Article
Oncology
Hung-Wen Tsai, Shu-Wen Cheng, Chou-Cheng Chen, I-Wen Chen, Chung-Liang Ho
Summary: In this study, a combined bioinformatics and experimental approach was used to identify potential target genes of the Wnt/beta-catenin signaling pathway. It was found that RMI2 is a new target gene of this pathway and that it promotes epithelial-mesenchymal transition markers, hepatocellular carcinoma cell invasion, and metastasis. These findings suggest that RMI2 could be a potential target for preventing or mitigating the progression of hepatocellular carcinoma.
Article
Multidisciplinary Sciences
Stephen Arnovitz, Priya Mathur, Melissa Tracy, Azam Mohsin, Soumi Mondal, Jasmin Quandt, Kyle M. Hernandez, Khashayarsha Khazaie, Marei Dose, Akinola Olumide Emmanuel, Fotini Gounari
Summary: This study reveals that aberrant activation of beta-catenin in thymocytes contributes to leukemias by promoting translocations and transformation. Lymphomas resembling T-ALL are sensitive to PARP inhibitors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Soyoung Kim, Gahyeon Song, Taebok Lee, Minseong Kim, Jeongrae Kim, Hyeryun Kwon, Jiyoung Kim, Wonyoung Jeong, Ukjin Lee, Chaebin Na, Sangwon Kang, Wantae Kim, Je Kyung Seong, Eek-hoon Jho
Summary: Wnt signaling induces nuclear localization of TFEB, which forms a complex with beta-catenin-TCF/LEF1 to regulate the expression of a subset of genes distinct from previously known targets. Knockdown of Axin or APC destabilizes the beta-catenin destruction complex, leading to nuclear localization of TFEB. In various types of cancer, levels of TFEB mediated Wnt target genes show strong correlations with Axin2 levels.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell Biology
Chi Chi, Wenjie Hou, Yi Zhang, Jie Chen, Zongji Shen, Youguo Chen, Min Li
Summary: In this study, it was found that the long non-coding RNA PDHB-AS is down-regulated in cervical cancer cells. Overexpression of PDHB-AS can suppress malignant behaviors of cervical cancer cells. PDHB-AS functions as a tumor suppressor by inhibiting the Wnt/β-catenin pathway, and it also interacts with other molecules such as miR-4536-5p, miR-582-5p, and DKK1 to regulate cisplatin resistance and tumor growth in cervical cancer. These findings suggest the therapeutic potential of PDHB-AS as a target for cervical cancer treatment.
CELL DEATH & DISEASE
(2023)
Article
Developmental Biology
Bo Wang, Xiaozhi Rong, Yumei Zhou, Yunzhang Liu, Jiqin Sun, Beibei Zhao, Bei Deng, Lei Lu, Ling Lu, Yun Li, Jianfeng Zhou
Summary: This study reveals that EIF4A3 acts as a Wnt inhibitor by interfering with the formation of beta-catenin/Tcf transcription activation complex, playing a crucial role in regulating embryonic development in zebrafish.
Article
Cell Biology
Yong Ji, Yiqian Liu, Changchun Sun, Lijiang Yu, Zhao Wang, Xu Du, Wu Yang, Chenggong Zhang, Chunmu Tao, Jianjiang Wang, Xi Yang, Sun Di, Yufeng Huang
Summary: Mutations in the Wnt/beta-catenin signaling pathway upstream lead to abnormal activation in colon cancer, and ADCK1 plays a crucial role in promoting cancer progression by interacting with TCF4 to activate the beta-catenin/TCF pathway. This research identifies potential therapeutic targets for colon cancer treatment.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Jian-Hua Chang, Bo-Wen Xu, Di Shen, Wei Zhao, Yue Wang, Jia-liang Liu, Guang-Xiao Meng, Guang-Zhen Li, Zong-Li Zhang
Summary: In this study, BRF2 was identified and validated as an oncogene in hepatocellular carcinoma (HCC), shedding light on the pathogenesis and therapeutic possibilities for HCC. BRF2 expression was upregulated in HCC, while its depletion inhibited HCC metastasis and invasion. Additionally, miR-409-3p was identified as a regulator of BRF2, and the Wnt/beta-catenin signaling pathway may play a role in early HCC development.
