Article
Immunology
Linpei Guo, Hui Xie, Zheng Zhang, Zhun Wang, Shuanghe Peng, Yuanjie Niu, Zhiqun Shang
Summary: The study demonstrated that a vaccine based on a fusion protein of Ag85B and a prostate cancer octapeptide epitope triggered a robust immune response and inhibited tumor growth in murine prostate cancer.
Review
Immunology
Jorge A. Soto, Nicolas M. S. Galvez, Catalina A. Andrade, Mario A. Ramirez, Claudia A. Riedel, Alexis M. Kalergis, Susan M. Bueno
Summary: BCG vaccine is used to prevent tuberculosis infection and has the ability to enhance immune response to other vaccines and promote nonspecific immunomodulatory effects through epigenetic reprogramming and metabolic shifts.
TRENDS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Raphael Bernard-Valnet, David Frieser, Xuan-Hung Nguyen, Leila Khajavi, Clemence Queriault, Sebastien Arthaud, Silvia Melzi, Maxime Fusade-Boyer, Frederick Masson, Matthias Zytnicki, Abdelhadi Saoudi, Yves Dauvilliers, Christelle Peyron, Jan Bauer, Roland S. Liblau
Summary: This study reveals that Pandemrix (R) vaccination may induce narcolepsy through immune cross-reactivity with a self-antigen, leading to an immunopathological process. This process relies on the synergy between CD4 and CD8 T cells.
Article
Multidisciplinary Sciences
Fatemeh Askarian, Chih-Ming Tsai, Gabriele Cordara, Raymond H. Zurich, Elisabet Bjanes, Ole Golten, Henrik Vinther Sorensen, Armin Kousha, Angela Meier, Elvis Chikwati, Jack-Ansgar Bruun, Judith Anita Ludviksen, Biswa Choudhury, Desmond Trieu, Stanley Davis, Per Kristian Thoren Edvardsen, Tom Eirik Mollnes, George Y. Liu, Ute Krengel, Douglas J. Conrad, Gustav Vaaje-Kolstad, Victor Nizet
Summary: The study reveals the virulence role of Pseudomonas aeruginosa (PA) CbpD in PA pneumonia, which is related to the impairment of the host complement function and opsonophagocytic clearance. The research shows that a PAΔCbpD mutant is more easily cleared and causes less mortality compared to the wild-type strain. Furthermore, the study provides insights into the structure and immunogenicity of CbpD, laying the foundation for the development of novel and effective vaccine antigens.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Licong Wang, Maoxia Yang, Sheng Luo, Guanjun Yang, Xinjiang Lu, Jianfei Lu, Jiong Chen
Summary: This study evaluated the protective efficacy of oral administration of surface-displayed ORF132 against CyHV-2 infection. The results showed that oral vaccination evoked strong immune responses and provided significant protection for crucian carp, resulting in a relative percent survival of 64%.
Article
Immunology
Chaojie Zhong, Hongjie Xia, Awadalkareem Adam, Binbin Wang, Renee L. Hajnik, Yuejin Liang, Grace H. Rafael, Jing Zou, Xiaofang Wang, Jiaren Sun, Lynn Soong, Alan D. T. Barrett, Scott C. Weaver, Pei-Yong Shi, Tian Wang, Haitao Hu
Summary: The candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing viral N and S proteins induced T-cell responses and binding antibodies, but not neutralizing antibodies. Intranasal immunization with the vaccine reduced viral loads and lung inflammation in mice after SARS-CoV-2 challenge, correlated with T-cell response in the lung, indicating the importance of T-cell immunity for protection against SARS-CoV-2 infection in addition to neutralizing antibodies.
Review
Biochemistry & Molecular Biology
Kevin Bode, Mathias Hauri-Hohl, Vincent Jaquet, Heiko Weyd
Summary: Reactive oxygen species (ROS) have diverse functions within cells and organisms, but their potential to damage biological structures has long been recognized. While phagocytes use ROS to defend against pathogens, regulated release of signaling ROS (sROS) modulates immune responses. This release is primarily attributed to the enzyme NOX2 expressed in myeloid cells. A comprehensive understanding of NOX2 activation and regulation is crucial for pharmaceutical interventions of ROS-related diseases. In this review, recent progress regarding immune regulation by NOX2-derived ROS and the consequences of its deregulation on immune disorders are summarized.
Article
Immunology
Seyedeh-Raheleh Niavarani, Guillaume St-Cyr, Lauren Daniel, Christine Lawson, Hugo Giguere, Almohanad A. Alkayyal, Lee-Hwa Tai
Summary: Triple negative breast cancer (TNBC) is a highly aggressive and difficult to treat subtype of breast cancer. Current treatment methods such as surgery, chemotherapy, and hormone/Her2 targeted therapies are not effective for TNBC patients. However, immunotherapies show promise in TNBC due to the high number of immune cells in the tumor. This preclinical study proposes a novel vaccination strategy using an oncolytic virus-infected cell vaccine to target TNBC.
