, Yi Zou, Hong Zhu, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Ratna K. Vadlamudi
Summary: PELP1 has been identified as a novel interacting protein of TFAP2C, and both factors regulate a set of genes that affect the progression of breast cancer.
MOLECULAR ONCOLOGY
(2021)
Review
Oncology
Valentina Diehl, Lisa Sophie Huber, Jonel Trebicka, Malgorzata Wygrecka, Renato V. Iozzo, Liliana Schaefer
Summary: Decorin and biglycan play critical roles in tumor biology by influencing key processes that affect tumor growth and progression. Despite their structural homology, these proteoglycans interact with different cell surface receptors, modulating distinct signaling pathways that ultimately impact cancer development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yujiro Nagata, Takuo Matsukawa, Takuro Goto, Yuki Teramoto, Guiyang Jiang, Naohiro Fujimoto, Hiroshi Miyamoto
Summary: The expression status of mineralocorticoid receptor (MR) and its biological significance in human urothelial carcinoma were investigated in this study. It was found that MR can suppress the development of urothelial cancer. Furthermore, inhibiting MR expression or using MR antagonists increased the expression of beta-catenin, c-Fos, and N-cadherin, while decreasing the expression of E-cadherin. These findings suggest that MR signaling functions as a suppressor for urothelial tumorigenesis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Zhen Zhang, Hong Zhao, Chu Chu, Xiaoxiao Fu, Yonglin Liu, Li Wang, Ran Wei, Ke Xu, Lihua Li, Xia Li
Summary: Ovarian cancer is fatal to women with a high mortality rate, and efforts to identify diagnostic and intervention strategies are ongoing with limited success. Inflammation plays a crucial role in the initiation and progression of ovarian cancer, triggered by various stimuli and innate immune system related receptors like Toll-like receptors and cyclic GMP-AMP synthase. The complexity of pathogenesis poses challenges in effectively managing ovarian cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jian Yi Chai, Vaisnevee Sugumar, Mohammed Abdullah Alshawsh, Won Fen Wong, Aditya Arya, Pei Pei Chong, Chung Yeng Looi
Summary: The Hedgehog (Hh)-glioma-associated oncogene homolog (GLI) signaling pathway is highly conserved in mammals and plays crucial roles in cancer initiation and progression. GLI transcription factors are regulated by both SMO-dependent and SMO-independent mechanisms, with dysregulation leading to tumorigenesis in various cancers. Understanding the complex interplay between GLI and signaling elements could inspire new therapeutic breakthroughs for Hh-GLI-dependent cancers.
Article
Biochemistry & Molecular Biology
Veena Kumari Vuttaradhi, Inemai Ezhil, Divya Ramani, Rahul Kanumuri, Swetha Raghavan, Vaishnavi Balasubramanian, Roshni Saravanan, Archana Kanakarajan, Leena Dennis Joseph, Ravi Shankar Pitani, Sandhya Sundaram, Anita Sjolander, Ganesh Venkatraman, Suresh Kumar Rayala
Summary: This study reveals the significant role of PELP1 in inflammation-induced oncogenesis and its expression regulation through specific transcriptional control by c-Rel. Additionally, overexpression of PELP1 in macrophages promotes cancer progression through paracrine secretion. These findings underscore the connection between PELP1 and inflammation-driven tumor development.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Oncology
Christen A. Khella, Lucyann Franciosa, Lorna Rodirguez-Rodriguez, Resha Rajkarnikar, Karthikeyan Mythreye, Michael L. Gatza
Summary: In this study, the researchers used a proteogenomic approach to analyze HGSOC tumor samples and identified the upregulation of hematopoietic cell kinase (HCK) expression and signaling in poor prognostic HGSOC patients. Further studies showed that HCK promotes cell proliferation, colony formation, and invasive capacity through CD44 and NOTCH3-dependent signaling. This study suggests that targeting the HCK-CD44-NOTCH3 signaling pathway could be a potential therapeutic opportunity for aggressive and recurrent HGSOC patients.