CANCER CELL INTERNATIONAL
(2023)
Review
Oncology
Yue Deng, Sicheng Cai, Jian Shen, Huiming Peng
Summary: Tetraspanins play diverse roles in the progression of gastric cancer, including promoting or inhibiting cell proliferation and invasion, regulating cell motility, and impacting lymph node metastasis. They also have significant clinical implications in therapeutic targeting, drug resistance development, and prognosis prediction for gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Food Science & Technology
Jing Li, Xiaoling Lyu, Pan Wang, Bao Ting Zhu
Summary: This study found that bilberry anthocyanins have a modulating effect on the pathogenesis of Alzheimer's disease. They reduce amyloid plaque load and beta-amyloid 1-42 levels, improve mitochondrial morphology, and decrease NO and ROS levels. In HT22 cells, bilberry anthocyanins also protect against A beta 42-induced cytotoxicity by reducing ROS levels and restoring mitochondrial homeostasis, partly through the upregulation of Mfn2. These findings suggest that bilberry anthocyanins can protect against the development of Alzheimer's disease by restoring mitochondrial homeostasis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Genetics & Heredity
Yun Wang, Qiang Fu, Yun-jian Tao, Sheng-nan Ying, Heng-gao Zhong, Yue Zhu, Xiao-han Qian, Lin Miao, Li-hua Yang
Summary: The present study investigated the expression and function of Girdin in gastric cancer (GC). Girdin expression was found to be elevated in GC samples and correlated with poor prognosis. Knockdown of Girdin inhibited GC cell proliferation, migration, and invasion, while promoting apoptosis and cell cycle arrest. Girdin was found to regulate AKT/GSK3 beta/beta-catenin signaling and its overexpression could be reversed by AKT inhibitor treatment and enhanced by GSK3 beta inhibitor treatment. In vivo experiments showed that Girdin delayed tumor growth. These findings suggest that Girdin plays a role in promoting GC development.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Oncology
Zhiyong Li, Yunning Huang, Yuanyi Xu, Xiaofei Wang, Honghong Wang, Shuai Zhao, Han Liu, Guangfu Yu, Xiangming Che
Summary: This study identified a novel oncogenic function of ADAR1 in peritoneal metastasis of gastric cancer through the Wnt/beta-catenin pathway. ADAR1 may serve as a potential marker and therapeutic target against gastric cancer metastasis by regulating key pathways in cancer progression.
Article
Plant Sciences
Wenhao Liao, Yueqiang Wen, Jing Wang, Maoyuan Zhao, Shangbin Lv, Nianzhi Chen, Yuchen Li, Lina Wan, Qiao Zheng, Yu Mou, Ziyi Zhao, Jianyuan Tang, Jinhao Zeng
Summary: This study aims to investigate the role and potential mechanism of GA on gastric precancerous lesions (GPL), the key turning point of gastritis to gastric cancer, with the aim of delaying, blocking or reversing the dynamic overall process of inflammation-cancer transformation and thus blocking GPL to prevent the development of gastric cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Li Wang, Rujun Zhai, Hong Shen, Guodong Song, Fangxin Wan, Qiang Li
Summary: The study demonstrates that overexpression of VRK1 in gastric cancer cells promotes cell proliferation, migration, and invasion, and possibly regulates the transcriptional level of beta-catenin by phosphorylating c-Jun. Knockdown of VRK1 inhibits these processes, suggesting a potential role for VRK1 in tumor progression in gastric carcinoma.
Article
Cell Biology
Yingyan Wang, Wen Lan, Mingxin Xu, Jing Song, Jun Mao, Chunyan Li, Xiaohui Du, Yunling Jiang, Encheng Li, Rui Zhang, Qi Wang
Summary: CAFs promote EMT in lung ADC through SDF-1, which enhances invasiveness and EMT by regulating CXCR4, beta-catenin, and PPAR delta. High expression of these proteins correlated with poor prognosis, suggesting targeting the SDF-1-mediated CXCR4 beta-catenin/PPAR delta cascade may be an effective approach for lung cancer treatment.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Xueyan Zang, Jiajia Jiang, Jianmei Gu, Yanke Chen, Maoye Wang, Yu Zhang, Min Fu, Hui Shi, Hui Cai, Hui Qian, Wenrong Xu, Xu Zhang
Summary: This study reveals that circEIF4G3 is downregulated in gastric cancer (GC) and is associated with poor clinical outcomes. Overexpression of circEIF4G3 inhibits GC growth and metastasis, while knockdown of circEIF4G3 has opposite effects. Mechanistically, circEIF4G3 promotes the degradation of delta-catenin protein and upregulates SIK1 expression through its interaction with miR-4449.
