Article
Dentistry, Oral Surgery & Medicine
Y. Zhang, S. Lin, J. Liu, Q. Chen, J. Kang, J. Zhong, M. Hu, M. S. Basabrain, Y. Liang, C. Yuan, C. Zhang
Summary: This study found that dental pulp stem cells can increase the lifespan and perfusion of blood vessels. The results revealed that dental pulp stem cells inhibit endothelial cell sprouting by activating the TEK tyrosine kinase (Tie2) signaling and regulating the expression levels of vascular endothelial (VE)-cadherin and vascular endothelial growth factor receptor 2 (VEGFR2).
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Cell Biology
Sinthu Pathmanapan, Raymond Poon, Tomasa Barrientos De Renshaw, Puviindran Nadesan, Makoto Nakagawa, Gireesh A. Seesankar, Adrian Kwan Ho Loe, Hongyuan H. Zhang, Joan J. Guinovart, Jordi Duran, Christopher B. Newgard, Jay S. Wunder, Benjamin A. Alman
Summary: Chondrosarcomas, the most common malignancy of cartilage, are linked to genetic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes. The presence of IDH mutations in enchondromas, the benign precursor lesions, suggests that these mutations occur early in the development of malignancy. Our studies on mutant IDH chondrosarcomas and mutant Idh mice have found that glycogen is deposited exclusively in mutant cells, and its utilization influences tumor cell behavior and energy pathways. The interaction between mutant IDH1 and hypoxia-inducible factor 1a (HIF1a) appears to regulate key enzymes in glycogen metabolism, suggesting a critical role for glycogen in enchondromas and chondrosarcomas.
Article
Biochemistry & Molecular Biology
Ni Yang, Yucong Zhang, Yi Huang, Jinhua Yan, Zonghao Qian, Han Li, Pengcheng Luo, Zhen Yang, Mandi Luo, Xiuxian Wei, Hao Nie, Lei Ruan, Yi Hao, Shangbang Gao, Kai Zheng, Cuntai Zhang, Le Zhang
Summary: This study explored the effects of serum FGF21 on vascular endothelial cells and found that FGF21 within the physiological concentration range has a beneficial effect on the cells, potentially through the regulation of SIRT1.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biology
Geetika Kaur, Deepti Sharma, Shivantika Bisen, Chandra Sekhar Mukhopadhyay, Katherine Gurdziel, Nikhlesh K. K. Singh
Summary: Vascular adhesion molecules, specifically VCAM-1, have been found to play a crucial role in retinal neovascularization and can be regulated by IL-33. The study also highlights the regulatory role of VCAM-1-JunB-IL-8 signaling in retinal endothelial cell sprouting and angiogenesis.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yan Wang, Jiahui Ni, Aiyu Wang, Run Zhang, Linjie Wang
Summary: This study found that VEGFA regulates glycolipid metabolism in Schizothorax prenanti through AMPK alpha, contributing to a better understanding of the functions of VEGFA in fish glycolipid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Likui Shen, Ran Sun, Shifeng Kan, Zhimin Wang, Zhengquan Yu
Summary: The study evaluated the expression levels of EphA2, VEGF, and vWF in primary lower grade glioma patients to assess their potential as prognostic biomarkers for predicting poor survival risk. Results showed that EphA2, VEGF, and vWF could be considered as prognostic markers for primary glioma, with strong VEGF expression being associated with poor prognosis and survival.
Article
Neurosciences
Jinfang Xu, Jianli Wang, Mingfei Zhao, Chenguang Li, Shen Hong, Jianmin Zhang
Summary: This study investigates the regulation of the lncRNA/miRNA axis on KNG1 in glioma. The results show that LINC01018 sponges miR-942-5p to regulate the expression of KNG1, which is associated with the survival rate of patients. MiR-942-5p is highly expressed, while KNG1 is lowly expressed in glioma, and they have a negative correlation. Knockdown of LINC01018 or KNG1 and miR-942-5p mimic enhance the migration, invasion, and proliferation of glioma cells, and regulate the expressions of metastasis-related and proliferation-related genes. LINC01018 knockdown and miR-942-5p mimic promote glioma tumor growth in mice. The LINC01018/miR-942-5p/KNG1 pathway plays a regulatory role in the development of glioma cells in vitro and in vivo.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Physiology
Dietmar Vestweber
Summary: VE-PTP, predominantly expressed in vascular endothelial cells, regulates vascular functions by controlling its substrates and shows therapeutic potential in various pathophysiological settings.