MOLECULAR CANCER RESEARCH
(2023)
Article
Oncology
Kristin A. Altwegg, Uday P. Pratap, Zexuan Liu, Junhao Liu, John R. Sanchez, Xue Yang, Behnam Ebrahimi, Durga Meenakshi Panneerdoss, Xiaonan Li, Gangadhara R. Sareddy, Suryavathi Viswanadhapalli, Manjeet K. Rao, Ratna K. Vadlamudi
Summary: PELP1 signaling plays a crucial role in the progression of TNBC. In this study, the effectiveness of a newly developed PELP1 inhibitor, SMIP34, for the treatment of TNBC was investigated. The results showed that SMIP34 effectively inhibited TNBC cell growth and invasion, and reduced tumor progression.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Biochemistry & Molecular Biology
Monika Englert-Golon, Miroslaw Andrusiewicz, Aleksandra Zbikowska, Malgorzata Chmielewska, Stefan Sajdak, Malgorzata Kotwicka
Summary: Ovarian cancer remains the leading cause of death in gynecologic malignancies. Estrogen-related pathways genes, especially PELP1, play important roles in ovarian tumorigenesis. The expression levels of PELP1 and SRC differ significantly in ovarian cancer patients compared to controls, indicating their potential as interesting targets in ovarian cancer biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Fabin Dang, Li Nie, Wenyi Wei
Summary: Cell cycle progression relies on the activation of cyclin-dependent kinases, regulated in part by ubiquitin-mediated proteolysis. Dysregulated proteolytic control can lead to uncontrolled cell proliferation and tumorigenesis. Targeting E3 ubiquitin ligases involved in cell cycle regulation may offer novel therapeutic strategies for cancer treatment.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biochemistry & Molecular Biology
Bikesh K. Nirala, Taku Yamamichi, Jason T. Yustein
Summary: Osteosarcoma is a common primary bone tumor in pediatric and adolescent populations, with high metastatic potential to the lungs. It lacks conserved translocations or genetic mutations but has heterogeneous abnormalities. Current treatment is based on surgical excision and multiagent therapies, but targeted therapies are being developed. This review focuses on the major signaling pathways and proposes the consideration of novel and targeted therapies in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sen Yu, Jie He, Keping Xie
Summary: Tight junction (TJ) is a barrier in epithelial and endothelial cells that maintains paracellular substrate transport and cell polarity. Zonula occludens (ZO) proteins, as cytoplasmic adaptor proteins adjacent to the cell membrane, connect transmembrane TJ proteins and cytoplasmic cytoskeleton to maintain barrier function. Besides their structural role, ZO proteins also play important roles in signal regulation, such as cell proliferation, motility, embryonic development, tissue homeostasis, inflammation, tumorigenesis, and cancer progression. This review focuses on the signal regulating function of ZO proteins in inflammation and tumorigenesis, and discusses the limitations and future challenges in ZO protein research.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Editorial Material
Cell Biology
Hyun Min Lee, Anushka Nayak, Jiyeon Kim
Summary: The tumor-supporting roles of ammonia have been recognized in recent years, primarily focusing on its role as a nitrogen source. However, a recent study published in Nature Metabolism reveals a novel non-nitrogen metabolism-related function of ammonia. The study shows that ammonia serves as a key activator for lipogenesis by facilitating SREBP-1 activation.