Article
Oncology
Cristiane Bergerot, Sun Young Rha, Sumanta Pal, Piotr Koralewski, Daniil Stroyakovskiy, Boris Alekseev, Francis Parnis, Daniel Castellano, Jae Lyun Lee, Kaisa Sunela, Tudor Ciuleanu, Daniel Heng, Hilary Glen, Jinyi Wang, Lee Bennett, Janice Pan, Karen O'Hara, Javier Puente
Summary: This study focuses on preserving health-related quality of life during renal cell carcinoma treatment. The results showed that patients who received an 18 mg lenvatinib starting dose had better health-related quality of life scores and longer time to deterioration on most scales compared to those who received a 14 mg starting dose. These findings are important for guiding the treatment of renal cell carcinoma.
Article
Gastroenterology & Hepatology
Mitesh J. Borad, Li-Yuan Bai, Donald Richards, Kabir Mody, Joleen Hubbard, Sun Young Rha, John Soong, Daniel McCormick, Emmett Tse, Daniel O'Brien, Ahmad Bayat, Daniel Ahn, S. Lindsey Davis, Joon Oh Park, Do-Youn Oh
Summary: This study investigates the safety and efficacy of silmitasertib in combination with gemcitabine and cisplatin for the treatment of cholangiocarcinoma. The results show promising preliminary evidence of efficacy for the first-line treatment of locally advanced/metastatic cholangiocarcinoma.
Article
Hematology
Jakoba J. Eertink, Gerben J. C. Zwezerijnen, Sanne E. Wiegers, Simone Pieplenbosch, Martine E. D. Chamuleau, Pieternella J. Lugtenburg, Daphne de Jong, Bauke Ylstra, Matias Mendeville, Ulrich Duehrsen, Christine Hanoun, Andreas Huettmann, Julia Richter, Wolfram Klapper, Yvonne W. S. Jauw, Otto S. Hoekstra, Henrica C. W. de Vet, Ronald Boellaard, Josee M. Zijlstra
Summary: This study investigated whether combining clinical, molecular genotype, and radiomics features can improve the outcome prediction of patients with aggressive B-cell lymphoma. The results showed that adding radiomics features improved the model performance and positive predictive values, aiding in the identification of poor prognosis patients.
Article
Oncology
Sanne ten Hoorn, Linda Mol, Dirkje W. Sommeijer, Lisanne Nijman, Tom van den Bosch, Tim R. de Back, Bauke Ylstra, Erik van Dijk, Carel J. M. van Noesel, Roy J. Reinten, Iris D. Nagtegaal, Miriam Koopman, Cornelis J. A. Punt, Louis Vermeulen
Summary: We evaluated the potential efficacy of adding anti-EGFR therapy to anti-VEGF therapy in a subgroup of patients with metastatic colorectal cancer. The retrospective study (CAIRO2 trial, n = 736) showed no benefit of anti-EGFR addition within the subgroup, but an overall survival increase of 6.5 months compared to the original trial.
CLINICAL COLORECTAL CANCER
(2023)
Review
Oncology
Sun Young Rha, Hyun Cheol Chung
Summary: Gastric cancer is heterogeneous and can be characterized by HER2 overexpression and FGFR2 alterations. Combination therapy with fluoropyrimidine/platinum and trastuzumab has been approved as a standard treatment for HER2-positive patients. However, other agents have shown limited efficacy in first- and second-line treatments. Recent trials with HER2-directed treatment and immune checkpoint inhibitors have shown promising results. The management of HER2-positive gastric cancer requires further optimization to achieve precision medicine with a chemotherapeutic backbone.
