Article
Cell Biology
Dan Li, Mingjun San, Jing Zhang, Anlan Yang, Wanhua Xie, Yang Chen, Xiaodan Lu, Yuntao Zhang, Mingyue Zhao, Xuechao Feng, Yaowu Zheng
Summary: The study using a transgenic mouse model of OXTR overexpression found that OXTR can promote mammary hyperplasia and tumorigenesis, as well as creating a microenvironment that promotes tumor growth, providing potential for targeted therapy in HER2-type breast cancer.
CELL DEATH & DISEASE
(2021)
Article
Neurosciences
Jiangning Zhao, Huanrong Lin, Kunsong Huang
Summary: Mesenchymal stem cell-derived extracellular vesicles (MSC-EV) can deliver microRNAs (miRNAs) into colorectal cancer (CRC) cells to inhibit malignant phenotype. In this study, it was found that transport of miR-34a-5p by MSC-EV suppressed CRC development by modulating the interaction of c-MYC, DNMT3a, and PTEN. Additionally, restoration of miR-34a-5p or depletion of c-MYC in MSC-EV limited CRC tumor formation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Jinping Li, Yaobang Liu, Bing Lian, Hong Li, Dahai Chai, Yali Gao, Yanbai Wang
Summary: This study found that histidine triad nucleotide-binding protein 3 (HINT3) is decreased in breast cancer tissues. In vitro experiments showed that HINT3 knockdown promoted the proliferation and migration of breast cancer cells, while overexpression inhibited these processes. Additionally, HINT3 inhibited breast cancer cell signaling pathway activation by upregulating phosphatase and tensin homolog (PTEN). These findings demonstrate the inhibitory role of HINT3 in the proliferation, migration, and tumor development of breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Cell Biology
Fu-Shu Li, Pei-Pei Li, Ling Li, Yan Deng, Ying Hu, Bai-Cheng He
Summary: The inhibitory effects of PTEN on BMP9's osteogenic potential may be partially mediated through decreasing the expression of Wnt10b via the disturbance of interaction between CREB and BMP/Smad signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Fengjie Zhu, Zhe Ren
Summary: This study found that Icariin can target the miR-205-5p/PTEN axis to suppress the malignant cell phenotype and inhibit the growth of lung cancer.
Article
Genetics & Heredity
Stetson Thacker, Charis Eng
Summary: PTEN gene is strongly associated with autism spectrum disorder, and animal models with PTEN mutations provide insight into the neurobiology and pathogenesis of autism. The study identified differential protein expression in P40, predominantly related to PTEN function and neurological processes, with ASD risk genes identified as major regulatory hubs in the affected pathways.
NPJ GENOMIC MEDICINE
(2021)
Article
Medicine, Research & Experimental
Lingyan Zhang, Zibin Bu, Juan Shen, Liping Shang, Yuanyuan Chen, Ping Zhang, Yan Wang
Summary: The study revealed that miR-221 acts as an oncogene in T-ALL, and its downregulation inhibits the development of ALL by targeting PTEN. Therefore, miR-221 may serve as a potential novel therapeutic target for ALL.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, General & Internal
Giovanni Innella, Elena Bonora, Iria Neri, Annalucia Virdi, Alba Guglielmo, Laura Maria Pradella, Claudio Ceccarelli, Laura Benedetta Amato, Anna Lanzoni, Sara Miccoli, Giuseppe Gasparre, Roberta Zuntini, Daniela Turchetti
Summary: Germline PTEN pathogenic variants cause PTEN Hamartoma Tumor Syndrome (PHTS), characterized by hamartomas, developmental anomalies, and increased cancer risk. Mucocutaneous features are crucial for diagnosing PHTS patients, with molecular analyses providing insights into the pathogenic processes induced by PTEN alterations.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Gang Wu, Weiyuan Huang, Junnv Xu, Wenzhu Li, Yu Wu, Qianyu Yang, Kun Liu, Mingyue Zhu, Priya S. Balasubramanian, Mengsen Li
Summary: In patients with nasopharyngeal carcinoma, PTEN negative status is associated with later TNM stage, later clinical-stage, shorter progression-free survival (PFS), and worse prognosis. K-trans and K-ep derived from DCE-MRI, with reliable capability, may serve as potential imaging markers correlated with PTEN expression for noninvasive prediction. Combining radiological and clinical features can enhance the classification performance of PTEN expression.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Cell Biology
Jing Zhao, Linlin Yin, Lin Jiang, Li Hou, Ling He, Chunyan Zhang
Summary: The study revealed the essential role of PTEN nuclear translocation in neuronal injury following oxygen-glucose deprivation in rat cortical neurons. The mechanism may involve modulation of cell signaling pathways and apoptosis-related proteins. Preventing PTEN nuclear translocation could be a potential strategy for preventing brain injury following hypoxia-ischemia.