Article
Multidisciplinary Sciences
Madhurima Ghosh, Sanjeev Das
Summary: PRAMEF2 is repressed under conditions of altered metabolic homeostasis in a FOXP3-dependent manner, and mediates polyubiquitylation of LATS1 kinase of the Hippo/YAP pathway, leading to enhanced nuclear accumulation of YAP and increased expression of proliferative and metastatic genes. This promotes a malignant phenotype.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Biochemistry & Molecular Biology
Xiaofan Gao, Bo Wang, Yibao Huang, Meng Wu, Yuting Li, Yinuo Li, Xiaoran Zhu, Mingfu Wu
Summary: The ovary, as a reproductive endocrine organ in women, plays a significant role in the aging process, leading to menopause, decreased fertility, and long-term health risks. Oxidative stress is closely associated with aging metabolic processes and affects both physiological and pathological ovarian aging. The Nrf2 pathway is crucial in regulating the antioxidant response, and therapeutic strategies aimed at modulating this pathway have been identified to ameliorate ovarian aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Evan F. Cromwell, Oksana Sirenko, Ekaterina Nikolov, Matthew Hammer, Courtney K. Brock, Margarite D. Matossian, Madlin S. Alzoubi, Bridgette M. Collins-Burow, Matthew E. Burow
Summary: 3D cell models derived from patient tumors can recapitulate the complex genetic and molecular compositions of solid cancers, making them valuable tools for drug target identification and drug testing. However, using these models for assays is still challenging. In this study, the authors describe methods for processing and multi-functional profiling of tumoroids to test compound effects using a novel flowchip system. The results provide an in-depth understanding of the drug sensitivity of individual tumor types, with important implications for personalized medicine.
Article
Biochemistry & Molecular Biology
Rashidra R. Walker, Jankiben R. Patel, Akash Gupta, A. Michael Davidson, Christopher C. Williams, Florastina Payton-Stewart, Stephen M. Boue, Matthew E. Burow, Rahul Khupse, Syreeta L. Tilghman
Summary: The combination treatment of glyceollins and lapatinib could reduce the proliferation of hormone-dependent letrozole-resistant breast cancer cells by inducing apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Katie M. Hamel, Connor T. King, Maryn B. Cavalier, Kara Q. Liimatta, Grace L. Rozanski, Timothy A. King, Meggie Lam, Grace C. Bingham, C. Ethan Byrne, Diensn Xing, Bridgette M. Collins-Burow, Matthew E. Burow, Jorge A. Belgodere, Melyssa R. Bratton, Bruce A. Bunnell, Elizabeth C. Martin
Summary: Adipose tissue acts as an endocrine organ and its signals contribute to the progression of breast cancer. Young breast tumors have more matrix and paracrine factors compared to aged tumors. Factors produced by young adipose tissue enhance the endocrine response in breast cancer cells.
STEM CELLS AND DEVELOPMENT
(2022)
Article
Oncology
Alifiani Bonita Hartono, Hong-Jun Kang, Lawrence Shi, Whitney Phipps, Nathan Ungerleider, Alexandra Giardina, WeiPing Chen, Lee Spraggon, Romel Somwar, Krzysztof Moroz, David H. Drewry, Matthew E. Burow, Erik Flemington, Marc Ladanyi, Sean Bong Lee
Summary: Desmoplastic Small Round Cell Tumor (DSRCT) is a rare and aggressive malignant cancer caused by a chromosomal translocation. The study identified SIK1 as a direct target of the oncogenic transcription factor EWSR1-WT1, and depletion of SIK1 inhibited tumor cell growth and DNA replication. Combined inhibition of SIK1 and CHEK1 showed enhanced cytotoxicity in DSRCT cells.
Article
Endocrinology & Metabolism
Fahima Munmun, Omair A. Mohiuddin, Van T. Hoang, Matthew E. Burow, Bruce A. Bunnell, Veronica M. Sola, Agata R. Carpentieri, Paula A. Witt-Enderby
Summary: This study demonstrates for the first time the role of MEK1/2 and MEK5 in modulating melatonin-mediated actions on bone formation in vivo and in a sex-specific manner.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shengli Dong, Hassan Yousefi, Isabella Van Savage, Samuel C. Okpechi, Maryl K. Wright, Margarite D. Matossian, Bridgette M. Collins-Burow, Matthew E. Burow, Suresh K. Alahari
Summary: Combination therapy with ceritinib and enzalutamide inhibits the growth of AR(+) TNBC cells, while combination therapy with ceritinib and paclitaxel drastically inhibits tumor growth. These findings suggest that combination treatment with these FDA-approved drugs can improve the therapeutic response in both AR-positive and negative breast cancer.