JOURNAL OF GASTRIC CANCER
(2023)
Article
Gastroenterology & Hepatology
Maarten te Groen, Lauranne A. A. P. Derikx, Lisa van Lierop, Bauke Ylstra, Frank Hoentjen, Iris D. Nagtegaal, Femke Simmer
Summary: The presence of previous colorectal neoplasia is the most significant indicator for the development of pouch neoplasia in inflammatory bowel disease. However, the underlying mechanism remains unknown. Our study found evidence of clonality between colorectal and pouch neoplasia in 30% of patients, suggesting that most pouch neoplasia develops independently from prior colorectal lesions.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Anna Lena van Gulik, Ellen Sluydts, Liesbet Vervoort, Mark Kockx, Pim Kortman, Bauke Ylstra, Stephen P. Finn, Lukas Bubendorf, Idris Bahce, Daoud Sie, Teodora Radonic, Birgit Lissenberg-Witte, Erik Thunnissen
Summary: This study investigates the impact of cell size and ploidy on FISH results. The results show that in liver cell nuclei, the number of FISH signals increases with nuclear size and section thickness. In non-small cell lung cancer cases, tumor cells with higher ploidy levels and nuclear size have an increased chance of single signals. In addition, no rearrangements were found in lung cancer samples with borderline ALK FISH results, proving a false positive result.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Oncology
Chang Gon Kim, Minkyu Jung, Hyo Song Kim, Choong-kun Lee, Hei-Cheul Jeung, Dong-Hoe Koo, Woo Kyun Bae, Dae Young Zang, Bum Jun Kim, Hyunki Kim, Un-Jung Yun, Jingmin Che, Sejung Park, Tae Soo Kim, Woo Sun Kwon, Juin Park, Sang Woo Cho, Chung Mo Nam, Hyun Cheol Chung, Sun Young Rha
Summary: Trastuzumab combined with ramucirumab and paclitaxel showed appreciable efficacy with manageable safety profiles in patients with previously treated HER2-positive G/GEJ cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Pathology
Tanya T. D. Soeratram, Hedde D. Biesma, Jacqueline M. P. Egthuijsen, Elma Meershoek-Klein Kranenbarg, Henk H. Hartgrink, Cornelis J. H. van de Velde, Aart Mookhoek, Erik van Dijk, Yongsoo Kim, Bauke Ylstra, Hanneke W. M. van Laarhoven, Nicole C. T. van Grieken
Summary: Tumor-infiltrating lymphocytes are important for the survival of gastric cancer patients, and T-cell densities in different regions of the tumor can serve as prognostic markers. CD8OIM and FOXP3TC are identified as key factors for survival, and the combination of their densities can stratify patients into distinct subgroups with different prognosis. These immune subgroups are independent predictors for cancer-specific survival in resectable gastric cancer.
Article
Multidisciplinary Sciences
Margaretha G. M. Roemer, Tim van de Brug, Erik Bosch, Daniella Berry, Nathalie Hijmering, Phylicia Stathi, Karin Weijers, Jeannette Doorduijn, Jacoline Bromberg, Mark van de Wiel, Bauke Ylstra, Daphne de Jong, Yongsoo Kim
Summary: In order to understand the clinical relevance of the tumor microenvironment (TME), it is important to study the interactions between malignant and non-malignant cells in clinical samples. Researchers have developed a computational framework to comprehensively analyze the spatial context of the TME, including close and long-distance interactions between different cell types. This framework was applied to imaging data from 88 primary central nervous system lymphomas, revealing significant prognostic subgroups mainly determined by the spatial context. The results highlight the importance of spatial context in predicting patient survival, particularly in relation to macrophage infiltration near specific cell types.
Article
Health Care Sciences & Services
Si Won Lee, Jung Hye Kwon, Seung-hoon Beom, Sang Joon Shin, Hyo Song Kim, Sun Young Rha, Minkyu Jung, Joo Hyuk Sohn, Joong-Bae Ahn, Hyun Cheol Chung, Gun Min Kim, Hye Ryun Kim, Beodeul Kang, Youn Jung Hu, Hye Jin Choi
Summary: This study evaluated the first-year outcomes of patients admitted to an acute palliative care unit (APCU) at a tertiary hospital in Korea. The results showed that during their stay in the APCU, the overall symptoms of inpatients were reduced.
PALLIATIVE MEDICINE REPORTS
(2023)
Article
Oncology
Moonki Hong, Mingee Choi, JiHyun Lee, Kyoo Hyun Kim, Hyunwook Kim, Choong-Kun Lee, Hyo Song Kim, Sun Young Rha, Gyu Young Pih, Yoon Jin Choi, Da Hyun Jung, Jun Chul Park, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Jaeyong Shin, Minkyu Jung
Summary: The COVID-19 pandemic has led to a significant decrease in the overall number of gastric cancer diagnoses, with cases being diagnosed at more advanced stages, especially among men and patients aged 40 and older in 2021. Further studies are needed to explore the impact of the pandemic on global gastric cancer detection.
JOURNAL OF GASTRIC CANCER
(2023)
Article
Oncology
Andrew H. Ko, Kyu-Pyo Kim, Jens T. Siveke, Charles D. Lopez, Jill Lacy, Eileen M. O'Reilly, Teresa Macarulla, Gulam A. Manji, Jeeyun Lee, Jaffer Ajani, Maria Alsina Maqueda, Sun-Young Rha, Janet Lau, Nedal Al-Sakaff, Simon Allen, Danny Lu, Colby S. Shemesh, Xinxin Gan, Edward Cha, Do-Youn Oh
Summary: This study evaluated the efficacy and safety of the combination of atezolizumab and PEGylated recombinant human hyaluronidase in patients with advanced pancreatic ductal adenocarcinoma and gastric cancer. The results showed limited clinical activity of atezolizumab plus PEGPH20 in patients with pancreatic cancer and no significant effect in patients with gastric cancer. The safety profile of this combination was consistent with the known safety profiles of the individual agents.