Article
Genetics & Heredity
Biao Hu, Tianju Liu, Zhe Wu, Sem H. Phan, Karen Blyth
Summary: P53 can suppress the transcription and translation of C/EBP beta gene, and regulate the translation of LAP and LIP isoforms of C/EBP beta through the expression of eIF4E and eIF4E-BP1; furthermore, the 5'UTR region plays an important role in the differential control of LAP and LIP translation of C/EBP beta.
Article
Biochemistry & Molecular Biology
JanWillem Duitman, Leonie Hartl, Joris J. T. H. Roelofs, Maarten F. Bijlsma, C. Arnold Spek
Summary: C/EBP delta is downregulated in pancreatic ductal adenocarcinoma (PDAC) cells and associated with decreased patient survival and pro-tumorigenic properties. Systemic C/EBP delta facilitates pancreatic cancer metastasis, potentially through C/EBP delta-PAFR-dependent tumor cell extravasation.
Article
Biochemistry & Molecular Biology
HaiXu Song, Jiahao Liu, Xiaoxiang Tian, Dan Liu, Jiayin Li, Xiaojie Zhao, Zhu Mei, Chenghui Yan, Yaling Han
Summary: The transcription factor CCAAT/enhancer-binding protein ? (C/EBP?) plays a crucial role in the differentiation and cell cycle control of megakaryocytes (MKs), potentially aiding in the treatment of thrombocytopenia and other platelet-related disorders.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Multidisciplinary Sciences
Pritpal Kaur, Shreya Nagar, Madhura Bhagwat, Mohammad Uddin, Yan Zhu, Ivana Vancurova, Ales Vancura
Summary: Heme synthesis influences cellular energy and anabolism pathways, potentially leading to oxidative stress. Exogenous supplementation of heme precursor ALA can suppress oxidative metabolism and glycolysis in cancer cells, reducing proliferation and destabilizing the transcription regulator Bach1, indicating a promising anti-cancer strategy.
Article
Physiology
Pengyuan Chen, Wanzi Hong, Ziying Chen, Flora Gordillo-Martinez, Siying Wang, Hualin Fan, Yuanhui Liu, Yining Dai, Bo Wang, Lei Jiang, Hongjiao Yu, PengCheng He
Summary: The transcription factor C/EBP alpha plays a crucial role in the osteochondrogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and vascular calcification. C/EBP alpha regulates the expression of the osteochondrogenic gene SOX9, and its overexpression or knockdown affects VSMC calcification. Silencing SOX9 expression significantly inhibits phosphate- and calcium-induced VSMC calcification.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zuochen Du, Lu Huang, Xin Dai, Di Yang, Linlin Niu, Heather Miller, Changshun Ruan, Han Li, Leling Hu, Lijia Zhou, Ding Jian, Jian Sun, Xiaoqi Shi, Pei Huang, Yan Chen, Xiaodong Zhao, Chaohong Liu
Summary: The study reveals a new pathway (PGRN-EZH2-PLZF) that regulates the Th2 responses of iNKT cells and provides a potentially new target for asthma treatment.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Cell Biology
Huijuan Dai, Xiaonan Sheng, Yaohui Wang, Liheng Zhou, Yanping Lin, Yueyao Du, Fan Yang, Rui Sha, Jing Peng, Linli Yao, Wenjin Yin, Jinsong Lu
Summary: The study revealed that high HIF1a expression leads to lower pathological complete response and worse prognosis in breast cancer patients receiving taxane-based neoadjuvant therapy. HIF1a participates in interleukin 17 signaling pathway, affecting the sensitivity of paclitaxel to cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Francesca Ferrante, Benedetto Daniele Giaimo, Tobias Friedrich, Toshiya Sugino, Daniel Mertens, Sabrina Kugler, Bernd Martin Gahr, Steffen Just, Leiling Pan, Marek Bartkuhn, Michael Potente, Franz Oswald, Tilman Borggrefe
Summary: Notch signaling is crucial in tumorigenesis and its response is regulated by the hydroxylation and deubiquitination of NICD, which is disrupted under hypoxic conditions.