Article
Biochemistry & Molecular Biology
Connor T. King, Margarite D. Matossian, Jonathan J. Savoie, Khoa Nguyen, Maryl K. Wright, C. Ethan Byrne, Steven Elliott, Hope E. Burks, Melyssa R. Bratton, Nicholas C. Pashos, Bruce A. Bunnell, Matthew E. Burow, Bridgette M. Collins-Burow, Elizabeth C. Martin
Summary: In this study, the role of liver kinase B1 (LKB1) in regulating the tumor microenvironment was evaluated. Results showed that LKB1 affects tumorigenesis and metastasis by altering matrix protein production and inhibiting adipogenesis. LKB1 overexpression decreases collagen production and suppresses tumor-mediated adipogenesis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Oncology
Bruce A. Bunnell, Elizabeth C. Martin, Margarite D. Matossian, Courtney K. Brock, Khoa Nguyen, Bridgette Collins-Burow, Matthew E. Burow
Summary: The increase in obesity has led to more adipose stromal/stem cells (ASCs) in the body, which have been shown to impact cancer progression. Obesity-induced alterations in the biological properties of ASCs contribute to enhanced tumorigenesis and metastasis of cancer cells. The interaction between obesity and ASCs plays a role in the development and aggressiveness of various cancers.
CANCER AND METASTASIS REVIEWS
(2022)
Meeting Abstract
Oncology
Oksana Sirenko, Angeline Lim, Courtney K. Brock, Katya Nikolov, Cathy Olsen, Evan F. Cromwell, Margarite D. Matossian, Matthew E. Burow
Article
Oncology
Khoa Nguyen, Emily McConnell, Orielle Edwards, Bridgette M. Collins-Burow, Matthew E. Burow
Summary: This article discusses the issue of resistance in breast cancer therapies, with a focus on the cancer stem cell subpopulation and their mechanisms for resistance.
CANCER DRUG RESISTANCE
(2022)
Review
Biochemistry & Molecular Biology
Khoa Nguyen, Hassan Yousefi, Thomas Cheng, Justin Magrath, Alifiani B. Hartono, Madlin Alzoubi, Katherine Hebert, Courtney K. Brock, Maryl K. Wright, Charles Ethan Byrne, Andrew Rivera, Sam C. Okpechi, Margarite Delores Matossian, Henri Wathieu, Steven Elliott, Mark J. Mondrinos, Sean B. Lee, Bridgette M. Collins-Burow, Suresh K. Alahari, David H. Drewry, Matthew E. Burow
Summary: In this study, we analyzed the expression levels of MAP3K19 in different tissue types using bioinformatics databases, and explored its correlation with patient survival in different cancers.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Review
Biochemistry & Molecular Biology
Khoa Nguyen, Minh N. Tran, Andrew Rivera, Thomas Cheng, Gabrielle O. Windsor, Abraham B. Chabot, Jane E. Cavanaugh, Bridgette M. Collins-Burow, Sean B. Lee, David H. Drewry, Patrick T. Flaherty, Matthew E. Burow
Summary: The mitogen-activated protein kinasc (MAPK) pathways play crucial roles in cellular signaling and proper biological functions. This review discusses the significance of the MAP3K family in the larger MAPK pathway, their correlation with cancer progression, and the understudied status of these kinases.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Meeting Abstract
Medicine, General & Internal
K. Hebert, M. Burow, F. Lau, E. C. Martin
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Meeting Abstract
Medicine, General & Internal
M. Wright, M. Matossian, K. Nguyen, C. King, S. Elliott, A. Giardina, M. Bratton, E. C. Martin, B. Collins-Burow, M. Burow
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
Meeting Abstract
Medicine, General & Internal
C. Brock, M. Wright, K. Nguyen, T. Cheng, B. Collins-Burow, B. Bunnell, M. Burow
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)