FRONTIERS IN IMMUNOLOGY
(2023)
Letter
Oncology
Xi Wu, Lu Wang, Lu Shen, Lin He, Kefu Tang
Summary: Recipients after HSCT or CAR-T therapy are at increased risk for unfavorable outcomes after SARS-CoV-2 infection. The immune response to COVID-19 vaccines is attenuated in these recipients, with time interval between transplant and vaccination, immunosuppressive therapy, and lymphocyte counts significantly affecting the humoral response in HSCT recipients. Seroconversion is higher in BCMA-based CAR-T patients compared to CD19-based CAR-T patients. An adapted vaccination strategy and further research on booster dose and cellular response are warranted for HSCT and CAR-T recipients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Immunology
Akhilesh Kumar Shakya, Kutty Selva Nandakumar
Summary: Activation of the immune system is crucial for designing new antigen/drug delivery systems and studying disease pathogenesis. Polymers are often needed to assist in controlling the release of antigens and efficiently activating the immune system. Different functional groups of polymers have different applications, such as protein-based antigens and nucleic acid-based antigens. Polymers can also be used in cancer immunotherapy and developing disease models.
Article
Cell Biology
Wenwen Jiang, Li Shi, Lukui Cai, Xiaoyu Wang, Jingyan Li, Heng Li, Jiangli Liang, Qin Gu, Guang Ji, Jing Li, Longding Liu, Mingbo Sun
Summary: The developed candidate vaccine combines N protein and prefusion-full S protein, generating stronger systemic and mucosal humoral immunity through the combination of flagellin and cyclic GMP-AMP. Additionally, administering the candidate vaccine via intranasal route can enhance local immune responses in the respiratory tract and protect against lethal SARS-CoV-2 challenge.
Article
Multidisciplinary Sciences
Takashi Ishii, Kensuke Hamada, Daisuke Jubishi, Hideki Hashimoto, Koh Okamoto, Naoko Hisasue, Mitsuhiro Sunohara, Minako Saito, Takayuki Shinohara, Marie Yamashita, Yuji Wakimoto, Amato Otani, Mahoko Ikeda, Sohei Harada, Shu Okugawa, Kyoji Moriya, Shintaro Yanagimoto
Summary: By analyzing the cellular immune responses of 321 healthcare workers vaccinated with BNT162b2 mRNA vaccines, we found that the durability and influencing factors of cellular immune responses have not been fully understood. The levels of interferon-gamma (IFN-& gamma;) produced by CD4+ and CD8+ T cells stimulated with spike epitopes gradually declined after vaccination. Factors such as age, dyslipidemia, adverse reactions to vaccination, and certain blood cell counts were significantly correlated with the long-lasting effects of cellular immune responses. These results highlight the importance of booster vaccines for sustaining cellular immunity against SARS-CoV-2.
SCIENTIFIC REPORTS
(2023)
Article
Biotechnology & Applied Microbiology
Ina Charlotta Werninghaus, Daniela Maria Hinke, Even Fossum, Bjarne Bogen, Ranveig Braathen
Summary: Conventional influenza vaccines primarily target hemagglutinin (HA), but this study demonstrates the importance of neuraminidase (NA) as an independent correlate of protection. The introduction of NA ectodomain into DNA vaccines, which specifically target antigen-presenting cells (APCs), resulted in the production of strong and long-lasting NA-specific antibodies in mice. These antibodies inhibited NA enzymatic activity, reduced viral replication, and provided complete protection against a homologous influenza virus. The study also found that NA immunity induced by this vaccine outperformed NA immunity induced by a traditional inactivated virus vaccine. Overall, this research highlights the potential of NA as a valuable antigen in influenza vaccine development.
Article
Multidisciplinary Sciences
Alexis J. Combes, Tristan Courau, Nicholas F. Kuhn, Kenneth H. Hu, Arja Ray, William S. Chen, Nayvin W. Chew, Simon J. Cleary, Divyashree Kushnoor, Gabriella C. Reeder, Alan Shen, Jessica Tsui, Kamir J. Hiam-Galvez, Priscila Munoz-Sandoval, Wandi S. Zhu, David S. Lee, Yang Sun, Ran You, Melia Magnen, Lauren Rodriguez, K. W. Im, Nina K. Serwas, Aleksandra Leligdowicz, Colin R. Zamecnik, Rita P. Loudermilk, Michael R. Wilson, Chun J. Ye, Gabriela K. Fragiadakis, Mark R. Looney, Vincent Chan, Alyssa Ward, Sidney Carrillo, Michael Matthay, David J. Erle, Prescott G. Woodruff, Charles Langelier, Kirsten Kangelaris, Carolyn M. Hendrickson, Carolyn Calfee, Arjun Arkal Rao, Matthew F. Krummel
Summary: Patients with mild COVID-19 exhibit a coordinated pattern of expression of interferon-stimulated genes (ISGs) across every cell population, whereas these ISG-expressing cells are systemically absent in patients with severe disease. Individuals with severe COVID-19 produce very high titres of anti-SARS-CoV-2 antibodies and have a lower viral load compared to individuals with mild disease.