Article
Medicine, Research & Experimental
Youmei Zi, Yingzi Zhang, Yanwei Wu, Lina Zhang, Ru Yang, Yan Huang
Summary: MicroRNA-25-3p has been shown to be upregulated in multiple myeloma tissues and cell lines, and this upregulation is associated with poor prognostic markers. The miR-25-3p regulates the PI3K/AKT signaling pathway by targeting the tumor suppressor PTEN, leading to promotion of cancer progression in multiple myeloma.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Fumitaka Obayashi, Atsuko Hamada, Sachiko Yamasaki, Taku Kanda, Shigeaki Toratani, Tetsuji Okamoto
Summary: This study presents a case of a Japanese woman diagnosed with Cowden syndrome (CS) who had multiple oral polyps, breast cancer, and thyroid cancer. Genetic analysis revealed novel mutations in the PTEN gene, a tumor suppressor gene known to be associated with CS. Further investigation using induced pluripotent stem cells (iPSCs) derived from the patient's blood cells confirmed reduced expression of PTEN transcript, potentially indicating PTENo as the cause for the disease.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2022)
Article
Oncology
Di Wu, Hong-Qiang Yu, Hao-Jun Xiong, Yu-Jun Zhang, Xiao-Tong Lin, Jie Zhang, Wu Wu, Teng Wang, Xiao-Yu Liu, Chuan-Ming Xie
Summary: The study revealed that elevated expression of the sodium pump alpha 3 subunit is associated with colorectal cancer metastasis. Through mechanisms involving decreased p53 expression and activated mTOR pathway, the alpha 3 subunit promotes migration of colorectal cancer cells. Additionally, a positive correlation between alpha 3 subunit expression and mTOR activity was observed in an aggressive colorectal cancer subtype.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yuan Zhang, Li Li, Xiao-Ping Ke, Ping Liu
Summary: This study identified a prognostic immunometabolic signature, SCGB2A1, for endometrial cancer (EC). The results indicate that PTEN mutation and SCGB2A1 expression are associated with immune infiltration, gene expression, and prognosis in EC patients.