CELL DEATH & DISEASE
(2022)
Article
Immunology
Mengyuan Zhu, Han Han, Lei Hu, Yu Cao, Zhipeng Fan
Summary: IGFBP5 regulates the balance between Th17 and Treg cells by inhibiting Th17 differentiation and promoting Treg differentiation, alleviating colitis severity in mice models. In addition, IGFBP5 can suppress pro-inflammatory cytokines and its function can be inhibited by ERK or JNK pathway inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Neena Lala-Tabbert, Hamood AlSudais, Francois Marchildon, Dechen Fu, Nadine Wiper-Bergeron
Summary: The study shows that the transcription factor C/EBP beta is necessary to maintain quiescence of satellite cells in uninjured muscle. Loss of C/EBP beta in satellite cells promotes premature exit from quiescence, while forced expression of C/EBP beta inhibits proliferation by upregulating quiescence-associated genes. Additionally, caveolin-1 is identified as a direct transcriptional target of C/EBP beta required for cell cycle exit in muscle satellite cells expressing C/EBP beta.
Article
Multidisciplinary Sciences
Kazuki Kumon, Said M. Afify, Ghmkin Hassan, Shunsuke Ueno, Sadia Monzur, Hend M. Nawara, Hagar A. Abu Quora, Mona Sheta, Yanning Xu, Xiaoying Fu, Maram H. Zahra, Akimasa Seno, Masaharu Seno
Summary: The study revealed that under chemical hypoxic conditions, CSCs may differentiate into blood cells, indicating an impact on tumor heterogeneity in the tumor microenvironment.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yijie Wang, Xiong Liu, Min Liu, Yu Wang, Shuo Wang, Lai Jin, Min Liu, Jun Zhou, Yan Chen
Summary: It has been found that UBE3B acts as an E3 ligase for HIF-2 alpha, promoting its polyubiquitination and inhibiting its degradation, which plays a crucial role in breast cancer growth and metastasis.
Article
Oncology
Li-Mei Zhang, Mo Li, Chen-Chen Tian, Tong-Tong Wang, Shu-Fang Mi
Summary: This study revealed that downregulation of CEBPA in ovarian cancer predicted poor prognosis. Knockout of CEBPA promoted various features of cancer in ovarian cancer cells, while overexpression of CEBPA suppressed these features.
Article
Multidisciplinary Sciences
Yongkang Yang, Chelsey Chen, Qiaozhu Zuo, Haiquan Lu, Shaima Salman, Yajing Lyu, Tina Yi-Ting Huang, Elizabeth E. Wicks, Walter Jackson III, Emmanuel Datan, Ru Wang, Yufeng Wang, Nguyet Le, Yayun Zhu, Wenxin Qin, Gregg L. Semenza
Summary: Hypoxia in the breast cancer microenvironment leads to increased expression of HIF-1, which is associated with poor patient outcome. In this study, NARF was identified as a hypoxia-inducible, HIF-1 target gene in human breast cancer cells. Knockdown of NARF significantly reduced the population of breast cancer stem cells and impaired tumor initiation capacity and lung metastasis in mouse models.
Article
Cell Biology
Jiang Huang, Hui-liang Shen, Ming-li Feng, Zheng Li, Shuai An, Guang-lei Cao
Summary: This study reveals the significant role of long non-coding RNA MALAT1 in promoting fracture healing under hypoxic conditions.
HISTOLOGY AND HISTOPATHOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Marie Caillaud, Mevidette El Madani, Liliane Massaad-Massade
JOURNAL OF CONTROLLED RELEASE
(2020)
Review
Medical Laboratory Technology
Suzan Boutary, Andoni Echaniz-Laguna, David Adams, Julien Loisel-Duwattez, Michael Schumacher, Charbel Massaad, Liliane Massaad-Massade
Summary: CMT1A, caused by a duplication on chromosome 17p11.2, is the most common form of CMT disease. Current treatments are symptomatic, but there is promising potential in PMP22-targeted small interfering RNA and antisense oligonucleotides.
TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
M. Caillot, J. Bourgeais, H. Dakik, E. Coste, N. M. Mazure, E. Lelievre, O. Coqueret, O. Herault, F. Mazurier, B. Sola
Article
Cell Biology
Hualong Bai, Nirvana Sadaghianloo, Jolanta Gorecka, Shirley Liu, Shun Ono, Abhay B. Ramachandra, Sophie Bonnet, Nathalie M. Mazure, Serge Declemy, Jay D. Humphrey, Alan Dardik
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Neurosciences
Nirvana Sadaghianloo, Julie Contenti, Serge Declemy, Damien Ambrosetti, Masa Zdralevic, Mounia Tannour-Louet, Lucilla Fabbri, Gilles Pages, Frederic Bost, Reda Hassen-Khodja, Jacques Pouyssegur, Elixene Jean-Baptiste, Alan Dardik, Nathalie M. Mazure
Summary: Patients with end-stage renal failure need AVFs for dialysis, but these AVFs often fail due to excessive venous thickness. This study found that venous cells adapt their metabolism depending on oxygen concentration, and targeting the hypoxic response pathway with drugs can help decrease excessive venous thickness. In a mouse model, inhibiting HIFs decreased neointimal hyperplasia, suggesting that drugs targeting HIFs could prevent AVF failure.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biology
Suzan Boutary, Marie Caillaud, Mevidette El Madani, Jean-Michel Vallat, Julien Loisel-Duwattez, Alice Rouyer, Laurence Richard, Celine Gracia, Giorgia Urbinati, Didier Desmaele, Andoni Echaniz-Laguna, David Adams, Patrick Couvreur, Michael Schumacher, Charbel Massaad, Liliane Massaad-Massade
Summary: The study introduces a treatment for CMT1A using siRNA conjugated to squalene nanoparticles, which resulted in the restoration of pathology and function, providing a potential therapeutic strategy for inherited peripheral neuropathies. This approach demonstrates the concept of precision medicine based on normalizing disease gene expression by using siRNA.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biology
Maeva Dufies, Annelies Verbiest, Lindsay S. Cooley, Papa Diogop Ndiaye, Xingkang He, Nicolas Nottet, Wilfried Souleyreau, Anais Hagege, Stephanie Torrino, Julien Parola, Sandy Giuliano, Delphine Borchiellini, Renaud Schiappa, Baharia Mograbi, Jessica Zucman-Rossi, Karim Bensalah, Alain Ravaud, Patrick Auberger, Andreas Bikfalvi, Emmanuel Chamorey, Nathalie Rioux-Leclercq, Nathalie M. Mazure, Benoit Beuselinck, Yihai Cao, Jean Christophe Bernhard, Damien Ambrosetti, Gilles Pages
Summary: Dufies et al. found high Plk1 expression levels in aggressive clear cell renal cell carcinoma and discovered that Plk1 is transcriptionally upregulated in a manner dependent on HIF-2. They also found that high Plk1 expression is correlated to a poor prognosis and resistance to tyrosine kinase inhibitor against VEGF receptor, suggesting a critical role for hypoxia/HIF-2-induced Plk1 in disease progression.
COMMUNICATIONS BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Marie Caillaud, Frederic Gobeaux, Miryana Hemadi, Suzan Boutary, Patrick Guenoun, Didier Desmaele, Patrick Couvreur, Frank Wien, Fabienne Testard, Liliane Massaad-Massade
Summary: siRNA-SQ nanoparticles have stability and the ability to interact with serum components, making them a promising targeted therapy for pathologies with gene expression dysregulation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Urology & Nephrology
Julie Contenti, Matthieu Durand, Sandor Vido, Serge Declemy, Juliette Raffort, Joseph Carboni, Sophie Bonnet, Christophe Koelsch, Reda Hassen-Khodja, Philippe Gual, Nathalie M. Mazure, Nirvana Sadaghianloo
Summary: The study found that the level of pOPN in hemodialysis patients was associated with the presence of AVF stenosis requiring intervention, suggesting its potential as a diagnostic biomarker for evaluation in a vascular access surveillance program.