Article
Multidisciplinary Sciences
Christina M. Termini, Amara Pang, Tiancheng Fang, Martina Roos, Vivian Y. Chang, Yurun Zhang, Nicollette J. Setiawan, Lia Signaevskaia, Michelle Li, Mindy M. Kim, Orel Tabibi, Paulina K. Lin, Joshua P. Sasine, Avradip Chatterjee, Ramachandran Murali, Heather A. Himburg, John P. Chute
Summary: Ionizing radiation and chemotherapy deplete hematopoietic stem cells and damage the vascular niche, leading to the secretion of SEMA3A from bone marrow endothelial cells. Inhibition of NRP1 promotes vascular and hematopoietic regeneration through increased expression of R spondin 2, suggesting a potential therapeutic target for improving hematopoietic recovery after myeloablation.
NATURE COMMUNICATIONS
(2021)
Article
Physiology
Paulina Villar-Fincheira, Aaron J. Paredes, Tomas Hernandez-Diaz, Ignacio Norambuena-Soto, Nicole Cancino-Arenas, Fernanda Sanhueza-Olivares, Felipe Contreras-Briceno, Jorge Mandiola, Nicole Bruneau, Lorena Garcia, Maria Paz Ocaranza, Rodrigo Troncoso, Luigi Gabrielli, Mario Chiong
Summary: The study aims to evaluate the effects of exercise on plasma IL-6 and sIL-6R levels, and their relationship with vascular remodeling. Results show that post-marathon HT athletes had higher post-race plasma sIL-6R levels than LT athletes, suggesting a possible role of IL-6 in vascular remodeling, with a proposed association between IL-6 and aortic dilation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Mengna Zhang, Yanan Peng, Zhenwei Yang, Hailin Zhang, Cong Xu, Lan Liu, Qiu Zhao, Jixiong Wu, Hongling Wang, Jing Liu
Summary: This study investigates the role and mechanism of DAB2IP and HSP90AA1 in colorectal cancer (CRC). Loss of DAB2IP is associated with poor prognosis, while elevated expression of HSP90AA1 is associated with malignant behavior in CRC. Mechanistically, DAB2IP promotes apoptosis through the HSP90AA1/SRP9/ASK1/JNK signaling axis. These findings suggest that targeting both DAB2IP and HSP90AA1 may be an effective treatment strategy for CRC.
Article
Immunology
Kiwan Kim, Ho-Shin Gwak, Nayoung Han, Eun Kyung Hong, Beom K. Choi, Sangeun Lee, Soyoung Choi, Ju-Hwang Park, Ji-Hye Seok, Yeongha Jeon, Hyuntae Cho, Song-Jae Lee, Yura Lee, Ki Taek Nam, Seong-Won Song
Summary: This study demonstrates the efficacy of IL13R alpha 2-targeted YYB-103 CAR T cells against MG cells. The modification of IL13 to construct a CAR enabled the selective targeting of IL13R alpha 2-expressing MG cells while sparing IL13R alpha 1-expressing cells. Additionally, YYB-103 CAR T cells showed effective blood-brain barrier crossing, suggesting compatibility with intravenous administration.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Qiaoyun Zhang, Guangheng Wu, Xiaoyu Zhang, Jie Zhang, Mengyang Jiang, Yiqiang Zhang, Lixiang Ding, Youxin Wang
Summary: This study investigated the causal relationship between vascular endothelial growth factor (VEGF) and different types of malignant brain tumors using genome-wide association study data. The findings did not provide evidence for a causal association between circulating VEGF levels and the risk of malignant brain tumors.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jean-Luc Wautier, Marie-Paule Wautier
Summary: The study of vascular permeability is important for understanding the mechanism that maintains the exchange between blood, tissues, and organs. Recent research has provided a better understanding of vascular cell functions and interactions between blood vessels. The identification of endothelial cell receptors and mediators and their role in homeostasis and disease has shed light on the maintenance of vascular permeability. Additionally, drugs and specific antibodies have been found to reduce the severity and mortality of diseases with enhanced vascular permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Vincent Roy, Jay P. Ross, Remy Pepin, Sergio Cortez Ghio, Alyssa Brodeur, Lydia Touzel Deschenes, Gaetan Le-Bel, Daniel E. Phillips, Genevieve Milot, Patrick A. Dion, Sylvain Guerin, Lucie Germain, Francois Berthod, Francois A. Auger, Guy A. Rouleau, Nicolas Dupre, Francois Gros-Louis
Summary: This study reveals that RNF213 may play a crucial role in maintaining cerebral endothelial cell integrity, and its disruption may contribute to the early pathological mechanism of Moyamoya disease. Additionally, the study further emphasizes the importance of blood-brain barrier integrity.