Article
Cell Biology
Inmaculada Martos-Folgado, Alberto del Monte-Monge, Cristina Lorenzo, Christian E. Busse, Pilar Delgado, Sonia M. Mur, Laura Cobos-Figueroa, Joan C. Escola-Gil, Jose L. Martin-Ventura, Hedda Wardemann, Almudena R. Ramiro
Summary: Immunization with MDA-LDL in mice can induce antibody responses, promote germinal center antibody responses, and prevent atherosclerosis. Chimeric animals lacking germinal center plasma cells show accelerated atherosclerosis.
Article
Multidisciplinary Sciences
Joseph G. Skeate, Diane M. Da Silva, Elena Chavez-Juan, Snjezana Anand, Richard Nuccitelli, W. Martin Kast
Article
Oncology
Irina Lerman, Xiaoting Ma, Christina Seger, Aerken Maolake, Maria de la Luz Garcia-Hernandez, Javier Rangel-Moreno, Jessica Ackerman, Kent L. Nastiuk, Martha Susiarjo, Stephen R. Hammes
MOLECULAR CANCER RESEARCH
(2019)
Article
Immunology
Diane M. Da Silva, Joseph G. Skeate, Elena Chavez-Juan, Kim P. Luhen, Jiun-Ming Wu, Chia-Mao Wu, W. Martin Kast, KinKai Hwang
Article
Rheumatology
Richard D. Bell, Emily K. Wu, Christopher A. Rudmann, Megan Forney, Claire R. W. Kaiser, Ronald W. Wood, Joe Chakkalakal, Nicole D. Paris, Alanna Klose, Guang-Qian Xiao, Javier Rangel-Moreno, Maria L. Garcia-Hernandez, Christopher T. Ritchlin, Edward M. Schwarz, Homaira Rahimi
ARTHRITIS & RHEUMATOLOGY
(2019)
Article
Multidisciplinary Sciences
Amanda Ardain, Racquel Domingo-Gonzalez, Shibali Das, Samuel W. Kazer, Nicole C. Howard, Alveera Singh, Mushtaq Ahmed, Shepherd Nhamoyebonde, Javier Rangel-Moreno, Paul Ogongo, Lan Lu, Duran Ramsuran, Maria de la Luz Garcia-Hernandez, Tyler K. Ulland, Matthew Darby, Eugene Park, Farina Karim, Laura Melocchi, Rajhmun Madansein, Kaylesh Jay Dullabh, Micah Dunlap, Nancy Marin-Agudelo, Takashi Ebihara, Thumbi Ndung'u, Deepak Kaushal, Alexander S. Pym, Jay K. Kolls, Adrie Steyn, Joaquin Zuniga, William Horsnell, Wayne M. Yokoyama, Alex K. Shalek, Henrik N. Kloverpris, Marco Colonna, Alasdair Leslie, Shabaana A. Khader
Correction
Multidisciplinary Sciences
Amanda Ardain, Racquel Domingo-Gonzalez, Shibali Das, Samuel W. Kazer, Nicole C. Howard, Alveera Singh, Mushtaq Ahmed, Shepherd Nhamoyebonde, Javier Rangel-Moreno, Paul Ogongo, Lan Lu, Duran Ramsuran, Maria de la Luz Garcia-Hernandez, Tyler K. Ulland, Matthew Darby, Eugene Park, Farina Karim, Laura Melocchi, Rajhmun Madansein, Kaylesh Jay Dullabh, Micah Dunlap, Nancy Marin-Agudelo, Takashi Ebihara, Thumbi Ndung'u, Deepak Kaushal, Alexander S. Pym, Jay K. Kolls, Adrie Steyn, Joaquin Zuniga, William Horsnell, Wayne M. Yokoyama, Alex K. Shalek, Henrik N. Kloverpris, Marco Colonna, Alasdair Leslie, Shabaana A. Khader
Article
Oncology
Manisha Taya, Maria de la Luz Garcia-Hernandez, Javier Rangel-Moreno, Briaunna Minor, Erin Gibbons, Stephen R. Hammes
ENDOCRINE-RELATED CANCER
(2020)
Article
Rheumatology
Richard D. Bell, R. James White, Maria L. Garcia-Hernandez, Emily Wu, Homaira Rahimi, Roberta G. Marangoni, Pamelia Slattery, Stacey Duemmel, Marc Nuzzo, Nelson Huertas, Min Yee, Michael A. O'Reilly, Craig Morrell, Christopher T. Ritchlin, Edward M. Schwarz, Benjamin D. Korman
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Cell Biology
Shantae M. Thornton, Varsha D. Samararatne, Joseph G. Skeate, Christopher Buser, Kim P. Luehen, Julia R. Taylor, Diane M. Da Silva, W. Martin Kast
Article
Immunology
Ji Young Hwang, Aaron Silva-Sanchez, Damian M. Carragher, Maria de la Luz Garcia-Hernandez, Javier Rangel-Moreno, Troy D. Randall
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Microbiology