TRANSLATIONAL CANCER RESEARCH
(2023)
Article
Oncology
Yeqian Zhang, Fengrong Yu, Bo Ni, Qing Li, Seong-Woo Bae, Jong-Ho Choi, Han-Kwang Yang, Seong-Ho Kong, Chunchao Zhu
Summary: The study revealed that DDX18 is overexpressed in gastric cancer tissues and is closely related to tumor characteristics, clinical data, and prognosis. DDX18 promotes cell proliferation, migration, and invasion while inhibiting apoptosis. DDX18 enhances the maturation of microRNA-21 by interacting with Drosha, thereby affecting the PTEN-AKT signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemical Research Methods
Vanessa Dumeaux, Bjorn Fjukstad, Hans E. Fjosne, Jan-Ole Frantzen, Marit Muri Holmen, Enno Rodegerdts, Ellen Schlichting, Anne-Lise Borresen-Dale, Lars Ailo Bongo, Eiliv Lund, Michael Hallett
PLOS COMPUTATIONAL BIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Melanie Busby, Michael T. Hallett, Isabelle Plante
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Genetics & Heredity
Vinayak Bhandari, Christianne Hoey, Lydia Y. Liu, Emilie Lalonde, Jessica Ray, Julie Livingstone, Robert Lesurf, Yu-Jia Shiah, Tina Vujcic, Xiaoyong Huang, Shadrielle M. G. Espiritu, Lawrence E. Heisler, Fouad Yousif, Vincent Huang, Takafumi N. Yamaguchi, Cindy Q. Yao, Veronica Y. Sabelnykova, Michael Fraser, Melvin L. K. Chua, Theodorus van der Kwast, Stanley K. Liu, Paul C. Boutros, Robert G. Bristow
Article
Medicine, Research & Experimental
Tina Gruosso, Mathieu Gigoux, Venkata Satya Kumar Manem, Nicholas Bertos, Dongmei Zuo, Irina Perlitch, Sadiq Mehdi Ismail Saleh, Hong Zhao, Margarita Souleimanova, Radia Marie Johnson, Anne Monette, Valentina Munoz Ramos, Michael Trevor Hallett, John Stagg, Rejean Lapointe, Atilla Omeroglu, Sarkis Meterissian, Laurence Buisseret, Gert Van den Eynden, Roberto Salgado, Marie-Christine Guiot, Benjamin Haibe-Kains, Morag Park
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Oncology
Eileen Rakovitch, Rinku Sutradhar, Michael Hallett, Alastair M. Thompson, Sumei Gu, Vanessa Dumeaux, Timothy J. Whelan, Lawrence Paszat
BREAST CANCER RESEARCH AND TREATMENT
(2019)
Article
Genetics & Heredity
Doris Skoric-Milosavljevic, Najim Lahrouchi, Fernanda M. Bosada, Gregor Dombrowsky, Simon G. Williams, Robert Lesurf, Fleur V. Y. Tjong, Roddy Walsh, Ihssane El Bouchikhi, Jeroen Breckpot, Enrique Audain, Aho Ilgun, Leander Beekman, Ilham Ratbi, Alanna Strong, Maximilian Muenke, Solveig Heide, Alison M. Muir, Mariam Hababa, Laura Cross, Dihong Zhou, Tomi Pastinen, Elaine Zackai, Samir Atmani, Karim Ouldim, Najlae Adadi, Katharina Steindl, Anita Rauch, David Brook, Anna Wilsdon, Irene Kuipers, Nico A. Blom, Barbara J. Mulder, Heather C. Mefford, Boris Keren, Pascal Joset, Paul Kruszka, Isabelle Thiffault, Sarah E. Sheppard, Amy Roberts, Elisabeth M. Lodder, Bernard D. Keavney, Sally-Ann B. Clur, Seema Mital, Marc-Philip Hitz, Vincent M. Christoffels, Alex V. Postma, Connie R. Bezzina
Summary: Rare genetic variants in KDR, particularly protein-truncating variants (PTVs), are strongly associated with TOF, likely playing a role in the pathogenesis of the disease in different inheritance patterns.
GENETICS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Julie Livingstone, Yu-Jia Shiah, Takafumi N. Yamaguchi, Lawrence E. Heisler, Vincent Huang, Robert Lesurf, Tsumugi Gebo, Benjamin Carlin, Stefan Eng, Erik Drysdale, Jeffrey Green, Theodorus van der Kwast, Robert G. Bristow, Michael Fraser, Paul C. Boutros
Summary: The study integrates telomere length, genomics, transcriptomics and proteomics in localized prostate cancer, revealing the links between telomere maintenance, disease drivers and clinical outcomes. Shorter tumor telomere lengths are associated with elevated genomic instability and genes involved in cell proliferation and signaling, while longer telomere lengths in non-tumor samples are associated with a lower rate of biochemical relapse.
