Article
Oncology
Bandish B. Kapadia, Anirban Roychowdhury, Forum Kayastha, Nahid Nanaji, Ronald B. Gartenhaus
Summary: In this study, the researchers found that PARK2 ubiquitinates eIF4B and regulates overall protein translational activity, which is negatively regulated by mTORC1 signaling. Phosphorylation of PARK2 reduces its ubiquitination activity, thereby hindering its tumor suppressor effect on eIF4B's stability.
MOLECULAR CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Xue Gong, Miao Tian, Nian Cao, Peili Yang, Zaicheng Xu, Shuo Zheng, Qiao Liao, Caiyu Chen, Cindy Zeng, Pedro A. Jose, Da-Zhi Wang, Zhao Jian, Yingbin Xiao, Ding-Sheng Jiang, Xiang Wei, Bing Zhang, Yibin Wang, Ken Chen, Gengze Wu, Chunyu Zeng
Summary: This study identified a potentially novel circRNA, circEsyt2, that regulates vascular remodeling by interacting with the protein PCBP1 to control RNA splicing, affecting proliferation and migration of vascular smooth muscle cells and neointima formation in atherosclerotic mouse models.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Benedetta Apollonio, Filomena Spada, Nedyalko Petrov, Domenico Cozzetto, Despoina Papazoglou, Peter Jarvis, Shichina Kannambath, Manuela Terranova-Barberio, Rose-Marie Amini, Gunilla Enblad, Charlotte Graham, Reuben Benjamin, Elisabeth Phillips, Richard Ellis, Rosamond Nuamah, Mansoor Saqi, Dinis P. Calado, Richard Rosenquist, Lesley A. Sutton, Jon Salisbury, Georgios Zacharioudakis, Anna Vardi, Patrick R. Hagner, Anita K. Gandhi, Marina Bacac, Christina Claus, Pablo Umana, Ruth F. Jarrett, Christian Klein, Alexander Deutsch, Alan G. Ramsay
Summary: Recent transcriptomic analysis has uncovered the clinical relevance of LN fibroblast and tumor-infiltrating lymphocyte (TIL) signatures in diffuse large B cell lymphoma (DLBCL). The study demonstrates that DLBCL activates fibroblastic reticular cells (FRCs) in the tumor microenvironment, leading to immunosuppression and inhibition of TIL migration and cytotoxicity. Inhibiting FRCs can enhance antilymphoma TIL cytotoxicity, suggesting the potential for immunotherapy optimization for DLBCL patients.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Markus Schick, Le Zhang, Sabine Maurer, Hans Carlo Maurer, Konstandina Isaakaidis, Lara Schneider, Upayan Patra, Kathrin Schunck, Elena Rohleder, Julia Hofstetter, Apoorva Baluapuri, Anna Katharina Scherger, Julia Slotta-Huspenina, Franziska Hettler, Julia Weber, Thomas Engleitner, Roman Maresch, Jolanta Slawska, Richard Lewis, Rouzanna Istvanffy, Stefan Habringer, Katja Steiger, Armin Baiker, Robert A. J. Oostendorp, Cornelius Miething, Hans-Peter Lenhof, Florian Bassermann, Bjoern Chapuy, Matthias Wirth, Elmar Wolf, Roland Rad, Stefan Mueller, Ulrich Keller
Summary: Loss of the SUMO isopeptidase SENP6 leads to unrestricted SUMOylation and genomic instability, promoting lymphomagenesis and generating vulnerability to PARP inhibition.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Xin Gao, Chenguang Wang, Suhaib Abdelrahman, Nermin Kady, Carlos Murga-Zamalloa, Peter Gann, Maria Sverdlov, Ashley Wolfe, Avery Polk, Noah Brown, Nathanael G. Bailey, Kedar Inamdar, Sandro Casavilca-Zambrano, Jaime Montes, Carlos Barrionuevo, Luis Taxa, John Reneau, Christian W. Siebel, Ivan Maillard, Ryan A. Wilcox
Summary: Notch signaling pathway plays a crucial role in the pathogenesis of peripheral T-cell lymphoma, and Notch1 activation is associated with proliferation. Blockade of Notch1/Notch2 and DLL1/DLL4 can inhibit the proliferation of malignant T cells and tumor progression.
Article
Oncology
Yichen Sun, Yan Gao, Jianfeng Chen, Ling Huang, Peng Deng, Jinghong Chen, Kelila Xin Ye Chai, Jing Han Hong, Jason Yongsheng Chan, Haixia He, Yali Wang, Daryl Cheah, Jing Quan Lim, Burton Kuan Hui Chia, Dachuan Huang, Lizhen Liu, Shini Liu, Xiaoxiao Wang, Yan Teng, Diwen Pang, Nicholas Francis Grigoropoulos, Bin Tean Teh, Qiang Yu, Soon Thye Lim, Wenyu Li, Choon Kiat Ong, Huiqiang Huang, Jing Tan
Summary: The study demonstrates that DLBCL patients with CREBBP deficiency respond well to the HDAC inhibitor chidamide, especially when combined with an AURKA inhibitor.