Article
Psychology, Multidisciplinary
Bing Chen, Xin Wu, Shawn N. Geniole, Qiqi Ge, Qi Chen, Yufang Zhao
Summary: This study examines neural activity during provocation and aggressive responses among individuals from different social classes. The findings suggest that low-class individuals display higher neural sensitivity during social provocation and aggressive responses than high-class individuals. The relationship between social class and aggression is moderated by the activity of orbitofrontal cortex (OFC) and anterior cingulate cortex (ACC) during provocation.
CURRENT PSYCHOLOGY
(2023)
Article
Ecology
Wei Zhang, Tao Qi, Lihe Yao, Wei Wang, Fanrong Yu, Yuqin Yan, El-Sayed Salama, Shaochen Su, Ming Bai
Summary: The current study investigated the impact of periodontitis and long-term heavy metal exposure on the salivary microbiome. The results showed that long-term exposure to heavy metals can alter the diversity and functioning of salivary microbiota.
Article
Cardiac & Cardiovascular Systems
Zhe Wang, Yi-Jia Wang, Zhi-Yu Liu, Qing Li, Ya-Wei Kong, Ying-Wei Chen, Yi-Hong Sun, Jian-Zeng Dong
Summary: This study aimed to investigate the relationship between insulin resistance (IR) and atrial fibrillation (AF) recurrence in non-diabetic patients who underwent catheter ablation. The results showed that IR patients were more likely to experience AF recurrence. Improving IR status may be a potential target for reducing the postoperative recurrence rate.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Zhen Chen, Zimo Huang, Xiaowei Zhao, Yi Zhou, Ping Zhang, Yuhong Li
Summary: This study identified immune-inflammation-related genes associated with susceptibility to periodontitis in aged mice's gingiva using RNA sequencing. Candidate genes were validated and showed high match with clinical data sets, providing potential targets for future prevention of periodontitis.
Article
Clinical Neurology
Jin-Tao Wang, Gang Xu, Ru-Jing Ren, Ying Wang, Ran Tang, Qiang Huang, Jian-Ping Li, Murad Al-Nusaif, Wei-Dong Le, Gang Wang
Summary: This study investigates the impact of health insurance and resources on the burden of Alzheimer's disease and related dementias (ADRD). The findings suggest that ADRD has an increasing burden on patients globally, both physically and economically. Moreover, health resources are negatively associated with certain burden factors, such as disability-adjusted life years (DALY) and death, but positively associated with years of life lived with disability (YLD).
ALZHEIMERS & DEMENTIA
(2023)
Article
Computer Science, Interdisciplinary Applications
Xiaogang Wang, Guanghui Yan, Zhifei Yang
Summary: In this paper, we propose a novel method for calculating the similarity between nodes based on the relative entropy of k-order edge capacity, which allows for flexible analysis of node similarity. The experiments and visual analysis demonstrate the rationality and effectiveness of the proposed method.
INTERNATIONAL JOURNAL OF MODERN PHYSICS C
(2023)
Review
Nursing
Lixia Chen, Juan Yin, Yanan Zheng, Chunhong Zhao, Han Zhang, Jianhua Li, Daihong Ji, Yin-Ping Zhang
Summary: This study is a systematic review and meta-analysis evaluating the effectiveness of background music listening on sleep quality, psychological outcomes, and physiological outcomes for critically ill patients in intensive care units (ICUs). The results showed that background music listening can improve sleep quality, anxiety, and depression in critically ill patients.