NATURE COMMUNICATIONS
(2021)
Article
Genetics & Heredity
Robert Lesurf, Abdelrahman Said, Oyediran Akinrinade, Jeroen Breckpot, Kathleen Delfosse, Ting Liu, Roderick Yao, Gabrielle Persad, Fintan McKenna, Ramil R. Noche, Winona Oliveros, Kaia Mattioli, Shreya Shah, Anastasia Miron, Qian Yang, Guoliang Meng, Michelle Chan Seng Yue, Wilson W. L. Sung, Bhooma Thiruvahindrapuram, Jane Lougheed, Erwin Oechslin, Tapas Mondal, Lynn Bergin, John Smythe, Shashank Jayappa, Vinay J. Rao, Jayaprakash Shenthar, Perundurai S. Dhandapany, Christopher Semsarian, Robert G. Weintraub, Richard D. Bagnall, Jodie Ingles, Marta Mele, Philipp G. Maass, James Ellis, Stephen W. Scherer, Seema Mital
Summary: This study analyzed WGS data of 209 pediatric CMP patients and 1953 replication genomes and exomes, and found that variants in new genes and regulatory elements of known CMP genes contribute significantly to early onset CMP.
NPJ GENOMIC MEDICINE
(2022)
Article
Oncology
Sadiq M. I. Saleh, Nicholas Bertos, Tina Gruosso, Mathieu Gigoux, Margarita Souleimanova, Hong Zhao, Atilla Omeroglu, Michael T. Hallett, Morag Park
Article
Endocrinology & Metabolism
Michael P. Whyte, Malachi Griffith, Lee Trani, Steven Mumm, Gary S. Gottesman, William H. McAlister, Kilannin Krysiak, Robert Lesurf, Zachary L. Skidmore, Katie M. Campbell, Ilana S. Rosman, Susan Bayliss, Vinieth N. Bijanki, Angela Nenninger, Brian A. Van Tine, Obi L. Griffith, Elaine R. Mardis
Article
Cell Biology
Huayang Liu, James A. Dowdle, Safiya Khurshid, Nicholas J. Sullivan, Nicholas Bertos, Komal Rambani, Markus Mair, Piotr Daniel, Esther Wheeler, Xing Tang, Kyle Toth, Michael Lause, Markus E. Harrigan, Karl Eiring, Connor Sullivan, Matthew J. Sullivan, Serena W. Chang, Siddhant Srivastava, Joseph S. Conway, Raleigh Kladney, Joseph McElroy, Sooin Bae, Yuanzhi Lu, Ali Tofigh, Sadiq M. I. Saleh, Soledad A. Fernandez, Jeffrey D. Parvin, Vincenzo Coppola, Erin R. Macrae, Sarmila Majumder, Charles L. Shapiro, Lisa D. Yee, Bhuvaneswari Ramaswamy, Michael Hallett, Michael C. Ostrowski, Morag Park, Helen M. Chamberlin, Gustavo Leone
DEVELOPMENTAL CELL
(2017)
Correction
Oncology
E. R. Paquet, R. Lesurf, A. Tofigh, V. Dumeaux, M. T. Hallett
BREAST CANCER RESEARCH
(2017)
Article
Oncology
R. Lesurf, O. L. Griffith, M. Griffith, J. Hundal, L. Trani, M. A. Watson, R. Aft, M. J. Ellis, D. Ota, V. J. Suman, F. Meric-Bernstam, A. M. Leitch, J. C. Boughey, G. Unzeitig, A. U. Buzdar, K. K. Hunt, E. R. Mardis
ANNALS OF ONCOLOGY
(2017)
Article
Oncology
E. R. Paquet, R. Lesurf, A. Tofigh, V. Dumeaux, M. T. Hallett
BREAST CANCER RESEARCH
(2017)
Proceedings Paper
Mathematical & Computational Biology
Bjorn Fjukstad, Vanessa Dumeaux, Karina Standahl Olsen, Eiliv Lund, Michael Hallett, Lars Ailo Bongo
ACM-BCB' 2017: PROCEEDINGS OF THE 8TH ACM INTERNATIONAL CONFERENCE ON BIOINFORMATICS, COMPUTATIONAL BIOLOGY,AND HEALTH INFORMATICS
(2017)