Article
Medical Laboratory Technology
Huixian Ma, Xiangrui Luo, Peng Zhou, Na He, Jun Zhou, Min Liu, Wei Xie
Summary: The study identified that the deubiquitinase USP21 promotes cell proliferation by stabilizing the EZH2 protein level in DLBCL, without affecting cell death. This mechanism further reveals the pathogenesis of DLBCL.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Jiehui Di, Guang Zhao, Hui Wang, Yaoyao Wu, Zhongjun Zhao, Bao Zhu, Yanping Zhang, Junnian Zheng, Yong Liu, Ying Hu
Summary: A novel regulatory feedback loop between p53 and CPEB2 was identified in this study, where CPEB2 promotes renal cancer cell proliferation and migration by reducing p53 levels. This suggests that CPEB2 may serve as a potential therapeutic target in human renal cancer.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Review
Biochemistry & Molecular Biology
Bodo C. Melnik, Rudolf Stadler, Ralf Weiskirchen, Claus Leitzmann, Gerd Schmitz
Summary: Epidemiological evidence suggests a link between cow's milk consumption and the risk of DLBCL. This review explores the role of milk-related agents, such as milk-derived exosomes (MDEs) and their microRNAs (miRs), in lymphomagenesis. MDE miRs during breastfeeding can upregulate BCL6 and suppress BLIMP1, promoting B cell proliferation. After weaning, the decline in MDE miR signaling leads to a decrease in BCL6 expression and an increase in BLIMP1-mediated B cell maturation. However, the consumption of pasteurized cow's milk in adults may maintain high BLC6/BLIMP1 ratio and facilitate B cell de-differentiation, potentially contributing to B cell lymphomagenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Margaret A. Potts, Shinsuke Mizutani, Alexandra L. Garnham, Connie S. N. Li Wai Suen, Andrew J. Kueh, Lin Tai, Martin Pal, Andreas Strasser, Marco J. Herold
Summary: Many lymphoid malignancies result from abnormal c-MYC expression along with other genetic abnormalities. While many of these genetic abnormalities have been discovered, there may still be others that have not been investigated. In this study, TFAP4 was identified as a suppressor of c-MYC driven lymphoma development. Deletion of TFAP4 accelerated lymphoma development and blocked differentiation during early B cell development.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Cell Biology
Xinde Ou, Xingyu Zhou, Jin Li, Jinning Ye, Haohan Liu, Deliang Fang, Qinbo Cai, Shirong Cai, Yulong He, Jianbo Xu
Summary: The study revealed that LINC00893 is downregulated in gastric cancer tissues and its low expression is associated with tumor growth, metastasis, and poor survival. Overexpression of LINC00893 inhibits the proliferation, migration, and invasion of gastric cancer cells. Mechanistically, LINC00893 promotes the degradation of RBFOX2 protein, thus suppressing the epithelial-mesenchymal transition (EMT) and related functions of gastric cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michael J. O'Connor, Tanay Thakar, Claudia M. Nicolae, George-Lucian Moldovan
Summary: PARP14 is identified as a regulator of cyclin D1 expression, with its depletion leading to decreased cyclin D1 protein levels and G1 cell-cycle arrest. This regulation is achieved through controlling cyclin D1 mRNA levels and is dependent on an intact p53-p21 pathway. The findings highlight a new role for PARP14 in promoting cell-cycle progression through cyclin D1 and the p53 pathway.
Article
Biochemistry & Molecular Biology
Huishan Sun, Li Li, Wei Li, Fan Yang, Zhenxi Zhang, Zizhao Liu, Wenjing Du
Summary: The research discovered that p53 can suppress cholesterol biosynthesis by inhibiting SQLE, and the downregulation of SQLE is critical for p53-mediated tumor suppression.
Article
Oncology
Jianhong Fu, Xiaoli Lou, Shan Wan, Xin Zhao, Zhi Chen, Minsheng Zhu, Lingchuan Guo, Depei Wu, Shouli Wang
Summary: The downregulation of miR-196a-3p in DLBCL was associated with poor prognosis, while its overexpression inhibited cell growth by regulating the cell cycle, promoting apoptosis, and suppressing proliferation in DLBCL cells. Additionally, ADP ribosylation factor 4 (ARF4) was identified as a downstream target gene of miR-196a-3p.
Article
Oncology
Hong Zeng, Yongqiang Wei, Xiaolei Wei, Ru Feng
Summary: The study found that in diffuse large B-cell lymphoma, LINC00908 promotes malignancy by regulating miR-671-5p. Silencing LINC00908 significantly inhibits the growth of DLBCL.
CANCER MANAGEMENT AND RESEARCH
(2021)