JOURNAL OF NEPHROLOGY
(2022)
Article
Oncology
Martina Poteti, Giulio Menegazzi, Silvia Peppicelli, Ignazia Tusa, Giulia Cheloni, Angela Silvano, Caterina Mancini, Alessio Biagioni, Alessandro Tubita, Nathalie M. Mazure, Matteo Lulli, Elisabetta Rovida, Persio Dello Sbarba
Summary: In chronic myeloid leukemia (CML), the persistence of a small subset of treatment-resistant leukemia stem cells (LSCs) prevents the achievement of cure, with their metabolic profile, particularly glutamine metabolism, playing a crucial role in therapy resistance. Targeting glutamine metabolism may help overcome the persistence of these therapy-resistant LSCs and improve treatment outcomes in CML.
Review
Immunology
Stephane J. C. Mancini, Karl Balabanian, Isabelle Corre, Julie Gavard, Gwendal Lazennec, Marie-Caroline Le Bousse-Kerdiles, Fawzia Louache, Veronique Maguer-Satta, Nathalie M. Mazure, Fatima Mechta-Grigoriou, Jean-Francois Peyron, Valerie Trichet, Olivier Herault
Summary: Recent advances in understanding the hematopoietic niche have been made through in vitro analysis and animal models. Insights from the study of solid tumor niches can provide valuable information for understanding the hematopoietic niche.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Carolina Duarte-Hospital, Arnaud Tete, Francois Brial, Louise Benoit, Meriem Koual, Celine Tomkiewicz, Min Ji Kim, Etienne B. Blanc, Xavier Coumoul, Sylvie Bortoli
Summary: Environmental factors have a significant impact on human health, including diet, sedentary lifestyle, and exposure to pollutants. The cellular and molecular events triggered by exposure to environmental pollutants vary greatly depending on age, chronicity, and exposure doses. Mitochondrial dysfunction is increasingly recognized as a major characteristic of environmental damage. This article reviews the multiple mechanisms by which pollutants cause mitochondrial toxicity in relation to chronic diseases and proposes the Aryl hydrocarbon Receptor (AhR) as an exposome receptor model that activates various toxic events through mitochondrial dysfunction. Finally, some remarks are provided on mitotoxicity and risk assessment.
Review
Biochemistry & Molecular Biology
Lea El Chemali, Yvette Akwa, Liliane Massaad-Massade
Summary: This review provides an overview of the functions of Translocator protein (TSPO) in the brain and peripheral nervous system. It highlights its contributions to important physiological functions such as mitochondrial homeostasis, energy metabolism, and steroidogenesis, as well as its involvement in neuroinflammation, brain injury, and diseases of the nervous system.
BIOCHEMICAL JOURNAL
(2022)
Article
Environmental Sciences
Charlotte Corporeau, Sebastien Petton, Romain Vilaca, Lizenn Delisle, Claudie Quere, Valerian Le Roy, Christine Dubreuil, Sandra Lacas-Gervais, Yann Guitton, Sebastien Artigaud, Benoit Bernay, Vianney Pichereau, Arnaud Huvet, Bruno Petton, Fabrice Pernet, Elodie Fleury, Stephanie Madec, Christophe Brigaudeau, Catherine Brenner, Nathalie M. Mazure
Summary: This study compared intertidal oysters with subtidal oysters and found that intertidal oysters at different depths delayed the onset of mortality associated with POMS. Despite slower growth, intertidal oysters showed increased resistance through metabolic, inflammatory, and immune responses, improving their overall health.
MARINE ENVIRONMENTAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Guy Khalaf, Claudia Mattern, Melina Begou, Odile Boespflug-Tanguy, Charbel Massaad, Liliane Massaad-Massade
Summary: Pelizaeus-Merzbacher Disease is a rare inherited leukodystrophy that primarily affects males. It is characterized by a significant reduction or absence of myelin sheaths in the white matter areas of the central nervous system. Mutations in the PLP1 gene cause a wide range of leukopathies, which pose challenges to the development of treatments.