Ekaterina Esaulova, Shibali Das, Dhiraj Kumar Singh, Jose Alberto Choreno-Parra, Amanda Swain, Laura Arthur, Javier Rangel-Moreno, Mushtaq Ahmed, Bindu Singh, Ananya Gupta, Luis Alejandro Fernandez-Lopez, Maria de la Luz Garcia-Hernandez, Allison Bucsan, Chivonne Moodley, Smriti Mehra, Ethel Garcia-Latorre, Joaquin Zuniga, Jeffrey Atkinson, Deepak Kaushal, Maxim N. Artyomov, Shabaana A. Khader
Summary: The immune landscape of the lungs in NHPs with LTBI and PTB was characterized using high-throughput technologies. PTB in macaque lungs is characterized by the influx of pDCs, an IFN-responsive macrophage population, and activated T cell responses. On the other hand, LTBI in macaques is marked by the accumulation of a CD27(+) NK cell subset in the lungs.
CELL HOST & MICROBE
(2021)
Article
Rheumatology
Javier Rangel-Moreno, Maria de la Luz Garcia-Hernandez, Teresa Owen, Jennifer Barnard, Enrique Becerril-Villanueva, Trinayan Kashyap, Christian Argueta, Armando Gamboa-Dominguez, Sharon Tamir, Yosef Landesman, Bruce I. Goldman, Christopher T. Ritchlin, Jennifer H. Anolik
Summary: This study investigates the potential of selective inhibitors of nuclear export (SINE compounds) in the treatment of lupus. The results show that SINE compound KPT-350 can effectively treat lupus nephritis and reduce autoreactive plasma cell counts. The compounds target multiple molecular and cellular pathways involved in lupus pathogenesis, including the production of cytokines and chemokines.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Ananta Paine, Paul S. S. Brookes, Soumyaroop Bhattacharya, Dongmei Li, Maria De La Luz Garcia-Hernandez, Francisco Tausk, Christopher Ritchlin
Summary: We found differences in serum metabolites between PsA patients, psoriasis patients, and healthy controls. Differential abundance of bile acids, purines, pyrimidines, glutathione, lipids, and amino acid metabolites were observed in these three groups. Differences were also noted between psoriasis patients who progressed and those who did not progress to PsA. Decreased bile acid and butyrate levels and increased guanine levels in psoriasis patients at risk for PsA were particularly significant and may be reflective of gut microbial dysbiosis and dysregulated hepatic metabolism, leading to altered immune cell proliferation and enhanced cytokine expression.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Oncology
Diane M. Da Silva, Emma A. Martinez, Lies Bogaert, W. Martin Kast
Summary: The selection of a therapeutic vaccine schedule can impact the magnitude, efficacy, and durability of immune responses. This study compared different prime-boost intervals in a human papillomavirus model and found that longer intervals can enhance long-term protective anti-tumor immunity.
Article
Virology
Luana Lorena Silva Rodrigues, Jose Henrique Pilotto, Katrini Guidolini Martinelli, Alcina F. Nicol, Vanessa Salete De Paula, Tarik Gheit, Nathalia Silva Carlos Oliveira, Carlos Silva-de-Jesus, Vikrant V. Sahasrabuddhe, Diane M. Da Silva, W. Martin Kast, Justin Hardick, Charlotte A. Gaydos, Mariza Goncalves Morgado
Summary: The aim of this study was to classify the diversity of anal HPV and non-HPV sexually transmitted infections (STIs) and compare the concordance between anal and genital infections in HIV-infected and uninfected women living in the Tapajos region, Amazon, Brazil. The overall prevalence of anal HPV infection was high, especially in HIV-infected women. The concordance analysis showed moderate to fair agreement between anal and genital HPV and non-HPV STIs.