NURSING IN CRITICAL CARE
(2023)
Article
Engineering, Environmental
Runyu Wang, Xinxin Ding, Jingzhi Wang, Zhibao Dong, Hongmei Xu, Ge Ma, Bo Gao, Han Song, Menghan Yang, Junji Cao
Summary: The study measured the PM2.5-bounded elements in two urban middle schools in Xi'an and found higher levels compared to previous studies. The main sources of these elements were coal combustion, geogenic dust, and industrial emissions. Arsenic and chromium posed potential non-carcinogenic health risks to students and teachers.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Environmental Studies
Lixun Liu, Yujiang Wang, Robin Hickman
Summary: This study aims to explore the interrelations between trip stage characteristics, socio-demographic attributes, and the built environment, as well as how rail transit is integrated as part of multimodal trips after it is introduced. Data are extracted from the Chongqing Urban Resident Travel Survey from 2014, three years after the new rail transit network was established. The results show that the separate trip stage characteristics have more impact on people's main mode choice of rail transit compared to general trip characteristics. The machine learning model reveals the non-linear effects and thresholds of impact by trip stage characteristics, suggesting an optimal radius of facility distribution along the transit lines. Synergistic effects between variables are also identified, including by groups of people and land use characteristics.
Letter
Clinical Neurology
Binghao Zhao, Hao Xing, Yu Xia, Wenbin Ma
JOURNAL OF NEUROSURGERY
(2023)
Article
Pediatrics
Zhiyi Zhang, Li Wang, Chuanping Xie, Yakun Liu, Xin Ni, Yajun Chen
Summary: This study investigates the relationship between IgE-mediated allergy and complicated appendicitis (CA) as well as the overall prognosis. A retrospective analysis was conducted on a consecutive series of pediatric patients with acute appendicitis who underwent appendectomy at Beijing Children's Hospital. The results showed that children with allergies had a decreased risk of developing CA after adjusting for various factors. There were no significant differences in operative time, length of hospital stay, readmission, or adhesive intestinal obstruction rate between allergy and non-allergy patients.
PEDIATRIC SURGERY INTERNATIONAL
(2023)
Article
Chemistry, Physical
Huafeng Li, Zelong Yuan, Wenjing Chen, Mengnan Yang, Yahao Sun, Shihao Zhang, Pengtao Ma, Jingping Wang, Jingyang Niu
Summary: Limited studies have been conducted on the synthesis of multifunctional catalysts for the redox reaction path cycle. In this study, two multifunctional Ru-containing polyoxometalate-based photocatalysts were prepared and showed superior catalytic performance. The paper also achieved a closed redox conversion cycle using a single multifunctional catalyst and discussed the relationship between catalytic active site composition and catalytic efficacy, as well as the underlying reaction mechanisms.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Environmental Sciences
Nian Wu, Lin Tao, Kunming Tian, Xia Wang, Caidie He, Songlin An, Yingkuan Tian, Xiang Liu, Wei Chen, Haonan Zhang, Pei Xu, Dengqing Liao, Juan Liao, Linglu Wang, Derong Fang, Zhongmei Hu, Hongyu Yuan, Jingyi Huang, Xiaoshan Chen, Li Zhang, Xiaohui Hou, Rong Zeng, Xingyan Liu, Shimin Xiong, Yan Xie, Yijun Liu, Quan Li, Xubo Shen, Yuanzhong Zhou, Xuejun Shang
Summary: This study investigated the urinary concentrations of nine phthalic acid ester (PAE) metabolites in pregnant women in China. The results showed cumulative exposure to PAEs among pregnant women, and residential characteristics were found to be associated with urinary PAE metabolite concentrations. Living in buildings and using coal/kerosene/wood/wheat straw as domestic fuel were associated with higher health risks.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Ophthalmology
Ningning Tang, Guangyi Huang, Daizai Lei, Li Jiang, Qi Chen, Wenjing He, Fen Tang, Yiyi Hong, Jian Lv, Yuanjun Qin, Yunru Lin, Qianqian Lan, Yikun Qin, Rushi Lan, Xipeng Pan, Min Li, Fan Xu, Peng Lu
Summary: In this study, deep learning was used to establish an automated method for identifying pathogenic fungal genera using in vivo confocal microscopy (IVCM) images. The results showed that the deep learning model can accurately classify and identify Fusarium and Aspergillus by learning effective features in the images. This automated IVCM image analysis has the potential to be applied in the early diagnosis and management of fungal keratitis.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Review
Medicine, Research & Experimental
Jiaqi Chen, Ding Zhang, Ying Yuan
Summary: Conversion treatment and salvage surgery can improve outcomes for patients with unresectable locally advanced hepatocellular carcinoma (HCC). The combination of immune checkpoint inhibitors and locoregional therapy is considered the most promising conversion therapy.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)