Review
Biochemistry & Molecular Biology
Jun-Hyuk Han, Jooho Park, Tae-Bong Kang, Kwang-Ho Lee
Summary: Initially classified as an apoptotic caspase, caspase-8 has now been found to play significant roles in regulating inflammatory processes. Recent research has shown its involvement in modulating inflammatory responses, inflammasome activation, cell death, and cytokine induction. This review summarizes the latest advances in understanding how caspase-8 impacts inflammatory reactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sonal Mundhra, Vijay P. Bondre
Summary: The level of apoptosis induced by low neurovirulent WNV lineage 5 strain 804994 and high neurovirulent lineage 1 strain 68856 in human neuroblastoma cells, IMR-32, was investigated. The results show that the higher replication fitness of strain 68856 is correlated with higher levels of cytopathology induced by apoptosis. This suggests that the virulence of a WNV strain may be determined by its replication capacity and ability to cause cellular damage.
Article
Environmental Sciences
Shanshan Hou, Xiayu Zhang, Xiaofan Ning, Hao Wu, Xinyue Li, Kai Ma, Huifang Hao, Chunping Lv, Chunrui Li, Zhongjun Du, Haiying Du, Minghua Jin
Summary: This study explores the role of ROS-mediated PARP/AIF apoptosis signaling pathway in MeHg-induced cell death. The results suggest that increased levels of ROS and calcium ion, as well as the activation of caspase cascades and PARP, are involved in MeHg-induced apoptosis. The inhibition of ROS production can reduce the apoptosis rate. The PARP/AIF apoptotic pathway is independent of the caspase pathway and regulates it.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Neurosciences
Xiangjun Yang, Qun Zeng, Gulgun Tezel
Summary: This study investigated the importance of caspase-8 in different fates of glaucomatous RGCs and astroglia, revealing cell type-specific distinct processes that regulate caspase-8 functions in experimental glaucoma. Deletion of caspase-8 in astroglia protected RGCs against glia-driven inflammatory injury, while inhibition of caspase-8 cleavage inhibited apoptosis in RGCs themselves, suggesting the multi-target potential of caspase-8 regulation in providing neuroprotection and immunomodulation in glaucoma.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Genetics & Heredity
Shijun Yang, Caixia Tan, Xuerong Sun, Xiong Tang, Xiao Huang, Fan Yan, Guangxiang Zhu, Qin Wang
Summary: This study investigates the mechanisms of metamorphosis in the Chinese giant salamander, focusing on the role of caspase genes and the effect of thyroid hormone treatment. The results show that caspase genes play a key role in the loss of external gills, and thyroid hormone treatment can accelerate this process.
Article
Biochemistry & Molecular Biology
Vera Belousova, Oxana Svitich, Elena Timokhina, Irina Ignatko, Irina Bogomazova, Svetlana Pesegova, Tatiana Silaeva, Tatiana Kuzmina, Oxana Skorobogatova
Summary: This article presents the hypothesis that premature placenta apoptosis could be a potential cause of preterm birth, supported by evaluating gene expression. The study found that during pregnancy, the expression of apoptosis-related genes in the placenta is low, but the expression of the apoptosis inhibitor XIAP is high. However, at the onset of preterm labor, the expression of apoptosis-related genes increases significantly, potentially initiating preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Valeria Coppola, Ilaria Marino, Uwe Warnken, Mario Falchi, Luca Pasquini, Mauro Biffoni, Ruggero De Maria, Tobias Longin Haas
Summary: We have identified FYCO1 as a protein that promotes the transport of autophagic and endosomal vesicles. It interacts with activated CASP8 and its loss leads to increased sensitivity of cells to apoptosis and impaired transport of TNFRSF10B/TRAIL-R2/DR5.
Article
Biochemistry & Molecular Biology
Pei-Shan Wu, Chih-Yang Wang, Hao-Jen Hsu, Jui-Hung Yen, Ming-Jiuan Wu
Summary: The compound 8-hydroxydaidzein (8-OHD) has been found to inhibit cell proliferation and induce apoptosis in acute myeloid leukemia (AML) cells. It downregulates the expression of AML-associated genes and interacts with key proteins involved in cell proliferation. Furthermore, a synergistic effect is observed when 8-OHD is used in combination with cytarabine (Ara-C), a standard chemotherapy drug for AML.
Article
Biochemistry & Molecular Biology
Hongyan Sun, Naying Li, Jishuang Tan, Huan Li, Jibin Zhang, Lujiang Qu, Susan J. Lamont
Summary: This study found that overexpression of NFIB accelerates APEC-induced apoptosis and inflammation through up-regulation of RIP2 mediated downstream pathways in chicken HD11 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Mingxia Jiang, Ling Qi, Lisha Li, Yiming Wu, Dongfeng Song, Yanjing Li
Summary: Caspase-8 is a key player in cancer, involved in multiple programmed cell death modes and closely associated with tumor growth, invasion, therapeutic resistance, etc.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Veterinary Sciences
Wonchul Jung, Inkyu Yoo, Jisoo Han, Minjeong Kim, Soohyung Lee, Yugeong Cheon, Minsun Hong, Bo-Young Jeon, Hakhyun Ka
Summary: Research has shown that caspases are dynamically expressed in the endometrium throughout the estrous cycle and at the maternal-conceptus interface during pregnancy in pigs. The expression of CASP3, CASP6, and CASP7 changes in a stage-specific manner in the endometrium during different reproductive stages. Additionally, the expression of caspases in endometrial cells is influenced by steroid hormones and cytokines, suggesting that caspase action may play an important role in regulating endometrial and placental function in pigs during the implantation period.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Cell Biology
Rosario Yerbes, Rocio Mora-Molina, F. Javier Fernandez-Farran, Laura Hiraldo, Abelardo Lopez-Rivas, Carmen Palacios
Summary: This study reveals a previously unknown cell death mechanism triggered in glutamine-addicted tumor cells in response to glutamine metabolism limitation. The mechanism is regulated by GCN2 activation induced by glutamine starvation and involves the activation of the extrinsic apoptotic pathway mediated by TRAIL-R2.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Marie-Anais Locquet, Gabriel Ichim, Joseph Bisaccial, Aurelie Dutour, Serge Lebeque, Marie Castets, Kathrin Weber
Summary: In cancer cells, activation of TLR3 without Caspase-8 can trigger a new form of cell death that is distinct from classical apoptosis. This type of cell death is associated with lysosomal permeabilization, which occurs upstream of caspase activation and represents a default death mechanism in the absence of Caspase-8.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Alex Zohmachhuana, Malsawmdawngliana, F. Lalnunmawia, Vabeiryureilai Mathipi, K. Lalrinzuali, N. Senthil Kumar
Summary: The aim of this study was to evaluate the phytochemical content, antioxidant and anti-cancer activities of different parts of Curcuma aeruginosa Roxb. The methanol extracts from C. aeruginosa showed cytotoxicity against lung adenocarcinoma and cervical cancer cells, induced DNA damage, and up-regulated caspase activity. Additionally, bioactive compounds identified from the plant have been found to possess anti-cancer properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Madalena Chaves, Luis C. Gomes-Pereira, Jeremie Roux
Summary: This study developed a modeling approach utilizing single-cell response data to identify regulatory reactions driving population heterogeneity in drug response, providing potential regulatory targets to curb cell dynamics of drug resistance.
SCIENTIFIC REPORTS
(2021)